Drosophila melanogaster

91 known processes

gcl (Dmel_CG8411)

germ cell-less

(Aliases: Dmel\CG8411,CG8411,GCL,gcl-1)

gcl biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
pole cell development GO:0007277 26 0.977
cellularization GO:0007349 90 0.962
meiosis i GO:0007127 59 0.860
meiotic nuclear division GO:0007126 151 0.817
pole cell formation GO:0007279 19 0.790
negative regulation of cellular biosynthetic process GO:0031327 277 0.625
meiotic cell cycle GO:0051321 171 0.603
response to other organism GO:0051707 293 0.602
male meiosis GO:0007140 52 0.538
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.523
germ cell migration GO:0008354 43 0.515
response to external biotic stimulus GO:0043207 293 0.478
organelle assembly GO:0070925 198 0.459
organelle fission GO:0048285 340 0.453
negative regulation of biosynthetic process GO:0009890 277 0.383
cellular response to chemical stimulus GO:0070887 199 0.373
negative regulation of rna biosynthetic process GO:1902679 240 0.366
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.361
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.356
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.334
response to organic substance GO:0010033 284 0.323
taxis GO:0042330 304 0.321
response to bacterium GO:0009617 198 0.319
cellular component assembly involved in morphogenesis GO:0010927 151 0.299
organonitrogen compound metabolic process GO:1901564 318 0.284
organophosphate metabolic process GO:0019637 195 0.280
response to abiotic stimulus GO:0009628 341 0.273
response to biotic stimulus GO:0009607 294 0.272
nucleobase containing compound catabolic process GO:0034655 165 0.265
nucleoside triphosphate metabolic process GO:0009141 120 0.253
small molecule metabolic process GO:0044281 305 0.243
positive regulation of catalytic activity GO:0043085 118 0.232
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.224
response to lipopolysaccharide GO:0032496 4 0.224
purine ribonucleoside metabolic process GO:0046128 127 0.221
ribonucleotide metabolic process GO:0009259 145 0.221
purine containing compound catabolic process GO:0072523 112 0.221
negative regulation of cellular metabolic process GO:0031324 382 0.216
nucleoside phosphate metabolic process GO:0006753 162 0.204
dorsal appendage formation GO:0046843 47 0.202
histolysis GO:0007559 102 0.196
defense response to other organism GO:0098542 225 0.195
negative regulation of nucleic acid templated transcription GO:1903507 240 0.185
central nervous system development GO:0007417 201 0.183
regulation of localization GO:0032879 275 0.179
immune system process GO:0002376 347 0.177
positive regulation of rna biosynthetic process GO:1902680 266 0.174
purine nucleotide catabolic process GO:0006195 109 0.171
oocyte construction GO:0007308 112 0.169
positive regulation of macromolecule metabolic process GO:0010604 405 0.160
regulation of molecular function GO:0065009 217 0.158
eggshell formation GO:0030703 105 0.152
nucleotide catabolic process GO:0009166 109 0.152
death GO:0016265 284 0.150
regionalization GO:0003002 416 0.149
purine nucleoside catabolic process GO:0006152 112 0.148
forebrain development GO:0030900 2 0.147
female meiotic division GO:0007143 70 0.143
nuclear division GO:0000280 332 0.137
segmentation GO:0035282 207 0.132
localization of cell GO:0051674 257 0.128
negative regulation of rna metabolic process GO:0051253 251 0.126
regulation of response to stress GO:0080134 200 0.124
ribonucleoside catabolic process GO:0042454 112 0.123
purine ribonucleotide catabolic process GO:0009154 109 0.121
response to organic cyclic compound GO:0014070 89 0.120
cellular response to abiotic stimulus GO:0071214 58 0.120
purine nucleoside metabolic process GO:0042278 127 0.119
ribonucleoside triphosphate metabolic process GO:0009199 119 0.118
response to alcohol GO:0097305 95 0.118
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.116
ribonucleotide catabolic process GO:0009261 109 0.115
positive regulation of transcription dna templated GO:0045893 266 0.114
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.114
purine ribonucleotide metabolic process GO:0009150 145 0.113
gland development GO:0048732 191 0.113
chorion containing eggshell formation GO:0007304 105 0.113
axis specification GO:0009798 167 0.110
regulation of catalytic activity GO:0050790 185 0.109
protein localization GO:0008104 284 0.109
organonitrogen compound catabolic process GO:1901565 128 0.109
regulation of multicellular organismal development GO:2000026 414 0.108
fertilization GO:0009566 26 0.108
cellular response to organic cyclic compound GO:0071407 32 0.107
purine nucleoside triphosphate metabolic process GO:0009144 119 0.106
anterior posterior axis specification embryo GO:0008595 103 0.104
cell motility GO:0048870 251 0.104
nucleoside catabolic process GO:0009164 112 0.104
regulation of immune system process GO:0002682 176 0.103
response to oxygen containing compound GO:1901700 200 0.103
pole plasm protein localization GO:0007318 10 0.102
heterocycle catabolic process GO:0046700 166 0.101
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.101
aromatic compound catabolic process GO:0019439 166 0.099
response to temperature stimulus GO:0009266 106 0.099
positive regulation of nucleotide metabolic process GO:0045981 55 0.099
response to monosaccharide GO:0034284 4 0.099
regulation of cell differentiation GO:0045595 302 0.098
ribose phosphate metabolic process GO:0019693 145 0.095
detection of light stimulus GO:0009583 58 0.094
pole plasm assembly GO:0007315 61 0.093
purine nucleotide metabolic process GO:0006163 146 0.091
glycosyl compound catabolic process GO:1901658 112 0.089
protein modification process GO:0036211 438 0.089
open tracheal system development GO:0007424 204 0.088
cellular response to ketone GO:1901655 17 0.087
meiotic cell cycle process GO:1903046 132 0.086
pole plasm oskar mrna localization GO:0045451 46 0.085
developmental programmed cell death GO:0010623 138 0.083
nucleotide metabolic process GO:0009117 161 0.082
negative regulation of developmental process GO:0051093 201 0.082
transcription from rna polymerase ii promoter GO:0006366 368 0.081
cellular amino acid metabolic process GO:0006520 61 0.081
programmed cell death GO:0012501 257 0.079
thermotaxis GO:0043052 16 0.079
cell migration GO:0016477 238 0.078
positive regulation of biosynthetic process GO:0009891 316 0.077
glycosyl compound metabolic process GO:1901657 127 0.076
purine nucleoside triphosphate catabolic process GO:0009146 108 0.076
ribonucleoside triphosphate catabolic process GO:0009203 108 0.076
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.075
chemotaxis GO:0006935 249 0.075
catabolic process GO:0009056 409 0.074
response to inorganic substance GO:0010035 44 0.073
cuticle development GO:0042335 86 0.073
ribonucleoside metabolic process GO:0009119 127 0.073
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.073
blastoderm segmentation GO:0007350 159 0.073
positive regulation of catabolic process GO:0009896 105 0.072
oocyte axis specification GO:0007309 108 0.072
positive regulation of rna metabolic process GO:0051254 271 0.071
cell death GO:0008219 279 0.071
purine ribonucleoside catabolic process GO:0046130 112 0.070
positive regulation of gene expression GO:0010628 290 0.070
nucleobase containing small molecule metabolic process GO:0055086 174 0.063
carbohydrate derivative metabolic process GO:1901135 217 0.061
tripartite regional subdivision GO:0007351 103 0.060
immune response GO:0006955 246 0.059
oxoacid metabolic process GO:0043436 103 0.059
embryonic pattern specification GO:0009880 174 0.059
salivary gland histolysis GO:0035070 88 0.058
cellular response to organic substance GO:0071310 132 0.058
tissue death GO:0016271 102 0.058
cell maturation GO:0048469 144 0.057
respiratory system development GO:0060541 213 0.057
cellular response to oxygen containing compound GO:1901701 79 0.057
regulation of cellular catabolic process GO:0031329 157 0.057
guanosine containing compound catabolic process GO:1901069 74 0.056
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.056
phosphorylation GO:0016310 294 0.055
spindle organization GO:0007051 253 0.053
organic substance catabolic process GO:1901575 308 0.053
developmental maturation GO:0021700 172 0.052
nucleoside phosphate catabolic process GO:1901292 110 0.052
establishment of localization in cell GO:0051649 402 0.052
defense response GO:0006952 300 0.052
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.052
detection of external stimulus GO:0009581 66 0.051
oocyte anterior posterior axis specification GO:0007314 72 0.051
carboxylic acid metabolic process GO:0019752 92 0.051
positive regulation of purine nucleotide catabolic process GO:0033123 46 0.050
positive regulation of gtpase activity GO:0043547 43 0.049
gtp catabolic process GO:0006184 72 0.049
single organism behavior GO:0044708 391 0.048
single organism catabolic process GO:0044712 228 0.048
vesicle mediated transport GO:0016192 381 0.048
eggshell chorion assembly GO:0007306 66 0.048
protein ubiquitination GO:0016567 70 0.048
gtp metabolic process GO:0046039 72 0.048
spermatogenesis GO:0007283 200 0.048
endocytosis GO:0006897 310 0.047
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.047
oocyte development GO:0048599 124 0.047
negative regulation of signaling GO:0023057 219 0.047
embryonic axis specification GO:0000578 107 0.046
cellular nitrogen compound catabolic process GO:0044270 165 0.046
response to endogenous stimulus GO:0009719 119 0.046
regulation of catabolic process GO:0009894 170 0.046
positive regulation of nucleoside metabolic process GO:0045979 47 0.046
regulation of nucleoside metabolic process GO:0009118 50 0.046
mitotic spindle organization GO:0007052 220 0.046
positive regulation of nucleic acid templated transcription GO:1903508 266 0.046
organophosphate catabolic process GO:0046434 112 0.046
purine containing compound metabolic process GO:0072521 155 0.045
regulation of anatomical structure size GO:0090066 163 0.045
regulation of cellular component size GO:0032535 98 0.045
regulation of ras gtpase activity GO:0032318 38 0.045
single fertilization GO:0007338 24 0.043
response to light stimulus GO:0009416 124 0.043
cellular response to nutrient levels GO:0031669 62 0.043
regulation of hydrolase activity GO:0051336 97 0.043
microtubule polymerization or depolymerization GO:0031109 39 0.043
spermatid development GO:0007286 98 0.042
regulation of cellular protein metabolic process GO:0032268 243 0.042
telencephalon development GO:0021537 2 0.042
positive regulation of purine nucleotide metabolic process GO:1900544 55 0.042
positive regulation of cellular catabolic process GO:0031331 95 0.042
regulation of purine nucleotide catabolic process GO:0033121 48 0.041
organic cyclic compound catabolic process GO:1901361 168 0.041
small gtpase mediated signal transduction GO:0007264 88 0.041
response to ketone GO:1901654 34 0.041
cellular response to extracellular stimulus GO:0031668 64 0.041
detection of abiotic stimulus GO:0009582 66 0.040
cellular catabolic process GO:0044248 372 0.040
regulation of nucleotide catabolic process GO:0030811 48 0.040
positive regulation of protein metabolic process GO:0051247 128 0.040
peptidyl amino acid modification GO:0018193 105 0.039
growth GO:0040007 359 0.039
meiotic chromosome segregation GO:0045132 59 0.039
regulation of cellular component biogenesis GO:0044087 201 0.039
anterior posterior axis specification GO:0009948 109 0.038
cellular response to lipid GO:0071396 20 0.038
positive regulation of molecular function GO:0044093 136 0.037
secretion GO:0046903 109 0.037
negative regulation of transcription dna templated GO:0045892 237 0.037
defense response to gram negative bacterium GO:0050829 94 0.037
response to lipid GO:0033993 38 0.037
regulation of transport GO:0051049 181 0.037
microtubule depolymerization GO:0007019 25 0.036
transmembrane transport GO:0055085 139 0.036
positive regulation of cellular protein metabolic process GO:0032270 118 0.036
brain development GO:0007420 120 0.035
rho protein signal transduction GO:0007266 14 0.035
anterior posterior pattern specification GO:0009952 136 0.035
innate immune response GO:0045087 144 0.035
defense response to bacterium GO:0042742 178 0.034
protein modification by small protein conjugation or removal GO:0070647 106 0.034
larval development GO:0002164 104 0.034
monocarboxylic acid metabolic process GO:0032787 29 0.033
cellular ketone metabolic process GO:0042180 24 0.033
nucleoside metabolic process GO:0009116 127 0.033
response to hexose GO:0009746 3 0.033
ras protein signal transduction GO:0007265 88 0.033
carbohydrate derivative catabolic process GO:1901136 118 0.033
regulation of tor signaling GO:0032006 21 0.032
muscle cell development GO:0055001 50 0.032
regulation of gtp catabolic process GO:0033124 44 0.032
regulation of purine nucleotide metabolic process GO:1900542 62 0.032
oocyte differentiation GO:0009994 145 0.031
biological adhesion GO:0022610 138 0.031
neuron projection guidance GO:0097485 241 0.031
salivary gland development GO:0007431 162 0.031
epithelial cell development GO:0002064 274 0.031
sarcomere organization GO:0045214 26 0.031
positive regulation of cellular biosynthetic process GO:0031328 316 0.030
detection of stimulus GO:0051606 156 0.030
cytoplasm organization GO:0007028 64 0.030
regulation of vesicle mediated transport GO:0060627 59 0.029
positive regulation of nucleotide catabolic process GO:0030813 46 0.029
eye photoreceptor cell development GO:0042462 81 0.029
synapse organization GO:0050808 196 0.028
cell division GO:0051301 248 0.028
organic acid metabolic process GO:0006082 103 0.028
regulation of nucleotide metabolic process GO:0006140 62 0.028
regulation of embryonic development GO:0045995 68 0.028
negative regulation of cell communication GO:0010648 223 0.028
response to nitrogen compound GO:1901698 90 0.027
intracellular transport GO:0046907 228 0.027
response to oxidative stress GO:0006979 86 0.027
dna recombination GO:0006310 32 0.027
establishment of tissue polarity GO:0007164 87 0.027
embryo development ending in birth or egg hatching GO:0009792 152 0.027
positive regulation of ras gtpase activity GO:0032320 36 0.027
gene silencing GO:0016458 138 0.027
pole plasm rna localization GO:0007316 52 0.027
regulation of pole plasm oskar mrna localization GO:0007317 27 0.026
purine ribonucleoside monophosphate metabolic process GO:0009167 50 0.026
intracellular signal transduction GO:0035556 300 0.026
dendrite morphogenesis GO:0048813 199 0.026
stem cell differentiation GO:0048863 117 0.025
muscle cell differentiation GO:0042692 103 0.025
regulation of gene silencing GO:0060968 63 0.025
regulation of cellular amino acid metabolic process GO:0006521 0 0.025
response to organonitrogen compound GO:0010243 75 0.025
synapse assembly GO:0007416 143 0.025
guanosine containing compound metabolic process GO:1901068 74 0.025
cellular protein modification process GO:0006464 438 0.025
eye morphogenesis GO:0048592 260 0.025
female meiosis chromosome segregation GO:0016321 33 0.025
nucleoside triphosphate catabolic process GO:0009143 108 0.025
cardiovascular system development GO:0072358 82 0.025
positive regulation of immune system process GO:0002684 68 0.024
response to radiation GO:0009314 155 0.024
synaptic transmission GO:0007268 288 0.024
organic substance transport GO:0071702 257 0.024
neurological system process GO:0050877 358 0.024
autophagic cell death GO:0048102 83 0.024
male gamete generation GO:0048232 201 0.024
axonogenesis GO:0007409 290 0.023
establishment or maintenance of bipolar cell polarity GO:0061245 34 0.023
regulation of organ morphogenesis GO:2000027 78 0.023
positive regulation of multicellular organismal process GO:0051240 143 0.023
response to wounding GO:0009611 94 0.022
regulation of small gtpase mediated signal transduction GO:0051056 93 0.022
sensory organ morphogenesis GO:0090596 260 0.022
humoral immune response GO:0006959 117 0.022
female meiosis i GO:0007144 8 0.022
oocyte microtubule cytoskeleton organization GO:0016325 35 0.021
striated muscle cell differentiation GO:0051146 90 0.021
regulation of phosphorus metabolic process GO:0051174 210 0.021
striated muscle cell development GO:0055002 50 0.021
cellular response to external stimulus GO:0071496 66 0.021
connective tissue development GO:0061448 3 0.021
gland morphogenesis GO:0022612 145 0.021
appendage morphogenesis GO:0035107 397 0.021
positive regulation of hydrolase activity GO:0051345 78 0.020
cellular response to radiation GO:0071478 52 0.020
asymmetric cell division GO:0008356 37 0.020
regulation of secretion GO:0051046 44 0.020
regulation of cellular localization GO:0060341 136 0.020
axon guidance GO:0007411 233 0.019
salivary gland cell autophagic cell death GO:0035071 83 0.019
neural precursor cell proliferation GO:0061351 75 0.019
single organism biosynthetic process GO:0044711 206 0.019
cell adhesion GO:0007155 136 0.019
negative regulation of immune response GO:0050777 39 0.019
muscle structure development GO:0061061 224 0.019
positive regulation of phosphorus metabolic process GO:0010562 139 0.019
response to glucose GO:0009749 2 0.019
positive regulation of cell differentiation GO:0045597 64 0.019
negative regulation of cellular component organization GO:0051129 108 0.018
positive regulation of phosphate metabolic process GO:0045937 139 0.018
regulation of cellular amine metabolic process GO:0033238 3 0.018
somatic muscle development GO:0007525 66 0.018
chromosome segregation GO:0007059 157 0.018
muscle fiber development GO:0048747 12 0.018
regulation of synapse assembly GO:0051963 94 0.017
homeostatic process GO:0042592 199 0.017
inter male aggressive behavior GO:0002121 60 0.017
reproductive structure development GO:0048608 74 0.017
regulation of secretion by cell GO:1903530 39 0.017
columnar cuboidal epithelial cell development GO:0002066 249 0.017
exocrine system development GO:0035272 162 0.017
regulation of protein localization GO:0032880 76 0.017
positive regulation of developmental process GO:0051094 143 0.016
positive regulation of response to stimulus GO:0048584 323 0.016
regulation of nervous system development GO:0051960 248 0.016
chromatin remodeling GO:0006338 72 0.016
ovarian follicle cell development GO:0030707 248 0.016
regulation of growth GO:0040008 233 0.016
sperm individualization GO:0007291 48 0.016
pole plasm mrna localization GO:0019094 49 0.016
wing disc morphogenesis GO:0007472 344 0.016
regulation of ras protein signal transduction GO:0046578 93 0.015
chaeta development GO:0022416 97 0.015
maternal determination of anterior posterior axis embryo GO:0008358 74 0.015
camera type eye development GO:0043010 4 0.015
cellular response to endogenous stimulus GO:0071495 80 0.015
negative regulation of translation GO:0017148 28 0.015
salivary gland morphogenesis GO:0007435 145 0.015
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.015
aggressive behavior GO:0002118 63 0.015
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 65 0.015
compound eye photoreceptor development GO:0042051 78 0.015
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.015
regulation of immune response GO:0050776 118 0.015
lipid homeostasis GO:0055088 33 0.015
nitrogen compound transport GO:0071705 85 0.015
regulation of protein metabolic process GO:0051246 256 0.015
synaptic growth at neuromuscular junction GO:0051124 119 0.015
protein polymerization GO:0051258 42 0.014
secretion by cell GO:0032940 101 0.014
negative regulation of gene expression epigenetic GO:0045814 77 0.014
regulation of cell cycle GO:0051726 291 0.014
cellular macromolecule localization GO:0070727 220 0.014
cellular response to molecule of bacterial origin GO:0071219 3 0.014
compound eye morphogenesis GO:0001745 249 0.014
cellular response to ethanol GO:0071361 4 0.014
cellular response to biotic stimulus GO:0071216 4 0.014
chromatin modification GO:0016568 147 0.014
compound eye development GO:0048749 307 0.013
regulation of defense response GO:0031347 102 0.013
regulation of heart contraction GO:0008016 21 0.013
actomyosin structure organization GO:0031032 56 0.013
protein modification by small protein conjugation GO:0032446 79 0.013
cellular response to oxidative stress GO:0034599 28 0.013
response to extracellular stimulus GO:0009991 116 0.013
gene silencing by mirna GO:0035195 22 0.013
negative regulation of protein metabolic process GO:0051248 85 0.013
regulation of developmental growth GO:0048638 174 0.013
photoreceptor cell development GO:0042461 96 0.013
oocyte localization involved in germarium derived egg chamber formation GO:0030720 12 0.013
atp metabolic process GO:0046034 49 0.012
imaginal disc pattern formation GO:0007447 91 0.012
organonitrogen compound biosynthetic process GO:1901566 117 0.012
rna localization GO:0006403 115 0.012
myotube cell development GO:0014904 3 0.012
epithelial cell differentiation GO:0030855 322 0.012
stem cell development GO:0048864 79 0.012
compound eye photoreceptor cell differentiation GO:0001751 140 0.012
reproductive system development GO:0061458 74 0.012
negative regulation of cell proliferation GO:0008285 69 0.012
apoptotic process GO:0006915 159 0.012
cellular protein complex assembly GO:0043623 71 0.012
cell aging GO:0007569 2 0.012
eye development GO:0001654 323 0.012
cellular response to dna damage stimulus GO:0006974 223 0.012
signal transduction in response to dna damage GO:0042770 3 0.012
heart contraction GO:0060047 26 0.012
circulatory system development GO:0072359 82 0.011
mrna catabolic process GO:0006402 33 0.011
single organism intracellular transport GO:1902582 207 0.011
egg activation GO:0007343 9 0.011
myofibril assembly GO:0030239 36 0.011
cellular homeostasis GO:0019725 80 0.011
regulation of cell morphogenesis GO:0022604 163 0.011
chitin based cuticle development GO:0040003 49 0.011
regulation of cell cycle process GO:0010564 181 0.011
cellular response to nitrogen compound GO:1901699 51 0.011
appendage development GO:0048736 401 0.011
negative regulation of gene expression GO:0010629 387 0.011
meiosis ii GO:0007135 23 0.010
immune response activating signal transduction GO:0002757 2 0.010
regulation of innate immune response GO:0045088 71 0.010
tor signaling GO:0031929 32 0.010
positive regulation of immune response GO:0050778 63 0.010
developmental growth GO:0048589 280 0.010
regulation of rho protein signal transduction GO:0035023 20 0.010
actin filament based process GO:0030029 220 0.010
atp catabolic process GO:0006200 38 0.010
aging GO:0007568 143 0.010
response to reactive oxygen species GO:0000302 24 0.010
microtubule polymerization GO:0046785 15 0.010
positive regulation of protein modification process GO:0031401 58 0.010
circadian rhythm GO:0007623 105 0.010
nucleoside monophosphate catabolic process GO:0009125 39 0.010

gcl disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.017
disease of anatomical entity DOID:7 0 0.013
cancer DOID:162 0 0.011