Drosophila melanogaster

42 known processes

Cg25C (Dmel_CG4145)

Collagen type IV

(Aliases: Dcg1,DCg1,gp125,Coll IV,Cgc25,CG4145,alpha(IV)1/Cg25C,Cgc25C,CG25C,Coll,Dmel\CG4145,alpha1,Dcg,CT12803)

Cg25C biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
anterior malpighian tubule development GO:0061327 12 0.984
Fly
extracellular structure organization GO:0043062 46 0.942
Human Mouse Worm
striated muscle cell differentiation GO:0051146 90 0.876
muscle attachment GO:0016203 36 0.772
actin filament based process GO:0030029 220 0.700
positive regulation of protein secretion GO:0050714 9 0.652
Worm
striated muscle cell development GO:0055002 50 0.562
kidney development GO:0001822 3 0.559
Human Mouse
regulation of developmental growth GO:0048638 174 0.526
Worm
positive regulation of developmental growth GO:0048639 62 0.507
Worm
response to abiotic stimulus GO:0009628 341 0.440
skeletal muscle organ development GO:0060538 48 0.372
Fly
growth GO:0040007 359 0.371
Worm
camera type eye development GO:0043010 4 0.365
Human
cell substrate adhesion GO:0031589 10 0.363
tube development GO:0035295 244 0.347
imaginal disc derived wing morphogenesis GO:0007476 337 0.340
connective tissue development GO:0061448 3 0.319
positive regulation of developmental process GO:0051094 143 0.316
Worm
basement membrane organization GO:0071711 10 0.306
Human
muscle cell development GO:0055001 50 0.299
appendage morphogenesis GO:0035107 397 0.297
cellular response to growth factor stimulus GO:0071363 30 0.287
Mouse
developmental growth GO:0048589 280 0.284
Worm
wing disc morphogenesis GO:0007472 344 0.283
positive regulation of growth GO:0045927 75 0.277
Worm
circulatory system development GO:0072359 82 0.276
vesicle mediated transport GO:0016192 381 0.255
Worm
imaginal disc derived appendage development GO:0048737 399 0.244
synapse organization GO:0050808 196 0.230
Mouse
muscle cell differentiation GO:0042692 103 0.221
positive regulation of multicellular organism growth GO:0040018 21 0.218
Worm
regulation of protein secretion GO:0050708 13 0.210
Worm
substrate adhesion dependent cell spreading GO:0034446 2 0.208
cellular response to organic substance GO:0071310 132 0.205
Mouse
extracellular matrix organization GO:0030198 32 0.203
Human Mouse Worm
renal tubule development GO:0061326 64 0.202
Human Fly
regulation of neurogenesis GO:0050767 158 0.189
imaginal disc derived appendage morphogenesis GO:0035114 395 0.188
regulation of anatomical structure morphogenesis GO:0022603 242 0.179
Human Mouse
antimicrobial humoral response GO:0019730 99 0.171
body morphogenesis GO:0010171 2 0.169
protein complex biogenesis GO:0070271 201 0.165
multi organism reproductive behavior GO:0044705 121 0.158
tissue morphogenesis GO:0048729 297 0.155
Human Fly
muscle organ development GO:0007517 127 0.154
Worm Fly
chemotaxis GO:0006935 249 0.154
negative regulation of multicellular organismal process GO:0051241 142 0.153
Human Mouse
cell migration GO:0016477 238 0.150
Worm
regulation of multicellular organismal development GO:2000026 414 0.140
Human Mouse
regulation of cell development GO:0060284 215 0.137
endocytosis GO:0006897 310 0.135
Worm
reproductive behavior GO:0019098 122 0.134
actin cytoskeleton organization GO:0030036 206 0.134
response to growth factor GO:0070848 31 0.131
Mouse
response to endogenous stimulus GO:0009719 119 0.125
Mouse
immune response GO:0006955 246 0.123
heart development GO:0007507 82 0.120
actomyosin structure organization GO:0031032 56 0.119
cellular response to chemical stimulus GO:0070887 199 0.118
Mouse
heart process GO:0003015 37 0.117
muscle structure development GO:0061061 224 0.114
malpighian tubule morphogenesis GO:0007443 44 0.108
Fly
reproductive structure development GO:0048608 74 0.102
cellular response to acid chemical GO:0071229 8 0.097
Mouse
regulation of epithelial cell proliferation GO:0050678 4 0.096
neuron projection guidance GO:0097485 241 0.095
detection of external stimulus GO:0009581 66 0.094
regulation of neuron projection development GO:0010975 69 0.094
retina development in camera type eye GO:0060041 4 0.091
Human
extracellular matrix assembly GO:0085029 13 0.091
neuromuscular junction development GO:0007528 149 0.088
Mouse
muscle tissue morphogenesis GO:0060415 2 0.087
response to acid chemical GO:0001101 25 0.085
Mouse
urogenital system development GO:0001655 72 0.081
Human Mouse Fly
cellular protein complex assembly GO:0043623 71 0.079
humoral immune response GO:0006959 117 0.079
taxis GO:0042330 304 0.077
ion transport GO:0006811 145 0.077
striated muscle myosin thick filament assembly GO:0071688 3 0.074
peptidyl amino acid modification GO:0018193 105 0.074
determination of adult lifespan GO:0008340 137 0.074
cellular response to amino acid stimulus GO:0071230 6 0.074
Mouse
regulation of catalytic activity GO:0050790 185 0.072
cellular response to endogenous stimulus GO:0071495 80 0.071
Mouse
detection of visible light GO:0009584 38 0.067
cellular amine metabolic process GO:0044106 12 0.065
regulation of growth GO:0040008 233 0.065
Worm
appendage development GO:0048736 401 0.063
eye morphogenesis GO:0048592 260 0.063
actin filament organization GO:0007015 126 0.063
sensory organ morphogenesis GO:0090596 260 0.062
ion transmembrane transport GO:0034220 122 0.061
heart contraction GO:0060047 26 0.061
circadian rhythm GO:0007623 105 0.060
chromosome segregation GO:0007059 157 0.059
small molecule metabolic process GO:0044281 305 0.058
muscle tissue development GO:0060537 30 0.058
organ growth GO:0035265 56 0.058
cellular catabolic process GO:0044248 372 0.057
regulation of molecular function GO:0065009 217 0.057
cell motility GO:0048870 251 0.056
Worm
detection of light stimulus GO:0009583 58 0.056
mesenchymal cell differentiation GO:0048762 1 0.055
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.055
axon guidance GO:0007411 233 0.055
regulation of multicellular organism growth GO:0040014 40 0.055
Worm
macromolecular complex assembly GO:0065003 256 0.055
striated muscle tissue development GO:0014706 27 0.054
response to biotic stimulus GO:0009607 294 0.054
digestive tract development GO:0048565 149 0.053
Human Fly
single organism catabolic process GO:0044712 228 0.053
response to light stimulus GO:0009416 124 0.051
protein complex assembly GO:0006461 200 0.051
positive regulation of protein transport GO:0051222 37 0.049
Worm
circadian sleep wake cycle GO:0042745 28 0.049
epidermis development GO:0008544 65 0.047
digestive tract morphogenesis GO:0048546 127 0.046
Human Fly
skeletal muscle fiber development GO:0048741 3 0.046
regulation of hydrolase activity GO:0051336 97 0.046
defense response GO:0006952 300 0.046
multicellular organismal reproductive behavior GO:0033057 110 0.045
positive regulation of phosphate metabolic process GO:0045937 139 0.044
renal tubule morphogenesis GO:0061333 44 0.044
Human Fly
positive regulation of secretion by cell GO:1903532 20 0.043
Worm
optokinetic behavior GO:0007634 3 0.042
endomembrane system organization GO:0010256 119 0.042
response to wounding GO:0009611 94 0.042
post embryonic appendage morphogenesis GO:0035120 385 0.042
response to radiation GO:0009314 155 0.041
organonitrogen compound metabolic process GO:1901564 318 0.041
response to hypoxia GO:0001666 53 0.041
phagocytosis GO:0006909 215 0.041
nucleobase containing small molecule metabolic process GO:0055086 174 0.040
cellular component assembly involved in morphogenesis GO:0010927 151 0.040
regulation of cellular catabolic process GO:0031329 157 0.040
response to hexose GO:0009746 3 0.039
cell cycle arrest GO:0007050 4 0.038
amine metabolic process GO:0009308 12 0.038
mesoderm development GO:0007498 78 0.038
skeletal muscle tissue development GO:0007519 13 0.037
Fly
detection of abiotic stimulus GO:0009582 66 0.037
cell adhesion mediated by integrin GO:0033627 12 0.036
mesenchymal cell development GO:0014031 1 0.036
organelle assembly GO:0070925 198 0.036
axon development GO:0061564 297 0.036
multi multicellular organism process GO:0044706 123 0.036
cell proliferation GO:0008283 299 0.036
metal ion transport GO:0030001 74 0.035
cellular response to organonitrogen compound GO:0071417 36 0.035
Mouse
nucleoside metabolic process GO:0009116 127 0.035
myofibril assembly GO:0030239 36 0.035
axonogenesis GO:0007409 290 0.034
response to organic cyclic compound GO:0014070 89 0.034
cellular macromolecular complex assembly GO:0034622 153 0.034
reactive oxygen species metabolic process GO:0072593 22 0.034
positive regulation of multicellular organismal process GO:0051240 143 0.033
Worm
response to metal ion GO:0010038 23 0.033
establishment of localization in cell GO:0051649 402 0.033
Worm
defense response to gram negative bacterium GO:0050829 94 0.033
embryonic organ development GO:0048568 50 0.033
regulation of multi organism process GO:0043900 131 0.032
tube morphogenesis GO:0035239 191 0.032
purine nucleotide metabolic process GO:0006163 146 0.032
heterotypic cell cell adhesion GO:0034113 1 0.031
ribonucleotide metabolic process GO:0009259 145 0.030
regulation of heart contraction GO:0008016 21 0.030
response to nitrogen compound GO:1901698 90 0.029
Mouse
positive regulation of molecular function GO:0044093 136 0.029
gland development GO:0048732 191 0.029
regulation of cell adhesion GO:0030155 27 0.029
regulation of actin filament based process GO:0032970 42 0.028
sensory perception of pain GO:0019233 4 0.028
secretion GO:0046903 109 0.028
Worm
regulation of protein transport GO:0051223 57 0.028
Worm
sarcomere organization GO:0045214 26 0.028
cellular response to nitrogen compound GO:1901699 51 0.028
Mouse
regulation of neuron differentiation GO:0045664 103 0.028
torso signaling pathway GO:0008293 21 0.027
nuclear division GO:0000280 332 0.027
regulation of reproductive process GO:2000241 54 0.027
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.026
regulation of locomotion GO:0040012 42 0.026
positive regulation of rna biosynthetic process GO:1902680 266 0.026
atp metabolic process GO:0046034 49 0.026
response to decreased oxygen levels GO:0036293 58 0.026
regulation of nervous system development GO:0051960 248 0.026
carboxylic acid metabolic process GO:0019752 92 0.025
negative regulation of developmental process GO:0051093 201 0.025
Human Mouse
detection of light stimulus involved in sensory perception GO:0050962 9 0.025
regulation of transport GO:0051049 181 0.025
Worm
response to lipopolysaccharide GO:0032496 4 0.025
multi organism behavior GO:0051705 175 0.025
lipid storage GO:0019915 38 0.025
sensory perception GO:0007600 196 0.025
regulation of cytoskeleton organization GO:0051493 89 0.024
regulation of organelle organization GO:0033043 196 0.024
hindgut morphogenesis GO:0007442 58 0.024
Fly
response to organophosphorus GO:0046683 2 0.024
terminal region determination GO:0007362 25 0.024
positive regulation of signaling GO:0023056 243 0.024
positive regulation of biosynthetic process GO:0009891 316 0.024
response to anesthetic GO:0072347 9 0.024
extrinsic apoptotic signaling pathway GO:0097191 1 0.024
organic substance catabolic process GO:1901575 308 0.024
oviposition GO:0018991 19 0.024
purine containing compound metabolic process GO:0072521 155 0.024
digestive system development GO:0055123 149 0.023
Human Fly
positive regulation of signal transduction GO:0009967 223 0.023
protein modification process GO:0036211 438 0.023
cell adhesion GO:0007155 136 0.023
myotube cell development GO:0014904 3 0.023
proteolysis GO:0006508 192 0.023
embryo development ending in birth or egg hatching GO:0009792 152 0.023
Worm
regulation of cellular localization GO:0060341 136 0.023
Worm
positive regulation of catalytic activity GO:0043085 118 0.023
homeostatic process GO:0042592 199 0.023
tripartite regional subdivision GO:0007351 103 0.022
actin filament based movement GO:0030048 26 0.022
secondary metabolic process GO:0019748 75 0.022
response to other organism GO:0051707 293 0.022
positive regulation of cellular amine metabolic process GO:0033240 0 0.022
gene silencing GO:0016458 138 0.022
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 4 0.021
spermatogenesis GO:0007283 200 0.021
regulation of secretion GO:0051046 44 0.021
Worm
motor neuron axon guidance GO:0008045 58 0.021
eye development GO:0001654 323 0.021
Human
cellular response to transforming growth factor beta stimulus GO:0071560 18 0.020
Mouse
defense response to bacterium GO:0042742 178 0.020
regulation of cell substrate adhesion GO:0010810 2 0.020
positive regulation of cellular amide metabolic process GO:0034250 26 0.020
cellular homeostasis GO:0019725 80 0.020
determination of muscle attachment site GO:0016204 7 0.020
axonal defasciculation GO:0007414 12 0.019
ribose phosphate metabolic process GO:0019693 145 0.019
glycosyl compound catabolic process GO:1901658 112 0.019
larval development GO:0002164 104 0.019
Worm
cell junction organization GO:0034330 57 0.019
positive regulation of intracellular signal transduction GO:1902533 116 0.019
regionalization GO:0003002 416 0.019
negative regulation of epithelial cell proliferation GO:0050680 4 0.019
heart morphogenesis GO:0003007 32 0.019
chemical homeostasis GO:0048878 92 0.019
innate immune response GO:0045087 144 0.019
positive regulation of defense response GO:0031349 59 0.019
purine ribonucleotide metabolic process GO:0009150 145 0.019
organic substance transport GO:0071702 257 0.018
Worm
immune system process GO:0002376 347 0.018
response to inorganic substance GO:0010035 44 0.018
hematopoietic or lymphoid organ development GO:0048534 57 0.018
regulation of circadian rhythm GO:0042752 49 0.018
regulation of cell projection organization GO:0031344 92 0.018
regulation of mitotic cell cycle phase transition GO:1901990 130 0.018
regulation of protein metabolic process GO:0051246 256 0.018
purine ribonucleoside metabolic process GO:0046128 127 0.017
neurological system process GO:0050877 358 0.017
microtubule organizing center organization GO:0031023 168 0.017
positive regulation of transport GO:0051050 92 0.017
Worm
protein depolymerization GO:0051261 31 0.017
extracellular matrix disassembly GO:0022617 4 0.017
regulation of actin cytoskeleton organization GO:0032956 42 0.017
cellular ketone metabolic process GO:0042180 24 0.017
positive regulation of secretion GO:0051047 22 0.017
Worm
response to alcohol GO:0097305 95 0.017
regulation of synapse assembly GO:0051963 94 0.017
cellular protein modification process GO:0006464 438 0.016
positive regulation of programmed cell death GO:0043068 62 0.016
response to oxygen levels GO:0070482 59 0.016
neuroblast fate determination GO:0007400 12 0.016
regulation of dendrite morphogenesis GO:0048814 28 0.016
muscle organ morphogenesis GO:0048644 7 0.016
positive regulation of mapk cascade GO:0043410 63 0.016
protein polymerization GO:0051258 42 0.016
response to ecdysone GO:0035075 34 0.016
catabolic process GO:0009056 409 0.016
enzyme linked receptor protein signaling pathway GO:0007167 179 0.016
imaginal disc derived wing margin morphogenesis GO:0008587 41 0.016
neurotransmitter metabolic process GO:0042133 2 0.015
ribonucleoside metabolic process GO:0009119 127 0.015
single organism cell adhesion GO:0098602 47 0.015
oxoacid metabolic process GO:0043436 103 0.015
regulation of establishment of protein localization GO:0070201 61 0.015
Worm
signal transduction by phosphorylation GO:0023014 107 0.015
positive regulation of cell death GO:0010942 69 0.015
actin filament polymerization GO:0030041 27 0.015
regulation of cellular component biogenesis GO:0044087 201 0.015
phototaxis GO:0042331 21 0.015
regulation of cellular amino acid metabolic process GO:0006521 0 0.015
regulation of stem cell differentiation GO:2000736 14 0.015
neuron recognition GO:0008038 101 0.015
regulation of cell morphogenesis involved in differentiation GO:0010769 61 0.015
positive regulation of cell motility GO:2000147 3 0.015
regulation of cardioblast differentiation GO:0051890 9 0.014
production of molecular mediator of immune response GO:0002440 46 0.014
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.014
regulation of localization GO:0032879 275 0.014
Worm
larval somatic muscle development GO:0007526 19 0.014
positive regulation of nucleotide catabolic process GO:0030813 46 0.014
regulation of cell morphogenesis GO:0022604 163 0.014
anatomical structure homeostasis GO:0060249 97 0.014
embryonic morphogenesis GO:0048598 206 0.014
Human Fly
response to organic substance GO:0010033 284 0.014
Mouse
male gamete generation GO:0048232 201 0.014
plasma membrane organization GO:0007009 26 0.014
nucleoside catabolic process GO:0009164 112 0.014
positive regulation of protein import into nucleus GO:0042307 21 0.013
positive regulation of cell proliferation GO:0008284 47 0.013
cell division GO:0051301 248 0.013
positive regulation of cellular component biogenesis GO:0044089 80 0.013
zygotic determination of anterior posterior axis embryo GO:0007354 27 0.013
response to sterol GO:0036314 34 0.013
action potential GO:0001508 13 0.013
protein catabolic process GO:0030163 101 0.013
negative regulation of cell differentiation GO:0045596 143 0.013
divalent metal ion transport GO:0070838 26 0.013
macromolecule catabolic process GO:0009057 161 0.013
mitotic nuclear division GO:0007067 213 0.013
regulation of cellular amine metabolic process GO:0033238 3 0.013
positive regulation of hydrolase activity GO:0051345 78 0.013
establishment of protein localization GO:0045184 163 0.013
Worm
kidney epithelium development GO:0072073 3 0.013
response to calcium ion GO:0051592 1 0.013
cellular biogenic amine catabolic process GO:0042402 1 0.013
regulation of response to external stimulus GO:0032101 115 0.013
development of primary sexual characteristics GO:0045137 50 0.013
renal system process GO:0003014 12 0.013
multicellular organismal metabolic process GO:0044236 1 0.012
epithelial to mesenchymal transition GO:0001837 1 0.012
ribonucleoside triphosphate metabolic process GO:0009199 119 0.012
intracellular transport GO:0046907 228 0.012
dna metabolic process GO:0006259 227 0.012
negative regulation of nervous system development GO:0051961 92 0.012
cell cycle phase transition GO:0044770 140 0.012
regulation of cellular protein metabolic process GO:0032268 243 0.012
regulation of extracellular matrix organization GO:1903053 4 0.012
ribonucleoside triphosphate biosynthetic process GO:0009201 2 0.012
positive regulation of rna metabolic process GO:0051254 271 0.012
regulation of mitotic cell cycle GO:0007346 190 0.012
cellular component disassembly GO:0022411 46 0.012
lymph gland development GO:0048542 28 0.012
peripheral nervous system development GO:0007422 52 0.012
positive regulation of response to stimulus GO:0048584 323 0.012
cell cell adhesion mediated by integrin GO:0033631 1 0.012
positive regulation of stem cell differentiation GO:2000738 3 0.011
protein localization GO:0008104 284 0.011
Worm
cardiac muscle cell development GO:0055013 3 0.011
organic cyclic compound catabolic process GO:1901361 168 0.011
gliogenesis GO:0042063 80 0.011
monocarboxylic acid transport GO:0015718 3 0.011
ribonucleoside catabolic process GO:0042454 112 0.011
lateral inhibition GO:0046331 206 0.011
actin mediated cell contraction GO:0070252 21 0.011
regulation of cell division GO:0051302 72 0.011
ventral cord development GO:0007419 16 0.011
photoreceptor cell differentiation GO:0046530 170 0.011
biological adhesion GO:0022610 138 0.011
hematopoietic progenitor cell differentiation GO:0002244 1 0.011
morphogenesis of an epithelium GO:0002009 276 0.011
Human Fly
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.011
maintenance of location GO:0051235 73 0.011
negative regulation of gene expression epigenetic GO:0045814 77 0.011
hormone metabolic process GO:0042445 33 0.011
carbohydrate derivative metabolic process GO:1901135 217 0.011
chromatin silencing GO:0006342 76 0.011
negative regulation of cellular component organization GO:0051129 108 0.011
regulation of apoptotic process GO:0042981 130 0.011
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090100 9 0.011
dna conformation change GO:0071103 105 0.011
cardiac cell development GO:0055006 3 0.011
single organism carbohydrate metabolic process GO:0044723 72 0.011
nucleoside triphosphate catabolic process GO:0009143 108 0.011
positive regulation of lipid metabolic process GO:0045834 4 0.011
regulation of immune effector process GO:0002697 52 0.011
positive regulation of phosphorus metabolic process GO:0010562 139 0.011
purine nucleoside metabolic process GO:0042278 127 0.010
regulation of dna templated transcription elongation GO:0032784 17 0.010
detection of stimulus GO:0051606 156 0.010
regulation of gene expression epigenetic GO:0040029 128 0.010
positive regulation of cell communication GO:0010647 250 0.010
regulation of cell death GO:0010941 173 0.010
lipid localization GO:0010876 54 0.010
renal system development GO:0072001 72 0.010
Human Mouse Fly
regulation of mapk cascade GO:0043408 92 0.010
outflow tract morphogenesis GO:0003151 4 0.010
cell cell junction organization GO:0045216 55 0.010
protein oligomerization GO:0051259 16 0.010
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.010

Cg25C disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.487
musculoskeletal system disease DOID:17 0 0.141
cardiovascular system disease DOID:1287 0 0.085
muscular disease DOID:0080000 0 0.041
muscle tissue disease DOID:66 0 0.041
myopathy DOID:423 0 0.034
heart disease DOID:114 0 0.033
cardiomyopathy DOID:0050700 0 0.033
intrinsic cardiomyopathy DOID:0060036 0 0.027
nervous system disease DOID:863 0 0.022
connective tissue disease DOID:65 0 0.017
sensory system disease DOID:0050155 0 0.017
dilated cardiomyopathy DOID:12930 0 0.015