Drosophila melanogaster

66 known processes

MED19 (Dmel_CG5546)

Mediator complex subunit 19

(Aliases: CG5546,Dmel\CG5546)

MED19 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
positive regulation of macromolecule metabolic process GO:0010604 405 0.706
axon development GO:0061564 297 0.561
regulation of developmental growth GO:0048638 174 0.504
negative regulation of cellular metabolic process GO:0031324 382 0.462
tube development GO:0035295 244 0.447
stem cell differentiation GO:0048863 117 0.406
eye morphogenesis GO:0048592 260 0.401
central nervous system development GO:0007417 201 0.400
regulation of anatomical structure morphogenesis GO:0022603 242 0.398
dna metabolic process GO:0006259 227 0.394
regulation of multicellular organismal development GO:2000026 414 0.392
regulation of response to stress GO:0080134 200 0.365
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.352
eye development GO:0001654 323 0.344
negative regulation of response to stimulus GO:0048585 258 0.321
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.320
larval development GO:0002164 104 0.315
negative regulation of rna metabolic process GO:0051253 251 0.307
growth GO:0040007 359 0.306
compound eye development GO:0048749 307 0.300
developmental growth GO:0048589 280 0.288
muscle structure development GO:0061061 224 0.257
camera type eye development GO:0043010 4 0.254
positive regulation of developmental process GO:0051094 143 0.248
digestive tract development GO:0048565 149 0.247
sensory organ morphogenesis GO:0090596 260 0.234
positive regulation of gene expression GO:0010628 290 0.234
negative regulation of signaling GO:0023057 219 0.226
negative regulation of gene expression GO:0010629 387 0.226
striated muscle cell differentiation GO:0051146 90 0.225
embryo development ending in birth or egg hatching GO:0009792 152 0.222
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.215
regulation of intracellular signal transduction GO:1902531 236 0.214
apoptotic signaling pathway GO:0097190 27 0.214
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.196
positive regulation of nucleic acid templated transcription GO:1903508 266 0.191
digestive system development GO:0055123 149 0.183
stem cell development GO:0048864 79 0.181
tube morphogenesis GO:0035239 191 0.172
compound eye morphogenesis GO:0001745 249 0.170
regulation of cell differentiation GO:0045595 302 0.167
heart development GO:0007507 82 0.164
negative regulation of nucleic acid templated transcription GO:1903507 240 0.162
immune system development GO:0002520 57 0.161
regulation of cell cycle phase transition GO:1901987 130 0.154
reproductive structure development GO:0048608 74 0.144
gonad development GO:0008406 50 0.144
negative regulation of cellular biosynthetic process GO:0031327 277 0.142
gastrulation GO:0007369 70 0.142
sex differentiation GO:0007548 81 0.141
cellular catabolic process GO:0044248 372 0.138
reproductive system development GO:0061458 74 0.137
macromolecule catabolic process GO:0009057 161 0.136
immune system process GO:0002376 347 0.136
organic substance catabolic process GO:1901575 308 0.135
protein phosphorylation GO:0006468 169 0.133
eye photoreceptor cell differentiation GO:0001754 145 0.132
digestive tract morphogenesis GO:0048546 127 0.129
hematopoietic or lymphoid organ development GO:0048534 57 0.129
rna processing GO:0006396 147 0.128
regulation of protein metabolic process GO:0051246 256 0.128
catabolic process GO:0009056 409 0.127
regionalization GO:0003002 416 0.127
positive regulation of protein metabolic process GO:0051247 128 0.125
negative regulation of biosynthetic process GO:0009890 277 0.119
cell proliferation GO:0008283 299 0.115
negative regulation of signal transduction GO:0009968 206 0.114
wnt signaling pathway GO:0016055 98 0.110
establishment of localization in cell GO:0051649 402 0.110
cellular protein modification process GO:0006464 438 0.107
cellular macromolecule catabolic process GO:0044265 136 0.101
striated muscle cell development GO:0055002 50 0.099
regulation of cell shape GO:0008360 113 0.098
mrna metabolic process GO:0016071 124 0.097
negative regulation of cell communication GO:0010648 223 0.096
regulation of growth GO:0040008 233 0.095
protein ubiquitination GO:0016567 70 0.095
positive regulation of cellular biosynthetic process GO:0031328 316 0.095
positive regulation of developmental growth GO:0048639 62 0.094
development of primary sexual characteristics GO:0045137 50 0.093
positive regulation of retinal cell programmed cell death GO:0046670 9 0.092
regulation of cellular protein metabolic process GO:0032268 243 0.092
cell fate specification GO:0001708 71 0.091
cellular response to chemical stimulus GO:0070887 199 0.090
organelle fission GO:0048285 340 0.086
compound eye photoreceptor cell differentiation GO:0001751 140 0.085
response to other organism GO:0051707 293 0.085
protein localization GO:0008104 284 0.085
response to heat GO:0009408 63 0.081
molting cycle GO:0042303 56 0.081
regulation of protein modification process GO:0031399 112 0.080
germ cell migration GO:0008354 43 0.080
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.079
positive regulation of multicellular organismal process GO:0051240 143 0.078
positive regulation of nucleocytoplasmic transport GO:0046824 24 0.078
male mating behavior GO:0060179 70 0.076
negative regulation of developmental process GO:0051093 201 0.073
smoothened signaling pathway GO:0007224 49 0.072
mrna processing GO:0006397 104 0.072
transcription from rna polymerase ii promoter GO:0006366 368 0.070
asymmetric cell division GO:0008356 37 0.069
rna localization GO:0006403 115 0.068
negative regulation of developmental growth GO:0048640 64 0.068
small gtpase mediated signal transduction GO:0007264 88 0.066
aromatic compound catabolic process GO:0019439 166 0.065
homeostatic process GO:0042592 199 0.065
apoptotic process GO:0006915 159 0.064
protein modification process GO:0036211 438 0.064
intracellular signal transduction GO:0035556 300 0.064
reproductive behavior GO:0019098 122 0.062
mesenchymal cell development GO:0014031 1 0.061
positive regulation of biosynthetic process GO:0009891 316 0.061
multi organism reproductive behavior GO:0044705 121 0.061
regulation of gene silencing GO:0060968 63 0.060
negative regulation of rna biosynthetic process GO:1902679 240 0.060
positive regulation of signal transduction GO:0009967 223 0.060
camera type eye morphogenesis GO:0048593 2 0.058
defense response to bacterium GO:0042742 178 0.058
cell migration GO:0016477 238 0.057
response to temperature stimulus GO:0009266 106 0.057
stem cell division GO:0017145 69 0.057
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.057
positive regulation of rna metabolic process GO:0051254 271 0.056
regulation of response to external stimulus GO:0032101 115 0.055
proteasomal protein catabolic process GO:0010498 59 0.054
nucleobase containing compound catabolic process GO:0034655 165 0.054
response to organic substance GO:0010033 284 0.054
mitotic spindle organization GO:0007052 220 0.053
defense response GO:0006952 300 0.052
regulation of immune response GO:0050776 118 0.052
phosphorylation GO:0016310 294 0.051
regulation of cell proliferation GO:0042127 163 0.051
regulation of dna metabolic process GO:0051052 34 0.050
single organism intracellular transport GO:1902582 207 0.050
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.050
regulation of epithelial cell proliferation GO:0050678 4 0.049
negative regulation of transcription dna templated GO:0045892 237 0.048
organic substance transport GO:0071702 257 0.048
macromolecular complex assembly GO:0065003 256 0.047
regulation of defense response GO:0031347 102 0.047
innate immune response GO:0045087 144 0.047
dendrite guidance GO:0070983 21 0.047
muscle organ development GO:0007517 127 0.046
epithelial cell migration GO:0010631 148 0.046
gliogenesis GO:0042063 80 0.046
rna transport GO:0050658 46 0.046
positive regulation of cell communication GO:0010647 250 0.046
response to bacterium GO:0009617 198 0.045
mrna polyadenylation GO:0006378 11 0.045
glial cell differentiation GO:0010001 35 0.043
rna splicing GO:0008380 83 0.043
cellular response to ionizing radiation GO:0071479 15 0.042
brain development GO:0007420 120 0.042
cell motility GO:0048870 251 0.042
mitotic cell cycle phase transition GO:0044772 138 0.041
cellular response to organic substance GO:0071310 132 0.041
regulation of cell cycle g1 s phase transition GO:1902806 23 0.041
regulation of mitotic cell cycle phase transition GO:1901990 130 0.040
negative regulation of cell differentiation GO:0045596 143 0.040
stem cell proliferation GO:0072089 88 0.040
negative regulation of multicellular organismal process GO:0051241 142 0.039
protein dna complex subunit organization GO:0071824 86 0.039
positive regulation of molecular function GO:0044093 136 0.039
negative regulation of cell cycle phase transition GO:1901988 103 0.039
embryonic morphogenesis GO:0048598 206 0.039
cellular component assembly involved in morphogenesis GO:0010927 151 0.039
stem cell maintenance GO:0019827 67 0.038
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.038
respiratory system development GO:0060541 213 0.038
negative regulation of intracellular signal transduction GO:1902532 57 0.038
positive regulation of rna biosynthetic process GO:1902680 266 0.037
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 38 0.037
regulation of immune system process GO:0002682 176 0.037
negative regulation of gene expression epigenetic GO:0045814 77 0.037
ubiquitin dependent protein catabolic process GO:0006511 78 0.037
muscle cell development GO:0055001 50 0.036
aging GO:0007568 143 0.036
multicellular organismal reproductive behavior GO:0033057 110 0.035
gene silencing GO:0016458 138 0.035
hindbrain development GO:0030902 2 0.034
nitrogen compound transport GO:0071705 85 0.034
modification dependent protein catabolic process GO:0019941 78 0.034
regulation of innate immune response GO:0045088 71 0.033
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.033
establishment of rna localization GO:0051236 47 0.032
mrna 3 end processing GO:0031124 28 0.032
positive regulation of response to stimulus GO:0048584 323 0.032
antimicrobial humoral response GO:0019730 99 0.032
death GO:0016265 284 0.032
meiosis i GO:0007127 59 0.032
protein complex biogenesis GO:0070271 201 0.031
genitalia development GO:0048806 26 0.031
mesenchymal cell differentiation GO:0048762 1 0.030
tissue migration GO:0090130 155 0.030
hemopoiesis GO:0030097 46 0.030
ameboidal type cell migration GO:0001667 151 0.030
photoreceptor cell differentiation GO:0046530 170 0.030
positive regulation of apoptotic process GO:0043065 47 0.030
negative regulation of cell death GO:0060548 81 0.029
mitotic nuclear division GO:0007067 213 0.029
response to external biotic stimulus GO:0043207 293 0.029
chromosome segregation GO:0007059 157 0.029
cellular response to dna damage stimulus GO:0006974 223 0.028
single organism biosynthetic process GO:0044711 206 0.028
positive regulation of signaling GO:0023056 243 0.028
endocytosis GO:0006897 310 0.028
meiotic chromosome segregation GO:0045132 59 0.028
retina development in camera type eye GO:0060041 4 0.028
regulation of protein catabolic process GO:0042176 55 0.028
protein modification by small protein conjugation GO:0032446 79 0.027
regulation of nucleocytoplasmic transport GO:0046822 35 0.027
cell fate determination GO:0001709 91 0.027
response to ionizing radiation GO:0010212 32 0.026
regulation of programmed cell death GO:0043067 152 0.026
organic cyclic compound catabolic process GO:1901361 168 0.026
regulation of cellular response to stress GO:0080135 89 0.026
small molecule metabolic process GO:0044281 305 0.026
positive regulation of cellular component biogenesis GO:0044089 80 0.026
negative regulation of apoptotic process GO:0043066 63 0.026
sister chromatid segregation GO:0000819 92 0.025
proteolysis GO:0006508 192 0.025
muscle cell differentiation GO:0042692 103 0.025
regulation of cellular component size GO:0032535 98 0.025
negative regulation of cell cycle process GO:0010948 109 0.025
positive regulation of growth GO:0045927 75 0.025
positive regulation of transcription dna templated GO:0045893 266 0.025
negative regulation of cell proliferation GO:0008285 69 0.025
endoderm formation GO:0001706 3 0.025
positive regulation of cell death GO:0010942 69 0.025
eggshell formation GO:0030703 105 0.025
response to biotic stimulus GO:0009607 294 0.025
positive regulation of phosphorylation GO:0042327 87 0.025
rna polyadenylation GO:0043631 12 0.024
programmed cell death GO:0012501 257 0.024
regulation of nurse cell apoptotic process GO:0045477 9 0.024
rna capping GO:0036260 1 0.024
response to oxygen containing compound GO:1901700 200 0.024
regulation of cellular catabolic process GO:0031329 157 0.024
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 11 0.024
cellular nitrogen compound catabolic process GO:0044270 165 0.024
spindle elongation GO:0051231 83 0.024
negative regulation of cell cycle g1 s phase transition GO:1902807 13 0.024
positive regulation of cellular protein metabolic process GO:0032270 118 0.024
response to gamma radiation GO:0010332 17 0.024
response to wounding GO:0009611 94 0.024
regulation of cell morphogenesis GO:0022604 163 0.024
cellular protein catabolic process GO:0044257 83 0.024
regulation of catabolic process GO:0009894 170 0.023
ovarian follicle cell development GO:0030707 248 0.023
regulation of response to dna damage stimulus GO:2001020 23 0.023
connective tissue development GO:0061448 3 0.023
chromatin silencing GO:0006342 76 0.023
cardiovascular system development GO:0072358 82 0.022
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 65 0.022
body morphogenesis GO:0010171 2 0.022
positive regulation of programmed cell death GO:0043068 62 0.022
spinal cord development GO:0021510 1 0.022
mapk cascade GO:0000165 107 0.022
signal transduction by phosphorylation GO:0023014 107 0.022
mitotic spindle elongation GO:0000022 81 0.022
response to abiotic stimulus GO:0009628 341 0.022
axonogenesis GO:0007409 290 0.022
g protein coupled receptor signaling pathway GO:0007186 136 0.022
regulation of catalytic activity GO:0050790 185 0.022
anatomical structure homeostasis GO:0060249 97 0.022
protein modification by small protein conjugation or removal GO:0070647 106 0.022
cell cycle phase transition GO:0044770 140 0.022
defense response to other organism GO:0098542 225 0.022
positive regulation of protein modification process GO:0031401 58 0.021
response to light stimulus GO:0009416 124 0.021
regulation of transport GO:0051049 181 0.021
regulation of cellular localization GO:0060341 136 0.021
meiotic cell cycle process GO:1903046 132 0.021
positive regulation of catabolic process GO:0009896 105 0.021
immune response GO:0006955 246 0.021
regulation of phosphorylation GO:0042325 147 0.021
dorsal ventral pattern formation GO:0009953 133 0.021
mating GO:0007618 120 0.021
appendage development GO:0048736 401 0.020
peptidyl amino acid modification GO:0018193 105 0.020
cell cycle g1 s phase transition GO:0044843 31 0.020
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.020
regulation of neurogenesis GO:0050767 158 0.020
wing disc pattern formation GO:0035222 66 0.020
multi organism behavior GO:0051705 175 0.020
multi multicellular organism process GO:0044706 123 0.020
regulation of cell death GO:0010941 173 0.020
regulation of cytoplasmic transport GO:1903649 47 0.019
regulation of molecular function GO:0065009 217 0.019
regulation of g1 s transition of mitotic cell cycle GO:2000045 23 0.019
genital disc development GO:0035215 44 0.019
sex comb development GO:0045498 8 0.019
positive regulation of cellular catabolic process GO:0031331 95 0.019
regulation of protein ubiquitination GO:0031396 22 0.019
rhabdomere development GO:0042052 38 0.019
open tracheal system development GO:0007424 204 0.019
histone h3 k4 methylation GO:0051568 16 0.018
germ line stem cell maintenance GO:0030718 50 0.018
defense response to gram negative bacterium GO:0050829 94 0.018
mating behavior GO:0007617 106 0.018
activin receptor signaling pathway GO:0032924 6 0.018
cellular protein localization GO:0034613 160 0.018
regulation of protein phosphorylation GO:0001932 64 0.018
lipid metabolic process GO:0006629 121 0.018
developmental growth involved in morphogenesis GO:0060560 65 0.018
multicellular organismal homeostasis GO:0048871 41 0.018
actin filament based process GO:0030029 220 0.018
maintenance of protein location in cell GO:0032507 26 0.018
nucleobase containing compound transport GO:0015931 56 0.018
epithelial cell type specification open tracheal system GO:0035153 11 0.018
response to organic cyclic compound GO:0014070 89 0.017
chromatin organization GO:0006325 207 0.017
telencephalon development GO:0021537 2 0.017
positive regulation of intracellular signal transduction GO:1902533 116 0.017
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 4 0.017
regulation of cell cell adhesion GO:0022407 21 0.017
cell division GO:0051301 248 0.016
cellular response to abiotic stimulus GO:0071214 58 0.016
limb development GO:0060173 1 0.016
appendage morphogenesis GO:0035107 397 0.016
tissue morphogenesis GO:0048729 297 0.016
heart morphogenesis GO:0003007 32 0.016
regulation of nervous system development GO:0051960 248 0.016
organophosphate catabolic process GO:0046434 112 0.016
negative regulation of protein metabolic process GO:0051248 85 0.016
multicellular organismal aging GO:0010259 140 0.016
circulatory system development GO:0072359 82 0.016
positive regulation of mapk cascade GO:0043410 63 0.016
columnar cuboidal epithelial cell development GO:0002066 249 0.016
mrna splicing via spliceosome GO:0000398 73 0.016
positive regulation of cell differentiation GO:0045597 64 0.016
response to ethanol GO:0045471 59 0.015
response to endogenous stimulus GO:0009719 119 0.015
modification dependent macromolecule catabolic process GO:0043632 79 0.015
regulation of mitotic cell cycle GO:0007346 190 0.015
negative regulation of cellular component organization GO:0051129 108 0.015
negative regulation of protein modification process GO:0031400 29 0.015
protein complex assembly GO:0006461 200 0.015
tracheal outgrowth open tracheal system GO:0007426 18 0.015
enzyme linked receptor protein signaling pathway GO:0007167 179 0.015
cellular response to endogenous stimulus GO:0071495 80 0.015
protein maturation GO:0051604 71 0.015
regulation of chromosome organization GO:0033044 64 0.015
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.014
transcription elongation from rna polymerase ii promoter GO:0006368 18 0.014
intrinsic apoptotic signaling pathway GO:0097193 16 0.014
positive regulation of transport GO:0051050 92 0.014
negative regulation of cellular protein metabolic process GO:0032269 85 0.014
disaccharide metabolic process GO:0005984 4 0.014
posttranscriptional regulation of gene expression GO:0010608 145 0.014
regulation of hemocyte proliferation GO:0035206 37 0.014
negative regulation of g1 s transition of mitotic cell cycle GO:2000134 13 0.014
taxis GO:0042330 304 0.014
regulation of proteolysis GO:0030162 87 0.014
cellular macromolecular complex assembly GO:0034622 153 0.014
neuron projection extension GO:1990138 32 0.014
regulation of cellular ketone metabolic process GO:0010565 3 0.014
purine nucleoside metabolic process GO:0042278 127 0.014
o glycan processing GO:0016266 3 0.014
neuronal stem cell division GO:0036445 35 0.014
guanosine containing compound metabolic process GO:1901068 74 0.013
regulation of intracellular transport GO:0032386 64 0.013
multicellular organism growth GO:0035264 46 0.013
somatic stem cell maintenance GO:0035019 14 0.013
positive regulation of multicellular organism growth GO:0040018 21 0.013
protein transport GO:0015031 155 0.013
endomembrane system organization GO:0010256 119 0.013
neurological system process GO:0050877 358 0.013
vesicle mediated transport GO:0016192 381 0.013
compound eye retinal cell programmed cell death GO:0046667 23 0.013
negative regulation of programmed cell death GO:0043069 72 0.013
regulation of synapse organization GO:0050807 110 0.013
positive regulation of phosphorus metabolic process GO:0010562 139 0.012
negative regulation of dna metabolic process GO:0051053 12 0.012
imaginal disc derived wing morphogenesis GO:0007476 337 0.012
extrinsic apoptotic signaling pathway GO:0097191 1 0.012
negative regulation of nervous system development GO:0051961 92 0.012
organelle assembly GO:0070925 198 0.012
regulation of wnt signaling pathway GO:0030111 68 0.012
cellular lipid metabolic process GO:0044255 83 0.012
developmental programmed cell death GO:0010623 138 0.012
cytoplasmic transport GO:0016482 130 0.012
actin cytoskeleton organization GO:0030036 206 0.012
blastoderm segmentation GO:0007350 159 0.012
positive regulation of mitotic cell cycle phase transition GO:1901992 20 0.012
kidney development GO:0001822 3 0.012
cell death GO:0008219 279 0.012
regulation of proteasomal protein catabolic process GO:0061136 39 0.012
regulation of smoothened signaling pathway GO:0008589 28 0.012
neural precursor cell proliferation GO:0061351 75 0.012
negative regulation of mitotic cell cycle GO:0045930 109 0.011
protein catabolic process GO:0030163 101 0.011
regulation of synapse assembly GO:0051963 94 0.011
hindgut morphogenesis GO:0007442 58 0.011
head development GO:0060322 135 0.011
regulation of cellular component biogenesis GO:0044087 201 0.011
regulation of cell cycle GO:0051726 291 0.011
cellular amine metabolic process GO:0044106 12 0.011
organonitrogen compound metabolic process GO:1901564 318 0.011
positive regulation of intracellular transport GO:0032388 42 0.011
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.011
nucleoside metabolic process GO:0009116 127 0.011
regulation of localization GO:0032879 275 0.011
neuroblast proliferation GO:0007405 74 0.011
response to ecdysone GO:0035075 34 0.011
heterocycle catabolic process GO:0046700 166 0.011
cell type specific apoptotic process GO:0097285 38 0.011
muscle fiber development GO:0048747 12 0.010
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 18 0.010
carbohydrate derivative biosynthetic process GO:1901137 85 0.010
positive regulation of immune system process GO:0002684 68 0.010
embryonic organ development GO:0048568 50 0.010
histone modification GO:0016570 106 0.010
negative regulation of protein processing GO:0010955 31 0.010
regulation of organ morphogenesis GO:2000027 78 0.010
humoral immune response GO:0006959 117 0.010

MED19 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.124
disease of anatomical entity DOID:7 0 0.081
cancer DOID:162 0 0.061
motor neuron disease DOID:231 0 0.021
central nervous system disease DOID:331 0 0.021
neurodegenerative disease DOID:1289 0 0.021
nervous system disease DOID:863 0 0.021
organ system cancer DOID:0050686 0 0.018
musculoskeletal system disease DOID:17 0 0.011