Drosophila melanogaster

104 known processes

Vps4 (Dmel_CG6842)

Vacuolar protein sorting 4

(Aliases: CG6842,bcDNA:GH02678,dvps4,Dmel\CG6842,DmBcDNA.GH02678,BcDNA:GH02678,vps4)

Vps4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
death GO:0016265 284 0.413
Worm
response to oxidative stress GO:0006979 86 0.346
cell death GO:0008219 279 0.308
Worm
imaginal disc derived appendage development GO:0048737 399 0.302
cellular catabolic process GO:0044248 372 0.250
regulation of growth GO:0040008 233 0.234
vacuolar transport GO:0007034 13 0.220
Yeast
cell growth GO:0016049 108 0.217
single organism membrane budding GO:1902591 2 0.213
Yeast
cytoplasmic transport GO:0016482 130 0.184
Human Yeast
actin filament based process GO:0030029 220 0.169
organic substance transport GO:0071702 257 0.162
Human Mouse
modification dependent macromolecule catabolic process GO:0043632 79 0.161
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.143
developmental growth GO:0048589 280 0.129
dna metabolic process GO:0006259 227 0.125
protein localization GO:0008104 284 0.118
Yeast
protein transport GO:0015031 155 0.116
actin cytoskeleton organization GO:0030036 206 0.108
meiotic nuclear division GO:0007126 151 0.108
negative regulation of response to stimulus GO:0048585 258 0.104
vesicle mediated transport GO:0016192 381 0.100
establishment of protein localization GO:0045184 163 0.094
small molecule metabolic process GO:0044281 305 0.091
Human Yeast
organic substance catabolic process GO:1901575 308 0.087
positive regulation of macromolecule metabolic process GO:0010604 405 0.083
endosome transport via multivesicular body sorting pathway GO:0032509 12 0.080
Human Yeast
meiotic chromosome segregation GO:0045132 59 0.079
single organism intracellular transport GO:1902582 207 0.078
Human Yeast
programmed cell death GO:0012501 257 0.076
Worm
establishment of localization in cell GO:0051649 402 0.076
Human Yeast
regulation of epidermal growth factor receptor signaling pathway GO:0042058 42 0.074
enzyme linked receptor protein signaling pathway GO:0007167 179 0.073
cellular macromolecule localization GO:0070727 220 0.073
Yeast
intracellular transport GO:0046907 228 0.072
Human Yeast
positive regulation of developmental process GO:0051094 143 0.072
negative regulation of signal transduction GO:0009968 206 0.064
regulation of erbb signaling pathway GO:1901184 42 0.063
ubiquitin dependent protein catabolic process GO:0006511 78 0.063
positive regulation of cellular catabolic process GO:0031331 95 0.063
response to abiotic stimulus GO:0009628 341 0.062
single organism membrane organization GO:0044802 93 0.058
regulation of transport GO:0051049 181 0.057
Human
axonogenesis GO:0007409 290 0.057
larval midgut histolysis GO:0035069 22 0.057
lateral inhibition GO:0046331 206 0.055
cellular response to chemical stimulus GO:0070887 199 0.055
membrane organization GO:0061024 112 0.054
response to other organism GO:0051707 293 0.053
autophagic vacuole assembly GO:0000045 2 0.053
regulation of multi organism process GO:0043900 131 0.053
regulation of synapse structure and activity GO:0050803 128 0.052
positive regulation of protein metabolic process GO:0051247 128 0.052
regulation of anatomical structure morphogenesis GO:0022603 242 0.050
eye morphogenesis GO:0048592 260 0.049
single organism cellular localization GO:1902580 180 0.048
Yeast
nucleobase containing small molecule metabolic process GO:0055086 174 0.047
Human Yeast
cell motility GO:0048870 251 0.047
nucleoside catabolic process GO:0009164 112 0.046
Human Yeast
protein targeting GO:0006605 64 0.046
endocytosis GO:0006897 310 0.046
growth GO:0040007 359 0.045
nucleoside phosphate catabolic process GO:1901292 110 0.045
Human Yeast
cellular macromolecule catabolic process GO:0044265 136 0.044
secretion by cell GO:0032940 101 0.043
Human
positive regulation of cellular biosynthetic process GO:0031328 316 0.043
organonitrogen compound metabolic process GO:1901564 318 0.043
Human Yeast
regulation of localization GO:0032879 275 0.042
Human
appendage development GO:0048736 401 0.042
apoptotic process GO:0006915 159 0.042
Worm
regulation of synapse organization GO:0050807 110 0.042
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.041
regulation of cell projection organization GO:0031344 92 0.041
membrane budding GO:0006900 4 0.041
Human Yeast
protein phosphorylation GO:0006468 169 0.040
imaginal disc derived wing margin morphogenesis GO:0008587 41 0.039
regulation of neuron projection development GO:0010975 69 0.039
molting cycle GO:0042303 56 0.039
Worm
negative regulation of erbb signaling pathway GO:1901185 29 0.038
regulation of organelle organization GO:0033043 196 0.038
cellular response to reactive oxygen species GO:0034614 14 0.038
cellular response to organic substance GO:0071310 132 0.038
ribonucleoside metabolic process GO:0009119 127 0.038
Human Yeast
positive regulation of growth GO:0045927 75 0.038
regulation of cell development GO:0060284 215 0.038
spindle organization GO:0007051 253 0.038
synaptic growth at neuromuscular junction GO:0051124 119 0.037
regulation of cell differentiation GO:0045595 302 0.037
embryo development ending in birth or egg hatching GO:0009792 152 0.036
Worm
negative regulation of cellular biosynthetic process GO:0031327 277 0.036
aromatic compound catabolic process GO:0019439 166 0.036
Human Yeast
regulation of intracellular protein transport GO:0033157 46 0.035
organophosphate metabolic process GO:0019637 195 0.035
Human Yeast
organelle fission GO:0048285 340 0.035
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.035
cellular response to external stimulus GO:0071496 66 0.034
ribonucleoside triphosphate metabolic process GO:0009199 119 0.034
Human Yeast
taxis GO:0042330 304 0.034
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.034
Human Yeast
glycosyl compound metabolic process GO:1901657 127 0.034
Human Yeast
modification dependent protein catabolic process GO:0019941 78 0.033
meiotic cell cycle process GO:1903046 132 0.033
nucleotide metabolic process GO:0009117 161 0.033
Human Yeast
macroautophagy GO:0016236 42 0.033
chromosome segregation GO:0007059 157 0.032
regulation of neuron differentiation GO:0045664 103 0.032
protein modification process GO:0036211 438 0.032
axon guidance GO:0007411 233 0.031
carbohydrate derivative catabolic process GO:1901136 118 0.031
Human Yeast
protein complex assembly GO:0006461 200 0.031
Yeast
imaginal disc derived wing morphogenesis GO:0007476 337 0.031
gtp catabolic process GO:0006184 72 0.031
regulation of cell death GO:0010941 173 0.031
purine nucleotide catabolic process GO:0006195 109 0.030
Human Yeast
chromosome organization GO:0051276 360 0.030
regulation of cellular localization GO:0060341 136 0.029
Human
cellular protein catabolic process GO:0044257 83 0.028
cellular protein localization GO:0034613 160 0.028
Yeast
intracellular protein transport GO:0006886 104 0.028
heterocycle catabolic process GO:0046700 166 0.028
Human Yeast
positive regulation of cellular component organization GO:0051130 156 0.027
regulation of programmed cell death GO:0043067 152 0.027
negative regulation of biosynthetic process GO:0009890 277 0.027
autophagy GO:0006914 108 0.026
response to endoplasmic reticulum stress GO:0034976 28 0.026
cellular homeostasis GO:0019725 80 0.026
maintenance of location in cell GO:0051651 28 0.026
Yeast
regulation of cell cycle GO:0051726 291 0.026
Human
negative regulation of cellular response to oxidative stress GO:1900408 1 0.026
developmental programmed cell death GO:0010623 138 0.026
single organism catabolic process GO:0044712 228 0.026
chemotaxis GO:0006935 249 0.026
regulation of cysteine type endopeptidase activity GO:2000116 27 0.026
muscle structure development GO:0061061 224 0.025
lipid modification GO:0030258 24 0.025
positive regulation of nucleic acid templated transcription GO:1903508 266 0.025
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.025
Human Yeast
establishment of organelle localization GO:0051656 122 0.025
regulation of cellular protein metabolic process GO:0032268 243 0.025
regulation of protein metabolic process GO:0051246 256 0.025
phagocytosis GO:0006909 215 0.025
regulation of molecular function GO:0065009 217 0.024
organic hydroxy compound metabolic process GO:1901615 83 0.024
Yeast
regulation of vesicle mediated transport GO:0060627 59 0.024
Human
appendage morphogenesis GO:0035107 397 0.024
purine ribonucleoside metabolic process GO:0046128 127 0.024
Human Yeast
regulation of epithelial cell proliferation GO:0050678 4 0.024
regulation of developmental growth GO:0048638 174 0.024
regulation of apoptotic process GO:0042981 130 0.024
nucleoside metabolic process GO:0009116 127 0.024
Human Yeast
eye development GO:0001654 323 0.024
meiotic cytokinesis GO:0033206 33 0.023
chemical homeostasis GO:0048878 92 0.023
immune response regulating signaling pathway GO:0002764 2 0.023
nucleocytoplasmic transport GO:0006913 72 0.023
defense response GO:0006952 300 0.023
determination of adult lifespan GO:0008340 137 0.023
ribose phosphate metabolic process GO:0019693 145 0.023
Human Yeast
intracellular signal transduction GO:0035556 300 0.023
neuromuscular junction development GO:0007528 149 0.023
positive regulation of cellular protein metabolic process GO:0032270 118 0.023
response to biotic stimulus GO:0009607 294 0.022
organic cyclic compound catabolic process GO:1901361 168 0.022
Human Yeast
regulation of response to stress GO:0080134 200 0.022
positive regulation of molecular function GO:0044093 136 0.022
regulation of response to external stimulus GO:0032101 115 0.022
purine nucleoside catabolic process GO:0006152 112 0.022
Human Yeast
centrosome organization GO:0051297 163 0.022
meiotic cell cycle GO:0051321 171 0.021
nuclear transport GO:0051169 72 0.021
nucleoside triphosphate metabolic process GO:0009141 120 0.021
Human Yeast
proteasomal protein catabolic process GO:0010498 59 0.021
transcription from rna polymerase ii promoter GO:0006366 368 0.021
positive regulation of multi organism process GO:0043902 40 0.021
Human
regulation of protein localization GO:0032880 76 0.021
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.020
purine nucleoside triphosphate metabolic process GO:0009144 119 0.020
Human Yeast
leg disc development GO:0035218 92 0.020
compound eye development GO:0048749 307 0.020
synapse organization GO:0050808 196 0.020
maintenance of location GO:0051235 73 0.020
Yeast
negative regulation of rna metabolic process GO:0051253 251 0.020
regulation of cell size GO:0008361 63 0.020
purine containing compound metabolic process GO:0072521 155 0.020
Human Yeast
small gtpase mediated signal transduction GO:0007264 88 0.020
secretion GO:0046903 109 0.019
Human
striated muscle cell development GO:0055002 50 0.019
regulation of cellular component size GO:0032535 98 0.019
response to extracellular stimulus GO:0009991 116 0.019
ribonucleotide catabolic process GO:0009261 109 0.019
Human Yeast
ribonucleoside triphosphate catabolic process GO:0009203 108 0.019
Human Yeast
positive regulation of programmed cell death GO:0043068 62 0.019
positive regulation of multicellular organismal process GO:0051240 143 0.019
imaginal disc derived appendage morphogenesis GO:0035114 395 0.019
regulation of intracellular signal transduction GO:1902531 236 0.018
positive regulation of cell death GO:0010942 69 0.018
regulation of locomotion GO:0040012 42 0.018
regulation of cytoskeleton organization GO:0051493 89 0.018
regulation of cell morphogenesis GO:0022604 163 0.018
regulation of i kappab kinase nf kappab signaling GO:0043122 2 0.018
regulation of multicellular organismal development GO:2000026 414 0.018
organelle assembly GO:0070925 198 0.018
positive regulation of hydrolase activity GO:0051345 78 0.018
nucleoside triphosphate catabolic process GO:0009143 108 0.018
Human Yeast
catabolic process GO:0009056 409 0.018
regulation of nervous system development GO:0051960 248 0.017
regulation of catalytic activity GO:0050790 185 0.017
interspecies interaction between organisms GO:0044419 16 0.017
positive regulation of gene expression GO:0010628 290 0.017
inorganic ion transmembrane transport GO:0098660 73 0.017
positive regulation of apoptotic process GO:0043065 47 0.017
actomyosin structure organization GO:0031032 56 0.017
purine nucleoside metabolic process GO:0042278 127 0.017
Human Yeast
tissue morphogenesis GO:0048729 297 0.017
regulation of hydrolase activity GO:0051336 97 0.017
positive regulation of catabolic process GO:0009896 105 0.017
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.016
regulation of phosphatase activity GO:0010921 3 0.016
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.016
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.016
protein catabolic process GO:0030163 101 0.016
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.016
positive regulation of phosphate metabolic process GO:0045937 139 0.016
nucleobase containing compound catabolic process GO:0034655 165 0.016
Human Yeast
post embryonic appendage morphogenesis GO:0035120 385 0.016
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.016
inorganic cation transmembrane transport GO:0098662 61 0.016
phosphatidylinositol mediated signaling GO:0048015 4 0.016
regulation of cellular ketone metabolic process GO:0010565 3 0.016
positive regulation of gtpase activity GO:0043547 43 0.016
immune system process GO:0002376 347 0.016
scf dependent proteasomal ubiquitin dependent protein catabolic process GO:0031146 1 0.016
microtubule based movement GO:0007018 51 0.016
g protein coupled receptor signaling pathway GO:0007186 136 0.016
single organism behavior GO:0044708 391 0.016
store operated calcium entry GO:0002115 3 0.016
phosphorylation GO:0016310 294 0.015
female meiotic division GO:0007143 70 0.015
cellular ketone metabolic process GO:0042180 24 0.015
purine containing compound catabolic process GO:0072523 112 0.015
Human Yeast
larval midgut cell programmed cell death GO:0035096 19 0.015
gtp metabolic process GO:0046039 72 0.015
phospholipid metabolic process GO:0006644 23 0.015
reproductive behavior GO:0019098 122 0.015
negative regulation of cellular metabolic process GO:0031324 382 0.015
cell cell signaling involved in cell fate commitment GO:0045168 210 0.015
larval development GO:0002164 104 0.015
Worm
carbohydrate derivative metabolic process GO:1901135 217 0.015
Human Yeast
negative regulation of cell communication GO:0010648 223 0.015
chaeta development GO:0022416 97 0.014
cation transmembrane transport GO:0098655 88 0.014
protein localization to organelle GO:0033365 82 0.014
Yeast
localization of cell GO:0051674 257 0.014
body morphogenesis GO:0010171 2 0.014
cellular amine metabolic process GO:0044106 12 0.014
regulation of hemocyte proliferation GO:0035206 37 0.014
immune response GO:0006955 246 0.014
spindle assembly GO:0051225 80 0.014
positive regulation of rna metabolic process GO:0051254 271 0.014
regulation of cytoplasmic transport GO:1903649 47 0.014
ameboidal type cell migration GO:0001667 151 0.014
regulation of response to biotic stimulus GO:0002831 63 0.014
vesicle organization GO:0016050 44 0.014
Human Yeast
tissue death GO:0016271 102 0.013
protein prenylation GO:0018342 3 0.013
cation transport GO:0006812 110 0.013
Mouse
response to ionizing radiation GO:0010212 32 0.013
aging GO:0007568 143 0.013
regulation of intracellular transport GO:0032386 64 0.013
regulation of protein transport GO:0051223 57 0.013
proteolysis GO:0006508 192 0.013
amine metabolic process GO:0009308 12 0.013
phospholipase c activating g protein coupled receptor signaling pathway GO:0007200 10 0.013
anatomical structure homeostasis GO:0060249 97 0.013
regulation of macroautophagy GO:0016241 15 0.013
multicellular organismal aging GO:0010259 140 0.013
positive regulation of purine nucleotide metabolic process GO:1900544 55 0.013
antimicrobial humoral response GO:0019730 99 0.013
regulation of phosphorylation GO:0042325 147 0.013
positive regulation of phosphorus metabolic process GO:0010562 139 0.012
protein secretion GO:0009306 45 0.012
ras protein signal transduction GO:0007265 88 0.012
protein kinase b signaling GO:0043491 1 0.012
regulation of cellular component biogenesis GO:0044087 201 0.012
positive regulation of cell development GO:0010720 61 0.012
macromolecule catabolic process GO:0009057 161 0.012
axon development GO:0061564 297 0.012
cellular response to starvation GO:0009267 61 0.012
instar larval development GO:0002168 55 0.012
erbb signaling pathway GO:0038127 58 0.012
translation GO:0006412 69 0.012
negative regulation of signaling GO:0023057 219 0.012
regulation of cellular amine metabolic process GO:0033238 3 0.012
regulation of cell shape GO:0008360 113 0.012
response to organic substance GO:0010033 284 0.012
Human
dna repair GO:0006281 54 0.012
cell division GO:0051301 248 0.012
Human
endomembrane system organization GO:0010256 119 0.012
Mouse
cellular amino acid metabolic process GO:0006520 61 0.012
cortical actin cytoskeleton organization GO:0030866 24 0.012
establishment of protein localization to organelle GO:0072594 62 0.011
regulation of secretion GO:0051046 44 0.011
Human
regulation of catabolic process GO:0009894 170 0.011
purine ribonucleoside catabolic process GO:0046130 112 0.011
Human Yeast
protein targeting to nucleus GO:0044744 51 0.011
regulation of cellular response to stress GO:0080135 89 0.011
purine nucleotide metabolic process GO:0006163 146 0.011
Human Yeast
kidney morphogenesis GO:0060993 3 0.011
response to light stimulus GO:0009416 124 0.011
positive regulation of phagocytosis engulfment GO:0060100 1 0.011
positive regulation of transport GO:0051050 92 0.011
Human
histone h4 k16 acetylation GO:0043984 4 0.011
antimicrobial peptide production GO:0002775 46 0.011
leg disc morphogenesis GO:0007478 80 0.011
cortical cytoskeleton organization GO:0030865 29 0.011
positive regulation of rna biosynthetic process GO:1902680 266 0.011
regulation of meiosis GO:0040020 3 0.011
epithelial cell development GO:0002064 274 0.011
phosphatidylinositol phosphorylation GO:0046854 10 0.011
organonitrogen compound catabolic process GO:1901565 128 0.011
Human Yeast
negative regulation of gene expression GO:0010629 387 0.011
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.011
regulation of establishment of protein localization GO:0070201 61 0.011
regulation of notch signaling pathway GO:0008593 100 0.011
defense response to other organism GO:0098542 225 0.011
regulation of transferase activity GO:0051338 58 0.010
positive regulation of response to external stimulus GO:0032103 44 0.010
autophagic cell death GO:0048102 83 0.010
cellular protein modification process GO:0006464 438 0.010
epithelial cell migration GO:0010631 148 0.010
guanosine containing compound catabolic process GO:1901069 74 0.010
organelle localization GO:0051640 148 0.010
positive regulation of intracellular signal transduction GO:1902533 116 0.010
positive regulation of autophagy GO:0010508 21 0.010
neuron projection guidance GO:0097485 241 0.010

Vps4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.097
nervous system disease DOID:863 0 0.097
central nervous system disease DOID:331 0 0.019
motor neuron disease DOID:231 0 0.015
neurodegenerative disease DOID:1289 0 0.015
cancer DOID:162 0 0.010
disease of cellular proliferation DOID:14566 0 0.010