Drosophila melanogaster

124 known processes

Dscam (Dmel_CG17800)

Down syndrome cell adhesion molecule

(Aliases: Dscam1,Dmel\CG17800,CT39257,FBgn0033159,43Bc,p270,Neu1,l(2)43Bc,dscam,DScam,dScam,DSCAM,CG17800,l(2)05518)

Dscam biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
axon development GO:0061564 297 0.999
dendrite development GO:0016358 204 0.992
dendrite morphogenesis GO:0048813 199 0.992
regulation of axon guidance GO:1902667 10 0.987
Human Mouse
axon guidance GO:0007411 233 0.984
axonogenesis GO:0007409 290 0.983
mushroom body development GO:0016319 70 0.981
chemotaxis GO:0006935 249 0.979
brain development GO:0007420 120 0.977
regulation of axon extension involved in axon guidance GO:0048841 4 0.976
Human Mouse
central nervous system development GO:0007417 201 0.970
neuron projection guidance GO:0097485 241 0.968
taxis GO:0042330 304 0.967
dendrite guidance GO:0070983 21 0.956
regulation of cell development GO:0060284 215 0.903
muscle structure development GO:0061061 224 0.880
positive regulation of cell projection organization GO:0031346 29 0.858
Human Mouse
head development GO:0060322 135 0.839
axon extension involved in axon guidance GO:0048846 10 0.839
regulation of dendrite morphogenesis GO:0048814 28 0.816
regulation of dendrite development GO:0050773 37 0.764
regulation of chemotaxis GO:0050920 12 0.763
Human Mouse
neuron recognition GO:0008038 101 0.720
activation of cysteine type endopeptidase activity GO:0097202 17 0.719
retinal ganglion cell axon guidance GO:0031290 12 0.705
regulation of neuron projection development GO:0010975 69 0.705
positive regulation of axonogenesis GO:0050772 2 0.683
Human Mouse
negative regulation of signaling GO:0023057 219 0.682
spindle elongation GO:0051231 83 0.673
regulation of cell projection organization GO:0031344 92 0.662
cell motility GO:0048870 251 0.660
Zebrafish
axon extension GO:0048675 32 0.648
regulation of localization GO:0032879 275 0.637
Human Mouse
ameboidal type cell migration GO:0001667 151 0.623
Zebrafish
dorsal ventral axon guidance GO:0033563 2 0.595
neuron projection extension GO:1990138 32 0.561
axon midline choice point recognition GO:0016199 26 0.550
epithelial cell development GO:0002064 274 0.540
regulation of cell differentiation GO:0045595 302 0.537
regulation of cell size GO:0008361 63 0.529
Human Mouse
positive regulation of cell morphogenesis involved in differentiation GO:0010770 12 0.519
Human Mouse
positive regulation of developmental process GO:0051094 143 0.476
Human Mouse
photoreceptor cell axon guidance GO:0072499 23 0.469
positive regulation of dendrite morphogenesis GO:0050775 9 0.466
positive regulation of neuron differentiation GO:0045666 26 0.465
Human Mouse
regulation of cysteine type endopeptidase activity GO:2000116 27 0.427
regulation of cellular component size GO:0032535 98 0.406
Human Mouse
positive regulation of developmental growth GO:0048639 62 0.401
Human Mouse
multi organism behavior GO:0051705 175 0.401
regulation of cell morphogenesis GO:0022604 163 0.401
exocrine system development GO:0035272 162 0.381
positive regulation of cell growth GO:0030307 19 0.378
Human Mouse
positive regulation of axon extension GO:0045773 2 0.371
Human Mouse
axon choice point recognition GO:0016198 26 0.364
neuron remodeling GO:0016322 29 0.355
eye development GO:0001654 323 0.346
Mouse
regulation of cellular component biogenesis GO:0044087 201 0.342
cell migration GO:0016477 238 0.341
Zebrafish
axon regeneration GO:0031103 8 0.327
response to alcohol GO:0097305 95 0.318
regulation of multicellular organismal development GO:2000026 414 0.308
regulation of synapse structure and activity GO:0050803 128 0.305
enzyme linked receptor protein signaling pathway GO:0007167 179 0.297
cell recognition GO:0008037 102 0.294
positive regulation of neuron projection development GO:0010976 14 0.293
Human Mouse
embryo development ending in birth or egg hatching GO:0009792 152 0.289
Human Worm
locomotory behavior GO:0007626 176 0.286
Mouse
gland development GO:0048732 191 0.279
positive regulation of neurogenesis GO:0050769 41 0.271
Human Mouse
positive regulation of locomotion GO:0040017 8 0.261
Human Mouse
negative regulation of cell communication GO:0010648 223 0.257
regulation of developmental growth GO:0048638 174 0.256
Human Mouse
neurological system process GO:0050877 358 0.255
central nervous system projection neuron axonogenesis GO:0021952 6 0.254
cell growth GO:0016049 108 0.245
negative regulation of signal transduction GO:0009968 206 0.241
regulation of anatomical structure size GO:0090066 163 0.233
Human Mouse
mitotic spindle elongation GO:0000022 81 0.231
establishment of localization in cell GO:0051649 402 0.228
cellular macromolecular complex assembly GO:0034622 153 0.222
negative regulation of gene expression GO:0010629 387 0.212
positive regulation of cellular component organization GO:0051130 156 0.210
Human Mouse
regulation of nervous system development GO:0051960 248 0.201
regulation of neuron differentiation GO:0045664 103 0.198
negative regulation of response to stimulus GO:0048585 258 0.197
regulation of growth GO:0040008 233 0.193
Human Mouse
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.186
homeostatic process GO:0042592 199 0.183
growth GO:0040007 359 0.179
central complex development GO:0048036 9 0.177
regulation of neurogenesis GO:0050767 158 0.175
regulation of cell morphogenesis involved in differentiation GO:0010769 61 0.174
synapse assembly GO:0007416 143 0.174
synapse organization GO:0050808 196 0.173
developmental growth GO:0048589 280 0.172
response to organic substance GO:0010033 284 0.170
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.167
negative regulation of multicellular organismal process GO:0051241 142 0.163
gland morphogenesis GO:0022612 145 0.159
regulation of behavior GO:0050795 75 0.158
Human Mouse
tissue morphogenesis GO:0048729 297 0.152
Mouse
imaginal disc derived appendage morphogenesis GO:0035114 395 0.149
regulation of cell cycle GO:0051726 291 0.147
olfactory bulb axon guidance GO:0071678 3 0.144
appendage development GO:0048736 401 0.143
mitotic spindle organization GO:0007052 220 0.139
positive regulation of cell development GO:0010720 61 0.137
Human Mouse
developmental cell growth GO:0048588 52 0.136
developmental growth involved in morphogenesis GO:0060560 65 0.130
localization of cell GO:0051674 257 0.127
Zebrafish
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 25 0.124
regulation of axon extension GO:0030516 8 0.124
Human Mouse
positive regulation of axon guidance GO:1902669 1 0.122
Human Mouse
ventral cord development GO:0007419 16 0.121
positive regulation of cell motility GO:2000147 3 0.120
positive regulation of cell migration GO:0030335 2 0.113
stem cell development GO:0048864 79 0.111
axonal fasciculation GO:0007413 12 0.111
lamellipodium organization GO:0097581 21 0.110
single organism behavior GO:0044708 391 0.110
appendage morphogenesis GO:0035107 397 0.104
actin filament based process GO:0030029 220 0.103
embryonic development via the syncytial blastoderm GO:0001700 148 0.102
regulation of peptidase activity GO:0052547 39 0.102
regulation of synapse organization GO:0050807 110 0.100
neuron projection extension involved in neuron projection guidance GO:1902284 10 0.099
single organism carbohydrate metabolic process GO:0044723 72 0.099
tissue migration GO:0090130 155 0.098
positive regulation of macromolecule metabolic process GO:0010604 405 0.097
cellular response to ketone GO:1901655 17 0.097
positive regulation of multicellular organismal process GO:0051240 143 0.094
Human Mouse
positive regulation of nervous system development GO:0051962 69 0.094
Human Mouse
positive regulation of gene expression GO:0010628 290 0.094
neuromuscular junction development GO:0007528 149 0.093
carbohydrate metabolic process GO:0005975 82 0.092
regulation of epithelial cell migration open tracheal system GO:2000274 11 0.092
imaginal disc derived wing morphogenesis GO:0007476 337 0.092
motor neuron axon guidance GO:0008045 58 0.092
negative regulation of cellular component organization GO:0051129 108 0.091
salivary gland development GO:0007431 162 0.088
negative regulation of neuroblast proliferation GO:0007406 27 0.088
forebrain development GO:0030900 2 0.086
negative regulation of cell differentiation GO:0045596 143 0.086
maintenance of location GO:0051235 73 0.083
morphogenesis of an epithelium GO:0002009 276 0.082
negative regulation of axon extension GO:0030517 3 0.082
regulation of photoreceptor cell axon guidance GO:2000289 5 0.081
actomyosin structure organization GO:0031032 56 0.080
phosphorylation GO:0016310 294 0.079
Human
protein complex assembly GO:0006461 200 0.079
apoptotic process GO:0006915 159 0.078
cellular nitrogen compound catabolic process GO:0044270 165 0.077
body morphogenesis GO:0010171 2 0.077
neuron maturation GO:0042551 31 0.076
intracellular transport GO:0046907 228 0.076
negative regulation of synapse assembly GO:0051964 39 0.074
cellular response to chemical stimulus GO:0070887 199 0.073
regulation of protein complex assembly GO:0043254 42 0.072
positive regulation of cellular component biogenesis GO:0044089 80 0.070
digestive tract morphogenesis GO:0048546 127 0.070
Zebrafish
synaptic growth at neuromuscular junction GO:0051124 119 0.070
negative regulation of cellular metabolic process GO:0031324 382 0.069
salivary gland boundary specification GO:0007432 8 0.068
negative regulation of developmental process GO:0051093 201 0.065
regionalization GO:0003002 416 0.064
vesicle mediated transport GO:0016192 381 0.062
regulation of axonogenesis GO:0050770 32 0.062
positive regulation of cellular biosynthetic process GO:0031328 316 0.060
negative regulation of nervous system development GO:0051961 92 0.060
regulation of proteolysis GO:0030162 87 0.060
organelle assembly GO:0070925 198 0.058
cation transport GO:0006812 110 0.056
cellular response to organic cyclic compound GO:0071407 32 0.055
negative regulation of growth GO:0045926 84 0.055
convergent extension GO:0060026 2 0.054
carbohydrate derivative metabolic process GO:1901135 217 0.054
chemical homeostasis GO:0048878 92 0.052
organophosphate metabolic process GO:0019637 195 0.051
proteolysis GO:0006508 192 0.050
cellular response to organic substance GO:0071310 132 0.049
macromolecular complex assembly GO:0065003 256 0.048
regulation of synapse assembly GO:0051963 94 0.047
neural precursor cell proliferation GO:0061351 75 0.046
actin cytoskeleton organization GO:0030036 206 0.045
negative regulation of biosynthetic process GO:0009890 277 0.045
regulation of phosphatase activity GO:0010921 3 0.045
endocytosis GO:0006897 310 0.045
inter male aggressive behavior GO:0002121 60 0.045
cell migration involved in gastrulation GO:0042074 9 0.045
Zebrafish
collateral sprouting GO:0048668 3 0.045
regulation of microtubule based process GO:0032886 49 0.044
transcription from rna polymerase ii promoter GO:0006366 368 0.044
post embryonic appendage morphogenesis GO:0035120 385 0.044
single organism cell adhesion GO:0098602 47 0.044
regulation of anatomical structure morphogenesis GO:0022603 242 0.043
small molecule metabolic process GO:0044281 305 0.042
cellular response to oxygen containing compound GO:1901701 79 0.042
semaphorin plexin signaling pathway GO:0071526 4 0.042
response to axon injury GO:0048678 12 0.041
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.040
ovarian follicle cell development GO:0030707 248 0.040
negative regulation of cell development GO:0010721 62 0.040
small gtpase mediated signal transduction GO:0007264 88 0.040
imaginal disc derived appendage development GO:0048737 399 0.039
regulation of protein metabolic process GO:0051246 256 0.039
eye morphogenesis GO:0048592 260 0.039
Mouse
cellular component assembly involved in morphogenesis GO:0010927 151 0.039
death GO:0016265 284 0.039
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 16 0.039
male gamete generation GO:0048232 201 0.038
establishment of proximal distal cell polarity GO:0022606 4 0.038
sex differentiation GO:0007548 81 0.038
regulation of synapse structural plasticity GO:0051823 3 0.038
regulation of cellular component movement GO:0051270 42 0.038
Human Mouse
tube morphogenesis GO:0035239 191 0.037
Zebrafish
formation of organ boundary GO:0010160 30 0.037
cell proliferation GO:0008283 299 0.037
ras protein signal transduction GO:0007265 88 0.036
regulation of microtubule cytoskeleton organization GO:0070507 41 0.036
protein polymerization GO:0051258 42 0.035
lamellipodium assembly GO:0030032 21 0.035
gene silencing by rna GO:0031047 57 0.034
single organism catabolic process GO:0044712 228 0.033
regulation of small gtpase mediated signal transduction GO:0051056 93 0.033
negative regulation of neurogenesis GO:0050768 53 0.033
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.032
regulation of endopeptidase activity GO:0052548 36 0.032
energy derivation by oxidation of organic compounds GO:0015980 32 0.032
ovarian follicle cell migration GO:0007297 121 0.031
rho protein signal transduction GO:0007266 14 0.031
muscle attachment GO:0016203 36 0.031
columnar cuboidal epithelial cell development GO:0002066 249 0.030
positive regulation of growth GO:0045927 75 0.029
Human Mouse
secretion by cell GO:0032940 101 0.029
neuron projection regeneration GO:0031102 8 0.029
tube development GO:0035295 244 0.029
Zebrafish
positive regulation of proteolysis GO:0045862 52 0.028
imaginal disc derived wing hair site selection GO:0035320 4 0.028
regulation of tube architecture open tracheal system GO:0035152 68 0.028
intracellular signal transduction GO:0035556 300 0.028
ribonucleoside catabolic process GO:0042454 112 0.027
substrate dependent cell migration GO:0006929 3 0.027
neuroblast proliferation GO:0007405 74 0.027
protein complex biogenesis GO:0070271 201 0.027
glycosyl compound catabolic process GO:1901658 112 0.026
ribose phosphate metabolic process GO:0019693 145 0.025
protein maturation GO:0051604 71 0.025
development of primary sexual characteristics GO:0045137 50 0.025
phagocytosis GO:0006909 215 0.025
negative regulation of neuron differentiation GO:0045665 16 0.025
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.025
spindle organization GO:0007051 253 0.024
epithelium migration GO:0090132 148 0.024
lipid localization GO:0010876 54 0.024
epithelial cell differentiation GO:0030855 322 0.024
male courtship behavior GO:0008049 63 0.024
cell division GO:0051301 248 0.024
cation homeostasis GO:0055080 51 0.024
oxidation reduction process GO:0055114 123 0.024
cytoskeleton dependent intracellular transport GO:0030705 44 0.024
purine nucleoside catabolic process GO:0006152 112 0.024
sensory perception of chemical stimulus GO:0007606 116 0.024
response to organic cyclic compound GO:0014070 89 0.024
purine containing compound catabolic process GO:0072523 112 0.024
organelle fission GO:0048285 340 0.023
Worm
polyol biosynthetic process GO:0046173 3 0.023
outflow tract morphogenesis GO:0003151 4 0.023
positive regulation of response to stimulus GO:0048584 323 0.023
Human Mouse
cell death GO:0008219 279 0.023
response to oxygen containing compound GO:1901700 200 0.022
wing disc morphogenesis GO:0007472 344 0.022
positive regulation of peptidase activity GO:0010952 29 0.022
regulation of stress activated mapk cascade GO:0032872 41 0.022
positive regulation of biosynthetic process GO:0009891 316 0.022
sensory perception of mechanical stimulus GO:0050954 72 0.022
regulation of neuroblast proliferation GO:1902692 34 0.021
purine ribonucleotide catabolic process GO:0009154 109 0.021
centrosome cycle GO:0007098 137 0.021
response to ecdysone GO:0035075 34 0.021
cellular response to endogenous stimulus GO:0071495 80 0.021
response to sterol GO:0036314 34 0.020
salivary gland morphogenesis GO:0007435 145 0.020
microtubule polymerization or depolymerization GO:0031109 39 0.020
cilium morphogenesis GO:0060271 39 0.020
response to ketone GO:1901654 34 0.020
protein modification by small protein conjugation GO:0032446 79 0.019
response to other organism GO:0051707 293 0.019
regulation of endocytosis GO:0030100 37 0.019
larval development GO:0002164 104 0.019
neuroblast development GO:0014019 13 0.019
regulation of ras protein signal transduction GO:0046578 93 0.019
segmentation GO:0035282 207 0.019
cellular response to hormone stimulus GO:0032870 44 0.019
protein catabolic process GO:0030163 101 0.019
ribonucleoside metabolic process GO:0009119 127 0.019
positive regulation of behavior GO:0048520 19 0.019
Human Mouse
multicellular organismal reproductive behavior GO:0033057 110 0.019
regulation of rho gtpase activity GO:0032319 20 0.019
cellular response to nitrogen compound GO:1901699 51 0.018
eye photoreceptor cell development GO:0042462 81 0.018
regulation of phosphorus metabolic process GO:0051174 210 0.018
Human
positive regulation of phosphorus metabolic process GO:0010562 139 0.018
Human
ribonucleotide catabolic process GO:0009261 109 0.018
cellular response to peptide hormone stimulus GO:0071375 28 0.018
aromatic compound catabolic process GO:0019439 166 0.018
cellular protein complex assembly GO:0043623 71 0.018
organonitrogen compound catabolic process GO:1901565 128 0.018
oocyte fate determination GO:0030716 27 0.018
compound eye photoreceptor cell differentiation GO:0001751 140 0.018
regulation of catabolic process GO:0009894 170 0.018
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.017
positive regulation of cell communication GO:0010647 250 0.017
phagocytosis engulfment GO:0006911 11 0.017
central nervous system neuron axonogenesis GO:0021955 7 0.017
regulation of transport GO:0051049 181 0.017
organonitrogen compound metabolic process GO:1901564 318 0.017
cell maturation GO:0048469 144 0.017
nucleoside phosphate metabolic process GO:0006753 162 0.017
regulation of catalytic activity GO:0050790 185 0.017
response to endogenous stimulus GO:0009719 119 0.016
purine ribonucleotide metabolic process GO:0009150 145 0.016
negative regulation of chemotaxis GO:0050922 1 0.016
photoreceptor cell differentiation GO:0046530 170 0.016
rhythmic behavior GO:0007622 76 0.016
actin filament organization GO:0007015 126 0.016
positive regulation of translation GO:0045727 12 0.016
regulation of cellular catabolic process GO:0031329 157 0.016
nucleobase containing small molecule metabolic process GO:0055086 174 0.016
regulation of cell death GO:0010941 173 0.016
organic substance catabolic process GO:1901575 308 0.016
response to external biotic stimulus GO:0043207 293 0.016
regulation of vesicle mediated transport GO:0060627 59 0.016
anatomical structure homeostasis GO:0060249 97 0.016
roundabout signaling pathway GO:0035385 4 0.016
actin polymerization or depolymerization GO:0008154 31 0.016
response to inorganic substance GO:0010035 44 0.016
regulation of cell substrate adhesion GO:0010810 2 0.016
regulation of response to external stimulus GO:0032101 115 0.016
Human Mouse
positive regulation of response to external stimulus GO:0032103 44 0.015
Human Mouse
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 24 0.015
regulation of programmed cell death GO:0043067 152 0.015
regulation of extent of cell growth GO:0061387 8 0.015
Human Mouse
regulation of response to oxidative stress GO:1902882 4 0.015
detection of stimulus GO:0051606 156 0.015
nucleotide metabolic process GO:0009117 161 0.015
nucleoside triphosphate catabolic process GO:0009143 108 0.014
skeletal muscle organ development GO:0060538 48 0.014
muscle cell differentiation GO:0042692 103 0.014
regulation of phosphate metabolic process GO:0019220 210 0.014
Human
stem cell proliferation GO:0072089 88 0.014
gonad development GO:0008406 50 0.014
centrosome duplication GO:0051298 121 0.014
nucleoside phosphate catabolic process GO:1901292 110 0.014
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.014
chemosensory behavior GO:0007635 106 0.014
positive regulation of ras protein signal transduction GO:0046579 43 0.014
protein ubiquitination GO:0016567 70 0.014
regulation of protein localization GO:0032880 76 0.014
regulation of cellular protein metabolic process GO:0032268 243 0.014
histone h3 k9 modification GO:0061647 12 0.014
neuronal stem cell division GO:0036445 35 0.014
muscle organ development GO:0007517 127 0.014
positive regulation of cellular component movement GO:0051272 11 0.013
Human Mouse
positive regulation of protein metabolic process GO:0051247 128 0.013
programmed cell death GO:0012501 257 0.013
cellular catabolic process GO:0044248 372 0.013
epithelial cell migration GO:0010631 148 0.013
positive regulation of cellular catabolic process GO:0031331 95 0.013
spermatogenesis GO:0007283 200 0.013
stem cell differentiation GO:0048863 117 0.013
protein modification by small protein conjugation or removal GO:0070647 106 0.013
positive regulation of hydrolase activity GO:0051345 78 0.013
cytoplasmic transport GO:0016482 130 0.013
gene silencing GO:0016458 138 0.012
regulation of cytoskeleton organization GO:0051493 89 0.012
organic cyclic compound catabolic process GO:1901361 168 0.012
startle response GO:0001964 16 0.012
antennal morphogenesis GO:0048800 14 0.012
cellular response to sterol GO:0036315 17 0.012
pupariation GO:0035073 14 0.012
formation of anatomical boundary GO:0048859 37 0.012
negative regulation of cell projection organization GO:0031345 13 0.012
convergent extension involved in gastrulation GO:0060027 2 0.012
glycosyl compound metabolic process GO:1901657 127 0.012
regulation of locomotion GO:0040012 42 0.012
Human Mouse
intracellular steroid hormone receptor signaling pathway GO:0030518 12 0.012
carbohydrate biosynthetic process GO:0016051 17 0.011
compound eye development GO:0048749 307 0.011
eye photoreceptor cell differentiation GO:0001754 145 0.011
ribonucleoside triphosphate metabolic process GO:0009199 119 0.011
sensory perception GO:0007600 196 0.011
reproductive behavior GO:0019098 122 0.011
positive regulation of signaling GO:0023056 243 0.011
single organismal cell cell adhesion GO:0016337 45 0.011
membrane organization GO:0061024 112 0.011
establishment of organelle localization GO:0051656 122 0.011
mitotic dna damage checkpoint GO:0044773 74 0.011
cilium assembly GO:0042384 38 0.011
negative regulation of developmental growth GO:0048640 64 0.011
response to wounding GO:0009611 94 0.011
positive regulation of gtp catabolic process GO:0033126 43 0.010
regulation of cell motility GO:2000145 23 0.010
organophosphate catabolic process GO:0046434 112 0.010
regulation of lamellipodium assembly GO:0010591 15 0.010
cellular response to insulin stimulus GO:0032869 28 0.010
macromolecule catabolic process GO:0009057 161 0.010
negative regulation of neuron death GO:1901215 18 0.010
cellular component maintenance GO:0043954 23 0.010
blood circulation GO:0008015 26 0.010
actin filament polymerization GO:0030041 27 0.010
multi organism reproductive behavior GO:0044705 121 0.010

Dscam disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.058
sensory system disease DOID:0050155 0 0.048
nervous system disease DOID:863 0 0.048
eye and adnexa disease DOID:1492 0 0.016
eye disease DOID:5614 0 0.016