Drosophila melanogaster

10 known processes

nAcRbeta-64B (Dmel_CG11348)

nicotinic Acetylcholine Receptor beta 64B

(Aliases: AChR64B,ard,CG12606,beta 64B,AchR64B,CG11348-PA,AChR,Dmel\CG11348,CG11348,ARD,AcrD,Acr64B,Ard,nAChR)

nAcRbeta-64B biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
single organism behavior GO:0044708 391 0.393
Human Fly
neurological system process GO:0050877 358 0.132
Human
locomotory behavior GO:0007626 176 0.125
Fly
response to light stimulus GO:0009416 124 0.111
Human Fly
response to organic substance GO:0010033 284 0.110
Human Mouse Rat
response to abiotic stimulus GO:0009628 341 0.107
Human Fly
cation transport GO:0006812 110 0.100
Human Mouse Rat Fly
salt aversion GO:0035199 3 0.089
behavioral response to ethanol GO:0048149 49 0.087
cation homeostasis GO:0055080 51 0.080
cation transmembrane transport GO:0098655 88 0.078
Human Mouse Rat Fly
response to extracellular stimulus GO:0009991 116 0.078
response to alcohol GO:0097305 95 0.076
sensory perception of salty taste GO:0050914 3 0.074
detection of visible light GO:0009584 38 0.074
transmembrane transport GO:0055085 139 0.073
Human Mouse Rat Fly
associative learning GO:0008306 65 0.072
Human
ion transport GO:0006811 145 0.071
Human Mouse Rat Fly
adult behavior GO:0030534 137 0.070
Human Fly
sensory perception of chemical stimulus GO:0007606 116 0.069
metal ion transport GO:0030001 74 0.069
adult locomotory behavior GO:0008344 76 0.068
Fly
detection of stimulus GO:0051606 156 0.068
sensory perception GO:0007600 196 0.067
response to oxygen containing compound GO:1901700 200 0.061
rhythmic process GO:0048511 106 0.054
response to ethanol GO:0045471 59 0.053
axonogenesis GO:0007409 290 0.053
organonitrogen compound metabolic process GO:1901564 318 0.052
axon development GO:0061564 297 0.050
developmental growth GO:0048589 280 0.048
Human
compound eye development GO:0048749 307 0.047
metal ion homeostasis GO:0055065 44 0.046
chemosensory behavior GO:0007635 106 0.045
store operated calcium entry GO:0002115 3 0.044
cell cycle phase transition GO:0044770 140 0.042
ion transmembrane transport GO:0034220 122 0.042
Human Mouse Rat Fly
memory GO:0007613 94 0.041
Human
homeostatic process GO:0042592 199 0.041
Human
actin filament based process GO:0030029 220 0.041
appendage development GO:0048736 401 0.038
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.038
mitotic cell cycle phase transition GO:0044772 138 0.037
learning GO:0007612 75 0.037
Human
eye development GO:0001654 323 0.036
small molecule metabolic process GO:0044281 305 0.036
synaptic transmission GO:0007268 288 0.036
sleep GO:0030431 49 0.035
Fly
circadian behavior GO:0048512 76 0.035
response to nutrient levels GO:0031667 114 0.034
response to other organism GO:0051707 293 0.034
appendage morphogenesis GO:0035107 397 0.034
mating GO:0007618 120 0.034
regulation of membrane potential GO:0042391 35 0.034
Human Mouse Fly
detection of light stimulus GO:0009583 58 0.033
regulation of heart rate GO:0002027 11 0.033
negative regulation of multicellular organismal process GO:0051241 142 0.033
compound eye morphogenesis GO:0001745 249 0.033
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.032
positive regulation of biosynthetic process GO:0009891 316 0.032
learning or memory GO:0007611 141 0.032
Human
multi organism behavior GO:0051705 175 0.032
taxis GO:0042330 304 0.031
neuron recognition GO:0008038 101 0.030
eye morphogenesis GO:0048592 260 0.030
chemical homeostasis GO:0048878 92 0.029
ion homeostasis GO:0050801 55 0.029
sensory organ morphogenesis GO:0090596 260 0.029
heart process GO:0003015 37 0.029
reproductive behavior GO:0019098 122 0.029
cell proliferation GO:0008283 299 0.029
calcium ion homeostasis GO:0055074 23 0.028
phagocytosis GO:0006909 215 0.028
vesicle mediated transport GO:0016192 381 0.028
catabolic process GO:0009056 409 0.028
response to radiation GO:0009314 155 0.028
Human Fly
positive regulation of cellular biosynthetic process GO:0031328 316 0.028
cellular metal ion homeostasis GO:0006875 31 0.028
regulation of multicellular organismal development GO:2000026 414 0.028
imaginal disc derived wing morphogenesis GO:0007476 337 0.028
olfactory learning GO:0008355 56 0.027
cellular divalent inorganic cation homeostasis GO:0072503 23 0.027
imaginal disc derived appendage morphogenesis GO:0035114 395 0.027
potassium ion transport GO:0006813 20 0.026
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.026
negative regulation of gene expression GO:0010629 387 0.026
cellular ion homeostasis GO:0006873 39 0.026
detection of abiotic stimulus GO:0009582 66 0.026
single organism biosynthetic process GO:0044711 206 0.026
post embryonic appendage morphogenesis GO:0035120 385 0.025
mating behavior GO:0007617 106 0.025
cellular protein modification process GO:0006464 438 0.025
axis specification GO:0009798 167 0.025
olfactory behavior GO:0042048 97 0.025
organic substance transport GO:0071702 257 0.025
Rat
wing disc morphogenesis GO:0007472 344 0.025
monovalent inorganic cation transport GO:0015672 40 0.025
sensory perception of taste GO:0050909 25 0.025
kidney development GO:0001822 3 0.025
divalent inorganic cation homeostasis GO:0072507 29 0.025
regulation of mitotic cell cycle phase transition GO:1901990 130 0.024
detection of external stimulus GO:0009581 66 0.024
lateral inhibition GO:0046331 206 0.024
circadian sleep wake cycle GO:0042745 28 0.024
regulation of anatomical structure size GO:0090066 163 0.024
macromolecular complex assembly GO:0065003 256 0.023
Rat
epithelial cell differentiation GO:0030855 322 0.023
regulation of actin filament based process GO:0032970 42 0.023
imaginal disc derived appendage development GO:0048737 399 0.023
regulation of circadian rhythm GO:0042752 49 0.023
response to lipopolysaccharide GO:0032496 4 0.023
regulation of tube size GO:0035150 46 0.023
regionalization GO:0003002 416 0.023
positive regulation of gene expression GO:0010628 290 0.023
developmental maturation GO:0021700 172 0.023
negative regulation of cellular metabolic process GO:0031324 382 0.023
positive regulation of response to stimulus GO:0048584 323 0.023
growth GO:0040007 359 0.023
Human
nucleoside phosphate metabolic process GO:0006753 162 0.023
regulation of behavior GO:0050795 75 0.023
negative regulation of developmental process GO:0051093 201 0.022
g protein coupled receptor signaling pathway GO:0007186 136 0.022
regulation of cell cycle phase transition GO:1901987 130 0.022
endocytosis GO:0006897 310 0.022
organic acid metabolic process GO:0006082 103 0.022
cellular cation homeostasis GO:0030003 38 0.022
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.022
response to biotic stimulus GO:0009607 294 0.022
cell death GO:0008219 279 0.022
regulation of cell development GO:0060284 215 0.022
response to toxic substance GO:0009636 22 0.021
Fly
negative regulation of signaling GO:0023057 219 0.021
eye photoreceptor cell differentiation GO:0001754 145 0.021
neuromuscular synaptic transmission GO:0007274 67 0.021
Human
organophosphate metabolic process GO:0019637 195 0.021
organic substance catabolic process GO:1901575 308 0.021
camera type eye development GO:0043010 4 0.021
body morphogenesis GO:0010171 2 0.021
circadian sleep wake cycle sleep GO:0050802 23 0.021
oxoacid metabolic process GO:0043436 103 0.021
cellular chemical homeostasis GO:0055082 40 0.021
photoreceptor cell differentiation GO:0046530 170 0.021
neurotransmitter metabolic process GO:0042133 2 0.021
forebrain development GO:0030900 2 0.020
inorganic ion transmembrane transport GO:0098660 73 0.020
cell recognition GO:0008037 102 0.020
regulation of cell cycle process GO:0010564 181 0.020
cellular homeostasis GO:0019725 80 0.020
Human
organic cyclic compound catabolic process GO:1901361 168 0.020
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.020
synaptic target recognition GO:0008039 45 0.020
positive regulation of rna biosynthetic process GO:1902680 266 0.020
carboxylic acid metabolic process GO:0019752 92 0.020
acetylcholine metabolic process GO:0008291 2 0.020
organelle fission GO:0048285 340 0.020
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.020
detection of stimulus involved in sensory perception GO:0050906 92 0.020
purine containing compound metabolic process GO:0072521 155 0.019
response to organic cyclic compound GO:0014070 89 0.019
Human Mouse Rat
chaeta development GO:0022416 97 0.019
central nervous system development GO:0007417 201 0.019
inorganic cation transmembrane transport GO:0098662 61 0.019
compound eye photoreceptor cell differentiation GO:0001751 140 0.019
muscle system process GO:0003012 21 0.019
Human Rat
aromatic compound catabolic process GO:0019439 166 0.019
rhythmic behavior GO:0007622 76 0.019
heterocycle catabolic process GO:0046700 166 0.019
regulation of cellular amine metabolic process GO:0033238 3 0.019
death GO:0016265 284 0.019
positive regulation of signaling GO:0023056 243 0.019
cognition GO:0050890 141 0.019
Human
dorsal ventral pattern formation GO:0009953 133 0.018
peptidyl proline hydroxylation GO:0019511 1 0.018
positive regulation of cell communication GO:0010647 250 0.018
developmental programmed cell death GO:0010623 138 0.018
response to external biotic stimulus GO:0043207 293 0.018
circulatory system process GO:0003013 37 0.018
cell growth GO:0016049 108 0.018
negative regulation of biosynthetic process GO:0009890 277 0.018
regulation of localization GO:0032879 275 0.018
Rat
embryonic axis specification GO:0000578 107 0.018
feeding behavior GO:0007631 50 0.018
positive regulation of nucleic acid templated transcription GO:1903508 266 0.018
nuclear division GO:0000280 332 0.018
detection of chemical stimulus GO:0009593 93 0.018
negative regulation of rna biosynthetic process GO:1902679 240 0.018
negative regulation of nucleic acid templated transcription GO:1903507 240 0.018
nucleobase containing small molecule metabolic process GO:0055086 174 0.017
purine nucleotide metabolic process GO:0006163 146 0.017
regulation of system process GO:0044057 36 0.017
intracellular signal transduction GO:0035556 300 0.017
nucleotide metabolic process GO:0009117 161 0.017
ribonucleotide metabolic process GO:0009259 145 0.017
protein modification process GO:0036211 438 0.017
cellular calcium ion homeostasis GO:0006874 21 0.017
dendrite morphogenesis GO:0048813 199 0.017
regulation of phosphorus metabolic process GO:0051174 210 0.017
positive regulation of purine nucleotide metabolic process GO:1900544 55 0.017
establishment of planar polarity GO:0001736 87 0.017
actin cytoskeleton organization GO:0030036 206 0.017
chemotaxis GO:0006935 249 0.017
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.017
regulation of synapse structure and activity GO:0050803 128 0.017
amine metabolic process GO:0009308 12 0.017
single organism catabolic process GO:0044712 228 0.017
cellular amino acid metabolic process GO:0006520 61 0.017
regulation of cellular ketone metabolic process GO:0010565 3 0.016
response to oxidative stress GO:0006979 86 0.016
Human
actin filament based movement GO:0030048 26 0.016
cellular nitrogen compound catabolic process GO:0044270 165 0.016
localization of cell GO:0051674 257 0.016
response to insecticide GO:0017085 14 0.016
Fly
dendrite development GO:0016358 204 0.016
anterior posterior axis specification GO:0009948 109 0.016
regulation of cell cycle GO:0051726 291 0.016
ras protein signal transduction GO:0007265 88 0.016
cellular catabolic process GO:0044248 372 0.016
heart contraction GO:0060047 26 0.016
flight behavior GO:0007629 26 0.016
carbohydrate derivative catabolic process GO:1901136 118 0.016
wnt signaling pathway GO:0016055 98 0.016
transcription from rna polymerase ii promoter GO:0006366 368 0.016
purine ribonucleotide metabolic process GO:0009150 145 0.016
regulation of intracellular signal transduction GO:1902531 236 0.016
divalent metal ion transport GO:0070838 26 0.016
negative regulation of signal transduction GO:0009968 206 0.016
regulation of cell proliferation GO:0042127 163 0.016
cell division GO:0051301 248 0.016
steroid catabolic process GO:0006706 1 0.016
segmentation GO:0035282 207 0.015
positive regulation of cell migration GO:0030335 2 0.015
regulation of heart contraction GO:0008016 21 0.015
protein localization GO:0008104 284 0.015
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.015
purine ribonucleoside metabolic process GO:0046128 127 0.015
negative regulation of cellular biosynthetic process GO:0031327 277 0.015
multi organism reproductive behavior GO:0044705 121 0.015
regulation of cellular amino acid metabolic process GO:0006521 0 0.015
tripartite regional subdivision GO:0007351 103 0.015
positive regulation of macromolecule metabolic process GO:0010604 405 0.015
response to organophosphorus GO:0046683 2 0.015
regulation of transport GO:0051049 181 0.015
Rat
enzyme linked receptor protein signaling pathway GO:0007167 179 0.015
regulation of nucleotide metabolic process GO:0006140 62 0.015
cellular response to chemical stimulus GO:0070887 199 0.015
programmed cell death GO:0012501 257 0.015
acetate ester metabolic process GO:1900619 2 0.015
defense response GO:0006952 300 0.015
cellular amine metabolic process GO:0044106 12 0.015
divalent inorganic cation transport GO:0072511 30 0.015
response to oxygen levels GO:0070482 59 0.015
Human
cell maturation GO:0048469 144 0.015
courtship behavior GO:0007619 68 0.015
regulation of cell differentiation GO:0045595 302 0.014
establishment of localization in cell GO:0051649 402 0.014
Rat
signal transduction by phosphorylation GO:0023014 107 0.014
negative regulation of rna metabolic process GO:0051253 251 0.014
negative regulation of cell communication GO:0010648 223 0.014
regulation of catalytic activity GO:0050790 185 0.014
neuropeptide signaling pathway GO:0007218 45 0.014
response to monosaccharide GO:0034284 4 0.014
regulation of synaptic transmission GO:0050804 69 0.014
circadian sleep wake cycle process GO:0022410 24 0.014
positive regulation of signal transduction GO:0009967 223 0.014
regulation of blood circulation GO:1903522 21 0.014
negative regulation of homeostatic process GO:0032845 2 0.014
protein complex biogenesis GO:0070271 201 0.014
Rat
response to organonitrogen compound GO:0010243 75 0.014
Human Mouse Rat
regulation of developmental growth GO:0048638 174 0.014
regulation of anatomical structure morphogenesis GO:0022603 242 0.014
cell cell signaling involved in cell fate commitment GO:0045168 210 0.014
epithelial cell development GO:0002064 274 0.014
negative regulation of response to stimulus GO:0048585 258 0.014
anterior posterior axis specification embryo GO:0008595 103 0.014
response to decreased oxygen levels GO:0036293 58 0.014
Human
establishment or maintenance of cell polarity GO:0007163 167 0.014
positive regulation of rna metabolic process GO:0051254 271 0.014
regulation of cellular component biogenesis GO:0044087 201 0.014
anterior posterior pattern specification GO:0009952 136 0.014
positive regulation of cell motility GO:2000147 3 0.014
defense response to other organism GO:0098542 225 0.013
sensory perception of smell GO:0007608 80 0.013
actin filament organization GO:0007015 126 0.013
cellular response to lipopolysaccharide GO:0071222 3 0.013
tissue morphogenesis GO:0048729 297 0.013
establishment of protein localization GO:0045184 163 0.013
immune system process GO:0002376 347 0.013
response to hexose GO:0009746 3 0.013
regulation of cellular component movement GO:0051270 42 0.013
response to mechanical stimulus GO:0009612 28 0.013
limb development GO:0060173 1 0.013
chromosome organization GO:0051276 360 0.013
cell migration GO:0016477 238 0.013
oocyte construction GO:0007308 112 0.013
actin mediated cell contraction GO:0070252 21 0.013
neuromuscular junction development GO:0007528 149 0.013
Human
positive regulation of phosphorus metabolic process GO:0010562 139 0.013
response to starvation GO:0042594 97 0.013
nephron epithelium development GO:0072009 3 0.013
organonitrogen compound biosynthetic process GO:1901566 117 0.013
regulation of growth GO:0040008 233 0.013
morphogenesis of an epithelium GO:0002009 276 0.013
regulation of synaptic activity GO:0060025 9 0.013
salivary gland development GO:0007431 162 0.013
neuron projection guidance GO:0097485 241 0.013
cellular ketone metabolic process GO:0042180 24 0.013
cranial nerve development GO:0021545 1 0.013
positive regulation of molecular function GO:0044093 136 0.013
salivary gland morphogenesis GO:0007435 145 0.013
negative regulation of transcription dna templated GO:0045892 237 0.013
carbohydrate derivative metabolic process GO:1901135 217 0.013
regulation of organelle organization GO:0033043 196 0.013
response to nitrogen compound GO:1901698 90 0.013
Human Mouse Rat
connective tissue development GO:0061448 3 0.012
detection of chemical stimulus involved in sensory perception GO:0050907 75 0.012
small gtpase mediated signal transduction GO:0007264 88 0.012
retina development in camera type eye GO:0060041 4 0.012
positive regulation of catalytic activity GO:0043085 118 0.012
cellular response to biotic stimulus GO:0071216 4 0.012
positive regulation of phosphate metabolic process GO:0045937 139 0.012
response to alkaloid GO:0043279 26 0.012
Human Mouse Rat
phosphorylation GO:0016310 294 0.012
cellular response to ethanol GO:0071361 4 0.012
response to glucose GO:0009749 2 0.012
digestive tract development GO:0048565 149 0.012
regulation of phosphate metabolic process GO:0019220 210 0.012
intracellular transport GO:0046907 228 0.012
regulation of circadian sleep wake cycle sleep GO:0045187 21 0.012
peptide metabolic process GO:0006518 80 0.012
purine ribonucleoside catabolic process GO:0046130 112 0.012
imaginal disc pattern formation GO:0007447 91 0.012
telencephalon development GO:0021537 2 0.012
gland development GO:0048732 191 0.012
blastoderm segmentation GO:0007350 159 0.012
regulation of molecular function GO:0065009 217 0.012
positive regulation of catabolic process GO:0009896 105 0.012
nucleobase containing compound catabolic process GO:0034655 165 0.012
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.012
ribose phosphate metabolic process GO:0019693 145 0.012
protein hydroxylation GO:0018126 1 0.012
locomotor rhythm GO:0045475 56 0.012
spermatogenesis GO:0007283 200 0.012
developmental cell growth GO:0048588 52 0.012
regulation of cell morphogenesis GO:0022604 163 0.012
cellular response to carbohydrate stimulus GO:0071322 4 0.012
kidney epithelium development GO:0072073 3 0.012
brain development GO:0007420 120 0.012
embryonic pattern specification GO:0009880 174 0.012
regulation of catabolic process GO:0009894 170 0.012
regulation of ion transport GO:0043269 39 0.012
Rat
photoreceptor cell development GO:0042461 96 0.012
axon guidance GO:0007411 233 0.011
eye photoreceptor cell development GO:0042462 81 0.011
organonitrogen compound catabolic process GO:1901565 128 0.011
tube development GO:0035295 244 0.011
hormone catabolic process GO:0042447 3 0.011
purine containing compound catabolic process GO:0072523 112 0.011
sensory perception of mechanical stimulus GO:0050954 72 0.011
regulation of transmembrane transport GO:0034762 27 0.011
response to endogenous stimulus GO:0009719 119 0.011
Human Mouse Rat
mapk cascade GO:0000165 107 0.011
leg disc development GO:0035218 92 0.011
photoreceptor cell fate commitment GO:0046552 41 0.011
positive regulation of intracellular signal transduction GO:1902533 116 0.011
adenylate cyclase modulating g protein coupled receptor signaling pathway GO:0007188 17 0.011
maternal determination of anterior posterior axis embryo GO:0008358 74 0.011
regulation of cellular catabolic process GO:0031329 157 0.011
cellular macromolecule localization GO:0070727 220 0.011
response to temperature stimulus GO:0009266 106 0.011
stem cell proliferation GO:0072089 88 0.011
purine nucleoside triphosphate metabolic process GO:0009144 119 0.011
nephron development GO:0072006 3 0.011
larval behavior GO:0030537 42 0.011
hindgut morphogenesis GO:0007442 58 0.011
ribose phosphate biosynthetic process GO:0046390 28 0.011
response to bacterium GO:0009617 198 0.011
mating behavior sex discrimination GO:0048047 7 0.011
nucleoside metabolic process GO:0009116 127 0.011
embryonic morphogenesis GO:0048598 206 0.011
cellular response to molecule of bacterial origin GO:0071219 3 0.011
nucleoside catabolic process GO:0009164 112 0.011
nucleotide catabolic process GO:0009166 109 0.011
rna localization GO:0006403 115 0.011
proteolysis GO:0006508 192 0.011
single organism intracellular transport GO:1902582 207 0.011
ribonucleoside triphosphate metabolic process GO:0009199 119 0.011
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger GO:0007187 17 0.011
negative regulation of developmental growth GO:0048640 64 0.011
rna processing GO:0006396 147 0.011
regulation of nervous system development GO:0051960 248 0.011
immune response GO:0006955 246 0.011
limb morphogenesis GO:0035108 1 0.011
regulation of programmed cell death GO:0043067 152 0.011
immune response activating signal transduction GO:0002757 2 0.011
estrogen metabolic process GO:0008210 1 0.011
positive regulation of nucleotide metabolic process GO:0045981 55 0.011
purine nucleoside metabolic process GO:0042278 127 0.010
molting cycle chitin based cuticle GO:0007591 56 0.010
male gamete generation GO:0048232 201 0.010
regulation of phosphorylation GO:0042325 147 0.010
camera type eye morphogenesis GO:0048593 2 0.010
vitamin metabolic process GO:0006766 2 0.010
regulation of circadian sleep wake cycle GO:0042749 25 0.010
mitotic nuclear division GO:0007067 213 0.010
tissue death GO:0016271 102 0.010
glycosyl compound metabolic process GO:1901657 127 0.010
protein transport GO:0015031 155 0.010
ovarian follicle cell development GO:0030707 248 0.010
hindbrain development GO:0030902 2 0.010
cellular response to oxygen containing compound GO:1901701 79 0.010
cellular potassium ion transport GO:0071804 18 0.010
regulation of cell death GO:0010941 173 0.010
aging GO:0007568 143 0.010
regulation of response to stress GO:0080134 200 0.010
positive regulation of cellular amine metabolic process GO:0033240 0 0.010
regulation of sequestering of calcium ion GO:0051282 3 0.010
cytosolic calcium ion homeostasis GO:0051480 11 0.010
nitrogen compound transport GO:0071705 85 0.010
Rat
negative regulation of cell differentiation GO:0045596 143 0.010
cell motility GO:0048870 251 0.010

nAcRbeta-64B disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.058
cardiovascular system disease DOID:1287 0 0.056
nervous system disease DOID:863 0 0.036
heart conduction disease DOID:10273 0 0.019
disease of metabolism DOID:0014667 0 0.012
cancer DOID:162 0 0.011
disease of cellular proliferation DOID:14566 0 0.011
inherited metabolic disorder DOID:655 0 0.011
artery disease DOID:0050828 0 0.011
vascular disease DOID:178 0 0.011
sensory system disease DOID:0050155 0 0.010