Drosophila melanogaster

70 known processes

Ext2 (Dmel_CG8433)

CG8433 gene product from transcript CG8433-RA

(Aliases: DEXT2,DExt2,BcDNA:GH02288,Dmel\CG8433,CG8433,CG33038,Sotv,sotv)

Ext2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
chondroitin sulfate metabolic process GO:0030204 2 1.000
cellular carbohydrate biosynthetic process GO:0034637 7 1.000
cellular polysaccharide biosynthetic process GO:0033692 7 0.999
heparan sulfate proteoglycan biosynthetic process GO:0015012 10 0.997
polysaccharide biosynthetic process GO:0000271 7 0.997
glycosaminoglycan biosynthetic process GO:0006024 7 0.996
chondroitin sulfate proteoglycan metabolic process GO:0050654 3 0.988
sulfur compound biosynthetic process GO:0044272 16 0.988
aminoglycan metabolic process GO:0006022 18 0.980
heparan sulfate proteoglycan metabolic process GO:0030201 10 0.962
heparan sulfate proteoglycan biosynthetic process polysaccharide chain biosynthetic process GO:0015014 5 0.958
chondroitin sulfate proteoglycan biosynthetic process GO:0050650 3 0.953
sulfur compound metabolic process GO:0006790 59 0.944
chondroitin sulfate biosynthetic process GO:0030206 2 0.921
heparin metabolic process GO:0030202 4 0.917
aminoglycan biosynthetic process GO:0006023 11 0.906
retinal ganglion cell axon guidance GO:0031290 12 0.904
Zebrafish
proteoglycan biosynthetic process GO:0030166 10 0.882
positive regulation of fibroblast growth factor receptor signaling pathway GO:0045743 5 0.814
Zebrafish
glycoprotein metabolic process GO:0009100 41 0.808
synaptic vesicle endocytosis GO:0048488 28 0.799
Fly
mitochondrion distribution GO:0048311 10 0.765
Fly
glycoprotein biosynthetic process GO:0009101 41 0.765
glycosaminoglycan metabolic process GO:0030203 11 0.730
imaginal disc derived wing vein specification GO:0007474 48 0.721
regionalization GO:0003002 416 0.700
post embryonic appendage morphogenesis GO:0035120 385 0.589
synaptic vesicle transport GO:0048489 50 0.539
Fly
intracellular distribution of mitochondria GO:0048312 5 0.530
Fly
wing disc morphogenesis GO:0007472 344 0.527
cellular polysaccharide metabolic process GO:0044264 11 0.516
cellular carbohydrate metabolic process GO:0044262 22 0.500
appendage morphogenesis GO:0035107 397 0.491
Zebrafish
imaginal disc derived wing morphogenesis GO:0007476 337 0.487
establishment of vesicle localization GO:0051650 51 0.476
Fly
cellular response to fibroblast growth factor stimulus GO:0044344 10 0.462
Zebrafish
segmentation GO:0035282 207 0.426
carbohydrate derivative biosynthetic process GO:1901137 85 0.386
neuron projection guidance GO:0097485 241 0.379
Zebrafish Fly
smoothened signaling pathway GO:0007224 49 0.361
response to fibroblast growth factor GO:0071774 10 0.347
Zebrafish
proteoglycan metabolic process GO:0006029 10 0.322
imaginal disc derived wing margin morphogenesis GO:0008587 41 0.306
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 65 0.297
mucopolysaccharide metabolic process GO:1903510 5 0.268
regulation of neuron differentiation GO:0045664 103 0.266
Zebrafish
synaptic vesicle localization GO:0097479 53 0.254
Fly
synapse organization GO:0050808 196 0.251
Fly
axon guidance GO:0007411 233 0.240
Zebrafish Fly
pharynx development GO:0060465 1 0.240
mitochondrion organization GO:0007005 65 0.239
Fly
germ cell migration GO:0008354 43 0.236
Fly
positive regulation of response to stimulus GO:0048584 323 0.215
Zebrafish
axonogenesis GO:0007409 290 0.213
Zebrafish Fly
single organism carbohydrate metabolic process GO:0044723 72 0.210
positive regulation of signal transduction GO:0009967 223 0.200
Zebrafish
fibroblast growth factor receptor signaling pathway GO:0008543 10 0.198
Zebrafish
imaginal disc derived appendage morphogenesis GO:0035114 395 0.194
mitochondrion localization GO:0051646 17 0.189
Fly
polysaccharide metabolic process GO:0005976 11 0.186
carbohydrate biosynthetic process GO:0016051 17 0.186
regulation of smoothened signaling pathway GO:0008589 28 0.167
Fly
oxoacid metabolic process GO:0043436 103 0.161
localization of cell GO:0051674 257 0.145
Fly
vesicle localization GO:0051648 55 0.143
Fly
peptidyl threonine phosphorylation GO:0018107 2 0.141
regulation of multicellular organismal development GO:2000026 414 0.133
Zebrafish
imaginal disc derived appendage development GO:0048737 399 0.125
organelle localization GO:0051640 148 0.124
Fly
cell motility GO:0048870 251 0.123
Fly
carbohydrate metabolic process GO:0005975 82 0.120
digestive tract development GO:0048565 149 0.119
Mouse
cellular protein modification process GO:0006464 438 0.119
chemotaxis GO:0006935 249 0.115
Zebrafish Fly
regulation of neurogenesis GO:0050767 158 0.105
Zebrafish
protein ubiquitination GO:0016567 70 0.105
synaptic transmission GO:0007268 288 0.104
Fly
segment polarity determination GO:0007367 25 0.098
digestive system development GO:0055123 149 0.093
Mouse
carbohydrate derivative metabolic process GO:1901135 217 0.091
embryonic morphogenesis GO:0048598 206 0.090
Zebrafish Mouse
organonitrogen compound biosynthetic process GO:1901566 117 0.089
small molecule metabolic process GO:0044281 305 0.088
regulation of cell morphogenesis involved in differentiation GO:0010769 61 0.087
Zebrafish
appendage development GO:0048736 401 0.085
Zebrafish
chromosome segregation GO:0007059 157 0.083
endocytosis GO:0006897 310 0.083
Fly
regulation of cell morphogenesis GO:0022604 163 0.081
Zebrafish
wnt signaling pathway GO:0016055 98 0.080
epithelium migration GO:0090132 148 0.076
periodic partitioning GO:0007365 29 0.076
embryonic organ development GO:0048568 50 0.073
single organism intracellular transport GO:1902582 207 0.072
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.069
connective tissue development GO:0061448 3 0.068
Zebrafish
leg disc development GO:0035218 92 0.068
protein catabolic process GO:0030163 101 0.063
cell migration GO:0016477 238 0.061
Fly
single organism cellular localization GO:1902580 180 0.058
Fly
vesicle mediated transport GO:0016192 381 0.055
Fly
apposition of dorsal and ventral imaginal disc derived wing surfaces GO:0007475 15 0.055
regulation of epithelial cell proliferation GO:0050678 4 0.054
cardiovascular system development GO:0072358 82 0.051
positive regulation of signaling GO:0023056 243 0.051
Zebrafish
macromolecular complex assembly GO:0065003 256 0.050
regulation of cellular amino acid metabolic process GO:0006521 0 0.049
regulation of cell differentiation GO:0045595 302 0.049
Zebrafish
regulation of cell projection organization GO:0031344 92 0.047
Zebrafish
protein localization GO:0008104 284 0.044
segment specification GO:0007379 33 0.044
synaptic vesicle recycling GO:0036465 28 0.044
Fly
regulation of cellular amine metabolic process GO:0033238 3 0.043
protein palmitoylation GO:0018345 2 0.042
lipid metabolic process GO:0006629 121 0.041
positive regulation of cell communication GO:0010647 250 0.041
Zebrafish
negative regulation of gene expression GO:0010629 387 0.040
protein modification by small protein conjugation or removal GO:0070647 106 0.040
regulation of nervous system development GO:0051960 248 0.040
Zebrafish
chromosome organization GO:0051276 360 0.039
forebrain development GO:0030900 2 0.039
cuticle development GO:0042335 86 0.039
tissue morphogenesis GO:0048729 297 0.038
Mouse
chromatin organization GO:0006325 207 0.038
tissue migration GO:0090130 155 0.037
blastoderm segmentation GO:0007350 159 0.037
enzyme linked receptor protein signaling pathway GO:0007167 179 0.037
ubiquitin dependent protein catabolic process GO:0006511 78 0.036
erbb signaling pathway GO:0038127 58 0.035
single organism biosynthetic process GO:0044711 206 0.035
axon development GO:0061564 297 0.034
Zebrafish Fly
regulation of fibroblast growth factor receptor signaling pathway GO:0040036 7 0.032
Zebrafish
regulation of reproductive process GO:2000241 54 0.032
imaginal disc derived leg morphogenesis GO:0007480 80 0.031
positive regulation of protein secretion GO:0050714 9 0.028
phagocytosis GO:0006909 215 0.027
mitotic spindle organization GO:0007052 220 0.027
cellular amino acid metabolic process GO:0006520 61 0.027
regulation of anatomical structure morphogenesis GO:0022603 242 0.026
Zebrafish
eye development GO:0001654 323 0.025
developmental growth involved in morphogenesis GO:0060560 65 0.025
Zebrafish
amine metabolic process GO:0009308 12 0.025
regulation of notch signaling pathway GO:0008593 100 0.025
regulation of extent of cell growth GO:0061387 8 0.025
Zebrafish
positive regulation of cellular component organization GO:0051130 156 0.024
proteolysis GO:0006508 192 0.024
positive regulation of cell motility GO:2000147 3 0.024
establishment of synaptic vesicle localization GO:0097480 50 0.024
Fly
single organism membrane organization GO:0044802 93 0.024
organic acid metabolic process GO:0006082 103 0.024
protein modification by small protein conjugation GO:0032446 79 0.024
cellular response to growth factor stimulus GO:0071363 30 0.024
Zebrafish
macromolecule catabolic process GO:0009057 161 0.024
homeostatic process GO:0042592 199 0.023
protein modification process GO:0036211 438 0.023
tube morphogenesis GO:0035239 191 0.023
Mouse
regulation of protein localization GO:0032880 76 0.022
anterior posterior axis specification GO:0009948 109 0.022
peptidyl amino acid modification GO:0018193 105 0.022
histone h3 k4 methylation GO:0051568 16 0.021
spindle organization GO:0007051 253 0.021
nucleocytoplasmic transport GO:0006913 72 0.021
proteasomal protein catabolic process GO:0010498 59 0.021
chaeta development GO:0022416 97 0.021
morphogenesis of embryonic epithelium GO:0016331 94 0.021
regulation of cellular component movement GO:0051270 42 0.021
methylation GO:0032259 47 0.020
regulation of anatomical structure size GO:0090066 163 0.020
Zebrafish
organonitrogen compound metabolic process GO:1901564 318 0.020
cellular macromolecule localization GO:0070727 220 0.020
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.020
cell recognition GO:0008037 102 0.020
positive regulation of wnt signaling pathway GO:0030177 25 0.020
golgi organization GO:0007030 66 0.020
mitotic sister chromatid segregation GO:0000070 87 0.020
cell adhesion GO:0007155 136 0.020
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.019
Zebrafish
mitotic cell cycle phase transition GO:0044772 138 0.019
cellular protein catabolic process GO:0044257 83 0.019
regulation of developmental growth GO:0048638 174 0.019
Zebrafish
regulation of axon extension GO:0030516 8 0.019
Zebrafish
negative regulation of cell cycle process GO:0010948 109 0.019
regulation of ras gtpase activity GO:0032318 38 0.018
taxis GO:0042330 304 0.018
Zebrafish Fly
intracellular transport GO:0046907 228 0.018
response to endogenous stimulus GO:0009719 119 0.018
Zebrafish
modification dependent macromolecule catabolic process GO:0043632 79 0.018
mesoderm morphogenesis GO:0048332 22 0.017
Mouse
phosphorylation GO:0016310 294 0.017
cellular amine metabolic process GO:0044106 12 0.017
protein secretion GO:0009306 45 0.017
establishment of localization in cell GO:0051649 402 0.017
Fly
lipid storage GO:0019915 38 0.017
imaginal disc derived wing vein morphogenesis GO:0008586 44 0.017
protein phosphorylation GO:0006468 169 0.017
cellular macromolecule catabolic process GO:0044265 136 0.016
sister chromatid segregation GO:0000819 92 0.016
establishment of organelle localization GO:0051656 122 0.016
Fly
negative regulation of signal transduction GO:0009968 206 0.016
organic substance transport GO:0071702 257 0.016
endomembrane system organization GO:0010256 119 0.016
chaeta morphogenesis GO:0008407 42 0.016
regulation of histone modification GO:0031056 20 0.016
cellular response to endogenous stimulus GO:0071495 80 0.016
Zebrafish
negative regulation of cell division GO:0051782 17 0.015
transcription from rna polymerase ii promoter GO:0006366 368 0.015
regulation of mitotic cell cycle GO:0007346 190 0.015
posttranscriptional gene silencing GO:0016441 46 0.015
chitin based cuticle development GO:0040003 49 0.015
mitotic nuclear division GO:0007067 213 0.015
protein heterooligomerization GO:0051291 4 0.015
regulation of wnt signaling pathway GO:0030111 68 0.015
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.015
rna localization GO:0006403 115 0.014
positive regulation of phosphorylation GO:0042327 87 0.014
regulation of localization GO:0032879 275 0.014
positive regulation of organelle organization GO:0010638 65 0.014
regulation of axonogenesis GO:0050770 32 0.014
Zebrafish
regulation of catalytic activity GO:0050790 185 0.014
positive regulation of cellular amine metabolic process GO:0033240 0 0.014
stem cell division GO:0017145 69 0.014
single organism membrane budding GO:1902591 2 0.014
axon extension GO:0048675 32 0.013
Zebrafish
formation of primary germ layer GO:0001704 24 0.013
Mouse
purine containing compound catabolic process GO:0072523 112 0.013
hematopoietic or lymphoid organ development GO:0048534 57 0.013
negative regulation of cellular component organization GO:0051129 108 0.013
pigment biosynthetic process GO:0046148 36 0.013
leg disc morphogenesis GO:0007478 80 0.013
phosphatidylinositol mediated signaling GO:0048015 4 0.013
positive regulation of molecular function GO:0044093 136 0.013
endodermal cell fate commitment GO:0001711 3 0.013
notch signaling pathway GO:0007219 120 0.013
regulation of intracellular transport GO:0032386 64 0.012
nitrogen compound transport GO:0071705 85 0.012
dna metabolic process GO:0006259 227 0.012
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.012
synaptic target recognition GO:0008039 45 0.012
positive regulation of gene expression GO:0010628 290 0.012
protein transport GO:0015031 155 0.012
inter male aggressive behavior GO:0002121 60 0.012
limb development GO:0060173 1 0.012
regulation of microtubule cytoskeleton organization GO:0070507 41 0.012
protein glycosylation GO:0006486 32 0.012
eye pigmentation GO:0048069 43 0.012
mesenchymal cell differentiation GO:0048762 1 0.012
response to organic substance GO:0010033 284 0.012
Zebrafish
regulation of cellular ketone metabolic process GO:0010565 3 0.011
muscle cell fate commitment GO:0042693 14 0.011
modification dependent protein catabolic process GO:0019941 78 0.011
morphogenesis of a branching structure GO:0001763 45 0.011
negative regulation of cell cycle GO:0045786 116 0.011
oviposition GO:0018991 19 0.011
carboxylic acid metabolic process GO:0019752 92 0.011
negative regulation of organelle organization GO:0010639 56 0.011
pigment metabolic process GO:0042440 84 0.011
regulation of immune system process GO:0002682 176 0.011
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.011
cellular lipid metabolic process GO:0044255 83 0.011
positive regulation of mapk cascade GO:0043410 63 0.011
secretion by cell GO:0032940 101 0.011
pigmentation GO:0043473 75 0.011
decapentaplegic signaling pathway GO:0008101 19 0.011
brain development GO:0007420 120 0.011
peptidyl threonine modification GO:0018210 3 0.011
limb morphogenesis GO:0035108 1 0.011
cell fate specification GO:0001708 71 0.011
cytoplasmic transport GO:0016482 130 0.010
negative regulation of catabolic process GO:0009895 36 0.010
epithelial cell migration GO:0010631 148 0.010
spinal cord development GO:0021510 1 0.010
cation transport GO:0006812 110 0.010
ameboidal type cell migration GO:0001667 151 0.010
cell cycle checkpoint GO:0000075 95 0.010
protein maturation GO:0051604 71 0.010
positive regulation of catalytic activity GO:0043085 118 0.010

Ext2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.070
disease of cellular proliferation DOID:14566 0 0.039
cancer DOID:162 0 0.032
bone disease DOID:0080001 0 0.025
musculoskeletal system disease DOID:17 0 0.025
connective tissue disease DOID:65 0 0.025
cardiovascular system disease DOID:1287 0 0.023
organ system cancer DOID:0050686 0 0.022