Drosophila melanogaster

50 known processes

MED1 (Dmel_CG7162)

Mediator complex subunit 1

(Aliases: Trap220,Dmel\CG7162,dTRAP220,Med1/SOP3/TRAP220,Med1,CG7162)

MED1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
chromosome organization GO:0051276 360 0.557
chromatin modification GO:0016568 147 0.201
organelle assembly GO:0070925 198 0.181
chromatin organization GO:0006325 207 0.168
positive regulation of gene expression GO:0010628 290 0.119
localization of cell GO:0051674 257 0.108
positive regulation of biosynthetic process GO:0009891 316 0.099
establishment of localization in cell GO:0051649 402 0.098
histone modification GO:0016570 106 0.089
neuron projection guidance GO:0097485 241 0.089
cellular component disassembly GO:0022411 46 0.082
covalent chromatin modification GO:0016569 106 0.072
regulation of multicellular organismal development GO:2000026 414 0.067
macromolecular complex assembly GO:0065003 256 0.065
kidney development GO:0001822 3 0.063
regulation of cell development GO:0060284 215 0.061
muscle organ development GO:0007517 127 0.061
cell motility GO:0048870 251 0.060
single organism intracellular transport GO:1902582 207 0.060
mitotic g2 m transition checkpoint GO:0044818 70 0.057
positive regulation of cellular biosynthetic process GO:0031328 316 0.055
rna splicing GO:0008380 83 0.055
aromatic compound catabolic process GO:0019439 166 0.054
positive regulation of rna metabolic process GO:0051254 271 0.050
chromatin remodeling GO:0006338 72 0.048
protein modification by small protein conjugation or removal GO:0070647 106 0.048
establishment or maintenance of cell polarity GO:0007163 167 0.047
positive regulation of rna biosynthetic process GO:1902680 266 0.047
death GO:0016265 284 0.046
taxis GO:0042330 304 0.045
positive regulation of apoptotic signaling pathway GO:2001235 4 0.044
immune system process GO:0002376 347 0.044
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.043
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.043
body morphogenesis GO:0010171 2 0.042
cellular protein modification process GO:0006464 438 0.042
negative regulation of gene expression GO:0010629 387 0.042
axon guidance GO:0007411 233 0.041
protein modification process GO:0036211 438 0.039
cell migration GO:0016477 238 0.039
central nervous system development GO:0007417 201 0.039
establishment or maintenance of cytoskeleton polarity GO:0030952 44 0.038
negative regulation of cellular metabolic process GO:0031324 382 0.037
cell division GO:0051301 248 0.036
histone acetylation GO:0016573 38 0.036
head development GO:0060322 135 0.035
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.035
negative regulation of programmed cell death GO:0043069 72 0.035
axon regeneration GO:0031103 8 0.034
chemotaxis GO:0006935 249 0.034
growth GO:0040007 359 0.034
tube morphogenesis GO:0035239 191 0.033
axon development GO:0061564 297 0.033
carboxylic acid metabolic process GO:0019752 92 0.032
positive regulation of signaling GO:0023056 243 0.032
positive regulation of response to stimulus GO:0048584 323 0.032
apoptotic process GO:0006915 159 0.032
embryo development ending in birth or egg hatching GO:0009792 152 0.031
cellular catabolic process GO:0044248 372 0.031
negative regulation of cell cycle phase transition GO:1901988 103 0.031
regulation of catalytic activity GO:0050790 185 0.030
cellular response to dna damage stimulus GO:0006974 223 0.030
response to organic substance GO:0010033 284 0.030
larval development GO:0002164 104 0.030
cellular macromolecule catabolic process GO:0044265 136 0.029
protein modification by small protein conjugation GO:0032446 79 0.029
imaginal disc growth GO:0007446 37 0.029
proteolysis GO:0006508 192 0.029
internal peptidyl lysine acetylation GO:0018393 38 0.028
negative regulation of cell cycle process GO:0010948 109 0.028
signal transduction by phosphorylation GO:0023014 107 0.028
regulation of cellular amino acid metabolic process GO:0006521 0 0.028
cellular amino acid metabolic process GO:0006520 61 0.028
regulation of localization GO:0032879 275 0.027
organic substance catabolic process GO:1901575 308 0.027
regulation of cellular localization GO:0060341 136 0.027
positive regulation of cell communication GO:0010647 250 0.027
regulation of mitotic cell cycle GO:0007346 190 0.027
phosphorylation GO:0016310 294 0.027
regulation of cell cycle GO:0051726 291 0.026
catabolic process GO:0009056 409 0.026
negative regulation of apoptotic process GO:0043066 63 0.026
negative regulation of cell death GO:0060548 81 0.026
positive regulation of signal transduction GO:0009967 223 0.026
intracellular transport GO:0046907 228 0.025
regulation of neurogenesis GO:0050767 158 0.025
protein complex assembly GO:0006461 200 0.025
nuclear rna surveillance GO:0071027 3 0.025
cellular macromolecular complex assembly GO:0034622 153 0.025
cell proliferation GO:0008283 299 0.025
positive regulation of intracellular signal transduction GO:1902533 116 0.025
hindbrain development GO:0030902 2 0.024
negative regulation of cell cycle GO:0045786 116 0.024
positive regulation of phosphate metabolic process GO:0045937 139 0.024
positive regulation of macromolecule metabolic process GO:0010604 405 0.024
gene silencing GO:0016458 138 0.024
regulation of mapk cascade GO:0043408 92 0.024
positive regulation of developmental process GO:0051094 143 0.023
cytoplasmic transport GO:0016482 130 0.023
response to sterol GO:0036314 34 0.023
regulation of molecular function GO:0065009 217 0.023
embryonic morphogenesis GO:0048598 206 0.023
hematopoietic or lymphoid organ development GO:0048534 57 0.023
vesicle mediated transport GO:0016192 381 0.023
brain development GO:0007420 120 0.023
modification dependent macromolecule catabolic process GO:0043632 79 0.023
macromolecule catabolic process GO:0009057 161 0.023
regulation of embryonic development GO:0045995 68 0.023
regulation of cell projection organization GO:0031344 92 0.022
regulation of cellular amine metabolic process GO:0033238 3 0.022
organelle localization GO:0051640 148 0.022
protein phosphorylation GO:0006468 169 0.022
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.022
developmental growth GO:0048589 280 0.022
axonogenesis GO:0007409 290 0.022
positive regulation of phosphorus metabolic process GO:0010562 139 0.021
intracellular signal transduction GO:0035556 300 0.021
dna metabolic process GO:0006259 227 0.021
homeostatic process GO:0042592 199 0.021
cell death GO:0008219 279 0.021
cellular ketone metabolic process GO:0042180 24 0.021
endocytosis GO:0006897 310 0.021
reproductive system development GO:0061458 74 0.021
organic cyclic compound catabolic process GO:1901361 168 0.021
chromosome segregation GO:0007059 157 0.020
microtubule organizing center organization GO:0031023 168 0.020
negative regulation of cell development GO:0010721 62 0.020
centrosome organization GO:0051297 163 0.020
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.019
regulation of phosphate metabolic process GO:0019220 210 0.019
single organism cellular localization GO:1902580 180 0.019
mitotic dna integrity checkpoint GO:0044774 75 0.019
establishment of protein localization GO:0045184 163 0.019
negative regulation of biosynthetic process GO:0009890 277 0.019
peptidyl lysine modification GO:0018205 57 0.019
regulation of phosphorus metabolic process GO:0051174 210 0.019
muscle structure development GO:0061061 224 0.018
regulation of transport GO:0051049 181 0.018
cellular protein catabolic process GO:0044257 83 0.018
organic acid metabolic process GO:0006082 103 0.018
digestive tract morphogenesis GO:0048546 127 0.018
protein complex biogenesis GO:0070271 201 0.018
cellular protein localization GO:0034613 160 0.017
organelle fission GO:0048285 340 0.017
cell cycle phase transition GO:0044770 140 0.017
epidermal growth factor receptor signaling pathway GO:0007173 58 0.017
macromolecular complex disassembly GO:0032984 37 0.017
digestive system development GO:0055123 149 0.017
mitotic dna damage checkpoint GO:0044773 74 0.016
regulation of cellular ketone metabolic process GO:0010565 3 0.016
protein acetylation GO:0006473 39 0.016
nucleocytoplasmic transport GO:0006913 72 0.016
gastrulation GO:0007369 70 0.016
mitotic sister chromatid segregation GO:0000070 87 0.016
negative regulation of protein metabolic process GO:0051248 85 0.016
regulation of cell cycle phase transition GO:1901987 130 0.016
hemopoiesis GO:0030097 46 0.015
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.015
negative regulation of mitotic cell cycle GO:0045930 109 0.015
cellular nitrogen compound catabolic process GO:0044270 165 0.015
male gamete generation GO:0048232 201 0.015
nuclear transport GO:0051169 72 0.015
cellular component assembly involved in morphogenesis GO:0010927 151 0.015
rhythmic process GO:0048511 106 0.015
tube development GO:0035295 244 0.015
response to ketone GO:1901654 34 0.015
cellular response to ketone GO:1901655 17 0.015
peptidyl amino acid modification GO:0018193 105 0.015
regulation of cell cycle process GO:0010564 181 0.015
rna splicing via transesterification reactions GO:0000375 73 0.015
dna repair GO:0006281 54 0.015
regulation of cellular protein metabolic process GO:0032268 243 0.015
response to abiotic stimulus GO:0009628 341 0.015
cell fate specification GO:0001708 71 0.015
nucleosome organization GO:0034728 59 0.014
dendrite development GO:0016358 204 0.014
mrna processing GO:0006397 104 0.014
positive regulation of nucleic acid templated transcription GO:1903508 266 0.014
protein transport GO:0015031 155 0.014
mitotic cell cycle phase transition GO:0044772 138 0.014
regulation of microtubule depolymerization GO:0031114 24 0.014
protein ubiquitination GO:0016567 70 0.014
negative regulation of rna biosynthetic process GO:1902679 240 0.014
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 73 0.014
protein processing GO:0016485 68 0.014
spindle organization GO:0007051 253 0.014
regulation of neuron differentiation GO:0045664 103 0.014
transcription from rna polymerase ii promoter GO:0006366 368 0.013
programmed cell death GO:0012501 257 0.013
protein depolymerization GO:0051261 31 0.013
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 41 0.013
indole containing compound biosynthetic process GO:0042435 4 0.013
immune system development GO:0002520 57 0.013
protein catabolic process GO:0030163 101 0.013
regulation of gene expression epigenetic GO:0040029 128 0.013
protein targeting to nucleus GO:0044744 51 0.013
cellular response to organic substance GO:0071310 132 0.013
regulation of vesicle mediated transport GO:0060627 59 0.013
appendage development GO:0048736 401 0.013
regulation of anatomical structure morphogenesis GO:0022603 242 0.013
nuclear import GO:0051170 51 0.013
neuroblast proliferation GO:0007405 74 0.013
organonitrogen compound metabolic process GO:1901564 318 0.013
positive regulation of cellular amine metabolic process GO:0033240 0 0.013
histone exchange GO:0043486 21 0.013
negative regulation of cellular biosynthetic process GO:0031327 277 0.012
chromatin silencing GO:0006342 76 0.012
larval lymph gland hemopoiesis GO:0035167 17 0.012
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.012
cellular macromolecule localization GO:0070727 220 0.012
negative regulation of erk1 and erk2 cascade GO:0070373 3 0.012
carbohydrate derivative metabolic process GO:1901135 217 0.012
response to wounding GO:0009611 94 0.012
regulation of nervous system development GO:0051960 248 0.012
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.012
cytokinesis GO:0000910 90 0.012
imaginal disc derived appendage development GO:0048737 399 0.012
response to ecdysone GO:0035075 34 0.012
internal protein amino acid acetylation GO:0006475 38 0.012
mitotic cell cycle checkpoint GO:0007093 88 0.012
peptidyl lysine acetylation GO:0018394 39 0.012
cellular response to chemical stimulus GO:0070887 199 0.012
camera type eye development GO:0043010 4 0.012
mapk cascade GO:0000165 107 0.011
negative regulation of epithelial cell proliferation GO:0050680 4 0.011
reproductive structure development GO:0048608 74 0.011
regulation of phosphorylation GO:0042325 147 0.011
endomembrane system organization GO:0010256 119 0.011
cellular homeostasis GO:0019725 80 0.011
regulation of hydrolase activity GO:0051336 97 0.011
tissue morphogenesis GO:0048729 297 0.011
sensory perception of sound GO:0007605 56 0.011
mitotic cytokinesis GO:0000281 50 0.011
enzyme linked receptor protein signaling pathway GO:0007167 179 0.011
regulation of apoptotic process GO:0042981 130 0.011
neurological system process GO:0050877 358 0.011
sex differentiation GO:0007548 81 0.011
peptidyl tyrosine modification GO:0018212 24 0.011
mrna splicing via spliceosome GO:0000398 73 0.011
circulatory system development GO:0072359 82 0.010
organic substance transport GO:0071702 257 0.010
translation GO:0006412 69 0.010
positive regulation of cell migration GO:0030335 2 0.010
response to endogenous stimulus GO:0009719 119 0.010
extrinsic apoptotic signaling pathway GO:0097191 1 0.010
negative regulation of rna metabolic process GO:0051253 251 0.010
protein import into nucleus GO:0006606 51 0.010
negative regulation of response to stimulus GO:0048585 258 0.010
embryonic hemopoiesis GO:0035162 26 0.010

MED1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.047
disease of cellular proliferation DOID:14566 0 0.026
cancer DOID:162 0 0.017
organ system cancer DOID:0050686 0 0.014
musculoskeletal system disease DOID:17 0 0.013
muscular disease DOID:0080000 0 0.013
muscle tissue disease DOID:66 0 0.012
nervous system disease DOID:863 0 0.010