Drosophila melanogaster

124 known processes

Cka (Dmel_CG7392)

Connector of kinase to AP-1

(Aliases: 5836,CKA,l(2)s1883,CG7392,l(2)05836,Dmel\CG7392,anon-WO0172774.179,Dcka,anon-WO0172774.177,cka,anon-WO0172774.175,anon-WO0172774.174)

Cka biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
gravitaxis GO:0042332 26 0.913
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.798
Human Rat
positive regulation of rna metabolic process GO:0051254 271 0.793
Human
tissue morphogenesis GO:0048729 297 0.773
morphogenesis of an epithelium GO:0002009 276 0.693
response to gravity GO:0009629 26 0.633
regulation of cell development GO:0060284 215 0.415
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.396
Human
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.360
Human
negative regulation of gene expression GO:0010629 387 0.286
Human Rat
regulation of cell proliferation GO:0042127 163 0.279
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.274
Human Rat
negative regulation of rna metabolic process GO:0051253 251 0.270
Human Rat
cellular protein modification process GO:0006464 438 0.245
tube development GO:0035295 244 0.239
negative regulation of response to stimulus GO:0048585 258 0.232
Rat
taxis GO:0042330 304 0.228
positive regulation of macromolecule metabolic process GO:0010604 405 0.222
Human
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.217
Human
embryonic morphogenesis GO:0048598 206 0.215
digestive system development GO:0055123 149 0.211
cell proliferation GO:0008283 299 0.209
positive regulation of transcription dna templated GO:0045893 266 0.206
Human
negative regulation of cellular metabolic process GO:0031324 382 0.195
Human Rat
dendrite morphogenesis GO:0048813 199 0.193
response to abiotic stimulus GO:0009628 341 0.184
embryo development ending in birth or egg hatching GO:0009792 152 0.179
eye development GO:0001654 323 0.177
nucleocytoplasmic transport GO:0006913 72 0.153
regulation of cell cycle GO:0051726 291 0.151
appendage development GO:0048736 401 0.150
embryonic development via the syncytial blastoderm GO:0001700 148 0.149
protein modification process GO:0036211 438 0.143
regulation of multicellular organismal development GO:2000026 414 0.143
regulation of organ morphogenesis GO:2000027 78 0.143
antimicrobial humoral response GO:0019730 99 0.139
enzyme linked receptor protein signaling pathway GO:0007167 179 0.139
chromatin mediated maintenance of transcription GO:0048096 7 0.136
transcription from rna polymerase ii promoter GO:0006366 368 0.133
Human
negative regulation of nucleic acid templated transcription GO:1903507 240 0.133
Human Rat
aging GO:0007568 143 0.133
cell death GO:0008219 279 0.132
regulation of localization GO:0032879 275 0.128
sensory organ morphogenesis GO:0090596 260 0.127
cellular amide metabolic process GO:0043603 80 0.124
growth GO:0040007 359 0.123
cellular response to chemical stimulus GO:0070887 199 0.122
organelle localization GO:0051640 148 0.122
cellular response to dna damage stimulus GO:0006974 223 0.121
regulation of cellular response to stress GO:0080135 89 0.115
response to other organism GO:0051707 293 0.114
epithelial cell differentiation GO:0030855 322 0.114
tube morphogenesis GO:0035239 191 0.111
regulation of anatomical structure morphogenesis GO:0022603 242 0.110
regulation of molecular function GO:0065009 217 0.109
imaginal disc derived appendage morphogenesis GO:0035114 395 0.107
immune system process GO:0002376 347 0.107
cell cell signaling involved in cell fate commitment GO:0045168 210 0.106
retina development in camera type eye GO:0060041 4 0.106
morphogenesis of embryonic epithelium GO:0016331 94 0.097
dna repair GO:0006281 54 0.096
organelle fission GO:0048285 340 0.093
regulation of cellular protein metabolic process GO:0032268 243 0.093
positive regulation of biosynthetic process GO:0009891 316 0.092
Human
dna metabolic process GO:0006259 227 0.091
r7 cell differentiation GO:0045466 43 0.090
negative regulation of intracellular signal transduction GO:1902532 57 0.089
retina morphogenesis in camera type eye GO:0060042 2 0.087
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.081
Human
phagocytosis GO:0006909 215 0.080
imaginal disc derived appendage development GO:0048737 399 0.080
negative regulation of rna biosynthetic process GO:1902679 240 0.078
Human Rat
chromosome segregation GO:0007059 157 0.074
regulation of neuron projection development GO:0010975 69 0.071
positive regulation of signal transduction GO:0009967 223 0.070
negative regulation of transcription dna templated GO:0045892 237 0.070
Human Rat
negative regulation of signal transduction GO:0009968 206 0.070
Rat
negative regulation of cellular biosynthetic process GO:0031327 277 0.069
Human Rat
cellular response to fibroblast growth factor stimulus GO:0044344 10 0.067
chromosome organization GO:0051276 360 0.066
skin development GO:0043588 65 0.065
appendage morphogenesis GO:0035107 397 0.065
humoral immune response GO:0006959 117 0.065
chromatin remodeling GO:0006338 72 0.064
positive regulation of cell proliferation GO:0008284 47 0.061
positive regulation of nucleic acid templated transcription GO:1903508 266 0.061
Human
double strand break repair GO:0006302 26 0.060
organonitrogen compound metabolic process GO:1901564 318 0.059
positive regulation of gene expression GO:0010628 290 0.058
Human
intracellular protein transport GO:0006886 104 0.057
negative regulation of biosynthetic process GO:0009890 277 0.057
Human Rat
digestive tract morphogenesis GO:0048546 127 0.057
establishment of mitotic spindle localization GO:0040001 17 0.056
protein complex assembly GO:0006461 200 0.055
response to organic substance GO:0010033 284 0.055
Rat
positive regulation of cellular biosynthetic process GO:0031328 316 0.054
Human
single organism intracellular transport GO:1902582 207 0.054
chromatin modification GO:0016568 147 0.052
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.052
Human Rat
rna splicing via transesterification reactions GO:0000375 73 0.051
camera type eye development GO:0043010 4 0.051
gland development GO:0048732 191 0.049
regulation of cell differentiation GO:0045595 302 0.048
spindle organization GO:0007051 253 0.048
cell cycle phase transition GO:0044770 140 0.047
regulation of proteasomal protein catabolic process GO:0061136 39 0.047
anatomical structure homeostasis GO:0060249 97 0.047
eye photoreceptor cell fate commitment GO:0042706 37 0.047
regulation of neurogenesis GO:0050767 158 0.046
eye photoreceptor cell differentiation GO:0001754 145 0.046
single organism behavior GO:0044708 391 0.046
dendrite development GO:0016358 204 0.045
Rat
establishment of localization in cell GO:0051649 402 0.045
mitotic spindle organization GO:0007052 220 0.045
protein localization GO:0008104 284 0.044
respiratory system development GO:0060541 213 0.044
embryonic hemopoiesis GO:0035162 26 0.044
photoreceptor cell fate commitment GO:0046552 41 0.044
muscle cell fate commitment GO:0042693 14 0.043
digestive tract development GO:0048565 149 0.043
photoreceptor cell differentiation GO:0046530 170 0.043
developmental growth GO:0048589 280 0.042
regulation of nervous system development GO:0051960 248 0.042
regulation of embryonic development GO:0045995 68 0.042
immune system development GO:0002520 57 0.042
regulation of protein localization GO:0032880 76 0.042
endocytosis GO:0006897 310 0.041
camera type eye morphogenesis GO:0048593 2 0.041
chemical homeostasis GO:0048878 92 0.039
regulation of anatomical structure size GO:0090066 163 0.039
compound eye photoreceptor development GO:0042051 78 0.039
programmed cell death GO:0012501 257 0.039
compound eye morphogenesis GO:0001745 249 0.039
response to biotic stimulus GO:0009607 294 0.038
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 37 0.038
outflow tract morphogenesis GO:0003151 4 0.037
small molecule metabolic process GO:0044281 305 0.037
regulation of protein metabolic process GO:0051246 256 0.037
regulation of transport GO:0051049 181 0.037
hematopoietic or lymphoid organ development GO:0048534 57 0.037
axonogenesis GO:0007409 290 0.036
cellular response to oxidative stress GO:0034599 28 0.036
compound eye photoreceptor cell differentiation GO:0001751 140 0.036
phototransduction GO:0007602 52 0.036
macromolecular complex assembly GO:0065003 256 0.035
ion transmembrane transport GO:0034220 122 0.035
imaginal disc growth GO:0007446 37 0.035
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.034
imaginal disc derived wing morphogenesis GO:0007476 337 0.034
periodic partitioning GO:0007365 29 0.034
regulation of protein transport GO:0051223 57 0.034
modification dependent macromolecule catabolic process GO:0043632 79 0.033
regulation of programmed cell death GO:0043067 152 0.033
chromatin organization GO:0006325 207 0.032
developmental growth involved in morphogenesis GO:0060560 65 0.032
single organism cellular localization GO:1902580 180 0.032
post embryonic appendage morphogenesis GO:0035120 385 0.031
peptide metabolic process GO:0006518 80 0.031
central nervous system development GO:0007417 201 0.031
establishment of protein localization GO:0045184 163 0.031
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.031
Human Rat
defense response GO:0006952 300 0.031
spindle assembly GO:0051225 80 0.030
neuron fate commitment GO:0048663 50 0.030
regulation of cell cycle phase transition GO:1901987 130 0.030
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.030
Human
regulation of protein modification process GO:0031399 112 0.029
cell type specific apoptotic process GO:0097285 38 0.029
cell recognition GO:0008037 102 0.029
meiotic chromosome segregation GO:0045132 59 0.029
regulation of mitotic cell cycle GO:0007346 190 0.028
negative regulation of cell communication GO:0010648 223 0.028
Rat
protein modification by small protein conjugation GO:0032446 79 0.028
positive regulation of rna biosynthetic process GO:1902680 266 0.028
Human
anterior posterior pattern specification GO:0009952 136 0.027
nuclear division GO:0000280 332 0.027
morphogenesis of a branching epithelium GO:0061138 45 0.027
eye morphogenesis GO:0048592 260 0.027
signal transduction in response to dna damage GO:0042770 3 0.027
protein transport GO:0015031 155 0.026
double strand break repair via homologous recombination GO:0000724 13 0.026
regulation of apoptotic process GO:0042981 130 0.026
response to oxygen containing compound GO:1901700 200 0.026
Rat
actin filament based process GO:0030029 220 0.026
antimicrobial peptide production GO:0002775 46 0.026
response to oxidative stress GO:0006979 86 0.025
establishment of cell polarity GO:0030010 40 0.025
establishment of spindle localization GO:0051293 22 0.025
defense response to other organism GO:0098542 225 0.025
death GO:0016265 284 0.024
mitotic cell cycle embryonic GO:0045448 38 0.024
regulation of epithelial cell differentiation GO:0030856 4 0.024
meiotic cell cycle process GO:1903046 132 0.023
peptidyl amino acid modification GO:0018193 105 0.023
negative regulation of cellular protein metabolic process GO:0032269 85 0.023
negative regulation of apoptotic process GO:0043066 63 0.023
oxoacid metabolic process GO:0043436 103 0.022
establishment or maintenance of cell polarity GO:0007163 167 0.022
circulatory system development GO:0072359 82 0.022
positive regulation of cell communication GO:0010647 250 0.022
positive regulation of phosphate metabolic process GO:0045937 139 0.022
epidermal cell differentiation GO:0009913 51 0.022
morphogenesis of a branching structure GO:0001763 45 0.022
regulation of antimicrobial peptide biosynthetic process GO:0002805 38 0.022
cell fate determination GO:0001709 91 0.022
homeostatic process GO:0042592 199 0.022
centrosome organization GO:0051297 163 0.022
female sex differentiation GO:0046660 20 0.021
development of primary sexual characteristics GO:0045137 50 0.021
Worm
reproductive system development GO:0061458 74 0.021
Worm
dna templated transcription elongation GO:0006354 18 0.021
regulation of gene silencing GO:0060968 63 0.021
regulation of r7 cell differentiation GO:0045676 15 0.021
positive regulation of transport GO:0051050 92 0.021
response to bacterium GO:0009617 198 0.021
regulation of mitotic cell cycle phase transition GO:1901990 130 0.021
multi organism behavior GO:0051705 175 0.021
maintenance of location GO:0051235 73 0.020
regulation of i kappab kinase nf kappab signaling GO:0043122 2 0.020
positive regulation of molecular function GO:0044093 136 0.020
compound eye cone cell differentiation GO:0042675 13 0.020
sister chromatid segregation GO:0000819 92 0.020
regulation of neuron differentiation GO:0045664 103 0.020
protein modification by small protein conjugation or removal GO:0070647 106 0.019
photoreceptor cell development GO:0042461 96 0.019
regulation of intracellular signal transduction GO:1902531 236 0.019
nuclear transport GO:0051169 72 0.019
eye antennal disc development GO:0035214 60 0.019
negative regulation of cell development GO:0010721 62 0.019
regulation of cell cycle process GO:0010564 181 0.019
regulation of alternative mrna splicing via spliceosome GO:0000381 60 0.019
regulation of growth GO:0040008 233 0.018
segmentation GO:0035282 207 0.018
protein complex biogenesis GO:0070271 201 0.018
positive regulation of signaling GO:0023056 243 0.018
cellular response to organic substance GO:0071310 132 0.018
antennal development GO:0007469 25 0.018
positive regulation of epithelial cell differentiation GO:0030858 1 0.018
intracellular transport GO:0046907 228 0.018
development of primary female sexual characteristics GO:0046545 12 0.018
establishment of organelle localization GO:0051656 122 0.018
sex differentiation GO:0007548 81 0.018
Worm
gene silencing GO:0016458 138 0.018
regulation of dna templated transcription elongation GO:0032784 17 0.017
response to fibroblast growth factor GO:0071774 10 0.017
negative regulation of cell death GO:0060548 81 0.017
regulation of cellular amide metabolic process GO:0034248 39 0.017
immune response GO:0006955 246 0.017
segment polarity determination GO:0007367 25 0.017
positive regulation of developmental process GO:0051094 143 0.017
protein localization to nucleus GO:0034504 55 0.017
regulation of lipid transport GO:0032368 3 0.017
amide biosynthetic process GO:0043604 42 0.017
regulation of gene expression epigenetic GO:0040029 128 0.017
gonad development GO:0008406 50 0.017
Worm
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.017
Human
antibacterial peptide biosynthetic process GO:0002780 22 0.017
dna alkylation GO:0006305 4 0.017
wnt signaling pathway GO:0016055 98 0.016
regulation of phosphorylation GO:0042325 147 0.016
response to external biotic stimulus GO:0043207 293 0.016
vesicle mediated transport GO:0016192 381 0.016
wing disc morphogenesis GO:0007472 344 0.016
positive regulation of immune system process GO:0002684 68 0.016
chitin based cuticle development GO:0040003 49 0.016
organonitrogen compound biosynthetic process GO:1901566 117 0.016
adult behavior GO:0030534 137 0.016
neural retina development GO:0003407 4 0.016
exocrine system development GO:0035272 162 0.016
cytoskeleton dependent cytokinesis GO:0061640 81 0.016
positive regulation of gene expression epigenetic GO:0045815 16 0.016
organ growth GO:0035265 56 0.016
regulation of defense response to bacterium GO:1900424 30 0.015
cellular response to extracellular stimulus GO:0031668 64 0.015
neurological system process GO:0050877 358 0.015
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 44 0.015
intracellular signal transduction GO:0035556 300 0.015
developmental programmed cell death GO:0010623 138 0.015
organic substance transport GO:0071702 257 0.015
protein modification by small protein removal GO:0070646 28 0.015
terminal region determination GO:0007362 25 0.015
axon guidance GO:0007411 233 0.015
mesenchymal cell development GO:0014031 1 0.015
compound eye retinal cell programmed cell death GO:0046667 23 0.015
protein targeting to nucleus GO:0044744 51 0.015
negative regulation of molecular function GO:0044092 51 0.015
ameboidal type cell migration GO:0001667 151 0.015
mitotic cell cycle phase transition GO:0044772 138 0.014
metal ion transport GO:0030001 74 0.014
regulation of dendrite morphogenesis GO:0048814 28 0.014
signal transduction by phosphorylation GO:0023014 107 0.014
actin cytoskeleton organization GO:0030036 206 0.014
regulation of cell projection organization GO:0031344 92 0.014
response to endogenous stimulus GO:0009719 119 0.014
Rat
cell division GO:0051301 248 0.014
positive regulation of response to stimulus GO:0048584 323 0.014
carboxylic acid metabolic process GO:0019752 92 0.014
skeletal muscle organ development GO:0060538 48 0.014
reproductive structure development GO:0048608 74 0.014
Worm
mitotic nuclear division GO:0007067 213 0.014
mrna splicing via spliceosome GO:0000398 73 0.014
negative regulation of programmed cell death GO:0043069 72 0.014
mesenchymal cell differentiation GO:0048762 1 0.014
protein import into nucleus GO:0006606 51 0.014
tissue death GO:0016271 102 0.014
positive regulation of multicellular organismal process GO:0051240 143 0.014
proteolysis GO:0006508 192 0.014
organic acid metabolic process GO:0006082 103 0.014
chromatin silencing GO:0006342 76 0.014
multicellular organismal aging GO:0010259 140 0.014
regionalization GO:0003002 416 0.014
regulation of immune system process GO:0002682 176 0.014
somatic stem cell division GO:0048103 37 0.014
regulation of chromosome organization GO:0033044 64 0.013
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 4 0.013
neuron recognition GO:0008038 101 0.013
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 41 0.013
protein phosphorylation GO:0006468 169 0.013
gastrulation GO:0007369 70 0.013
protein acetylation GO:0006473 39 0.013
olfactory behavior GO:0042048 97 0.013
chemotaxis GO:0006935 249 0.013
regulation of antimicrobial humoral response GO:0002759 50 0.013
response to lipid GO:0033993 38 0.013
Rat
instar larval development GO:0002168 55 0.013
immune effector process GO:0002252 98 0.013
regulation of embryonic cell shape GO:0016476 30 0.013
telencephalon development GO:0021537 2 0.013
regulation of cellular protein catabolic process GO:1903362 44 0.012
localization of cell GO:0051674 257 0.012
rna processing GO:0006396 147 0.012
proteasomal protein catabolic process GO:0010498 59 0.012
eye photoreceptor cell development GO:0042462 81 0.012
stem cell differentiation GO:0048863 117 0.012
epithelial tube morphogenesis GO:0060562 88 0.012
salivary gland morphogenesis GO:0007435 145 0.012
hair cell differentiation GO:0035315 47 0.012
epithelial cell development GO:0002064 274 0.012
phosphorylation GO:0016310 294 0.012
regulation of establishment of protein localization GO:0070201 61 0.012
dorsal appendage formation GO:0046843 47 0.012
blood circulation GO:0008015 26 0.012
cytokinesis GO:0000910 90 0.012
regulation of ion transmembrane transporter activity GO:0032412 6 0.012
negative regulation of protein metabolic process GO:0051248 85 0.012
regulation of hydrolase activity GO:0051336 97 0.011
modification dependent protein catabolic process GO:0019941 78 0.011
ubiquitin dependent protein catabolic process GO:0006511 78 0.011
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 73 0.011
negative regulation of r7 cell differentiation GO:0045677 2 0.011
secretion GO:0046903 109 0.011
regulation of mrna splicing via spliceosome GO:0048024 64 0.011
hindbrain development GO:0030902 2 0.011
cellular protein catabolic process GO:0044257 83 0.011
histolysis GO:0007559 102 0.011
regulation of epithelial cell proliferation GO:0050678 4 0.011
cell junction assembly GO:0034329 42 0.011
antimicrobial peptide biosynthetic process GO:0002777 38 0.011
myotube cell development GO:0014904 3 0.011
hemopoiesis GO:0030097 46 0.011
lateral inhibition GO:0046331 206 0.011
microtubule cytoskeleton organization involved in mitosis GO:1902850 52 0.011
negative regulation of catalytic activity GO:0043086 42 0.011
negative regulation of response to external stimulus GO:0032102 22 0.011
regulation of catalytic activity GO:0050790 185 0.011
female meiotic division GO:0007143 70 0.011
intracellular receptor signaling pathway GO:0030522 19 0.011
Rat
dorsal ventral axis specification GO:0009950 66 0.010
regulation of chromatin organization GO:1902275 32 0.010
larval development GO:0002164 104 0.010
Worm
stem cell proliferation GO:0072089 88 0.010
response to ecdysone GO:0035075 34 0.010
regulation of phosphorus metabolic process GO:0051174 210 0.010
compound eye development GO:0048749 307 0.010
synapse assembly GO:0007416 143 0.010
establishment of mitotic spindle orientation GO:0000132 13 0.010
initiation of dorsal closure GO:0007392 12 0.010
covalent chromatin modification GO:0016569 106 0.010
peptide biosynthetic process GO:0043043 42 0.010
response to calcium ion GO:0051592 1 0.010
cell aging GO:0007569 2 0.010

Cka disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.016
cancer DOID:162 0 0.013
disease of cellular proliferation DOID:14566 0 0.013
organ system cancer DOID:0050686 0 0.013