Drosophila melanogaster

0 known processes

Psa (Dmel_CG1009)

Puromycin sensitive aminopeptidase

(Aliases: dPsa,CG1009,PSA,Dmel\CG1009,dPSA,l(3)06226)

Psa biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
protein modification by small protein conjugation or removal GO:0070647 106 0.249
cellular macromolecule catabolic process GO:0044265 136 0.241
segmentation GO:0035282 207 0.233
proteolysis GO:0006508 192 0.229
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.211
anterior posterior axis specification GO:0009948 109 0.190
protein ubiquitination GO:0016567 70 0.168
modification dependent macromolecule catabolic process GO:0043632 79 0.142
posttranscriptional regulation of gene expression GO:0010608 145 0.139
protein modification by small protein conjugation GO:0032446 79 0.129
regulation of cellular protein metabolic process GO:0032268 243 0.129
intracellular signal transduction GO:0035556 300 0.126
regulation of pole plasm oskar mrna localization GO:0007317 27 0.121
ubiquitin dependent protein catabolic process GO:0006511 78 0.121
cellular protein catabolic process GO:0044257 83 0.111
regulation of cellular component biogenesis GO:0044087 201 0.109
catabolic process GO:0009056 409 0.107
pole plasm mrna localization GO:0019094 49 0.102
macromolecule catabolic process GO:0009057 161 0.102
protein catabolic process GO:0030163 101 0.098
cellular protein modification process GO:0006464 438 0.096
modification dependent protein catabolic process GO:0019941 78 0.092
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.090
positive regulation of macromolecule metabolic process GO:0010604 405 0.089
protein modification process GO:0036211 438 0.086
phosphorylation GO:0016310 294 0.085
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 25 0.084
sperm individualization GO:0007291 48 0.083
cellular macromolecule localization GO:0070727 220 0.082
mapk cascade GO:0000165 107 0.081
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.076
cellular catabolic process GO:0044248 372 0.075
organic substance catabolic process GO:1901575 308 0.075
positive regulation of response to stimulus GO:0048584 323 0.074
regulation of protein metabolic process GO:0051246 256 0.072
mitotic cytokinesis GO:0000281 50 0.070
lateral inhibition GO:0046331 206 0.069
protein maturation GO:0051604 71 0.064
cellularization GO:0007349 90 0.062
oocyte construction GO:0007308 112 0.062
oocyte differentiation GO:0009994 145 0.061
oocyte microtubule cytoskeleton polarization GO:0008103 22 0.060
translation GO:0006412 69 0.060
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.060
regulation of multicellular organismal development GO:2000026 414 0.059
proteasomal protein catabolic process GO:0010498 59 0.052
positive regulation of signal transduction GO:0009967 223 0.052
intracellular mrna localization involved in anterior posterior axis specification GO:0060811 53 0.050
protein complex biogenesis GO:0070271 201 0.049
positive regulation of gene expression GO:0010628 290 0.048
regulation of nf kappab import into nucleus GO:0042345 1 0.047
intracellular protein transmembrane transport GO:0065002 4 0.046
immune effector process GO:0002252 98 0.046
tissue morphogenesis GO:0048729 297 0.042
apoptotic process GO:0006915 159 0.042
negative regulation of cellular metabolic process GO:0031324 382 0.042
cell division GO:0051301 248 0.042
regulation of programmed cell death GO:0043067 152 0.041
oocyte dorsal ventral axis specification GO:0007310 34 0.041
pole plasm rna localization GO:0007316 52 0.041
intracellular transport GO:0046907 228 0.041
oocyte anterior posterior axis specification GO:0007314 72 0.041
aging GO:0007568 143 0.040
imaginal disc derived wing morphogenesis GO:0007476 337 0.040
nephron development GO:0072006 3 0.040
oocyte axis specification GO:0007309 108 0.039
chromosome organization GO:0051276 360 0.039
protein transport GO:0015031 155 0.038
connective tissue development GO:0061448 3 0.038
cytoskeleton dependent cytokinesis GO:0061640 81 0.037
regulation of cell death GO:0010941 173 0.037
cytokinesis GO:0000910 90 0.037
muscle organ development GO:0007517 127 0.037
cellular amide metabolic process GO:0043603 80 0.035
protein processing GO:0016485 68 0.035
regulation of organ morphogenesis GO:2000027 78 0.035
regulation of synapse structure and activity GO:0050803 128 0.035
regulation of reproductive process GO:2000241 54 0.035
oocyte development GO:0048599 124 0.035
multicellular organismal aging GO:0010259 140 0.034
determination of dorsal ventral asymmetry GO:0048262 3 0.034
endocytosis GO:0006897 310 0.033
cellular macromolecular complex assembly GO:0034622 153 0.033
maternal determination of anterior posterior axis embryo GO:0008358 74 0.032
chromosome separation GO:0051304 42 0.032
axis specification GO:0009798 167 0.032
protein transmembrane transport GO:0071806 4 0.030
muscle structure development GO:0061061 224 0.030
negative regulation of gene expression GO:0010629 387 0.030
single organism cellular localization GO:1902580 180 0.030
protein deubiquitination GO:0016579 17 0.030
pole plasm assembly GO:0007315 61 0.029
tripartite regional subdivision GO:0007351 103 0.029
embryonic morphogenesis GO:0048598 206 0.029
regulation of multi organism process GO:0043900 131 0.029
larval development GO:0002164 104 0.028
regulation of mrna 3 end processing GO:0031440 7 0.028
response to abiotic stimulus GO:0009628 341 0.028
regulation of proteolysis GO:0030162 87 0.028
macromolecular complex assembly GO:0065003 256 0.028
compound eye development GO:0048749 307 0.027
positive regulation of cellular protein metabolic process GO:0032270 118 0.027
regulation of metaphase anaphase transition of cell cycle GO:1902099 26 0.027
imaginal disc derived appendage development GO:0048737 399 0.027
response to bacterium GO:0009617 198 0.027
cell cell signaling involved in cell fate commitment GO:0045168 210 0.027
protein complex assembly GO:0006461 200 0.027
embryonic pattern specification GO:0009880 174 0.026
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.026
oxoacid metabolic process GO:0043436 103 0.026
positive regulation of mapk cascade GO:0043410 63 0.025
vesicle mediated transport GO:0016192 381 0.025
developmental maturation GO:0021700 172 0.024
pigmentation GO:0043473 75 0.024
cytoplasm organization GO:0007028 64 0.024
regionalization GO:0003002 416 0.024
negative regulation of biosynthetic process GO:0009890 277 0.023
intracellular mrna localization involved in pattern specification process GO:0060810 56 0.023
dorsal ventral pattern formation GO:0009953 133 0.023
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 37 0.023
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.023
rna localization GO:0006403 115 0.022
positive regulation of signaling GO:0023056 243 0.022
rna processing GO:0006396 147 0.022
negative regulation of cell cycle phase transition GO:1901988 103 0.022
embryonic axis specification GO:0000578 107 0.022
molting cycle GO:0042303 56 0.021
death GO:0016265 284 0.021
positive regulation of intracellular signal transduction GO:1902533 116 0.021
oocyte microtubule cytoskeleton organization GO:0016325 35 0.021
determination of adult lifespan GO:0008340 137 0.021
establishment of body hair planar orientation GO:0048105 1 0.021
regulation of peptidase activity GO:0052547 39 0.021
mitochondrion organization GO:0007005 65 0.021
cell maturation GO:0048469 144 0.021
defense response to other organism GO:0098542 225 0.021
regulation of embryonic pattern specification GO:1902875 27 0.021
response to organic substance GO:0010033 284 0.021
cellular component assembly involved in morphogenesis GO:0010927 151 0.021
positive regulation of cellular biosynthetic process GO:0031328 316 0.020
regulation of cell cycle GO:0051726 291 0.020
imaginal disc derived appendage morphogenesis GO:0035114 395 0.020
positive regulation of mrna processing GO:0050685 4 0.020
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.020
peptide metabolic process GO:0006518 80 0.020
protein modification by small protein removal GO:0070646 28 0.020
regulation of protein complex assembly GO:0043254 42 0.020
transition metal ion transport GO:0000041 16 0.019
transcription from rna polymerase ii promoter GO:0006366 368 0.019
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 44 0.019
negative regulation of erbb signaling pathway GO:1901185 29 0.019
mushroom body development GO:0016319 70 0.019
negative regulation of response to stimulus GO:0048585 258 0.019
gland development GO:0048732 191 0.019
anterior posterior axis specification embryo GO:0008595 103 0.019
regulation of defense response to bacterium GO:1900424 30 0.019
establishment of protein localization GO:0045184 163 0.019
growth GO:0040007 359 0.018
regulation of apoptotic process GO:0042981 130 0.018
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 41 0.018
establishment or maintenance of cytoskeleton polarity GO:0030952 44 0.018
negative regulation of cell death GO:0060548 81 0.018
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process GO:0031145 30 0.018
positive regulation of cellular component organization GO:0051130 156 0.018
intracellular mrna localization GO:0008298 66 0.018
nf kappab import into nucleus GO:0042348 1 0.018
response to external biotic stimulus GO:0043207 293 0.018
negative regulation of protein processing GO:0010955 31 0.018
nuclear transcribed mrna poly a tail shortening GO:0000289 12 0.018
nuclear transcribed mrna catabolic process GO:0000956 24 0.018
rna interference GO:0016246 27 0.018
small molecule metabolic process GO:0044281 305 0.017
spermatid development GO:0007286 98 0.017
blastoderm segmentation GO:0007350 159 0.017
regulation of mrna metabolic process GO:1903311 72 0.017
morphogenesis of embryonic epithelium GO:0016331 94 0.017
carboxylic acid metabolic process GO:0019752 92 0.017
forebrain development GO:0030900 2 0.017
intracellular protein transport GO:0006886 104 0.017
nucleobase containing compound catabolic process GO:0034655 165 0.017
regulation of response to stress GO:0080134 200 0.017
post embryonic appendage morphogenesis GO:0035120 385 0.017
organonitrogen compound metabolic process GO:1901564 318 0.017
epithelial cell differentiation GO:0030855 322 0.017
positive regulation of cell communication GO:0010647 250 0.017
embryo development ending in birth or egg hatching GO:0009792 152 0.017
pole plasm oskar mrna localization GO:0045451 46 0.017
regulation of intracellular signal transduction GO:1902531 236 0.016
organic substance transport GO:0071702 257 0.016
protein targeting GO:0006605 64 0.016
mrna catabolic process GO:0006402 33 0.016
regulation of nuclear transcribed mrna poly a tail shortening GO:0060211 4 0.016
regulation of chromosome organization GO:0033044 64 0.016
regulation of epithelial cell differentiation GO:0030856 4 0.016
regulation of r7 cell differentiation GO:0045676 15 0.016
establishment of localization in cell GO:0051649 402 0.016
negative regulation of protein metabolic process GO:0051248 85 0.016
atp metabolic process GO:0046034 49 0.016
regulation of mitotic sister chromatid segregation GO:0033047 28 0.016
positive regulation of biosynthetic process GO:0009891 316 0.016
regulation of epidermal growth factor receptor signaling pathway GO:0042058 42 0.016
hair cell differentiation GO:0035315 47 0.015
nephron tubule morphogenesis GO:0072078 3 0.015
regulation of cell cycle process GO:0010564 181 0.015
immune system process GO:0002376 347 0.015
organic cyclic compound catabolic process GO:1901361 168 0.015
body morphogenesis GO:0010171 2 0.015
terminal region determination GO:0007362 25 0.015
positive regulation of mrna catabolic process GO:0061014 5 0.015
negative regulation of developmental process GO:0051093 201 0.015
response to dsrna GO:0043331 15 0.015
kidney epithelium development GO:0072073 3 0.015
regulation of phosphorylation GO:0042325 147 0.015
response to oxidative stress GO:0006979 86 0.015
regulation of cell differentiation GO:0045595 302 0.015
mitotic sister chromatid segregation GO:0000070 87 0.015
response to biotic stimulus GO:0009607 294 0.015
regulation of cellular protein catabolic process GO:1903362 44 0.015
embryonic development via the syncytial blastoderm GO:0001700 148 0.015
skin development GO:0043588 65 0.015
mrna processing GO:0006397 104 0.014
germline ring canal formation GO:0030725 13 0.014
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 24 0.014
cellular nitrogen compound catabolic process GO:0044270 165 0.014
appendage segmentation GO:0035285 26 0.014
protein localization GO:0008104 284 0.014
positive regulation of cell death GO:0010942 69 0.014
aromatic compound catabolic process GO:0019439 166 0.014
organic acid metabolic process GO:0006082 103 0.014
stem cell development GO:0048864 79 0.014
regulation of chromosome segregation GO:0051983 32 0.014
head development GO:0060322 135 0.014
protein polymerization GO:0051258 42 0.014
compound eye photoreceptor cell differentiation GO:0001751 140 0.014
regulation of localization GO:0032879 275 0.014
immune response GO:0006955 246 0.013
compound eye morphogenesis GO:0001745 249 0.013
sister chromatid segregation GO:0000819 92 0.013
negative regulation of programmed cell death GO:0043069 72 0.013
posttranscriptional gene silencing GO:0016441 46 0.013
regulation of protein modification by small protein conjugation or removal GO:1903320 25 0.013
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.013
regulation of establishment of planar polarity GO:0090175 22 0.013
establishment of protein localization to organelle GO:0072594 62 0.013
regulation of i kappab kinase nf kappab signaling GO:0043122 2 0.013
appendage morphogenesis GO:0035107 397 0.013
regulation of translation GO:0006417 56 0.013
cellular response to ethanol GO:0071361 4 0.013
regulation of protein catabolic process GO:0042176 55 0.013
positive regulation of mrna 3 end processing GO:0031442 4 0.013
production of small rna involved in gene silencing by rna GO:0070918 15 0.013
epidermal cell differentiation GO:0009913 51 0.013
determination of ventral identity GO:0048264 1 0.013
anterior posterior pattern specification GO:0009952 136 0.013
imaginal disc derived leg segmentation GO:0036011 26 0.013
limb morphogenesis GO:0035108 1 0.013
cellular protein complex assembly GO:0043623 71 0.013
regulation of chitin based cuticle tanning GO:0007564 14 0.013
regulation of anatomical structure size GO:0090066 163 0.012
regulation of organelle organization GO:0033043 196 0.012
mitochondrion morphogenesis GO:0070584 8 0.012
imaginal disc pattern formation GO:0007447 91 0.012
er associated ubiquitin dependent protein catabolic process GO:0030433 3 0.012
cell death GO:0008219 279 0.012
regulation of histone deacetylation GO:0031063 2 0.012
response to radiation GO:0009314 155 0.012
regulation of mapk cascade GO:0043408 92 0.012
negative regulation of proteolysis GO:0045861 31 0.012
nephron morphogenesis GO:0072028 3 0.012
signal transduction by phosphorylation GO:0023014 107 0.012
kidney morphogenesis GO:0060993 3 0.012
regulation of phosphorus metabolic process GO:0051174 210 0.012
mitotic cell cycle phase transition GO:0044772 138 0.012
equator specification GO:0045317 4 0.012
cellular response to organic substance GO:0071310 132 0.012
imaginal disc derived wing vein specification GO:0007474 48 0.012
negative regulation of cellular biosynthetic process GO:0031327 277 0.012
heterocycle catabolic process GO:0046700 166 0.012
purine nucleotide metabolic process GO:0006163 146 0.011
somatic muscle development GO:0007525 66 0.011
gland morphogenesis GO:0022612 145 0.011
retina development in camera type eye GO:0060041 4 0.011
positive regulation of catabolic process GO:0009896 105 0.011
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.011
regulation of proteasomal protein catabolic process GO:0061136 39 0.011
unidimensional cell growth GO:0009826 15 0.011
regulation of cell division GO:0051302 72 0.011
wing disc morphogenesis GO:0007472 344 0.011
neuron projection guidance GO:0097485 241 0.011
cuticle pigmentation GO:0048067 22 0.011
regulation of sister chromatid segregation GO:0033045 28 0.011
regulation of response to biotic stimulus GO:0002831 63 0.011
spermatid differentiation GO:0048515 114 0.011
peripheral nervous system development GO:0007422 52 0.011
necrotic cell death GO:0070265 1 0.011
nucleotide metabolic process GO:0009117 161 0.011
response to lipopolysaccharide GO:0032496 4 0.011
membrane budding GO:0006900 4 0.011
negative regulation of cell differentiation GO:0045596 143 0.011
regulation of immune system process GO:0002682 176 0.011
cell aging GO:0007569 2 0.011
regulation of protein modification process GO:0031399 112 0.011
regulation of cell development GO:0060284 215 0.011
muscle cell differentiation GO:0042692 103 0.010
regulation of synapse organization GO:0050807 110 0.010
molting cycle chitin based cuticle GO:0007591 56 0.010
mesenchymal cell differentiation GO:0048762 1 0.010
negative regulation of endopeptidase activity GO:0010951 11 0.010
negative regulation of proteolysis involved in cellular protein catabolic process GO:1903051 17 0.010
cell proliferation GO:0008283 299 0.010
regulation of cellular amine metabolic process GO:0033238 3 0.010
single organism membrane fusion GO:0044801 42 0.010
cellular amine metabolic process GO:0044106 12 0.010
membrane organization GO:0061024 112 0.010
phagocytosis GO:0006909 215 0.010
gene silencing by rna GO:0031047 57 0.010
nucleoside phosphate metabolic process GO:0006753 162 0.010
negative regulation of mitotic cell cycle GO:0045930 109 0.010

Psa disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.028
nervous system disease DOID:863 0 0.027
neurodegenerative disease DOID:1289 0 0.027
motor neuron disease DOID:231 0 0.027
central nervous system disease DOID:331 0 0.027
cardiovascular system disease DOID:1287 0 0.015
sensory system disease DOID:0050155 0 0.010
autosomal dominant nonsyndromic deafness DOID:0050564 0 0.010
auditory system disease DOID:2742 0 0.010
nonsyndromic deafness DOID:0050563 0 0.010