Drosophila melanogaster

44 known processes

Top3alpha (Dmel_CG10123)

Topoisomerase 3alpha

(Aliases: DmTop3alpha,Topo IIIalpha,Dmel\CG10123,CG10123,Top3a,top3alpha,dTopoIIIa)

Top3alpha biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
catabolic process GO:0009056 409 0.382
organonitrogen compound metabolic process GO:1901564 318 0.337
amine metabolic process GO:0009308 12 0.307
gland development GO:0048732 191 0.248
nucleobase containing compound catabolic process GO:0034655 165 0.240
meiotic cell cycle process GO:1903046 132 0.234
purine nucleoside metabolic process GO:0042278 127 0.220
regulation of cellular component biogenesis GO:0044087 201 0.214
axon development GO:0061564 297 0.210
protein complex assembly GO:0006461 200 0.190
organic acid metabolic process GO:0006082 103 0.189
negative regulation of cellular metabolic process GO:0031324 382 0.182
cellular nitrogen compound catabolic process GO:0044270 165 0.175
enzyme linked receptor protein signaling pathway GO:0007167 179 0.171
regulation of anatomical structure size GO:0090066 163 0.169
heterocycle catabolic process GO:0046700 166 0.167
positive regulation of hydrolase activity GO:0051345 78 0.165
single organism catabolic process GO:0044712 228 0.158
regulation of cellular amino acid metabolic process GO:0006521 0 0.157
nucleotide catabolic process GO:0009166 109 0.144
response to abiotic stimulus GO:0009628 341 0.140
cellular amine metabolic process GO:0044106 12 0.139
actin filament based process GO:0030029 220 0.136
positive regulation of cellular catabolic process GO:0031331 95 0.132
cellular catabolic process GO:0044248 372 0.130
cellular amino acid metabolic process GO:0006520 61 0.126
carbohydrate derivative metabolic process GO:1901135 217 0.125
positive regulation of molecular function GO:0044093 136 0.124
central nervous system development GO:0007417 201 0.120
purine nucleoside catabolic process GO:0006152 112 0.117
ribonucleoside catabolic process GO:0042454 112 0.111
negative regulation of biosynthetic process GO:0009890 277 0.109
morphogenesis of embryonic epithelium GO:0016331 94 0.087
small molecule metabolic process GO:0044281 305 0.085
organic cyclic compound catabolic process GO:1901361 168 0.085
aromatic compound catabolic process GO:0019439 166 0.085
protein complex biogenesis GO:0070271 201 0.084
growth GO:0040007 359 0.083
dna metabolic process GO:0006259 227 0.081
organonitrogen compound catabolic process GO:1901565 128 0.080
organic substance catabolic process GO:1901575 308 0.080
dna replication GO:0006260 48 0.079
axonogenesis GO:0007409 290 0.078
protein phosphorylation GO:0006468 169 0.075
nucleobase containing small molecule metabolic process GO:0055086 174 0.074
regulation of hydrolase activity GO:0051336 97 0.074
regulation of cellular response to stress GO:0080135 89 0.070
nucleotide metabolic process GO:0009117 161 0.070
regulation of cellular ketone metabolic process GO:0010565 3 0.069
regulation of cell cycle GO:0051726 291 0.066
negative regulation of phosphorus metabolic process GO:0010563 45 0.065
purine ribonucleoside metabolic process GO:0046128 127 0.064
neurological system process GO:0050877 358 0.062
nucleoside metabolic process GO:0009116 127 0.061
brain development GO:0007420 120 0.060
negative regulation of cell communication GO:0010648 223 0.060
multicellular organism growth GO:0035264 46 0.058
negative regulation of response to stimulus GO:0048585 258 0.058
ribonucleotide metabolic process GO:0009259 145 0.055
negative regulation of cell cycle process GO:0010948 109 0.053
regulation of cellular protein metabolic process GO:0032268 243 0.053
positive regulation of macromolecule metabolic process GO:0010604 405 0.053
oxoacid metabolic process GO:0043436 103 0.052
response to light stimulus GO:0009416 124 0.052
cellular response to dna damage stimulus GO:0006974 223 0.052
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.051
macromolecular complex assembly GO:0065003 256 0.049
regulation of protein metabolic process GO:0051246 256 0.048
ribonucleotide catabolic process GO:0009261 109 0.048
ribose phosphate metabolic process GO:0019693 145 0.048
spermatogenesis GO:0007283 200 0.048
negative regulation of phosphorylation GO:0042326 35 0.047
positive regulation of catalytic activity GO:0043085 118 0.046
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 38 0.045
transmembrane transport GO:0055085 139 0.045
negative regulation of erbb signaling pathway GO:1901185 29 0.045
regulation of molecular function GO:0065009 217 0.044
male gamete generation GO:0048232 201 0.044
response to radiation GO:0009314 155 0.044
macromolecule catabolic process GO:0009057 161 0.043
regulation of cell death GO:0010941 173 0.042
positive regulation of peptidase activity GO:0010952 29 0.042
carbohydrate derivative catabolic process GO:1901136 118 0.042
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.042
regulation of cell cycle phase transition GO:1901987 130 0.042
establishment or maintenance of cell polarity GO:0007163 167 0.041
positive regulation of catabolic process GO:0009896 105 0.041
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 23 0.041
organelle assembly GO:0070925 198 0.040
purine nucleotide catabolic process GO:0006195 109 0.039
head development GO:0060322 135 0.038
glycosyl compound catabolic process GO:1901658 112 0.038
embryonic morphogenesis GO:0048598 206 0.037
regulation of catalytic activity GO:0050790 185 0.037
signal transduction in response to dna damage GO:0042770 3 0.037
regulation of cellular catabolic process GO:0031329 157 0.036
multicellular organismal aging GO:0010259 140 0.036
negative regulation of signal transduction GO:0009968 206 0.035
positive regulation of protein metabolic process GO:0051247 128 0.034
regulation of response to stress GO:0080134 200 0.034
actin cytoskeleton organization GO:0030036 206 0.034
ribonucleoside metabolic process GO:0009119 127 0.034
ribonucleoside triphosphate catabolic process GO:0009203 108 0.033
negative regulation of cellular biosynthetic process GO:0031327 277 0.033
ribonucleoside monophosphate catabolic process GO:0009158 39 0.033
organophosphate metabolic process GO:0019637 195 0.032
peptidyl tyrosine phosphorylation GO:0018108 24 0.031
forebrain development GO:0030900 2 0.031
programmed cell death GO:0012501 257 0.031
cellular macromolecular complex assembly GO:0034622 153 0.030
regulation of organelle organization GO:0033043 196 0.030
single organism intracellular transport GO:1902582 207 0.029
apoptotic process GO:0006915 159 0.029
regulation of gene expression epigenetic GO:0040029 128 0.029
intracellular signal transduction GO:0035556 300 0.029
negative regulation of signaling GO:0023057 219 0.029
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.029
purine nucleotide metabolic process GO:0006163 146 0.029
positive regulation of cellular biosynthetic process GO:0031328 316 0.028
regulation of catabolic process GO:0009894 170 0.028
positive regulation of proteolysis GO:0045862 52 0.028
nucleoside catabolic process GO:0009164 112 0.028
embryo development ending in birth or egg hatching GO:0009792 152 0.027
carboxylic acid metabolic process GO:0019752 92 0.027
gland morphogenesis GO:0022612 145 0.027
response to organic substance GO:0010033 284 0.027
nucleoside phosphate catabolic process GO:1901292 110 0.027
nucleoside phosphate metabolic process GO:0006753 162 0.026
negative regulation of phosphate metabolic process GO:0045936 45 0.026
negative regulation of catalytic activity GO:0043086 42 0.026
purine ribonucleoside catabolic process GO:0046130 112 0.026
heart process GO:0003015 37 0.025
positive regulation of phosphorus metabolic process GO:0010562 139 0.025
kidney development GO:0001822 3 0.025
response to endogenous stimulus GO:0009719 119 0.025
nucleoside triphosphate catabolic process GO:0009143 108 0.025
cellular response to organic substance GO:0071310 132 0.024
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.024
regulation of blood circulation GO:1903522 21 0.024
regulation of purine nucleotide metabolic process GO:1900542 62 0.023
death GO:0016265 284 0.022
positive regulation of purine nucleotide metabolic process GO:1900544 55 0.022
regulation of system process GO:0044057 36 0.022
regulation of mitotic cell cycle GO:0007346 190 0.022
glycosyl compound metabolic process GO:1901657 127 0.022
regulation of nucleotide metabolic process GO:0006140 62 0.022
cellular macromolecule catabolic process GO:0044265 136 0.021
regulation of cellular component size GO:0032535 98 0.021
larval development GO:0002164 104 0.021
imaginal disc derived appendage development GO:0048737 399 0.021
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.021
nucleoside triphosphate metabolic process GO:0009141 120 0.021
regulation of protein modification process GO:0031399 112 0.021
developmental growth GO:0048589 280 0.020
heart contraction GO:0060047 26 0.020
compound eye retinal cell programmed cell death GO:0046667 23 0.020
regulation of apoptotic process GO:0042981 130 0.020
cell growth GO:0016049 108 0.020
ras protein signal transduction GO:0007265 88 0.020
positive regulation of cellular component biogenesis GO:0044089 80 0.020
blood circulation GO:0008015 26 0.020
regulation of anatomical structure morphogenesis GO:0022603 242 0.019
proteolysis GO:0006508 192 0.019
negative regulation of cell cycle phase transition GO:1901988 103 0.019
negative regulation of cellular protein metabolic process GO:0032269 85 0.019
single organism biosynthetic process GO:0044711 206 0.019
regulation of programmed cell death GO:0043067 152 0.019
intracellular transport GO:0046907 228 0.019
aging GO:0007568 143 0.019
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.018
oocyte construction GO:0007308 112 0.018
non recombinational repair GO:0000726 7 0.018
posttranscriptional regulation of gene expression GO:0010608 145 0.018
positive regulation of cellular protein metabolic process GO:0032270 118 0.018
regulation of proteolysis GO:0030162 87 0.018
purine ribonucleotide metabolic process GO:0009150 145 0.018
rhythmic process GO:0048511 106 0.017
histolysis GO:0007559 102 0.017
mitotic g2 m transition checkpoint GO:0044818 70 0.017
pole plasm protein localization GO:0007318 10 0.017
epidermal growth factor receptor signaling pathway GO:0007173 58 0.017
purine ribonucleotide catabolic process GO:0009154 109 0.017
organophosphate catabolic process GO:0046434 112 0.017
regulation of nucleoside metabolic process GO:0009118 50 0.017
purine nucleoside triphosphate catabolic process GO:0009146 108 0.016
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.016
purine containing compound metabolic process GO:0072521 155 0.016
cuticle development GO:0042335 86 0.016
regionalization GO:0003002 416 0.016
spermatid differentiation GO:0048515 114 0.016
actin filament organization GO:0007015 126 0.016
negative regulation of peptidyl tyrosine phosphorylation GO:0050732 6 0.016
dendrite development GO:0016358 204 0.016
vitelline membrane formation GO:0030704 11 0.015
single organism cellular localization GO:1902580 180 0.015
regulation of cellular amine metabolic process GO:0033238 3 0.015
cell death GO:0008219 279 0.015
anterior posterior axis specification GO:0009948 109 0.015
response to alkaloid GO:0043279 26 0.015
tissue morphogenesis GO:0048729 297 0.015
cellular response to organic cyclic compound GO:0071407 32 0.015
cell maturation GO:0048469 144 0.015
negative regulation of protein phosphorylation GO:0001933 17 0.015
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.014
activation of cysteine type endopeptidase activity GO:0097202 17 0.014
regulation of transferase activity GO:0051338 58 0.014
homeostatic process GO:0042592 199 0.014
purine nucleoside triphosphate metabolic process GO:0009144 119 0.014
body morphogenesis GO:0010171 2 0.014
regulation of multicellular organismal development GO:2000026 414 0.014
positive regulation of rna biosynthetic process GO:1902680 266 0.013
columnar cuboidal epithelial cell development GO:0002066 249 0.013
carbohydrate metabolic process GO:0005975 82 0.013
positive regulation of signaling GO:0023056 243 0.013
ribonucleoside triphosphate metabolic process GO:0009199 119 0.013
regulation of erbb signaling pathway GO:1901184 42 0.013
antimicrobial humoral response GO:0019730 99 0.013
regulation of response to dna damage stimulus GO:2001020 23 0.013
regulation of actin polymerization or depolymerization GO:0008064 27 0.013
regulation of organ morphogenesis GO:2000027 78 0.012
regulation of phosphorylation GO:0042325 147 0.012
sex determination GO:0007530 18 0.012
connective tissue development GO:0061448 3 0.012
response to organic cyclic compound GO:0014070 89 0.012
positive regulation of protein complex assembly GO:0031334 22 0.012
locomotory behavior GO:0007626 176 0.012
purine nucleoside monophosphate catabolic process GO:0009128 38 0.012
positive regulation of cellular amine metabolic process GO:0033240 0 0.012
regulation of peptidyl tyrosine phosphorylation GO:0050730 10 0.012
cellular response to oxygen containing compound GO:1901701 79 0.012
negative regulation of gene expression GO:0010629 387 0.012
response to oxygen containing compound GO:1901700 200 0.012
regulation of localization GO:0032879 275 0.012
negative regulation of intracellular signal transduction GO:1902532 57 0.012
positive regulation of purine nucleotide catabolic process GO:0033123 46 0.012
lipid metabolic process GO:0006629 121 0.011
regulation of nucleotide catabolic process GO:0030811 48 0.011
cellular response to external stimulus GO:0071496 66 0.011
response to nitrogen compound GO:1901698 90 0.011
digestive system development GO:0055123 149 0.011
embryonic development via the syncytial blastoderm GO:0001700 148 0.011
endocytosis GO:0006897 310 0.011
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.011
gtp catabolic process GO:0006184 72 0.011
taxis GO:0042330 304 0.011
negative regulation of erk1 and erk2 cascade GO:0070373 3 0.011
action potential GO:0001508 13 0.011
cell proliferation GO:0008283 299 0.011
telencephalon development GO:0021537 2 0.011
response to organophosphorus GO:0046683 2 0.010
sensory perception GO:0007600 196 0.010
compound eye photoreceptor cell differentiation GO:0001751 140 0.010
regulation of nervous system development GO:0051960 248 0.010
reciprocal meiotic recombination GO:0007131 19 0.010
cellular response to nitrogen compound GO:1901699 51 0.010
compound eye development GO:0048749 307 0.010
peptidyl tyrosine modification GO:0018212 24 0.010
pole cell development GO:0007277 26 0.010
cell fate specification GO:0001708 71 0.010

Top3alpha disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.052
cardiovascular system disease DOID:1287 0 0.052
cancer DOID:162 0 0.029
disease of cellular proliferation DOID:14566 0 0.029
musculoskeletal system cancer DOID:0060100 0 0.021
organ system cancer DOID:0050686 0 0.021
nervous system disease DOID:863 0 0.011
sensory system disease DOID:0050155 0 0.011