Drosophila melanogaster

7 known processes

Rpn6 (Dmel_CG10149)

Proteasome p44.5 subunit

(Aliases: Pros44.5,BcDNA.LD18931,Dmel\CG10149,CG10149,BcDNA:LD18931,p42B,l(2)k00103)

Rpn6 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
positive regulation of proteasomal protein catabolic process GO:1901800 20 0.853
modification dependent macromolecule catabolic process GO:0043632 79 0.845
Human Yeast Worm
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.623
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 24 0.568
ubiquitin dependent protein catabolic process GO:0006511 78 0.545
Human Yeast Worm
cellular macromolecule catabolic process GO:0044265 136 0.472
Human Yeast Worm
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 19 0.466
proteasome assembly GO:0043248 2 0.455
Human Yeast Worm
proteolysis GO:0006508 192 0.432
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 37 0.420
columnar cuboidal epithelial cell development GO:0002066 249 0.387
positive regulation of proteolysis GO:0045862 52 0.371
chemotaxis GO:0006935 249 0.360
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.333
Human Yeast Worm
modification dependent protein catabolic process GO:0019941 78 0.307
Human Yeast Worm
er associated ubiquitin dependent protein catabolic process GO:0030433 3 0.280
protein catabolic process GO:0030163 101 0.275
Human Yeast Worm
positive regulation of endopeptidase activity GO:0010950 26 0.275
determination of adult lifespan GO:0008340 137 0.263
Worm
proteasomal protein catabolic process GO:0010498 59 0.238
positive regulation of peptidase activity GO:0010952 29 0.220
catabolic process GO:0009056 409 0.210
Human Yeast Worm
cell proliferation GO:0008283 299 0.207
autophagy GO:0006914 108 0.193
macromolecule catabolic process GO:0009057 161 0.189
Human Yeast Worm
rna catabolic process GO:0006401 37 0.182
cullin deneddylation GO:0010388 3 0.178
spindle elongation GO:0051231 83 0.174
neuron remodeling GO:0016322 29 0.162
central nervous system development GO:0007417 201 0.161
body morphogenesis GO:0010171 2 0.155
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.154
larval development GO:0002164 104 0.154
Worm
multicellular organismal aging GO:0010259 140 0.154
Worm
positive regulation of cellular component biogenesis GO:0044089 80 0.149
positive regulation of catabolic process GO:0009896 105 0.146
protein modification by small protein conjugation or removal GO:0070647 106 0.142
regulation of endopeptidase activity GO:0052548 36 0.131
cellular response to dna damage stimulus GO:0006974 223 0.124
mitotic spindle elongation GO:0000022 81 0.123
protein k48 linked ubiquitination GO:0070936 3 0.110
cellular protein catabolic process GO:0044257 83 0.109
Human Yeast Worm
embryo development ending in birth or egg hatching GO:0009792 152 0.106
Worm
protein deneddylation GO:0000338 8 0.099
dendrite development GO:0016358 204 0.098
regulation of catabolic process GO:0009894 170 0.097
regulation of cellular protein metabolic process GO:0032268 243 0.096
neuron projection guidance GO:0097485 241 0.096
ovarian follicle cell development GO:0030707 248 0.095
mushroom body development GO:0016319 70 0.094
organic substance catabolic process GO:1901575 308 0.091
Human Yeast Worm
protein ubiquitination GO:0016567 70 0.090
regulation of cell cycle GO:0051726 291 0.089
compound eye photoreceptor cell differentiation GO:0001751 140 0.089
wing disc morphogenesis GO:0007472 344 0.087
regulation of proteasomal protein catabolic process GO:0061136 39 0.086
axon midline choice point recognition GO:0016199 26 0.085
mitotic nuclear division GO:0007067 213 0.085
regulation of proteolysis GO:0030162 87 0.084
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 44 0.084
neuron maturation GO:0042551 31 0.082
protein complex biogenesis GO:0070271 201 0.082
Human Yeast Worm
negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 4 0.082
positive regulation of cellular component organization GO:0051130 156 0.081
regulation of peptidase activity GO:0052547 39 0.076
spindle assembly GO:0051225 80 0.073
posttranscriptional gene silencing by rna GO:0035194 45 0.070
cellular catabolic process GO:0044248 372 0.069
Human Yeast Worm
regulation of cell development GO:0060284 215 0.059
regulation of cellular catabolic process GO:0031329 157 0.059
death GO:0016265 284 0.057
Worm
regulation of molecular function GO:0065009 217 0.057
synapse organization GO:0050808 196 0.056
positive regulation of cellular protein metabolic process GO:0032270 118 0.055
protein modification process GO:0036211 438 0.053
ribonucleotide metabolic process GO:0009259 145 0.052
regulation of mitotic cell cycle GO:0007346 190 0.051
positive regulation of protein complex assembly GO:0031334 22 0.051
regulation of multi organism process GO:0043900 131 0.050
regulation of protein catabolic process GO:0042176 55 0.049
cell death GO:0008219 279 0.049
Worm
glycosyl compound metabolic process GO:1901657 127 0.048
protein modification by small protein conjugation GO:0032446 79 0.048
gene silencing by rna GO:0031047 57 0.047
neuromuscular synaptic transmission GO:0007274 67 0.047
compound eye development GO:0048749 307 0.047
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 6 0.047
cellular protein modification process GO:0006464 438 0.047
purine containing compound catabolic process GO:0072523 112 0.046
regulation of cell differentiation GO:0045595 302 0.045
eye development GO:0001654 323 0.045
regulation of cellular protein catabolic process GO:1903362 44 0.045
negative regulation of gene expression GO:0010629 387 0.045
endosome to lysosome transport GO:0008333 7 0.044
positive regulation of rna biosynthetic process GO:1902680 266 0.044
protein modification by small protein removal GO:0070646 28 0.044
cell division GO:0051301 248 0.044
positive regulation of transcription dna templated GO:0045893 266 0.043
cellular macromolecular complex assembly GO:0034622 153 0.043
Human Yeast Worm
positive regulation of protein catabolic process GO:0045732 34 0.043
regulation of protein complex assembly GO:0043254 42 0.042
regulation of cellular component size GO:0032535 98 0.042
purine ribonucleotide catabolic process GO:0009154 109 0.042
negative regulation of transcription dna templated GO:0045892 237 0.042
regulation of response to stress GO:0080134 200 0.042
regulation of catalytic activity GO:0050790 185 0.042
lamellipodium assembly GO:0030032 21 0.041
eggshell formation GO:0030703 105 0.041
homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 18 0.040
aging GO:0007568 143 0.040
Worm
endosomal vesicle fusion GO:0034058 4 0.039
axon guidance GO:0007411 233 0.039
regulation of cellular component biogenesis GO:0044087 201 0.039
macromolecular complex assembly GO:0065003 256 0.038
Human Yeast Worm
dendrite morphogenesis GO:0048813 199 0.038
regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0045898 1 0.038
brain development GO:0007420 120 0.037
positive regulation of cellular catabolic process GO:0031331 95 0.037
positive regulation of mitotic cell cycle GO:0045931 34 0.037
stem cell differentiation GO:0048863 117 0.037
Human
phosphorylation GO:0016310 294 0.036
response to abiotic stimulus GO:0009628 341 0.036
regulation of epithelial cell proliferation GO:0050678 4 0.035
tissue death GO:0016271 102 0.035
cellular protein complex assembly GO:0043623 71 0.034
Human Yeast Worm
stem cell division GO:0017145 69 0.034
regulation of lamellipodium organization GO:1902743 15 0.034
scf dependent proteasomal ubiquitin dependent protein catabolic process GO:0031146 1 0.034
organophosphate metabolic process GO:0019637 195 0.034
ribose phosphate metabolic process GO:0019693 145 0.034
compound eye photoreceptor development GO:0042051 78 0.033
posttranscriptional regulation of gene expression GO:0010608 145 0.033
nucleoside triphosphate metabolic process GO:0009141 120 0.033
compound eye morphogenesis GO:0001745 249 0.033
epithelial cell development GO:0002064 274 0.032
double strand break repair GO:0006302 26 0.032
positive regulation of protein metabolic process GO:0051247 128 0.031
positive regulation of autophagy GO:0010508 21 0.031
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.031
lipid storage GO:0019915 38 0.031
multicellular organismal reproductive behavior GO:0033057 110 0.031
mitotic dna damage checkpoint GO:0044773 74 0.030
dna damage checkpoint GO:0000077 78 0.030
nuclear division GO:0000280 332 0.030
dna templated transcriptional preinitiation complex assembly GO:0070897 20 0.030
apoptotic process GO:0006915 159 0.030
Worm
regulation of multicellular organismal development GO:2000026 414 0.030
cuticle pigmentation GO:0048067 22 0.030
organelle assembly GO:0070925 198 0.029
mitotic g2 m transition checkpoint GO:0044818 70 0.029
regulation of dna templated transcription elongation GO:0032784 17 0.029
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 38 0.029
cell maturation GO:0048469 144 0.029
response to transforming growth factor beta GO:0071559 18 0.029
response to ionizing radiation GO:0010212 32 0.028
regulation of stem cell proliferation GO:0072091 40 0.028
homeostatic process GO:0042592 199 0.028
aromatic compound catabolic process GO:0019439 166 0.027
regulation of cellular response to stress GO:0080135 89 0.027
positive regulation of molecular function GO:0044093 136 0.027
purine nucleotide metabolic process GO:0006163 146 0.027
response to organic substance GO:0010033 284 0.027
positive regulation of cell cycle GO:0045787 43 0.027
regulation of neuron differentiation GO:0045664 103 0.026
microtubule organizing center organization GO:0031023 168 0.026
histone ubiquitination GO:0016574 4 0.026
ribonucleotide catabolic process GO:0009261 109 0.026
rna polymerase ii transcriptional preinitiation complex assembly GO:0051123 20 0.026
heterocycle catabolic process GO:0046700 166 0.026
nucleobase containing compound catabolic process GO:0034655 165 0.025
regulation of synapse assembly GO:0051963 94 0.025
axonogenesis GO:0007409 290 0.025
single organism catabolic process GO:0044712 228 0.025
rna interference GO:0016246 27 0.025
positive regulation of rna metabolic process GO:0051254 271 0.025
establishment of protein localization GO:0045184 163 0.025
small gtpase mediated signal transduction GO:0007264 88 0.025
regulation of protein metabolic process GO:0051246 256 0.025
sensory organ morphogenesis GO:0090596 260 0.024
small molecule metabolic process GO:0044281 305 0.024
regulation of hydrolase activity GO:0051336 97 0.024
stem cell development GO:0048864 79 0.024
nucleobase containing small molecule metabolic process GO:0055086 174 0.024
negative regulation of cellular response to growth factor stimulus GO:0090288 6 0.023
male gamete generation GO:0048232 201 0.023
synaptic transmission GO:0007268 288 0.023
positive regulation of catalytic activity GO:0043085 118 0.023
gene silencing GO:0016458 138 0.023
transcription initiation from rna polymerase ii promoter GO:0006367 25 0.023
ribonucleoside triphosphate catabolic process GO:0009203 108 0.023
endomembrane system organization GO:0010256 119 0.022
negative regulation of signaling GO:0023057 219 0.022
protein complex disassembly GO:0043241 36 0.022
dna templated transcription elongation GO:0006354 18 0.022
mesenchymal cell differentiation GO:0048762 1 0.022
axon development GO:0061564 297 0.021
positive regulation of hydrolase activity GO:0051345 78 0.021
negative regulation of cellular biosynthetic process GO:0031327 277 0.021
cellular protein complex disassembly GO:0043624 35 0.021
stem cell proliferation GO:0072089 88 0.021
regulation of transcription elongation from rna polymerase ii promoter GO:0034243 15 0.021
nucleotide metabolic process GO:0009117 161 0.021
oocyte microtubule cytoskeleton polarization GO:0008103 22 0.021
regulation of phosphate metabolic process GO:0019220 210 0.020
spindle assembly involved in mitosis GO:0090307 50 0.020
spermatid differentiation GO:0048515 114 0.020
chromosome segregation GO:0007059 157 0.020
positive regulation of cellular biosynthetic process GO:0031328 316 0.019
regulation of intracellular signal transduction GO:1902531 236 0.019
head development GO:0060322 135 0.019
mitotic dna integrity checkpoint GO:0044774 75 0.019
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 16 0.019
lamellipodium organization GO:0097581 21 0.019
synapse assembly GO:0007416 143 0.019
taxis GO:0042330 304 0.019
eye photoreceptor cell differentiation GO:0001754 145 0.019
negative regulation of signal transduction GO:0009968 206 0.019
positive regulation of cell cycle process GO:0090068 28 0.019
maintenance of location GO:0051235 73 0.018
protein complex assembly GO:0006461 200 0.018
Human Yeast Worm
regulation of bmp signaling pathway GO:0030510 23 0.018
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 65 0.018
eye photoreceptor cell development GO:0042462 81 0.018
organophosphate catabolic process GO:0046434 112 0.018
eye morphogenesis GO:0048592 260 0.018
purine containing compound metabolic process GO:0072521 155 0.018
protein localization GO:0008104 284 0.017
cell recognition GO:0008037 102 0.017
glycosyl compound catabolic process GO:1901658 112 0.017
positive regulation of nucleic acid templated transcription GO:1903508 266 0.017
positive regulation of phosphorus metabolic process GO:0010562 139 0.017
multi organism behavior GO:0051705 175 0.017
regulation of ras protein signal transduction GO:0046578 93 0.017
regulation of establishment of protein localization GO:0070201 61 0.016
regulation of gene expression epigenetic GO:0040029 128 0.016
dna templated transcription initiation GO:0006352 25 0.016
nucleoside metabolic process GO:0009116 127 0.016
regulation of autophagy GO:0010506 62 0.016
defense response to virus GO:0051607 23 0.016
ribonucleoside catabolic process GO:0042454 112 0.016
mesenchymal cell development GO:0014031 1 0.016
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.016
tube development GO:0035295 244 0.016
positive regulation of cellular protein catabolic process GO:1903364 24 0.015
multi multicellular organism process GO:0044706 123 0.015
negative regulation of biosynthetic process GO:0009890 277 0.015
early endosome to late endosome transport GO:0045022 3 0.015
negative regulation of cellular protein metabolic process GO:0032269 85 0.015
histone h2a ubiquitination GO:0033522 2 0.015
actin filament capping GO:0051693 2 0.015
regulation of protein localization GO:0032880 76 0.015
positive regulation of gene expression GO:0010628 290 0.015
photoreceptor cell development GO:0042461 96 0.014
purine nucleotide catabolic process GO:0006195 109 0.014
larval midgut cell programmed cell death GO:0035096 19 0.014
purine nucleoside catabolic process GO:0006152 112 0.014
dna metabolic process GO:0006259 227 0.014
negative regulation of nucleic acid templated transcription GO:1903507 240 0.014
mitochondrion organization GO:0007005 65 0.014
regulation of cell division GO:0051302 72 0.014
female sex differentiation GO:0046660 20 0.014
chorion containing eggshell formation GO:0007304 105 0.014
purine nucleoside triphosphate metabolic process GO:0009144 119 0.014
synaptic vesicle recycling GO:0036465 28 0.014
nucleoside phosphate metabolic process GO:0006753 162 0.014
transcription from rna polymerase ii promoter GO:0006366 368 0.014
pigment biosynthetic process GO:0046148 36 0.014
eggshell chorion gene amplification GO:0007307 9 0.014
regulation of phosphorus metabolic process GO:0051174 210 0.014
ras protein signal transduction GO:0007265 88 0.013
camera type eye morphogenesis GO:0048593 2 0.013
macroautophagy GO:0016236 42 0.013
transcription elongation from rna polymerase ii promoter GO:0006368 18 0.013
cellular component disassembly GO:0022411 46 0.013
cell cycle phase transition GO:0044770 140 0.013
guanosine containing compound catabolic process GO:1901069 74 0.013
positive regulation of organelle organization GO:0010638 65 0.013
positive regulation of apoptotic signaling pathway GO:2001235 4 0.013
cellularization GO:0007349 90 0.013
regulation of transport GO:0051049 181 0.013
nuclear migration GO:0007097 20 0.013
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 4 0.013
histolysis GO:0007559 102 0.013
regulation of protein stability GO:0031647 43 0.013
cytoplasmic transport GO:0016482 130 0.013
regulation of anatomical structure size GO:0090066 163 0.013
protein deubiquitination GO:0016579 17 0.012
protein transport GO:0015031 155 0.012
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 18 0.012
negative regulation of cell proliferation GO:0008285 69 0.012
mrna catabolic process GO:0006402 33 0.012
regulation of response to extracellular stimulus GO:0032104 18 0.012
nucleoside catabolic process GO:0009164 112 0.012
epithelial cell migration GO:0010631 148 0.012
synaptic growth at neuromuscular junction GO:0051124 119 0.012
negative regulation of developmental process GO:0051093 201 0.012
heart development GO:0007507 82 0.012
wnt signaling pathway GO:0016055 98 0.012
determination of dorsal ventral asymmetry GO:0048262 3 0.012
negative regulation of cellular metabolic process GO:0031324 382 0.012
imaginal disc derived leg morphogenesis GO:0007480 80 0.012
regulation of nucleotide metabolic process GO:0006140 62 0.012
regulation of cell projection organization GO:0031344 92 0.012
negative regulation of response to stimulus GO:0048585 258 0.012
response to radiation GO:0009314 155 0.011
regulation of localization GO:0032879 275 0.011
positive regulation of synapse assembly GO:0051965 29 0.011
nucleotide catabolic process GO:0009166 109 0.011
dendrite guidance GO:0070983 21 0.011
mitotic cell cycle checkpoint GO:0007093 88 0.011
regulation of gtp catabolic process GO:0033124 44 0.011
posttranscriptional gene silencing GO:0016441 46 0.011
programmed cell death GO:0012501 257 0.011
Worm
protein heterooligomerization GO:0051291 4 0.011
protein deglycosylation GO:0006517 1 0.011
chromosome organization GO:0051276 360 0.011
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.011
guanosine containing compound metabolic process GO:1901068 74 0.011
chromatin organization GO:0006325 207 0.011
regulation of synapse structure and activity GO:0050803 128 0.011
female gonad development GO:0008585 12 0.011
protein neddylation GO:0045116 5 0.011
actin filament organization GO:0007015 126 0.011
regulation of response to biotic stimulus GO:0002831 63 0.011
positive regulation of phosphate metabolic process GO:0045937 139 0.011
signal transduction in response to dna damage GO:0042770 3 0.011
hematopoietic progenitor cell differentiation GO:0002244 1 0.011
mitotic spindle organization GO:0007052 220 0.011
enzyme linked receptor protein signaling pathway GO:0007167 179 0.011
establishment of oocyte nucleus localization involved in oocyte dorsal ventral axis specification GO:0030722 6 0.011
negative regulation of synapse assembly GO:0051964 39 0.011
salivary gland morphogenesis GO:0007435 145 0.011
regulation of small gtpase mediated signal transduction GO:0051056 93 0.010
gtp metabolic process GO:0046039 72 0.010
negative regulation of protein metabolic process GO:0051248 85 0.010
chromosome separation GO:0051304 42 0.010
photoreceptor cell differentiation GO:0046530 170 0.010
macromolecular complex disassembly GO:0032984 37 0.010
microtubule cytoskeleton organization involved in mitosis GO:1902850 52 0.010
developmental growth GO:0048589 280 0.010
morphogenesis of an epithelium GO:0002009 276 0.010
regulation of hemocyte differentiation GO:0045610 22 0.010
negative regulation of cell death GO:0060548 81 0.010
translational termination GO:0006415 2 0.010
embryonic development via the syncytial blastoderm GO:0001700 148 0.010
appendage morphogenesis GO:0035107 397 0.010
multi organism reproductive behavior GO:0044705 121 0.010

Rpn6 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.013