Drosophila melanogaster

68 known processes

Nup98 (Dmel_CG10198)

Nucleoporin 98

(Aliases: l(3)95BCd,Nup96,Nup98-Nup96,CG10198,Nup98/96,Dmel\CG10198,CG10201)

Nup98 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 65 0.477
nucleocytoplasmic transport GO:0006913 72 0.461
chromatin modification GO:0016568 147 0.387
cell death GO:0008219 279 0.357
positive regulation of biosynthetic process GO:0009891 316 0.326
chromosome organization GO:0051276 360 0.321
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.316
protein import into nucleus GO:0006606 51 0.312
nuclear transport GO:0051169 72 0.299
chromatin organization GO:0006325 207 0.232
positive regulation of gene expression GO:0010628 290 0.231
single organism nuclear import GO:1902593 51 0.228
cellular response to dna damage stimulus GO:0006974 223 0.227
protein localization to nucleus GO:0034504 55 0.211
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.203
smad protein import into nucleus GO:0007184 11 0.191
cytoplasmic transport GO:0016482 130 0.189
protein targeting GO:0006605 64 0.189
protein localization GO:0008104 284 0.180
nuclear import GO:0051170 51 0.179
protein transport GO:0015031 155 0.177
cellular macromolecule localization GO:0070727 220 0.176
cell proliferation GO:0008283 299 0.172
vesicle mediated transport GO:0016192 381 0.168
positive regulation of rna metabolic process GO:0051254 271 0.167
centrosome organization GO:0051297 163 0.165
chromatin remodeling GO:0006338 72 0.162
dna metabolic process GO:0006259 227 0.162
Human
spindle elongation GO:0051231 83 0.148
protein targeting to nucleus GO:0044744 51 0.145
nuclear export GO:0051168 24 0.145
negative regulation of cell cycle phase transition GO:1901988 103 0.140
regulation of cell cycle GO:0051726 291 0.138
centrosome cycle GO:0007098 137 0.133
rna localization GO:0006403 115 0.122
positive regulation of transcription dna templated GO:0045893 266 0.121
intracellular transport GO:0046907 228 0.121
negative regulation of signal transduction by p53 class mediator GO:1901797 1 0.119
positive regulation of macromolecule metabolic process GO:0010604 405 0.118
nuclear division GO:0000280 332 0.117
microtubule organizing center organization GO:0031023 168 0.115
macromolecular complex assembly GO:0065003 256 0.112
Human
cellular protein localization GO:0034613 160 0.109
establishment of localization in cell GO:0051649 402 0.108
regulation of localization GO:0032879 275 0.098
negative regulation of cell cycle GO:0045786 116 0.096
protein import GO:0017038 55 0.095
regulation of cellular localization GO:0060341 136 0.091
embryonic axis specification GO:0000578 107 0.090
axis specification GO:0009798 167 0.087
regulation of transcription by chromatin organization GO:0034401 3 0.086
autophagy GO:0006914 108 0.086
cellular protein modification process GO:0006464 438 0.085
meiotic nuclear division GO:0007126 151 0.083
single organism intracellular transport GO:1902582 207 0.081
organic substance transport GO:0071702 257 0.081
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.081
intracellular signal transduction GO:0035556 300 0.081
positive regulation of nucleic acid templated transcription GO:1903508 266 0.080
nuclear pore organization GO:0006999 1 0.079
Human
protein localization to organelle GO:0033365 82 0.077
sex differentiation GO:0007548 81 0.076
cell maturation GO:0048469 144 0.076
single organism biosynthetic process GO:0044711 206 0.071
mitotic cell cycle checkpoint GO:0007093 88 0.070
regulation of transport GO:0051049 181 0.070
cytoplasm organization GO:0007028 64 0.068
positive regulation of signaling GO:0023056 243 0.068
positive regulation of response to stimulus GO:0048584 323 0.067
dna repair GO:0006281 54 0.067
organelle fission GO:0048285 340 0.066
regulation of cellular protein metabolic process GO:0032268 243 0.065
regionalization GO:0003002 416 0.064
death GO:0016265 284 0.063
histone modification GO:0016570 106 0.062
translation GO:0006412 69 0.061
enzyme linked receptor protein signaling pathway GO:0007167 179 0.059
multicellular organismal aging GO:0010259 140 0.059
negative regulation of mitotic cell cycle GO:0045930 109 0.059
regulation of cytoplasmic transport GO:1903649 47 0.057
positive regulation of cell communication GO:0010647 250 0.056
response to abiotic stimulus GO:0009628 341 0.056
rna processing GO:0006396 147 0.054
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.053
regulation of nucleocytoplasmic transport GO:0046822 35 0.053
establishment of protein localization to organelle GO:0072594 62 0.050
negative regulation of gene expression GO:0010629 387 0.050
transcription from rna polymerase ii promoter GO:0006366 368 0.050
embryonic pattern specification GO:0009880 174 0.049
developmental maturation GO:0021700 172 0.049
intracellular protein transport GO:0006886 104 0.049
microtubule cytoskeleton organization involved in mitosis GO:1902850 52 0.048
positive regulation of signal transduction GO:0009967 223 0.048
single organism cellular localization GO:1902580 180 0.048
positive regulation of intracellular signal transduction GO:1902533 116 0.045
cellular protein complex disassembly GO:0043624 35 0.045
stem cell development GO:0048864 79 0.044
intracellular mrna localization GO:0008298 66 0.043
negative regulation of developmental process GO:0051093 201 0.041
regulation of cell cycle process GO:0010564 181 0.041
regulation of cell development GO:0060284 215 0.037
regulation of mitotic cell cycle GO:0007346 190 0.037
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.037
establishment of protein localization GO:0045184 163 0.037
anterior posterior axis specification GO:0009948 109 0.037
phagocytosis GO:0006909 215 0.036
regulation of cell proliferation GO:0042127 163 0.036
growth GO:0040007 359 0.036
purine nucleoside monophosphate metabolic process GO:0009126 50 0.036
negative regulation of cell cycle process GO:0010948 109 0.035
positive regulation of rna biosynthetic process GO:1902680 266 0.035
protein modification process GO:0036211 438 0.034
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.033
dna damage checkpoint GO:0000077 78 0.032
pole plasm assembly GO:0007315 61 0.032
ribonucleoprotein complex biogenesis GO:0022613 31 0.032
regulation of apoptotic process GO:0042981 130 0.031
regulation of programmed cell death GO:0043067 152 0.031
regulation of intracellular signal transduction GO:1902531 236 0.031
programmed cell death GO:0012501 257 0.031
mitotic nuclear division GO:0007067 213 0.030
covalent chromatin modification GO:0016569 106 0.030
regulation of mitotic cell cycle phase transition GO:1901990 130 0.029
g2 dna damage checkpoint GO:0031572 69 0.029
mrna transport GO:0051028 15 0.029
protein complex biogenesis GO:0070271 201 0.029
Human
atp metabolic process GO:0046034 49 0.029
regulation of protein localization GO:0032880 76 0.029
regulation of intracellular protein transport GO:0033157 46 0.029
positive regulation of cellular biosynthetic process GO:0031328 316 0.029
regulation of protein transport GO:0051223 57 0.028
wing disc morphogenesis GO:0007472 344 0.028
cellular catabolic process GO:0044248 372 0.027
purine ribonucleoside monophosphate metabolic process GO:0009167 50 0.027
embryo development ending in birth or egg hatching GO:0009792 152 0.027
positive regulation of protein metabolic process GO:0051247 128 0.026
negative regulation of biosynthetic process GO:0009890 277 0.025
reproductive behavior GO:0019098 122 0.025
regulation of intracellular transport GO:0032386 64 0.025
negative regulation of neurotransmitter secretion GO:0046929 2 0.023
pole plasm oskar mrna localization GO:0045451 46 0.022
apoptotic signaling pathway GO:0097190 27 0.022
appendage morphogenesis GO:0035107 397 0.021
rna transport GO:0050658 46 0.021
spermatid differentiation GO:0048515 114 0.021
regulation of meiosis GO:0040020 3 0.021
cellular response to lipopolysaccharide GO:0071222 3 0.021
nucleobase containing compound transport GO:0015931 56 0.020
larval development GO:0002164 104 0.020
organelle localization GO:0051640 148 0.020
rna export from nucleus GO:0006405 12 0.019
segmentation GO:0035282 207 0.019
posttranscriptional regulation of gene expression GO:0010608 145 0.019
cellular response to heat GO:0034605 24 0.019
regulation of protein import into nucleus GO:0042306 28 0.019
connective tissue development GO:0061448 3 0.019
nitrogen compound transport GO:0071705 85 0.019
protein complex assembly GO:0006461 200 0.019
Human
catabolic process GO:0009056 409 0.018
regulation of cell death GO:0010941 173 0.018
determination of adult lifespan GO:0008340 137 0.018
endocytosis GO:0006897 310 0.018
maintenance of location GO:0051235 73 0.018
epithelial cell migration GO:0010631 148 0.018
purine nucleoside triphosphate metabolic process GO:0009144 119 0.018
mitotic spindle organization GO:0007052 220 0.018
histone h3 k9 modification GO:0061647 12 0.018
axon development GO:0061564 297 0.018
establishment of rna localization GO:0051236 47 0.018
heterocycle catabolic process GO:0046700 166 0.017
cell cell signaling involved in cell fate commitment GO:0045168 210 0.017
nucleoside catabolic process GO:0009164 112 0.017
oocyte development GO:0048599 124 0.017
anterior posterior pattern specification GO:0009952 136 0.017
cellular protein complex assembly GO:0043623 71 0.017
Human
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.017
maternal determination of anterior posterior axis embryo GO:0008358 74 0.016
positive regulation of cellular protein metabolic process GO:0032270 118 0.016
lateral inhibition GO:0046331 206 0.016
spindle organization GO:0007051 253 0.016
regulation of protein export from nucleus GO:0046825 3 0.016
dorsal ventral axis specification GO:0009950 66 0.016
regulation of autophagy GO:0010506 62 0.016
rna 3 end processing GO:0031123 45 0.016
nucleoside phosphate metabolic process GO:0006753 162 0.016
multi multicellular organism process GO:0044706 123 0.016
response to heat GO:0009408 63 0.016
regulation of cell cycle phase transition GO:1901987 130 0.016
reproductive system development GO:0061458 74 0.016
aging GO:0007568 143 0.016
pole plasm rna localization GO:0007316 52 0.015
apoptotic process GO:0006915 159 0.015
small molecule metabolic process GO:0044281 305 0.015
oocyte construction GO:0007308 112 0.015
atp catabolic process GO:0006200 38 0.015
regulation of translation GO:0006417 56 0.015
cell migration GO:0016477 238 0.015
nls bearing protein import into nucleus GO:0006607 5 0.015
regulation of organelle organization GO:0033043 196 0.015
nucleus organization GO:0006997 45 0.015
Human
mitotic dna integrity checkpoint GO:0044774 75 0.015
macromolecular complex disassembly GO:0032984 37 0.014
tripartite regional subdivision GO:0007351 103 0.014
nucleotide metabolic process GO:0009117 161 0.014
negative regulation of nervous system development GO:0051961 92 0.014
oocyte anterior posterior axis specification GO:0007314 72 0.014
body morphogenesis GO:0010171 2 0.014
mitotic dna damage checkpoint GO:0044773 74 0.014
regulation of nucleobase containing compound transport GO:0032239 4 0.014
mitotic g2 dna damage checkpoint GO:0007095 69 0.013
mitotic cell cycle phase transition GO:0044772 138 0.013
ribonucleoside catabolic process GO:0042454 112 0.013
response to bacterium GO:0009617 198 0.013
organic substance catabolic process GO:1901575 308 0.013
cell cycle phase transition GO:0044770 140 0.013
regulation of cellular component biogenesis GO:0044087 201 0.013
protein modification by small protein conjugation or removal GO:0070647 106 0.013
regulation of phosphate metabolic process GO:0019220 210 0.013
regulation of response to stress GO:0080134 200 0.013
response to oxygen containing compound GO:1901700 200 0.013
regulation of protein metabolic process GO:0051246 256 0.012
cellular nitrogen compound catabolic process GO:0044270 165 0.012
negative regulation of multicellular organismal process GO:0051241 142 0.012
oocyte axis specification GO:0007309 108 0.012
ribonucleoside monophosphate metabolic process GO:0009161 51 0.012
epithelial cell differentiation GO:0030855 322 0.012
cell cycle checkpoint GO:0000075 95 0.012
imaginal disc derived wing morphogenesis GO:0007476 337 0.012
regulation of catalytic activity GO:0050790 185 0.012
blastoderm segmentation GO:0007350 159 0.012
dna integrity checkpoint GO:0031570 81 0.012
regulation of cell differentiation GO:0045595 302 0.012
regulation of establishment of protein localization GO:0070201 61 0.012
regulation of cellular ketone metabolic process GO:0010565 3 0.011
chromosome segregation GO:0007059 157 0.011
protein alkylation GO:0008213 43 0.011
defense response to bacterium GO:0042742 178 0.011
protein export from nucleus GO:0006611 10 0.011
response to lipopolysaccharide GO:0032496 4 0.011
regulation of dna metabolic process GO:0051052 34 0.011
nucleic acid transport GO:0050657 46 0.011
dorsal ventral pattern formation GO:0009953 133 0.011
carbohydrate derivative metabolic process GO:1901135 217 0.011
positive regulation of mapk cascade GO:0043410 63 0.011
regulation of cellular response to stress GO:0080135 89 0.011
imaginal disc derived appendage morphogenesis GO:0035114 395 0.011
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.011
dna replication GO:0006260 48 0.011
Human
icosanoid biosynthetic process GO:0046456 1 0.011
cell motility GO:0048870 251 0.010
establishment of organelle localization GO:0051656 122 0.010
female germ line cyst formation GO:0048135 42 0.010
signal transduction by phosphorylation GO:0023014 107 0.010
regulation of chromosome organization GO:0033044 64 0.010
phosphorylation GO:0016310 294 0.010

Nup98 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.029
central nervous system disease DOID:331 0 0.011
neurodegenerative disease DOID:1289 0 0.011
nervous system disease DOID:863 0 0.011
osteochondrodysplasia DOID:2256 0 0.011
osteogenesis imperfecta DOID:12347 0 0.011
bone development disease DOID:0080006 0 0.011
bone disease DOID:0080001 0 0.011
musculoskeletal system disease DOID:17 0 0.011
connective tissue disease DOID:65 0 0.011