Drosophila melanogaster

0 known processes

Pak (Dmel_CG10295)

PAK-kinase

(Aliases: DPak,dPAK,PaK,pak1,pak,D-Pak,p65[PAK],Dpak1,CG10295,Dmel\CG10295,Pak1,DPAK,dPAK1,dpak,PAK2,Dpak,dPak,PAK,dpak1,PAK1,DmPAK1)

Pak biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
axonogenesis GO:0007409 290 0.998
Mouse
regulation of nervous system development GO:0051960 248 0.992
Rat Fly
regulation of synaptic growth at neuromuscular junction GO:0008582 89 0.988
chemotaxis GO:0006935 249 0.986
axon development GO:0061564 297 0.979
Mouse
establishment of localization in cell GO:0051649 402 0.976
Yeast
developmental growth involved in morphogenesis GO:0060560 65 0.975
synaptic growth at neuromuscular junction GO:0051124 119 0.974
taxis GO:0042330 304 0.946
neuromuscular junction development GO:0007528 149 0.922
Mouse
regulation of neurogenesis GO:0050767 158 0.907
Rat
regulation of synapse structure and activity GO:0050803 128 0.903
Fly
actin filament bundle organization GO:0061572 28 0.896
Human
death GO:0016265 284 0.891
Human Yeast Rat
negative regulation of synaptic growth at neuromuscular junction GO:0045886 39 0.890
regulation of phosphate metabolic process GO:0019220 210 0.888
Human Yeast
imaginal disc derived appendage morphogenesis GO:0035114 395 0.879
vesicle mediated transport GO:0016192 381 0.866
protein modification process GO:0036211 438 0.858
Human Yeast Mouse Rat Worm
axon guidance GO:0007411 233 0.856
regulation of anatomical structure morphogenesis GO:0022603 242 0.846
Rat
appendage development GO:0048736 401 0.825
axis specification GO:0009798 167 0.818
regulation of cell development GO:0060284 215 0.816
Rat
cellular protein modification process GO:0006464 438 0.814
Human Yeast Mouse Rat Worm
axon extension involved in axon guidance GO:0048846 10 0.810
regulation of programmed cell death GO:0043067 152 0.810
Human Yeast Rat
phosphorylation GO:0016310 294 0.801
Human Yeast Mouse Rat Worm
tube development GO:0035295 244 0.798
Human
neuron projection extension GO:1990138 32 0.786
regulation of neuron differentiation GO:0045664 103 0.786
Rat
regulation of multicellular organismal development GO:2000026 414 0.784
Rat Fly
regulation of cell morphogenesis involved in differentiation GO:0010769 61 0.777
Rat
gland development GO:0048732 191 0.773
positive regulation of molecular function GO:0044093 136 0.744
Human Yeast
tissue morphogenesis GO:0048729 297 0.741
Human
morphogenesis of an epithelium GO:0002009 276 0.741
Human
positive regulation of cell projection organization GO:0031346 29 0.736
Rat
appendage morphogenesis GO:0035107 397 0.726
cell death GO:0008219 279 0.711
Human Yeast Rat
regulation of localization GO:0032879 275 0.691
Yeast
dendrite development GO:0016358 204 0.688
Mouse Rat
regulation of synapse assembly GO:0051963 94 0.674
Fly
imaginal disc derived appendage development GO:0048737 399 0.656
eye development GO:0001654 323 0.654
positive regulation of cellular component organization GO:0051130 156 0.653
Human Rat Fly
regulation of cell projection organization GO:0031344 92 0.649
Rat
regulation of molecular function GO:0065009 217 0.622
Human Yeast
organelle localization GO:0051640 148 0.607
regulation of cell differentiation GO:0045595 302 0.602
Rat
developmental programmed cell death GO:0010623 138 0.594
regulation of cell morphogenesis GO:0022604 163 0.593
Rat
positive regulation of macromolecule metabolic process GO:0010604 405 0.590
Human Yeast Rat
non sensory hair organization GO:0035316 47 0.585
negative regulation of response to stimulus GO:0048585 258 0.576
regulation of cell death GO:0010941 173 0.575
Human Yeast Rat
embryonic development via the syncytial blastoderm GO:0001700 148 0.561
embryonic morphogenesis GO:0048598 206 0.552
Worm
catabolic process GO:0009056 409 0.550
actin filament organization GO:0007015 126 0.545
Human Fly
regulation of cell shape GO:0008360 113 0.530
cell migration GO:0016477 238 0.525
Worm
neuron projection guidance GO:0097485 241 0.509
positive regulation of synaptic growth at neuromuscular junction GO:0045887 26 0.505
lipid localization GO:0010876 54 0.499
Yeast
small molecule metabolic process GO:0044281 305 0.496
negative regulation of cell communication GO:0010648 223 0.478
growth GO:0040007 359 0.475
Yeast
regulation of axon extension GO:0030516 8 0.462
retinal ganglion cell axon guidance GO:0031290 12 0.459
developmental cell growth GO:0048588 52 0.459
regulation of cytoskeleton organization GO:0051493 89 0.456
Human Rat
positive regulation of nervous system development GO:0051962 69 0.454
Rat Fly
regulation of cellular component size GO:0032535 98 0.447
Human
regulation of axon extension involved in axon guidance GO:0048841 4 0.439
cell growth GO:0016049 108 0.436
Yeast
imaginal disc derived wing morphogenesis GO:0007476 337 0.430
regulation of endopeptidase activity GO:0052548 36 0.425
Human
negative regulation of growth GO:0045926 84 0.418
negative regulation of developmental process GO:0051093 201 0.418
dorsal closure GO:0007391 79 0.411
wing disc morphogenesis GO:0007472 344 0.407
axon extension GO:0048675 32 0.405
wnt signaling pathway GO:0016055 98 0.403
negative regulation of cell differentiation GO:0045596 143 0.403
positive regulation of multicellular organismal process GO:0051240 143 0.401
Rat Fly
synapse assembly GO:0007416 143 0.400
Fly
developmental growth GO:0048589 280 0.393
protein phosphorylation GO:0006468 169 0.390
Human Yeast Mouse Rat Worm
negative regulation of signaling GO:0023057 219 0.386
apoptotic process GO:0006915 159 0.386
Human Yeast Rat
negative regulation of signal transduction GO:0009968 206 0.381
regulation of axon guidance GO:1902667 10 0.379
endocytosis GO:0006897 310 0.378
regulation of actin filament polymerization GO:0030833 25 0.377
Human
actin filament bundle assembly GO:0051017 26 0.376
Human
regulation of cell size GO:0008361 63 0.376
regulation of actin filament length GO:0030832 27 0.372
Human
actin filament based process GO:0030029 220 0.369
Human Rat Fly
dendrite morphogenesis GO:0048813 199 0.367
Rat
cell proliferation GO:0008283 299 0.361
Human
localization of cell GO:0051674 257 0.356
Worm
regulation of vesicle mediated transport GO:0060627 59 0.354
negative regulation of developmental growth GO:0048640 64 0.348
actin filament polymerization GO:0030041 27 0.348
Human
positive regulation of hydrolase activity GO:0051345 78 0.345
enzyme linked receptor protein signaling pathway GO:0007167 179 0.343
regulation of synapse organization GO:0050807 110 0.341
Fly
regulation of endocytosis GO:0030100 37 0.331
organic substance catabolic process GO:1901575 308 0.329
regulation of growth GO:0040008 233 0.318
positive regulation of response to stimulus GO:0048584 323 0.316
Human Yeast
negative regulation of synapse assembly GO:0051964 39 0.316
regulation of phosphorylation GO:0042325 147 0.315
Human Yeast
salivary gland morphogenesis GO:0007435 145 0.309
nucleotide catabolic process GO:0009166 109 0.307
ribonucleoside catabolic process GO:0042454 112 0.298
asymmetric cell division GO:0008356 37 0.295
stem cell proliferation GO:0072089 88 0.292
larval development GO:0002164 104 0.289
Worm
sensory organ morphogenesis GO:0090596 260 0.288
regionalization GO:0003002 416 0.282
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.281
Rat
neuron projection extension involved in neuron projection guidance GO:1902284 10 0.279
eye morphogenesis GO:0048592 260 0.275
regulation of neuron projection development GO:0010975 69 0.274
Rat
cellular nitrogen compound catabolic process GO:0044270 165 0.265
regulation of catalytic activity GO:0050790 185 0.264
Human Yeast
positive regulation of signal transduction GO:0009967 223 0.263
Human Yeast
maintenance of location GO:0051235 73 0.248
positive regulation of catalytic activity GO:0043085 118 0.248
Human Yeast
positive regulation of axon guidance GO:1902669 1 0.244
purine nucleoside triphosphate catabolic process GO:0009146 108 0.242
guanosine containing compound metabolic process GO:1901068 74 0.242
biological adhesion GO:0022610 138 0.242
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.242
positive regulation of phosphorus metabolic process GO:0010562 139 0.241
Human Yeast
embryo development ending in birth or egg hatching GO:0009792 152 0.238
Worm
morphogenesis of embryonic epithelium GO:0016331 94 0.236
purine nucleotide catabolic process GO:0006195 109 0.236
regulation of cell proliferation involved in imaginal disc derived wing morphogenesis GO:0090256 2 0.232
tube morphogenesis GO:0035239 191 0.231
Human
programmed cell death GO:0012501 257 0.231
Human Yeast Rat
regulation of anatomical structure size GO:0090066 163 0.228
Human
aromatic compound catabolic process GO:0019439 166 0.225
mapk cascade GO:0000165 107 0.223
Human Yeast
heterocycle catabolic process GO:0046700 166 0.220
establishment of organelle localization GO:0051656 122 0.220
regulation of hydrolase activity GO:0051336 97 0.220
Human
regulation of developmental growth GO:0048638 174 0.218
regulation of cell proliferation GO:0042127 163 0.218
Human
regulation of apoptotic process GO:0042981 130 0.216
Human Yeast Rat
intracellular signal transduction GO:0035556 300 0.208
Human Yeast
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 25 0.207
Human
regulation of proteolysis GO:0030162 87 0.202
Human
carbohydrate derivative catabolic process GO:1901136 118 0.201
negative regulation of cellular component organization GO:0051129 108 0.201
regulation of intracellular signal transduction GO:1902531 236 0.200
Human Yeast
regulation of cellular component movement GO:0051270 42 0.197
imaginal disc derived wing hair organization GO:0035317 45 0.193
gland morphogenesis GO:0022612 145 0.190
post embryonic appendage morphogenesis GO:0035120 385 0.184
negative regulation of cell development GO:0010721 62 0.184
purine ribonucleotide catabolic process GO:0009154 109 0.182
positive regulation of developmental process GO:0051094 143 0.182
Rat Fly
cellular protein complex assembly GO:0043623 71 0.173
Human
salivary gland development GO:0007431 162 0.173
negative regulation of cell death GO:0060548 81 0.173
Human
synapse organization GO:0050808 196 0.171
Mouse Fly
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 65 0.171
mushroom body development GO:0016319 70 0.170
cell fate specification GO:0001708 71 0.166
retina morphogenesis in camera type eye GO:0060042 2 0.165
negative regulation of cellular metabolic process GO:0031324 382 0.162
Human
positive regulation of axonogenesis GO:0050772 2 0.162
regulation of axonogenesis GO:0050770 32 0.160
tissue death GO:0016271 102 0.159
regulation of protein modification process GO:0031399 112 0.157
Human Yeast
epithelial cell migration GO:0010631 148 0.157
glycosyl compound catabolic process GO:1901658 112 0.157
ribonucleotide catabolic process GO:0009261 109 0.155
imaginal disc derived leg morphogenesis GO:0007480 80 0.154
purine containing compound catabolic process GO:0072523 112 0.153
positive regulation of axon extension GO:0045773 2 0.152
ameboidal type cell migration GO:0001667 151 0.148
cell proliferation involved in imaginal disc derived wing morphogenesis GO:0090255 2 0.147
cellular catabolic process GO:0044248 372 0.140
rho protein signal transduction GO:0007266 14 0.139
apoptotic cell clearance GO:0043277 14 0.138
regulation of phosphorus metabolic process GO:0051174 210 0.138
Human Yeast
cell maturation GO:0048469 144 0.138
regulation of cysteine type endopeptidase activity GO:2000116 27 0.137
Human
purine ribonucleoside catabolic process GO:0046130 112 0.132
protein complex assembly GO:0006461 200 0.131
Human
defense response to other organism GO:0098542 225 0.131
positive regulation of cell migration GO:0030335 2 0.130
regulation of stress activated protein kinase signaling cascade GO:0070302 42 0.125
Human
guanosine containing compound catabolic process GO:1901069 74 0.124
adherens junction organization GO:0034332 27 0.122
cell motility GO:0048870 251 0.120
Worm
unidimensional cell growth GO:0009826 15 0.117
negative regulation of multicellular organismal process GO:0051241 142 0.114
muscle structure development GO:0061061 224 0.114
Fly
regulation of actin filament based process GO:0032970 42 0.114
Human Rat
ribonucleoside triphosphate metabolic process GO:0009199 119 0.114
oocyte development GO:0048599 124 0.113
instar larval development GO:0002168 55 0.112
protein polymerization GO:0051258 42 0.111
Human
developmental maturation GO:0021700 172 0.111
cell cycle checkpoint GO:0000075 95 0.111
regulation of multi organism process GO:0043900 131 0.109
purine nucleoside catabolic process GO:0006152 112 0.109
positive regulation of catabolic process GO:0009896 105 0.108
compound eye development GO:0048749 307 0.108
regulation of cellular localization GO:0060341 136 0.106
Yeast
positive regulation of cell morphogenesis involved in differentiation GO:0010770 12 0.106
Rat
organic cyclic compound catabolic process GO:1901361 168 0.105
negative regulation of gene expression GO:0010629 387 0.104
Human Yeast
nucleoside triphosphate catabolic process GO:0009143 108 0.103
ribonucleoside metabolic process GO:0009119 127 0.103
organophosphate metabolic process GO:0019637 195 0.101
phagocytosis GO:0006909 215 0.100
negative regulation of nervous system development GO:0051961 92 0.100
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.100
exocrine system development GO:0035272 162 0.099
cell division GO:0051301 248 0.099
Yeast
positive regulation of synapse assembly GO:0051965 29 0.098
Fly
nucleobase containing compound catabolic process GO:0034655 165 0.095
regulation of protein polymerization GO:0032271 28 0.093
Human
positive regulation of peptidase activity GO:0010952 29 0.093
cellular response to organic substance GO:0071310 132 0.092
Yeast Rat
organonitrogen compound catabolic process GO:1901565 128 0.091
response to organic substance GO:0010033 284 0.091
Yeast Rat
oocyte axis specification GO:0007309 108 0.090
purine ribonucleoside metabolic process GO:0046128 127 0.088
notch signaling pathway GO:0007219 120 0.088
single organism intracellular transport GO:1902582 207 0.088
Yeast
cellular amine metabolic process GO:0044106 12 0.087
response to external biotic stimulus GO:0043207 293 0.084
organic substance transport GO:0071702 257 0.082
Yeast
regulation of actin cytoskeleton organization GO:0032956 42 0.081
Human Rat
negative regulation of cellular protein metabolic process GO:0032269 85 0.081
Human
ovarian follicle cell development GO:0030707 248 0.080
positive regulation of jun kinase activity GO:0043507 4 0.080
Human
secretion by cell GO:0032940 101 0.079
immune system process GO:0002376 347 0.079
negative regulation of programmed cell death GO:0043069 72 0.079
Human
oocyte construction GO:0007308 112 0.078
regulation of purine nucleotide catabolic process GO:0033121 48 0.078
positive regulation of biosynthetic process GO:0009891 316 0.077
Rat
muscle organ development GO:0007517 127 0.076
response to growth factor GO:0070848 31 0.075
gastrulation GO:0007369 70 0.074
organonitrogen compound metabolic process GO:1901564 318 0.074
epithelial cell development GO:0002064 274 0.074
leg disc development GO:0035218 92 0.073
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.073
regulation of protein metabolic process GO:0051246 256 0.073
Human Yeast
regulation of cell cycle process GO:0010564 181 0.072
Yeast
fatty acid metabolic process GO:0006631 20 0.072
response to other organism GO:0051707 293 0.072
muscle cell differentiation GO:0042692 103 0.070
Fly
central nervous system development GO:0007417 201 0.070
initiation of dorsal closure GO:0007392 12 0.069
protein complex biogenesis GO:0070271 201 0.069
Human
secretion GO:0046903 109 0.069
regulation of locomotion GO:0040012 42 0.068
regulation of peptidase activity GO:0052547 39 0.068
Human
oxidation reduction process GO:0055114 123 0.066
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.066
response to extracellular stimulus GO:0009991 116 0.066
positive regulation of filopodium assembly GO:0051491 15 0.066
positive regulation of endopeptidase activity GO:0010950 26 0.065
regulation of dendrite morphogenesis GO:0048814 28 0.064
Rat
macromolecular complex assembly GO:0065003 256 0.063
Human Yeast
cellular response to growth factor stimulus GO:0071363 30 0.063
regulation of stress activated mapk cascade GO:0032872 41 0.063
Human
negative regulation of apoptotic process GO:0043066 63 0.062
Human
establishment of imaginal disc derived wing hair orientation GO:0001737 24 0.061
positive regulation of immune system process GO:0002684 68 0.061
salivary gland histolysis GO:0035070 88 0.060
peripheral nervous system development GO:0007422 52 0.059
camera type eye morphogenesis GO:0048593 2 0.058
dorsal ventral axon guidance GO:0033563 2 0.058
regulation of protein modification by small protein conjugation or removal GO:1903320 25 0.058
collateral sprouting GO:0048668 3 0.058
cholesterol homeostasis GO:0042632 3 0.058
regulation of cell motility GO:2000145 23 0.057
anterior posterior axis specification GO:0009948 109 0.057
positive regulation of cellular biosynthetic process GO:0031328 316 0.057
Rat
regulation of cellular catabolic process GO:0031329 157 0.057
response to biotic stimulus GO:0009607 294 0.056
oocyte differentiation GO:0009994 145 0.056
epithelium migration GO:0090132 148 0.055
positive regulation of protein metabolic process GO:0051247 128 0.053
Human Yeast
spindle organization GO:0007051 253 0.053
actin polymerization or depolymerization GO:0008154 31 0.052
Human
negative regulation of phosphorus metabolic process GO:0010563 45 0.052
nucleobase containing small molecule metabolic process GO:0055086 174 0.052
regulation of wnt signaling pathway GO:0030111 68 0.051
nucleoside catabolic process GO:0009164 112 0.051
establishment of synaptic vesicle localization GO:0097480 50 0.051
retina development in camera type eye GO:0060041 4 0.050
ribonucleotide metabolic process GO:0009259 145 0.049
cellular macromolecular complex assembly GO:0034622 153 0.047
Human Yeast
positive regulation of cellular component biogenesis GO:0044089 80 0.047
Human Fly
regulation of stress fiber assembly GO:0051492 6 0.047
Human
branching morphogenesis of an epithelial tube GO:0048754 45 0.046
Human
dorsal ventral pattern formation GO:0009953 133 0.046
negative regulation of molecular function GO:0044092 51 0.046
Human
protein ubiquitination GO:0016567 70 0.045
mesoderm development GO:0007498 78 0.045
regulation of cellular response to stress GO:0080135 89 0.045
Human
epithelial cell differentiation GO:0030855 322 0.045
regulation of nucleotide metabolic process GO:0006140 62 0.044
proteolysis GO:0006508 192 0.044
Human
salivary gland cell autophagic cell death GO:0035071 83 0.044
digestive tract morphogenesis GO:0048546 127 0.044
organophosphate catabolic process GO:0046434 112 0.044
positive regulation of intracellular signal transduction GO:1902533 116 0.043
Human Yeast
regulation of mapk cascade GO:0043408 92 0.043
Human Yeast
regulation of dendrite development GO:0050773 37 0.042
Rat
glycosyl compound metabolic process GO:1901657 127 0.041
positive regulation of cellular catabolic process GO:0031331 95 0.040
purine nucleoside triphosphate metabolic process GO:0009144 119 0.040
detection of stimulus GO:0051606 156 0.040
actomyosin structure organization GO:0031032 56 0.039
Human
vesicle organization GO:0016050 44 0.039
nucleoside phosphate metabolic process GO:0006753 162 0.039
neural precursor cell proliferation GO:0061351 75 0.039
endosomal transport GO:0016197 44 0.039
regulation of protein phosphorylation GO:0001932 64 0.039
Human Yeast
regulation of extent of cell growth GO:0061387 8 0.039
nucleoside phosphate catabolic process GO:1901292 110 0.038
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.038
positive regulation of lamellipodium organization GO:1902745 7 0.037
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.037
dorsal closure elongation of leading edge cells GO:0007394 10 0.037
cellular response to chemical stimulus GO:0070887 199 0.037
Yeast Rat
stem cell maintenance GO:0019827 67 0.037
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.037
Rat
membrane tubulation GO:0097320 4 0.037
oxoacid metabolic process GO:0043436 103 0.037
regulation of cellular amine metabolic process GO:0033238 3 0.037
negative regulation of epithelial cell proliferation GO:0050680 4 0.036
regulation of mitotic cell cycle GO:0007346 190 0.036
Yeast
camera type eye development GO:0043010 4 0.036
positive regulation of rna biosynthetic process GO:1902680 266 0.035
regulation of immune system process GO:0002682 176 0.035
ion transmembrane transport GO:0034220 122 0.035
response to organic cyclic compound GO:0014070 89 0.035
positive regulation of establishment of protein localization to plasma membrane GO:0090004 3 0.035
positive regulation of cellular protein metabolic process GO:0032270 118 0.035
Human Yeast
organelle assembly GO:0070925 198 0.035
Yeast
positive regulation of cell development GO:0010720 61 0.034
Rat
regulation of actin polymerization or depolymerization GO:0008064 27 0.034
Human
signal release GO:0023061 49 0.034
response to insulin GO:0032868 29 0.034
Rat
anterior posterior axis specification embryo GO:0008595 103 0.033
protein localization GO:0008104 284 0.033
Yeast Mouse
transcription from rna polymerase ii promoter GO:0006366 368 0.033
regulation of cell cycle GO:0051726 291 0.033
Yeast
regulation of neuron death GO:1901214 26 0.033
Rat
transmembrane transport GO:0055085 139 0.033
Yeast
histolysis GO:0007559 102 0.033
receptor clustering GO:0043113 3 0.032
Mouse
defense response to virus GO:0051607 23 0.032
motor neuron axon guidance GO:0008045 58 0.031
regulation of lamellipodium organization GO:1902743 15 0.031
organelle fission GO:0048285 340 0.031
Yeast
gtp catabolic process GO:0006184 72 0.030
response to unfolded protein GO:0006986 9 0.030
positive regulation of actin filament polymerization GO:0030838 11 0.030
positive regulation of phosphorylation GO:0042327 87 0.030
Human Yeast
regulation of cellular protein metabolic process GO:0032268 243 0.030
Human Yeast
organic acid metabolic process GO:0006082 103 0.030
cell cell junction organization GO:0045216 55 0.030
positive regulation of proteolysis GO:0045862 52 0.030
regulation of lipid transport GO:0032368 3 0.029
compound eye morphogenesis GO:0001745 249 0.029
non canonical wnt signaling pathway GO:0035567 8 0.029
regulation of ras protein signal transduction GO:0046578 93 0.029
positive regulation of signaling GO:0023056 243 0.029
Human Yeast
immune response regulating signaling pathway GO:0002764 2 0.028
regulation of organ morphogenesis GO:2000027 78 0.028
single organism catabolic process GO:0044712 228 0.028
adult locomotory behavior GO:0008344 76 0.028
chromatin organization GO:0006325 207 0.028
Yeast
actin cytoskeleton reorganization GO:0031532 22 0.028
Human
leg disc morphogenesis GO:0007478 80 0.028
sensory perception of touch GO:0050975 11 0.028
syncytium formation GO:0006949 43 0.028
Fly
cell recognition GO:0008037 102 0.027
monovalent inorganic cation transport GO:0015672 40 0.027
autophagic cell death GO:0048102 83 0.027
response to transforming growth factor beta GO:0071559 18 0.027
regulation of organelle organization GO:0033043 196 0.027
Human Yeast Rat
regulation of jnk cascade GO:0046328 40 0.026
Human
cholesterol transport GO:0030301 2 0.026
positive regulation of gtp catabolic process GO:0033126 43 0.026
neural retina development GO:0003407 4 0.025
endoderm formation GO:0001706 3 0.025
generation of precursor metabolites and energy GO:0006091 42 0.025
heart morphogenesis GO:0003007 32 0.025
regulation of transferase activity GO:0051338 58 0.025
Human Yeast
regulation of cell migration GO:0030334 22 0.025
purine nucleotide metabolic process GO:0006163 146 0.025
purine ribonucleotide metabolic process GO:0009150 145 0.025
positive regulation of phosphate metabolic process GO:0045937 139 0.024
Human Yeast
homeostatic process GO:0042592 199 0.024
transforming growth factor beta receptor signaling pathway GO:0007179 16 0.024
eye photoreceptor cell differentiation GO:0001754 145 0.024
positive regulation of cell death GO:0010942 69 0.024
Human Yeast Rat
axon midline choice point recognition GO:0016199 26 0.024
bmp signaling pathway involved in malpighian tubule cell chemotaxis GO:0061353 3 0.023
positive regulation of phagocytosis engulfment GO:0060100 1 0.023
syncytium formation by plasma membrane fusion GO:0000768 43 0.023
Fly
positive regulation of purine nucleotide metabolic process GO:1900544 55 0.023
positive regulation of neurogenesis GO:0050769 41 0.023
Rat
negative regulation of transferase activity GO:0051348 18 0.023
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.023
negative regulation of protein metabolic process GO:0051248 85 0.023
Human
regulation of canonical wnt signaling pathway GO:0060828 15 0.023
mitotic spindle organization GO:0007052 220 0.023
filopodium assembly GO:0046847 33 0.023
positive regulation of gtpase activity GO:0043547 43 0.023
stress fiber assembly GO:0043149 6 0.022
Human
regulation of behavior GO:0050795 75 0.022
regulation of chemotaxis GO:0050920 12 0.022
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 38 0.022
nucleoside triphosphate metabolic process GO:0009141 120 0.022
positive regulation of transcription dna templated GO:0045893 266 0.022
negative regulation of cell cycle process GO:0010948 109 0.022
intracellular transport GO:0046907 228 0.022
Yeast
ras protein signal transduction GO:0007265 88 0.022
endodermal cell fate commitment GO:0001711 3 0.022
formation of organ boundary GO:0010160 30 0.021
meiotic cell cycle process GO:1903046 132 0.021
pseudocleavage involved in syncytial blastoderm formation GO:0030589 9 0.021
cellular response to unfolded protein GO:0034620 9 0.021
negative regulation of rna biosynthetic process GO:1902679 240 0.021
positive regulation of neuron projection development GO:0010976 14 0.021
Rat
negative regulation of cellular biosynthetic process GO:0031327 277 0.021
nucleocytoplasmic transport GO:0006913 72 0.021
Yeast
brain development GO:0007420 120 0.021
regulation of filopodium assembly GO:0051489 24 0.021
positive regulation of protein modification process GO:0031401 58 0.021
Human Yeast
neuron maturation GO:0042551 31 0.021
nucleoside metabolic process GO:0009116 127 0.021
cortical actin cytoskeleton organization GO:0030866 24 0.021
jnk cascade GO:0007254 50 0.021
Human
establishment of spindle localization GO:0051293 22 0.021
regulation of notch signaling pathway GO:0008593 100 0.020
positive regulation of cell motility GO:2000147 3 0.020
negative regulation of nucleic acid templated transcription GO:1903507 240 0.020
cellular response to endogenous stimulus GO:0071495 80 0.020
Rat
morphogenesis of larval imaginal disc epithelium GO:0016335 5 0.020
regulation of stem cell proliferation GO:0072091 40 0.020
forebrain development GO:0030900 2 0.020
regulation of hemocyte proliferation GO:0035206 37 0.020
stress activated protein kinase signaling cascade GO:0031098 55 0.019
Human
cell competition in a multicellular organism GO:0035212 10 0.019
positive regulation of protein polymerization GO:0032273 14 0.019
purine containing compound metabolic process GO:0072521 155 0.019
response to bacterium GO:0009617 198 0.019
regulation of small gtpase mediated signal transduction GO:0051056 93 0.019
meiotic cell cycle GO:0051321 171 0.019
ribonucleoside triphosphate catabolic process GO:0009203 108 0.018
positive regulation of purine nucleotide catabolic process GO:0033123 46 0.018
monocarboxylic acid transport GO:0015718 3 0.018
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.018
cellular macromolecule localization GO:0070727 220 0.017
Yeast Mouse
extracellular structure organization GO:0043062 46 0.017
negative regulation of notch signaling pathway GO:0045746 41 0.017
cellular response to topologically incorrect protein GO:0035967 10 0.017
regulation of protein localization GO:0032880 76 0.017
Yeast
dna integrity checkpoint GO:0031570 81 0.017
response to abiotic stimulus GO:0009628 341 0.017
Yeast Rat
pupal development GO:0035209 11 0.017
hair cell differentiation GO:0035315 47 0.017
negative regulation of neurogenesis GO:0050768 53 0.017
endodermal cell differentiation GO:0035987 3 0.016
glutamate secretion GO:0014047 1 0.016
negative regulation of cellular response to growth factor stimulus GO:0090288 6 0.016
maintenance of location in cell GO:0051651 28 0.016
autophagy GO:0006914 108 0.016
cellular respiration GO:0045333 26 0.016
response to topologically incorrect protein GO:0035966 10 0.016
axon choice point recognition GO:0016198 26 0.016
regulation of kinase activity GO:0043549 53 0.016
Human Yeast
positive regulation of immune response GO:0050778 63 0.016
gtp metabolic process GO:0046039 72 0.016
cytoplasmic microtubule organization GO:0031122 22 0.015
posttranscriptional gene silencing by rna GO:0035194 45 0.015
positive regulation of autophagy GO:0010508 21 0.015
ethanolamine containing compound metabolic process GO:0042439 4 0.015

Pak disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.025
disease of cellular proliferation DOID:14566 0 0.022
cardiovascular system disease DOID:1287 0 0.016