Drosophila melanogaster

8 known processes

Tbp-1 (Dmel_CG10370)

Tat-binding protein-1

(Aliases: Dm_Rpt5a,anon-WO0153538.10,CG10370,Dm_Rpt5b,Rpt5,Tbp1,Pros26S,Pros26S-RS6A,dRpt5,TBP-1,DmTBP-1,BcDNA.GH12068,anon-WO0153538.9,Dmel\CG10370,anon-WO0153538.8,BcDNA:GH12068,l(3)04210,p50,tbp-1)

Tbp-1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
proteasome assembly GO:0043248 2 0.848
Yeast
positive regulation of endopeptidase activity GO:0010950 26 0.657
proteolysis GO:0006508 192 0.623
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.612
regulation of endopeptidase activity GO:0052548 36 0.572
positive regulation of proteolysis GO:0045862 52 0.571
modification dependent protein catabolic process GO:0019941 78 0.541
Yeast
positive regulation of peptidase activity GO:0010952 29 0.487
modification dependent macromolecule catabolic process GO:0043632 79 0.459
Yeast
er associated ubiquitin dependent protein catabolic process GO:0030433 3 0.397
regulation of peptidase activity GO:0052547 39 0.397
cellular macromolecule catabolic process GO:0044265 136 0.369
Yeast
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 37 0.364
multicellular organismal aging GO:0010259 140 0.352
Worm
proteasomal protein catabolic process GO:0010498 59 0.320
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.290
Yeast
cellular response to dna damage stimulus GO:0006974 223 0.290
cellular protein catabolic process GO:0044257 83 0.283
Yeast
spindle elongation GO:0051231 83 0.280
macromolecule catabolic process GO:0009057 161 0.280
Yeast
mitotic spindle elongation GO:0000022 81 0.260
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.215
Yeast
regulation of proteolysis GO:0030162 87 0.213
positive regulation of cellular biosynthetic process GO:0031328 316 0.210
Yeast
regulation of cellular component biogenesis GO:0044087 201 0.206
Yeast
positive regulation of proteasomal protein catabolic process GO:1901800 20 0.204
positive regulation of macromolecule metabolic process GO:0010604 405 0.194
Yeast
determination of adult lifespan GO:0008340 137 0.188
Worm
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.183
Yeast
protein catabolic process GO:0030163 101 0.177
Yeast
macromolecular complex assembly GO:0065003 256 0.170
Yeast
organic substance catabolic process GO:1901575 308 0.167
Yeast
cellular catabolic process GO:0044248 372 0.164
Yeast
nucleotide excision repair GO:0006289 8 0.161
catabolic process GO:0009056 409 0.161
Yeast
protein complex biogenesis GO:0070271 201 0.154
Yeast
rna polymerase ii transcriptional preinitiation complex assembly GO:0051123 20 0.152
Yeast
mitotic nuclear division GO:0007067 213 0.146
mitotic spindle organization GO:0007052 220 0.144
ubiquitin dependent protein catabolic process GO:0006511 78 0.142
Yeast
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 24 0.139
protein complex assembly GO:0006461 200 0.138
Yeast
nuclear division GO:0000280 332 0.128
regulation of cellular protein metabolic process GO:0032268 243 0.120
positive regulation of cellular component biogenesis GO:0044089 80 0.117
Yeast
larval development GO:0002164 104 0.107
Worm
aging GO:0007568 143 0.106
Worm
cellular protein complex assembly GO:0043623 71 0.105
Yeast
organelle assembly GO:0070925 198 0.102
dna repair GO:0006281 54 0.102
dna templated transcription initiation GO:0006352 25 0.095
Yeast
organelle fission GO:0048285 340 0.094
regulation of proteasomal protein catabolic process GO:0061136 39 0.092
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 19 0.090
transcription initiation from rna polymerase ii promoter GO:0006367 25 0.081
Yeast
dna metabolic process GO:0006259 227 0.080
positive regulation of rna biosynthetic process GO:1902680 266 0.078
Yeast
regulation of cell cycle GO:0051726 291 0.077
spindle organization GO:0007051 253 0.076
cullin deneddylation GO:0010388 3 0.074
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 44 0.071
organonitrogen compound metabolic process GO:1901564 318 0.067
positive regulation of cellular component organization GO:0051130 156 0.064
Yeast
dna templated transcriptional preinitiation complex assembly GO:0070897 20 0.062
Yeast
microtubule organizing center organization GO:0031023 168 0.062
regulation of mitotic cell cycle GO:0007346 190 0.061
protein deneddylation GO:0000338 8 0.060
positive regulation of nucleic acid templated transcription GO:1903508 266 0.058
Yeast
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.056
Yeast
positive regulation of cellular protein metabolic process GO:0032270 118 0.055
lateral inhibition GO:0046331 206 0.051
death GO:0016265 284 0.051
phagocytosis GO:0006909 215 0.049
regulation of cellular protein catabolic process GO:1903362 44 0.049
regulation of mitosis GO:0007088 56 0.048
transcription from rna polymerase ii promoter GO:0006366 368 0.047
Yeast
programmed cell death GO:0012501 257 0.047
body morphogenesis GO:0010171 2 0.047
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 16 0.043
regulation of protein metabolic process GO:0051246 256 0.042
regulation of protein complex assembly GO:0043254 42 0.042
Yeast
mitotic g2 m transition checkpoint GO:0044818 70 0.041
endocytosis GO:0006897 310 0.040
mitotic g2 dna damage checkpoint GO:0007095 69 0.039
peptide metabolic process GO:0006518 80 0.038
regulation of localization GO:0032879 275 0.037
positive regulation of biosynthetic process GO:0009891 316 0.037
Yeast
cellular macromolecular complex assembly GO:0034622 153 0.037
Yeast
protein modification process GO:0036211 438 0.037
regulation of cell cycle process GO:0010564 181 0.036
negative regulation of cellular protein metabolic process GO:0032269 85 0.036
compound eye morphogenesis GO:0001745 249 0.035
regulation of vesicle mediated transport GO:0060627 59 0.034
positive regulation of transcription factor import into nucleus GO:0042993 19 0.034
regulation of cellular ketone metabolic process GO:0010565 3 0.033
apoptotic process GO:0006915 159 0.033
vesicle mediated transport GO:0016192 381 0.033
embryo development ending in birth or egg hatching GO:0009792 152 0.032
Mouse Worm
cell proliferation GO:0008283 299 0.032
positive regulation of protein metabolic process GO:0051247 128 0.031
regulation of protein catabolic process GO:0042176 55 0.031
protein targeting to nucleus GO:0044744 51 0.030
negative regulation of protein metabolic process GO:0051248 85 0.029
regulation of catalytic activity GO:0050790 185 0.029
cell cell signaling involved in cell fate commitment GO:0045168 210 0.029
spindle assembly GO:0051225 80 0.029
pigment metabolic process GO:0042440 84 0.028
positive regulation of rna metabolic process GO:0051254 271 0.028
Yeast
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.028
Yeast
cell death GO:0008219 279 0.028
mitotic cell cycle checkpoint GO:0007093 88 0.027
protein modification by small protein removal GO:0070646 28 0.026
dorsal ventral pattern formation GO:0009953 133 0.026
single organism biosynthetic process GO:0044711 206 0.025
positive regulation of gene expression GO:0010628 290 0.025
Yeast
positive regulation of protein complex assembly GO:0031334 22 0.025
Yeast
protein deubiquitination GO:0016579 17 0.025
negative regulation of proteolysis GO:0045861 31 0.025
regulation of multicellular organismal development GO:2000026 414 0.024
organonitrogen compound biosynthetic process GO:1901566 117 0.024
cell division GO:0051301 248 0.023
regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0045898 1 0.022
Yeast
ion transport GO:0006811 145 0.022
regulation of molecular function GO:0065009 217 0.022
negative regulation of cellular metabolic process GO:0031324 382 0.022
negative regulation of signaling GO:0023057 219 0.022
regulation of cell differentiation GO:0045595 302 0.022
regulation of hydrolase activity GO:0051336 97 0.022
positive regulation of molecular function GO:0044093 136 0.022
positive regulation of transcription dna templated GO:0045893 266 0.021
Yeast
response to radiation GO:0009314 155 0.021
cellular protein modification process GO:0006464 438 0.021
synaptic transmission GO:0007268 288 0.021
aromatic compound catabolic process GO:0019439 166 0.021
mitotic dna damage checkpoint GO:0044773 74 0.020
regulation of cell division GO:0051302 72 0.020
double strand break repair via homologous recombination GO:0000724 13 0.020
carbohydrate derivative metabolic process GO:1901135 217 0.019
negative regulation of endopeptidase activity GO:0010951 11 0.019
positive regulation of catabolic process GO:0009896 105 0.019
g2 dna damage checkpoint GO:0031572 69 0.019
response to ethanol GO:0045471 59 0.019
negative regulation of protein processing GO:0010955 31 0.019
positive regulation of protein catabolic process GO:0045732 34 0.018
regulation of developmental growth GO:0048638 174 0.018
protein heterooligomerization GO:0051291 4 0.018
protein ubiquitination GO:0016567 70 0.018
regulation of response to external stimulus GO:0032101 115 0.018
cell cycle phase transition GO:0044770 140 0.017
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.017
centrosome organization GO:0051297 163 0.017
regulation of transport GO:0051049 181 0.017
cellular amide metabolic process GO:0043603 80 0.017
negative regulation of gene expression GO:0010629 387 0.017
heterocycle catabolic process GO:0046700 166 0.017
mitotic cell cycle phase transition GO:0044772 138 0.017
developmental growth GO:0048589 280 0.017
regulation of immune system process GO:0002682 176 0.017
response to other organism GO:0051707 293 0.016
regulation of intracellular protein transport GO:0033157 46 0.016
camera type eye development GO:0043010 4 0.016
immune effector process GO:0002252 98 0.016
negative regulation of cell cycle process GO:0010948 109 0.016
single organism nuclear import GO:1902593 51 0.016
organic cyclic compound catabolic process GO:1901361 168 0.016
regulation of protein import into nucleus GO:0042306 28 0.016
negative regulation of peptidase activity GO:0010466 11 0.015
negative regulation of signal transduction GO:0009968 206 0.015
positive regulation of cell death GO:0010942 69 0.015
negative regulation of cell communication GO:0010648 223 0.015
mitochondrion organization GO:0007005 65 0.015
positive regulation of nfat protein import into nucleus GO:0051533 16 0.015
small molecule metabolic process GO:0044281 305 0.015
regulation of catabolic process GO:0009894 170 0.015
cellular nitrogen compound catabolic process GO:0044270 165 0.015
regulation of intracellular transport GO:0032386 64 0.015
protein dna complex subunit organization GO:0071824 86 0.014
Yeast
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 4 0.014
negative regulation of molecular function GO:0044092 51 0.014
protein modification by small protein conjugation or removal GO:0070647 106 0.014
peptide biosynthetic process GO:0043043 42 0.014
regulation of cellular catabolic process GO:0031329 157 0.014
secretion GO:0046903 109 0.013
regulation of synapse organization GO:0050807 110 0.013
negative regulation of immune system process GO:0002683 50 0.013
phosphorylation GO:0016310 294 0.013
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.013
Yeast
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 25 0.013
regulation of anatomical structure size GO:0090066 163 0.013
appendage morphogenesis GO:0035107 397 0.013
protein import into nucleus GO:0006606 51 0.013
entry into cell of other organism involved in symbiotic interaction GO:0051806 3 0.013
dna templated transcription elongation GO:0006354 18 0.013
microtubule cytoskeleton organization involved in mitosis GO:1902850 52 0.013
organic substance transport GO:0071702 257 0.012
stem cell differentiation GO:0048863 117 0.012
skin development GO:0043588 65 0.012
regulation of transcription factor import into nucleus GO:0042990 22 0.012
dna damage checkpoint GO:0000077 78 0.012
protein modification by small protein conjugation GO:0032446 79 0.012
chemotaxis GO:0006935 249 0.012
photoreceptor cell differentiation GO:0046530 170 0.012
response to biotic stimulus GO:0009607 294 0.012
carbohydrate derivative catabolic process GO:1901136 118 0.012
positive regulation of cellular catabolic process GO:0031331 95 0.011
establishment of localization in cell GO:0051649 402 0.011
eye morphogenesis GO:0048592 260 0.011
immune response GO:0006955 246 0.011
response to external biotic stimulus GO:0043207 293 0.011
regulation of locomotion GO:0040012 42 0.011
regulation of response to stress GO:0080134 200 0.011
spindle assembly involved in mitosis GO:0090307 50 0.011
intracellular signal transduction GO:0035556 300 0.011
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.011
response to abiotic stimulus GO:0009628 341 0.011
peroxisome organization GO:0007031 14 0.011
double strand break repair GO:0006302 26 0.011
negative regulation of developmental process GO:0051093 201 0.010
response to extracellular stimulus GO:0009991 116 0.010
negative regulation of cell cycle GO:0045786 116 0.010
dna integrity checkpoint GO:0031570 81 0.010
regulation of defense response GO:0031347 102 0.010
interspecies interaction between organisms GO:0044419 16 0.010
regulation of organelle organization GO:0033043 196 0.010

Tbp-1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.039
nervous system disease DOID:863 0 0.018
motor neuron disease DOID:231 0 0.013
central nervous system disease DOID:331 0 0.013
neurodegenerative disease DOID:1289 0 0.013