Drosophila melanogaster

71 known processes

Pole2 (Dmel_CG10489)

CG10489 gene product from transcript CG10489-RA

(Aliases: 10489,DNApol-epsilon,Dmel\CG10489,POLE2,CG10489)

Pole2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
dna metabolic process GO:0006259 227 0.391
dna conformation change GO:0071103 105 0.209
cellular response to dna damage stimulus GO:0006974 223 0.197
dna replication GO:0006260 48 0.180
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.164
nuclear division GO:0000280 332 0.096
negative regulation of gene expression GO:0010629 387 0.089
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.082
cellular catabolic process GO:0044248 372 0.072
macromolecular complex assembly GO:0065003 256 0.068
negative regulation of transcription dna templated GO:0045892 237 0.065
negative regulation of rna metabolic process GO:0051253 251 0.054
meiotic chromosome segregation GO:0045132 59 0.053
negative regulation of nucleic acid templated transcription GO:1903507 240 0.051
heterocycle catabolic process GO:0046700 166 0.049
nucleobase containing compound catabolic process GO:0034655 165 0.048
spindle organization GO:0007051 253 0.047
organelle fission GO:0048285 340 0.046
dna dependent dna replication GO:0006261 17 0.046
organic substance catabolic process GO:1901575 308 0.046
dna packaging GO:0006323 91 0.046
organic cyclic compound catabolic process GO:1901361 168 0.046
aromatic compound catabolic process GO:0019439 166 0.045
regulation of cell cycle process GO:0010564 181 0.040
positive regulation of cellular biosynthetic process GO:0031328 316 0.039
dna integrity checkpoint GO:0031570 81 0.038
regionalization GO:0003002 416 0.038
cell proliferation GO:0008283 299 0.037
chromosome segregation GO:0007059 157 0.037
negative regulation of rna biosynthetic process GO:1902679 240 0.035
dna repair GO:0006281 54 0.035
cellular nitrogen compound catabolic process GO:0044270 165 0.035
protein complex assembly GO:0006461 200 0.035
regulation of mitotic cell cycle GO:0007346 190 0.035
chorion containing eggshell formation GO:0007304 105 0.034
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.033
mitotic cell cycle phase transition GO:0044772 138 0.032
ovarian follicle cell development GO:0030707 248 0.032
sister chromatid segregation GO:0000819 92 0.031
chromosome organization GO:0051276 360 0.031
catabolic process GO:0009056 409 0.031
centrosome organization GO:0051297 163 0.031
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.031
endocytosis GO:0006897 310 0.031
organic substance transport GO:0071702 257 0.031
positive regulation of macromolecule metabolic process GO:0010604 405 0.030
spindle elongation GO:0051231 83 0.030
regulation of cellular component biogenesis GO:0044087 201 0.030
nucleobase containing small molecule metabolic process GO:0055086 174 0.029
cellular amino acid metabolic process GO:0006520 61 0.029
response to abiotic stimulus GO:0009628 341 0.028
developmental growth GO:0048589 280 0.028
glycosyl compound catabolic process GO:1901658 112 0.028
glycosyl compound metabolic process GO:1901657 127 0.028
nucleoside metabolic process GO:0009116 127 0.027
negative regulation of cellular metabolic process GO:0031324 382 0.027
microtubule organizing center organization GO:0031023 168 0.026
organonitrogen compound metabolic process GO:1901564 318 0.025
regulation of cell cycle GO:0051726 291 0.025
intracellular signal transduction GO:0035556 300 0.025
nucleotide metabolic process GO:0009117 161 0.025
protein dna complex subunit organization GO:0071824 86 0.025
eggshell formation GO:0030703 105 0.024
macromolecule catabolic process GO:0009057 161 0.024
regulation of anatomical structure morphogenesis GO:0022603 242 0.024
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.024
cell cycle checkpoint GO:0000075 95 0.023
protein complex biogenesis GO:0070271 201 0.023
body morphogenesis GO:0010171 2 0.023
growth GO:0040007 359 0.023
transcription from rna polymerase ii promoter GO:0006366 368 0.023
negative regulation of biosynthetic process GO:0009890 277 0.023
cell cycle phase transition GO:0044770 140 0.023
regulation of mitotic cell cycle phase transition GO:1901990 130 0.023
programmed cell death GO:0012501 257 0.023
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.023
meiotic cell cycle process GO:1903046 132 0.023
ribonucleoside metabolic process GO:0009119 127 0.022
ribonucleoside triphosphate catabolic process GO:0009203 108 0.022
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.022
embryo development ending in birth or egg hatching GO:0009792 152 0.021
cellular response to abiotic stimulus GO:0071214 58 0.021
cellular macromolecular complex assembly GO:0034622 153 0.021
nucleoside phosphate metabolic process GO:0006753 162 0.021
mitotic nuclear division GO:0007067 213 0.021
nucleotide catabolic process GO:0009166 109 0.021
cellular macromolecule catabolic process GO:0044265 136 0.020
ribonucleoside triphosphate metabolic process GO:0009199 119 0.020
carbohydrate derivative metabolic process GO:1901135 217 0.020
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.020
nuclear dna replication GO:0033260 1 0.020
regulation of organelle organization GO:0033043 196 0.019
small molecule metabolic process GO:0044281 305 0.019
protein phosphorylation GO:0006468 169 0.019
cellular protein modification process GO:0006464 438 0.019
cell fate determination GO:0001709 91 0.019
response to radiation GO:0009314 155 0.018
organophosphate metabolic process GO:0019637 195 0.018
male meiosis GO:0007140 52 0.018
protein dna complex assembly GO:0065004 63 0.018
negative regulation of signaling GO:0023057 219 0.017
purine ribonucleotide catabolic process GO:0009154 109 0.017
double strand break repair GO:0006302 26 0.017
mitotic spindle elongation GO:0000022 81 0.017
regulation of molecular function GO:0065009 217 0.017
nucleoside triphosphate metabolic process GO:0009141 120 0.016
rna processing GO:0006396 147 0.016
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.016
cell death GO:0008219 279 0.016
single organism catabolic process GO:0044712 228 0.016
ribonucleoside catabolic process GO:0042454 112 0.016
purine ribonucleoside catabolic process GO:0046130 112 0.016
nucleosome organization GO:0034728 59 0.016
negative regulation of cell communication GO:0010648 223 0.016
mitotic spindle organization GO:0007052 220 0.016
dna recombination GO:0006310 32 0.016
single organism cellular localization GO:1902580 180 0.016
actin cytoskeleton organization GO:0030036 206 0.016
organelle assembly GO:0070925 198 0.016
meiotic nuclear division GO:0007126 151 0.015
positive regulation of biosynthetic process GO:0009891 316 0.015
dna biosynthetic process GO:0071897 24 0.015
purine containing compound catabolic process GO:0072523 112 0.015
metaphase plate congression GO:0051310 19 0.015
mitotic cell cycle checkpoint GO:0007093 88 0.015
regulation of developmental growth GO:0048638 174 0.015
purine nucleoside triphosphate metabolic process GO:0009144 119 0.015
appendage morphogenesis GO:0035107 397 0.015
epithelial cell differentiation GO:0030855 322 0.014
regulation of multicellular organismal development GO:2000026 414 0.014
death GO:0016265 284 0.014
spindle midzone assembly GO:0051255 4 0.014
lipid metabolic process GO:0006629 121 0.014
nucleoside catabolic process GO:0009164 112 0.014
dna damage checkpoint GO:0000077 78 0.014
purine ribonucleotide metabolic process GO:0009150 145 0.014
actin filament based process GO:0030029 220 0.014
regulation of nervous system development GO:0051960 248 0.014
purine nucleoside triphosphate catabolic process GO:0009146 108 0.013
purine nucleoside catabolic process GO:0006152 112 0.013
purine containing compound metabolic process GO:0072521 155 0.013
centrosome cycle GO:0007098 137 0.013
regulation of cellular amino acid metabolic process GO:0006521 0 0.013
regulation of cellular component size GO:0032535 98 0.013
positive regulation of cellular protein metabolic process GO:0032270 118 0.013
regulation of programmed cell death GO:0043067 152 0.013
response to biotic stimulus GO:0009607 294 0.013
purine ribonucleoside metabolic process GO:0046128 127 0.013
response to external biotic stimulus GO:0043207 293 0.013
cell motility GO:0048870 251 0.013
regulation of cell cycle phase transition GO:1901987 130 0.013
regulation of cell morphogenesis GO:0022604 163 0.013
vesicle mediated transport GO:0016192 381 0.013
regulation of cellular ketone metabolic process GO:0010565 3 0.013
protein modification process GO:0036211 438 0.012
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.012
regulation of nucleotide metabolic process GO:0006140 62 0.012
ribose phosphate metabolic process GO:0019693 145 0.012
endomembrane system organization GO:0010256 119 0.012
regulation of anatomical structure size GO:0090066 163 0.012
regulation of protein complex assembly GO:0043254 42 0.012
dna geometric change GO:0032392 16 0.012
negative regulation of cellular biosynthetic process GO:0031327 277 0.012
positive regulation of nucleic acid templated transcription GO:1903508 266 0.012
phagocytosis GO:0006909 215 0.012
columnar cuboidal epithelial cell development GO:0002066 249 0.012
regulation of protein metabolic process GO:0051246 256 0.012
regulation of phosphate metabolic process GO:0019220 210 0.012
gene silencing GO:0016458 138 0.011
dna replication initiation GO:0006270 6 0.011
regulation of catalytic activity GO:0050790 185 0.011
immune system process GO:0002376 347 0.011
positive regulation of cellular component biogenesis GO:0044089 80 0.011
response to organophosphorus GO:0046683 2 0.011
response to other organism GO:0051707 293 0.011
regulation of catabolic process GO:0009894 170 0.011
microtubule cytoskeleton organization involved in mitosis GO:1902850 52 0.011
regulation of growth GO:0040008 233 0.011
organophosphate catabolic process GO:0046434 112 0.011
wound healing GO:0042060 75 0.011
cellular amine metabolic process GO:0044106 12 0.011
phosphorylation GO:0016310 294 0.011
response to wounding GO:0009611 94 0.011
salivary gland development GO:0007431 162 0.011
ribonucleotide catabolic process GO:0009261 109 0.011
guanosine containing compound catabolic process GO:1901069 74 0.011
segmentation GO:0035282 207 0.011
protein alkylation GO:0008213 43 0.011
membrane organization GO:0061024 112 0.011
dna amplification GO:0006277 11 0.011
embryonic development via the syncytial blastoderm GO:0001700 148 0.010
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.010
ubiquitin dependent protein catabolic process GO:0006511 78 0.010
cellular ketone metabolic process GO:0042180 24 0.010
regulation of gene expression epigenetic GO:0040029 128 0.010
nucleoside phosphate catabolic process GO:1901292 110 0.010
mitotic dna integrity checkpoint GO:0044774 75 0.010
guanosine containing compound metabolic process GO:1901068 74 0.010
mitotic g2 dna damage checkpoint GO:0007095 69 0.010
dendrite development GO:0016358 204 0.010
rho protein signal transduction GO:0007266 14 0.010

Pole2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.023
nervous system disease DOID:863 0 0.011