Drosophila melanogaster

23 known processes

hk (Dmel_CG10653)

hook

(Aliases: CG10653,Dmel\CG10653,dHk)

hk biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
locomotory behavior GO:0007626 176 0.837
membrane fusion GO:0061025 42 0.819
response to starvation GO:0042594 97 0.805
single organism behavior GO:0044708 391 0.781
establishment of localization in cell GO:0051649 402 0.748
endosome to lysosome transport GO:0008333 7 0.681
single organism membrane fusion GO:0044801 42 0.529
synaptic vesicle endocytosis GO:0048488 28 0.470
single organism intracellular transport GO:1902582 207 0.444
organelle fusion GO:0048284 46 0.365
cellular response to extracellular stimulus GO:0031668 64 0.361
regulation of cell differentiation GO:0045595 302 0.314
entrainment of circadian clock GO:0009649 16 0.313
cellular response to starvation GO:0009267 61 0.283
determination of adult lifespan GO:0008340 137 0.256
synaptic vesicle recycling GO:0036465 28 0.241
regulation of nervous system development GO:0051960 248 0.223
organelle membrane fusion GO:0090174 16 0.214
synaptic transmission GO:0007268 288 0.200
purine ribonucleotide metabolic process GO:0009150 145 0.195
positive regulation of rna biosynthetic process GO:1902680 266 0.194
purine containing compound metabolic process GO:0072521 155 0.190
macroautophagy GO:0016236 42 0.188
autophagic vacuole fusion GO:0000046 15 0.186
synaptic vesicle localization GO:0097479 53 0.186
adult behavior GO:0030534 137 0.184
cell death GO:0008219 279 0.172
establishment of synaptic vesicle localization GO:0097480 50 0.168
aging GO:0007568 143 0.164
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.151
multi organism reproductive behavior GO:0044705 121 0.151
ribonucleotide metabolic process GO:0009259 145 0.141
regulation of autophagy GO:0010506 62 0.128
adult locomotory behavior GO:0008344 76 0.127
endocytosis GO:0006897 310 0.127
regulation of cell cycle process GO:0010564 181 0.123
gliogenesis GO:0042063 80 0.119
enzyme linked receptor protein signaling pathway GO:0007167 179 0.113
lysosomal transport GO:0007041 13 0.112
cellular response to nutrient levels GO:0031669 62 0.102
regulation of catabolic process GO:0009894 170 0.101
cell proliferation GO:0008283 299 0.097
neuroblast proliferation GO:0007405 74 0.097
organelle localization GO:0051640 148 0.096
multicellular organismal aging GO:0010259 140 0.095
regulation of growth GO:0040008 233 0.094
establishment of protein localization to organelle GO:0072594 62 0.092
regulation of mitotic cell cycle GO:0007346 190 0.089
positive regulation of response to stimulus GO:0048584 323 0.084
regulation of catalytic activity GO:0050790 185 0.081
regulation of cell death GO:0010941 173 0.078
regulation of protein transport GO:0051223 57 0.078
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.077
cytoplasmic transport GO:0016482 130 0.076
regulation of phosphorus metabolic process GO:0051174 210 0.075
endosomal transport GO:0016197 44 0.074
secretion GO:0046903 109 0.073
negative regulation of developmental process GO:0051093 201 0.072
regulation of molecular function GO:0065009 217 0.071
death GO:0016265 284 0.071
developmental programmed cell death GO:0010623 138 0.070
positive regulation of hydrolase activity GO:0051345 78 0.069
regulation of cell development GO:0060284 215 0.068
programmed cell death GO:0012501 257 0.066
cellular catabolic process GO:0044248 372 0.065
negative regulation of developmental growth GO:0048640 64 0.064
notch receptor processing GO:0007220 13 0.064
organophosphate metabolic process GO:0019637 195 0.062
organelle assembly GO:0070925 198 0.059
regulation of phosphate metabolic process GO:0019220 210 0.058
positive regulation of multicellular organismal process GO:0051240 143 0.057
regulation of cellular catabolic process GO:0031329 157 0.057
positive regulation of rna metabolic process GO:0051254 271 0.057
regulation of transport GO:0051049 181 0.056
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.055
regulation of organelle organization GO:0033043 196 0.054
regulation of vesicle mediated transport GO:0060627 59 0.054
secretion by cell GO:0032940 101 0.054
developmental growth GO:0048589 280 0.053
negative regulation of molecular function GO:0044092 51 0.053
compound eye development GO:0048749 307 0.052
anatomical structure homeostasis GO:0060249 97 0.052
nucleobase containing small molecule metabolic process GO:0055086 174 0.051
mitotic cell cycle phase transition GO:0044772 138 0.051
organonitrogen compound metabolic process GO:1901564 318 0.051
regulation of hydrolase activity GO:0051336 97 0.050
signal release GO:0023061 49 0.048
protein targeting GO:0006605 64 0.048
intracellular transport GO:0046907 228 0.046
response to extracellular stimulus GO:0009991 116 0.046
regulation of developmental growth GO:0048638 174 0.045
dorsal ventral pattern formation GO:0009953 133 0.045
homeostatic process GO:0042592 199 0.044
mitotic dna damage checkpoint GO:0044773 74 0.044
regulation of localization GO:0032879 275 0.044
notch signaling pathway GO:0007219 120 0.043
purine nucleotide metabolic process GO:0006163 146 0.043
regulation of response to stress GO:0080134 200 0.043
phenol containing compound metabolic process GO:0018958 57 0.043
vesicle mediated transport GO:0016192 381 0.042
immune system development GO:0002520 57 0.042
regulation of programmed cell death GO:0043067 152 0.041
positive regulation of nucleic acid templated transcription GO:1903508 266 0.041
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.041
regulation of multicellular organismal development GO:2000026 414 0.040
negative regulation of response to stimulus GO:0048585 258 0.040
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.039
regulation of synaptic growth at neuromuscular junction GO:0008582 89 0.038
glycosyl compound metabolic process GO:1901657 127 0.037
negative regulation of cell communication GO:0010648 223 0.034
regulation of cell cycle GO:0051726 291 0.034
central nervous system development GO:0007417 201 0.033
eye development GO:0001654 323 0.033
purine containing compound biosynthetic process GO:0072522 30 0.033
nucleotide metabolic process GO:0009117 161 0.033
negative regulation of programmed cell death GO:0043069 72 0.033
positive regulation of developmental process GO:0051094 143 0.033
regulation of cellular response to stress GO:0080135 89 0.033
small molecule metabolic process GO:0044281 305 0.032
regulation of anatomical structure size GO:0090066 163 0.032
forebrain development GO:0030900 2 0.032
stem cell proliferation GO:0072089 88 0.032
learning or memory GO:0007611 141 0.032
eye pigment granule organization GO:0008057 12 0.032
positive regulation of cell development GO:0010720 61 0.031
cell cycle checkpoint GO:0000075 95 0.031
response to nutrient levels GO:0031667 114 0.031
dopamine biosynthetic process GO:0042416 3 0.031
negative regulation of cell differentiation GO:0045596 143 0.031
cellular response to external stimulus GO:0071496 66 0.029
regulation of cellular component biogenesis GO:0044087 201 0.029
establishment of vesicle localization GO:0051650 51 0.029
negative regulation of nervous system development GO:0051961 92 0.029
positive regulation of catabolic process GO:0009896 105 0.029
early endosome to late endosome transport GO:0045022 3 0.028
telencephalon development GO:0021537 2 0.028
protein localization GO:0008104 284 0.028
negative regulation of multicellular organismal process GO:0051241 142 0.028
oocyte maturation GO:0001556 3 0.028
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.028
response to decreased oxygen levels GO:0036293 58 0.027
gtp catabolic process GO:0006184 72 0.027
single organism catabolic process GO:0044712 228 0.027
pigment granule organization GO:0048753 12 0.027
response to organonitrogen compound GO:0010243 75 0.026
catabolic process GO:0009056 409 0.026
cellular homeostasis GO:0019725 80 0.025
regulation of purine nucleotide catabolic process GO:0033121 48 0.024
mitotic dna integrity checkpoint GO:0044774 75 0.024
response to ethanol GO:0045471 59 0.024
negative regulation of signal transduction GO:0009968 206 0.023
brain development GO:0007420 120 0.023
establishment of organelle localization GO:0051656 122 0.023
purine nucleoside catabolic process GO:0006152 112 0.021
positive regulation of transcription dna templated GO:0045893 266 0.021
response to oxygen containing compound GO:1901700 200 0.021
dna double strand break processing GO:0000729 3 0.021
regulation of cell cycle phase transition GO:1901987 130 0.021
regulation of steroid metabolic process GO:0019218 2 0.021
dna damage checkpoint GO:0000077 78 0.021
positive regulation of molecular function GO:0044093 136 0.021
response to anesthetic GO:0072347 9 0.021
centrosome cycle GO:0007098 137 0.020
regulation of nurse cell apoptotic process GO:0045477 9 0.020
neurological system process GO:0050877 358 0.020
response to reactive oxygen species GO:0000302 24 0.020
carbohydrate derivative metabolic process GO:1901135 217 0.019
positive regulation of intracellular protein transport GO:0090316 30 0.019
cellular response to dna damage stimulus GO:0006974 223 0.019
purine nucleotide catabolic process GO:0006195 109 0.019
regulation of response to external stimulus GO:0032101 115 0.019
guanosine containing compound catabolic process GO:1901069 74 0.019
regulation of nucleotide metabolic process GO:0006140 62 0.019
cell cycle phase transition GO:0044770 140 0.019
negative regulation of neuron apoptotic process GO:0043524 14 0.019
axonogenesis GO:0007409 290 0.019
protein targeting to nucleus GO:0044744 51 0.019
response to temperature stimulus GO:0009266 106 0.018
exocytosis GO:0006887 28 0.018
regulation of mitotic cell cycle phase transition GO:1901990 130 0.018
tube development GO:0035295 244 0.017
appendage segmentation GO:0035285 26 0.017
taxis GO:0042330 304 0.017
positive regulation of gene expression GO:0010628 290 0.017
regulation of notch signaling pathway GO:0008593 100 0.017
protein phosphorylation GO:0006468 169 0.017
membrane organization GO:0061024 112 0.017
negative regulation of cell death GO:0060548 81 0.017
neuromuscular process GO:0050905 21 0.017
phosphorylation GO:0016310 294 0.017
purine ribonucleoside metabolic process GO:0046128 127 0.017
regulation of cell cycle g1 s phase transition GO:1902806 23 0.016
regulation of wnt signaling pathway GO:0030111 68 0.016
regulation of neuron apoptotic process GO:0043523 16 0.016
regulation of epithelial cell proliferation GO:0050678 4 0.016
regulation of cell proliferation GO:0042127 163 0.015
positive regulation of apoptotic process GO:0043065 47 0.015
catecholamine metabolic process GO:0006584 10 0.015
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.015
regulation of cellular localization GO:0060341 136 0.015
positive regulation of biosynthetic process GO:0009891 316 0.015
nucleoside phosphate metabolic process GO:0006753 162 0.015
positive regulation of signal transduction GO:0009967 223 0.015
regulation of apoptotic process GO:0042981 130 0.015
purine nucleoside metabolic process GO:0042278 127 0.015
head development GO:0060322 135 0.015
cellular metal ion homeostasis GO:0006875 31 0.015
regulation of intracellular protein transport GO:0033157 46 0.014
neural precursor cell proliferation GO:0061351 75 0.014
negative regulation of apoptotic process GO:0043066 63 0.014
endomembrane system organization GO:0010256 119 0.014
regulation of nucleoside metabolic process GO:0009118 50 0.014
ribonucleoside triphosphate metabolic process GO:0009199 119 0.014
organic substance transport GO:0071702 257 0.014
regulation of purine nucleotide metabolic process GO:1900542 62 0.014
positive regulation of macromolecule metabolic process GO:0010604 405 0.014
purine nucleoside triphosphate catabolic process GO:0009146 108 0.014
regulation of protein targeting GO:1903533 29 0.014
regulation of protein metabolic process GO:0051246 256 0.014
axon guidance GO:0007411 233 0.014
negative regulation of signaling GO:0023057 219 0.013
organonitrogen compound catabolic process GO:1901565 128 0.013
nucleoside triphosphate catabolic process GO:0009143 108 0.013
regulation of necrotic cell death GO:0010939 1 0.013
nucleoside catabolic process GO:0009164 112 0.013
compound eye morphogenesis GO:0001745 249 0.013
purine ribonucleoside catabolic process GO:0046130 112 0.013
intracellular protein transport GO:0006886 104 0.013
negative regulation of biosynthetic process GO:0009890 277 0.013
regulation of intracellular signal transduction GO:1902531 236 0.013
leg disc morphogenesis GO:0007478 80 0.013
entrainment of circadian clock by photoperiod GO:0043153 9 0.013
positive regulation of cell death GO:0010942 69 0.012
positive regulation of protein transport GO:0051222 37 0.012
regulation of synapse assembly GO:0051963 94 0.012
regulation of nucleotide catabolic process GO:0030811 48 0.012
protein catabolic process GO:0030163 101 0.012
purine containing compound catabolic process GO:0072523 112 0.012
positive regulation of cellular catabolic process GO:0031331 95 0.012
regulation of circadian rhythm GO:0042752 49 0.012
positive regulation of neuron apoptotic process GO:0043525 1 0.012
positive regulation of phosphorus metabolic process GO:0010562 139 0.012
growth GO:0040007 359 0.012
regulation of g1 s transition of mitotic cell cycle GO:2000045 23 0.012
larval development GO:0002164 104 0.012
negative regulation of rna metabolic process GO:0051253 251 0.012
ribonucleoside catabolic process GO:0042454 112 0.011
lysosome organization GO:0007040 4 0.011
organonitrogen compound biosynthetic process GO:1901566 117 0.011
regulation of synaptic vesicle transport GO:1902803 10 0.011
cell maturation GO:0048469 144 0.011
organic hydroxy compound metabolic process GO:1901615 83 0.011
regulation of cytoskeleton organization GO:0051493 89 0.011
cell cycle arrest GO:0007050 4 0.011
vesicle localization GO:0051648 55 0.011
response to calcium ion GO:0051592 1 0.011
negative regulation of mitotic cell cycle GO:0045930 109 0.011
cellular pigmentation GO:0033059 12 0.011
negative regulation of cell proliferation GO:0008285 69 0.011
camera type eye morphogenesis GO:0048593 2 0.011
imaginal disc pattern formation GO:0007447 91 0.011
neuron maturation GO:0042551 31 0.011
cell growth GO:0016049 108 0.010
flight behavior GO:0007629 26 0.010
positive regulation of cell communication GO:0010647 250 0.010
wnt signaling pathway GO:0016055 98 0.010
regulation of synaptic transmission GO:0050804 69 0.010
purine ribonucleoside monophosphate biosynthetic process GO:0009168 3 0.010

hk disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.028
disease of cellular proliferation DOID:14566 0 0.028
organ system cancer DOID:0050686 0 0.028
disease of anatomical entity DOID:7 0 0.027
central nervous system disease DOID:331 0 0.017
neurodegenerative disease DOID:1289 0 0.017
nervous system disease DOID:863 0 0.017
synucleinopathy DOID:0050890 0 0.013