Drosophila melanogaster

46 known processes

eIF-4B (Dmel_CG10837)

Eukaryotic initiation factor 4B

(Aliases: eIF-4B-S,eIf4b,eIF-4b,EIF-4B,Dm-eIF4B,CG10837,Dmel\CG10837,eIF4B,eIF-4B-L,Eif4B)

eIF-4B biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
growth GO:0040007 359 0.241
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.178
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.164
defense response to bacterium GO:0042742 178 0.155
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.139
catabolic process GO:0009056 409 0.119
regulation of cell differentiation GO:0045595 302 0.119
cellular catabolic process GO:0044248 372 0.112
chromatin organization GO:0006325 207 0.111
negative regulation of gene expression GO:0010629 387 0.106
cytoplasmic transport GO:0016482 130 0.104
regulation of intracellular signal transduction GO:1902531 236 0.100
positive regulation of response to stimulus GO:0048584 323 0.090
response to bacterium GO:0009617 198 0.089
vesicle mediated transport GO:0016192 381 0.085
autophagy GO:0006914 108 0.084
organic substance transport GO:0071702 257 0.084
response to biotic stimulus GO:0009607 294 0.078
positive regulation of macromolecule metabolic process GO:0010604 405 0.078
establishment of localization in cell GO:0051649 402 0.077
establishment of protein localization GO:0045184 163 0.075
protein complex assembly GO:0006461 200 0.071
protein localization GO:0008104 284 0.070
intracellular protein transport GO:0006886 104 0.069
appendage development GO:0048736 401 0.069
ion transport GO:0006811 145 0.069
chemotaxis GO:0006935 249 0.068
segmentation GO:0035282 207 0.067
phagocytosis GO:0006909 215 0.067
cellular macromolecule localization GO:0070727 220 0.066
response to external biotic stimulus GO:0043207 293 0.065
phosphorylation GO:0016310 294 0.064
protein import GO:0017038 55 0.063
response to organic substance GO:0010033 284 0.063
negative regulation of cellular biosynthetic process GO:0031327 277 0.062
positive regulation of rna biosynthetic process GO:1902680 266 0.062
intracellular transport GO:0046907 228 0.060
single organism intracellular transport GO:1902582 207 0.060
negative regulation of cellular metabolic process GO:0031324 382 0.058
regulation of cellular catabolic process GO:0031329 157 0.058
macromolecular complex assembly GO:0065003 256 0.058
organonitrogen compound biosynthetic process GO:1901566 117 0.057
dna metabolic process GO:0006259 227 0.057
protein phosphorylation GO:0006468 169 0.056
regulation of autophagy GO:0010506 62 0.056
regulation of growth GO:0040008 233 0.055
negative regulation of cell cycle phase transition GO:1901988 103 0.054
cellular protein localization GO:0034613 160 0.053
microtubule organizing center organization GO:0031023 168 0.052
single organism nuclear import GO:1902593 51 0.051
protein targeting to nucleus GO:0044744 51 0.051
regulation of cell proliferation GO:0042127 163 0.050
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.049
appendage morphogenesis GO:0035107 397 0.049
positive regulation of catalytic activity GO:0043085 118 0.049
regulation of protein metabolic process GO:0051246 256 0.048
enzyme linked receptor protein signaling pathway GO:0007167 179 0.047
negative regulation of biosynthetic process GO:0009890 277 0.047
positive regulation of signal transduction GO:0009967 223 0.047
developmental growth GO:0048589 280 0.046
cell death GO:0008219 279 0.046
regulation of catabolic process GO:0009894 170 0.046
establishment of protein localization to organelle GO:0072594 62 0.045
positive regulation of biosynthetic process GO:0009891 316 0.045
protein localization to nucleus GO:0034504 55 0.044
protein import into nucleus GO:0006606 51 0.044
regulation of programmed cell death GO:0043067 152 0.044
macromolecule catabolic process GO:0009057 161 0.044
regulation of multicellular organismal development GO:2000026 414 0.044
organic substance catabolic process GO:1901575 308 0.043
cellular protein complex assembly GO:0043623 71 0.043
tube development GO:0035295 244 0.043
regulation of cellular protein metabolic process GO:0032268 243 0.042
regulation of cellular component biogenesis GO:0044087 201 0.041
centrosome cycle GO:0007098 137 0.041
response to other organism GO:0051707 293 0.040
organic hydroxy compound metabolic process GO:1901615 83 0.040
protein modification process GO:0036211 438 0.040
positive regulation of phosphate metabolic process GO:0045937 139 0.039
nucleocytoplasmic transport GO:0006913 72 0.039
positive regulation of cellular component organization GO:0051130 156 0.039
single organism cellular localization GO:1902580 180 0.038
regulation of immune system process GO:0002682 176 0.037
transcription from rna polymerase ii promoter GO:0006366 368 0.037
endocytosis GO:0006897 310 0.037
imaginal disc derived appendage development GO:0048737 399 0.036
positive regulation of intracellular signal transduction GO:1902533 116 0.036
cellular protein modification process GO:0006464 438 0.036
cell growth GO:0016049 108 0.035
positive regulation of signaling GO:0023056 243 0.035
death GO:0016265 284 0.034
single organism membrane organization GO:0044802 93 0.034
eye development GO:0001654 323 0.033
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.033
positive regulation of catabolic process GO:0009896 105 0.033
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 65 0.033
positive regulation of protein metabolic process GO:0051247 128 0.033
regulation of apoptotic process GO:0042981 130 0.033
embryonic axis specification GO:0000578 107 0.033
regulation of mitotic cell cycle phase transition GO:1901990 130 0.033
intracellular signal transduction GO:0035556 300 0.032
regulation of localization GO:0032879 275 0.032
immune response GO:0006955 246 0.032
protein localization to organelle GO:0033365 82 0.031
anterior posterior pattern specification GO:0009952 136 0.031
protein catabolic process GO:0030163 101 0.031
positive regulation of nucleic acid templated transcription GO:1903508 266 0.030
nuclear import GO:0051170 51 0.030
negative regulation of neurogenesis GO:0050768 53 0.030
negative regulation of cellular catabolic process GO:0031330 34 0.029
organonitrogen compound metabolic process GO:1901564 318 0.029
response to endogenous stimulus GO:0009719 119 0.029
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.029
regulation of nervous system development GO:0051960 248 0.029
innate immune response GO:0045087 144 0.029
regulation of phosphorylation GO:0042325 147 0.029
negative regulation of catabolic process GO:0009895 36 0.028
centrosome organization GO:0051297 163 0.028
taxis GO:0042330 304 0.028
protein targeting GO:0006605 64 0.028
regulation of phosphorus metabolic process GO:0051174 210 0.028
response to abiotic stimulus GO:0009628 341 0.028
anterior posterior axis specification embryo GO:0008595 103 0.028
negative regulation of growth GO:0045926 84 0.027
apoptotic process GO:0006915 159 0.027
sensory organ morphogenesis GO:0090596 260 0.027
lipid metabolic process GO:0006629 121 0.027
imaginal disc derived appendage morphogenesis GO:0035114 395 0.027
negative regulation of cell proliferation GO:0008285 69 0.026
negative regulation of developmental process GO:0051093 201 0.026
aging GO:0007568 143 0.026
imaginal disc derived wing morphogenesis GO:0007476 337 0.026
salivary gland morphogenesis GO:0007435 145 0.026
protein complex biogenesis GO:0070271 201 0.026
positive regulation of gene expression GO:0010628 290 0.026
endomembrane system organization GO:0010256 119 0.026
negative regulation of nucleic acid templated transcription GO:1903507 240 0.026
phenol containing compound metabolic process GO:0018958 57 0.026
regulation of catalytic activity GO:0050790 185 0.025
ubiquitin dependent protein catabolic process GO:0006511 78 0.025
response to oxygen containing compound GO:1901700 200 0.024
carbohydrate derivative metabolic process GO:1901135 217 0.024
chromatin modification GO:0016568 147 0.024
stem cell division GO:0017145 69 0.024
single organism carbohydrate metabolic process GO:0044723 72 0.023
gland morphogenesis GO:0022612 145 0.023
negative regulation of cellular component organization GO:0051129 108 0.023
positive regulation of rna metabolic process GO:0051254 271 0.023
organic acid metabolic process GO:0006082 103 0.023
positive regulation of cellular biosynthetic process GO:0031328 316 0.023
cellular amino acid metabolic process GO:0006520 61 0.023
compound eye morphogenesis GO:0001745 249 0.023
imaginal disc derived leg morphogenesis GO:0007480 80 0.023
regulation of chromatin modification GO:1903308 28 0.023
cellular response to organic substance GO:0071310 132 0.023
proteolysis GO:0006508 192 0.023
negative regulation of cell differentiation GO:0045596 143 0.023
kidney development GO:0001822 3 0.022
protein transport GO:0015031 155 0.022
regulation of synapse organization GO:0050807 110 0.022
transforming growth factor beta receptor signaling pathway GO:0007179 16 0.022
axon guidance GO:0007411 233 0.022
organic hydroxy compound biosynthetic process GO:1901617 21 0.022
organelle fission GO:0048285 340 0.022
positive regulation of cell communication GO:0010647 250 0.021
regionalization GO:0003002 416 0.021
regulation of protein modification process GO:0031399 112 0.021
extrinsic apoptotic signaling pathway GO:0097191 1 0.021
nucleus organization GO:0006997 45 0.021
negative regulation of nervous system development GO:0051961 92 0.021
regulation of mitotic cell cycle GO:0007346 190 0.021
negative regulation of transcription dna templated GO:0045892 237 0.020
aminoglycan biosynthetic process GO:0006023 11 0.020
purine ribonucleotide metabolic process GO:0009150 145 0.020
regulation of immune response GO:0050776 118 0.020
regulation of transport GO:0051049 181 0.020
response to lipopolysaccharide GO:0032496 4 0.020
ras protein signal transduction GO:0007265 88 0.020
cellular lipid metabolic process GO:0044255 83 0.020
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.020
regulation of small gtpase mediated signal transduction GO:0051056 93 0.020
cellular response to dna damage stimulus GO:0006974 223 0.020
embryonic pattern specification GO:0009880 174 0.019
sterol homeostasis GO:0055092 4 0.019
regulation of molecular function GO:0065009 217 0.019
meiotic nuclear division GO:0007126 151 0.019
nuclear transport GO:0051169 72 0.019
translation GO:0006412 69 0.019
neuromuscular junction development GO:0007528 149 0.019
positive regulation of cellular protein metabolic process GO:0032270 118 0.019
regulation of neurogenesis GO:0050767 158 0.019
regulation of cell death GO:0010941 173 0.019
membrane organization GO:0061024 112 0.019
small gtpase mediated signal transduction GO:0007264 88 0.018
peptidyl threonine phosphorylation GO:0018107 2 0.018
cellular macromolecular complex assembly GO:0034622 153 0.018
response to extracellular stimulus GO:0009991 116 0.018
regulation of cell growth GO:0001558 43 0.018
negative regulation of apoptotic process GO:0043066 63 0.018
programmed cell death GO:0012501 257 0.018
cellular protein catabolic process GO:0044257 83 0.018
cellular carbohydrate metabolic process GO:0044262 22 0.018
defense response GO:0006952 300 0.018
cellular nitrogen compound catabolic process GO:0044270 165 0.018
connective tissue development GO:0061448 3 0.018
neuron projection guidance GO:0097485 241 0.018
nitrogen compound transport GO:0071705 85 0.018
regulation of cellular amine metabolic process GO:0033238 3 0.018
wing disc morphogenesis GO:0007472 344 0.018
response to alcohol GO:0097305 95 0.017
negative regulation of cell development GO:0010721 62 0.017
immune system process GO:0002376 347 0.017
regulation of cell development GO:0060284 215 0.017
compound eye development GO:0048749 307 0.017
protein modification by small protein conjugation GO:0032446 79 0.017
small molecule metabolic process GO:0044281 305 0.017
blastoderm segmentation GO:0007350 159 0.017
carboxylic acid metabolic process GO:0019752 92 0.017
modification dependent macromolecule catabolic process GO:0043632 79 0.017
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.017
body morphogenesis GO:0010171 2 0.017
axon development GO:0061564 297 0.017
homeostatic process GO:0042592 199 0.017
salivary gland histolysis GO:0035070 88 0.017
positive regulation of molecular function GO:0044093 136 0.016
estrogen metabolic process GO:0008210 1 0.016
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.016
cell cell signaling involved in cell fate commitment GO:0045168 210 0.016
olfactory behavior GO:0042048 97 0.016
response to monosaccharide GO:0034284 4 0.016
eye morphogenesis GO:0048592 260 0.016
regulation of response to stress GO:0080134 200 0.016
extracellular structure organization GO:0043062 46 0.016
positive regulation of phosphorylation GO:0042327 87 0.016
localization of cell GO:0051674 257 0.016
positive regulation of transcription dna templated GO:0045893 266 0.016
epithelial tube morphogenesis GO:0060562 88 0.016
response to glucose GO:0009749 2 0.016
nuclear division GO:0000280 332 0.016
negative regulation of protein metabolic process GO:0051248 85 0.016
leg disc morphogenesis GO:0007478 80 0.016
response to drug GO:0042493 17 0.016
cellular response to external stimulus GO:0071496 66 0.016
negative regulation of cellular protein metabolic process GO:0032269 85 0.015
single organism biosynthetic process GO:0044711 206 0.015
mitotic cell cycle checkpoint GO:0007093 88 0.015
regulation of protein localization GO:0032880 76 0.015
regulation of cytoplasmic transport GO:1903649 47 0.015
regulation of establishment of protein localization GO:0070201 61 0.015
cell cycle checkpoint GO:0000075 95 0.015
cell migration GO:0016477 238 0.015
regulation of cellular localization GO:0060341 136 0.015
negative regulation of rna biosynthetic process GO:1902679 240 0.015
regulation of proteolysis GO:0030162 87 0.015
positive regulation of apoptotic signaling pathway GO:2001235 4 0.015
regulation of neuron differentiation GO:0045664 103 0.015
camera type eye development GO:0043010 4 0.015
negative regulation of response to stimulus GO:0048585 258 0.015
multicellular organismal aging GO:0010259 140 0.015
cytoplasm organization GO:0007028 64 0.014
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.014
single organism catabolic process GO:0044712 228 0.014
rrna processing GO:0006364 3 0.014
organic cyclic compound catabolic process GO:1901361 168 0.014
protein modification by small protein conjugation or removal GO:0070647 106 0.014
tissue death GO:0016271 102 0.014
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.014
mapk cascade GO:0000165 107 0.014
ribonucleotide metabolic process GO:0009259 145 0.014
positive regulation of cell motility GO:2000147 3 0.014
positive regulation of phosphorus metabolic process GO:0010562 139 0.014
regulation of mapk cascade GO:0043408 92 0.014
digestive tract development GO:0048565 149 0.014
cellular response to chemical stimulus GO:0070887 199 0.014
regulation of apoptotic signaling pathway GO:2001233 10 0.014
cellular response to endogenous stimulus GO:0071495 80 0.014
catechol containing compound metabolic process GO:0009712 10 0.013
response to nutrient levels GO:0031667 114 0.013
purine nucleoside monophosphate metabolic process GO:0009126 50 0.013
tripartite regional subdivision GO:0007351 103 0.013
regulation of hydrolase activity GO:0051336 97 0.013
regulation of cell cycle phase transition GO:1901987 130 0.013
exocrine system development GO:0035272 162 0.013
negative regulation of programmed cell death GO:0043069 72 0.013
cell proliferation GO:0008283 299 0.013
organophosphate metabolic process GO:0019637 195 0.013
carbohydrate derivative catabolic process GO:1901136 118 0.013
hormone catabolic process GO:0042447 3 0.013
synapse organization GO:0050808 196 0.013
protein ubiquitination GO:0016567 70 0.013
regulation of intracellular protein transport GO:0033157 46 0.013
mitochondrion organization GO:0007005 65 0.013
regulation of protein complex assembly GO:0043254 42 0.013
regulation of cellular ketone metabolic process GO:0010565 3 0.013
autophagic cell death GO:0048102 83 0.013
positive regulation of protein modification process GO:0031401 58 0.013
negative regulation of signal transduction GO:0009968 206 0.013
purine nucleoside triphosphate catabolic process GO:0009146 108 0.013
cellular macromolecule catabolic process GO:0044265 136 0.013
morphogenesis of an epithelium GO:0002009 276 0.012
cholesterol homeostasis GO:0042632 3 0.012
purine containing compound metabolic process GO:0072521 155 0.012
chemosensory behavior GO:0007635 106 0.012
telencephalon development GO:0021537 2 0.012
purine nucleotide metabolic process GO:0006163 146 0.012
regulation of alternative mrna splicing via spliceosome GO:0000381 60 0.012
maintenance of location GO:0051235 73 0.012
response to nitrogen compound GO:1901698 90 0.012
cellular amine metabolic process GO:0044106 12 0.012
nucleoside catabolic process GO:0009164 112 0.012
peptidyl threonine modification GO:0018210 3 0.012
positive regulation of hydrolase activity GO:0051345 78 0.012
nucleoside metabolic process GO:0009116 127 0.012
carbohydrate metabolic process GO:0005975 82 0.012
positive regulation of developmental growth GO:0048639 62 0.012
cellular response to nutrient levels GO:0031669 62 0.012
cellular response to extracellular stimulus GO:0031668 64 0.012
nucleoside phosphate metabolic process GO:0006753 162 0.012
regulation of synapse structure and activity GO:0050803 128 0.012
chorion containing eggshell formation GO:0007304 105 0.012
salivary gland development GO:0007431 162 0.012
mitotic spindle organization GO:0007052 220 0.012
anterior posterior axis specification GO:0009948 109 0.012
smad protein import into nucleus GO:0007184 11 0.012
histolysis GO:0007559 102 0.012
axis specification GO:0009798 167 0.011
developmental programmed cell death GO:0010623 138 0.011
mitotic cell cycle phase transition GO:0044772 138 0.011
meiotic cell cycle GO:0051321 171 0.011
guanosine containing compound metabolic process GO:1901068 74 0.011
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 38 0.011
aminoglycan metabolic process GO:0006022 18 0.011
positive regulation of organelle organization GO:0010638 65 0.011
actin filament based movement GO:0030048 26 0.011
cellular ketone metabolic process GO:0042180 24 0.011
defense response to gram negative bacterium GO:0050829 94 0.011
regulation of synapse assembly GO:0051963 94 0.011
oxoacid metabolic process GO:0043436 103 0.011
positive regulation of cellular catabolic process GO:0031331 95 0.011
regulation of phosphate metabolic process GO:0019220 210 0.011
ribonucleoside metabolic process GO:0009119 127 0.011
ribose phosphate metabolic process GO:0019693 145 0.011
positive regulation of cell migration GO:0030335 2 0.011
dna replication GO:0006260 48 0.011
establishment of rna localization GO:0051236 47 0.011
heterocycle catabolic process GO:0046700 166 0.011
carbohydrate derivative biosynthetic process GO:1901137 85 0.011
positive regulation of mapk cascade GO:0043410 63 0.011
cellular response to lipopolysaccharide GO:0071222 3 0.011
negative regulation of translation GO:0017148 28 0.011
signal transduction by phosphorylation GO:0023014 107 0.011
nucleobase containing compound catabolic process GO:0034655 165 0.011
regulation of chromosome organization GO:0033044 64 0.011
regulation of intracellular transport GO:0032386 64 0.011
negative regulation of cell cycle process GO:0010948 109 0.011
negative regulation of cell communication GO:0010648 223 0.011
positive regulation of i kappab kinase nf kappab signaling GO:0043123 1 0.010
nucleoside triphosphate metabolic process GO:0009141 120 0.010
salivary gland cell autophagic cell death GO:0035071 83 0.010
digestive system development GO:0055123 149 0.010
proteasomal protein catabolic process GO:0010498 59 0.010
mesenchymal cell development GO:0014031 1 0.010
ribonucleotide catabolic process GO:0009261 109 0.010
positive regulation of growth GO:0045927 75 0.010
regulation of protein localization to nucleus GO:1900180 29 0.010
response to transforming growth factor beta GO:0071559 18 0.010
positive regulation of nucleotide metabolic process GO:0045981 55 0.010
cellular modified amino acid metabolic process GO:0006575 45 0.010
cellular response to biotic stimulus GO:0071216 4 0.010
dopamine biosynthetic process GO:0042416 3 0.010
positive regulation of multicellular organismal process GO:0051240 143 0.010

eIF-4B disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.047
nervous system disease DOID:863 0 0.020
musculoskeletal system disease DOID:17 0 0.020
disease of metabolism DOID:0014667 0 0.019
central nervous system disease DOID:331 0 0.015
neurodegenerative disease DOID:1289 0 0.013
bone disease DOID:0080001 0 0.012
connective tissue disease DOID:65 0 0.012