Drosophila melanogaster

22 known processes

MP1 (Dmel_CG1102)

Melanization Protease 1

(Aliases: proPO-AE,SP25,BEST:GH02921,CG1102,Dmel\CG1102)

MP1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
melanization defense response GO:0035006 45 0.685
response to fungus GO:0009620 50 0.564
Fly
peptide metabolic process GO:0006518 80 0.538
Fly
melanin metabolic process GO:0006582 47 0.364
defense response GO:0006952 300 0.361
immune system process GO:0002376 347 0.350
secondary metabolic process GO:0019748 75 0.251
pigment metabolic process GO:0042440 84 0.245
regulation of neuron differentiation GO:0045664 103 0.234
regulation of immune system process GO:0002682 176 0.212
Fly
response to external biotic stimulus GO:0043207 293 0.204
Fly
response to wounding GO:0009611 94 0.197
positive regulation of biosynthetic process GO:0009891 316 0.191
Fly
post embryonic appendage morphogenesis GO:0035120 385 0.185
regulation of multi organism process GO:0043900 131 0.165
Fly
vesicle mediated transport GO:0016192 381 0.161
Fly
positive regulation of response to external stimulus GO:0032103 44 0.157
Fly
negative regulation of developmental process GO:0051093 201 0.152
response to other organism GO:0051707 293 0.151
Fly
defense response to fungus GO:0050832 48 0.146
Fly
regulation of secondary metabolic process GO:0043455 7 0.143
Fly
response to bacterium GO:0009617 198 0.137
Fly
regulation of response to stress GO:0080134 200 0.128
Fly
regulation of cellular component size GO:0032535 98 0.126
positive regulation of immune system process GO:0002684 68 0.124
Fly
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.122
Fly
appendage morphogenesis GO:0035107 397 0.119
phenol containing compound metabolic process GO:0018958 57 0.118
defense response to gram negative bacterium GO:0050829 94 0.117
Fly
regulation of cell differentiation GO:0045595 302 0.112
gland development GO:0048732 191 0.111
regulation of production of molecular mediator of immune response GO:0002700 44 0.111
Fly
proteolysis GO:0006508 192 0.106
Fly
dorsal ventral pattern formation GO:0009953 133 0.099
Fly
endocytosis GO:0006897 310 0.092
Fly
regulation of cellular amide metabolic process GO:0034248 39 0.088
Fly
phagocytosis GO:0006909 215 0.087
Fly
protein processing GO:0016485 68 0.087
Fly
immune response GO:0006955 246 0.086
positive regulation of defense response GO:0031349 59 0.085
Fly
axis specification GO:0009798 167 0.082
Fly
innate immune response GO:0045087 144 0.082
positive regulation of immune effector process GO:0002699 28 0.081
Fly
negative regulation of cellular component organization GO:0051129 108 0.081
positive regulation of signal transduction GO:0009967 223 0.080
Fly
protein maturation GO:0051604 71 0.080
Fly
dna metabolic process GO:0006259 227 0.079
negative regulation of cellular metabolic process GO:0031324 382 0.078
imaginal disc derived appendage development GO:0048737 399 0.078
negative regulation of signaling GO:0023057 219 0.077
regulation of cell morphogenesis GO:0022604 163 0.077
negative regulation of gene expression GO:0010629 387 0.076
positive regulation of cell communication GO:0010647 250 0.075
Fly
wing disc morphogenesis GO:0007472 344 0.074
positive regulation of signaling GO:0023056 243 0.074
Fly
regulation of protein kinase activity GO:0045859 51 0.074
response to abiotic stimulus GO:0009628 341 0.073
organic hydroxy compound metabolic process GO:1901615 83 0.070
response to biotic stimulus GO:0009607 294 0.069
Fly
imaginal disc derived wing morphogenesis GO:0007476 337 0.067
regulation of molecular function GO:0065009 217 0.066
regulation of kinase activity GO:0043549 53 0.065
regulation of nervous system development GO:0051960 248 0.061
regulation of response to wounding GO:1903034 19 0.060
hormone catabolic process GO:0042447 3 0.060
regulation of neurogenesis GO:0050767 158 0.059
regulation of multicellular organismal development GO:2000026 414 0.059
positive regulation of defense response to bacterium GO:1900426 23 0.059
Fly
regulation of anatomical structure morphogenesis GO:0022603 242 0.058
gastrulation GO:0007369 70 0.057
regulation of cell development GO:0060284 215 0.056
homeostatic process GO:0042592 199 0.055
humoral immune response GO:0006959 117 0.054
Fly
melanotic encapsulation of foreign target GO:0035011 30 0.053
lipid metabolic process GO:0006629 121 0.052
single organism behavior GO:0044708 391 0.051
regulation of protein modification process GO:0031399 112 0.051
regulation of defense response GO:0031347 102 0.050
Fly
cellular response to organic substance GO:0071310 132 0.047
establishment of localization in cell GO:0051649 402 0.047
wound healing GO:0042060 75 0.047
regulation of catalytic activity GO:0050790 185 0.047
growth GO:0040007 359 0.046
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.045
regulation of cellular protein metabolic process GO:0032268 243 0.045
negative regulation of protein metabolic process GO:0051248 85 0.044
positive regulation of response to stimulus GO:0048584 323 0.043
Fly
cellular amide metabolic process GO:0043603 80 0.042
Fly
negative regulation of cellular protein metabolic process GO:0032269 85 0.041
appendage development GO:0048736 401 0.041
salivary gland histolysis GO:0035070 88 0.040
cellular response to cadmium ion GO:0071276 6 0.040
regulation of protein serine threonine kinase activity GO:0071900 25 0.040
developmental programmed cell death GO:0010623 138 0.039
neurological system process GO:0050877 358 0.037
cellular protein modification process GO:0006464 438 0.036
gliogenesis GO:0042063 80 0.035
cellular response to lipid GO:0071396 20 0.034
response to lipopolysaccharide GO:0032496 4 0.033
regulation of immune response GO:0050776 118 0.033
Fly
aging GO:0007568 143 0.033
nurse cell apoptotic process GO:0045476 17 0.032
regulation of cell size GO:0008361 63 0.032
actin filament organization GO:0007015 126 0.031
chemosensory behavior GO:0007635 106 0.031
regulation of response to external stimulus GO:0032101 115 0.031
Fly
cellular response to chemical stimulus GO:0070887 199 0.031
antimicrobial peptide production GO:0002775 46 0.031
Fly
negative regulation of growth GO:0045926 84 0.030
small molecule metabolic process GO:0044281 305 0.030
defense response to gram positive bacterium GO:0050830 41 0.030
Fly
defense response to bacterium GO:0042742 178 0.029
Fly
regulation of transferase activity GO:0051338 58 0.029
organophosphate metabolic process GO:0019637 195 0.029
dorsal ventral axis specification GO:0009950 66 0.029
Fly
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.029
negative regulation of multicellular organismal process GO:0051241 142 0.029
negative regulation of cell development GO:0010721 62 0.029
pigment biosynthetic process GO:0046148 36 0.028
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.028
regulation of intracellular signal transduction GO:1902531 236 0.028
cellular response to abiotic stimulus GO:0071214 58 0.028
positive regulation of cellular biosynthetic process GO:0031328 316 0.028
Fly
retina development in camera type eye GO:0060041 4 0.028
negative regulation of cell communication GO:0010648 223 0.028
organic substance transport GO:0071702 257 0.027
activation of mapk activity GO:0000187 9 0.027
compound eye development GO:0048749 307 0.027
rhythmic process GO:0048511 106 0.027
regulation of response to biotic stimulus GO:0002831 63 0.027
Fly
regulation of growth GO:0040008 233 0.027
imaginal disc derived appendage morphogenesis GO:0035114 395 0.027
carbohydrate metabolic process GO:0005975 82 0.026
reproductive structure development GO:0048608 74 0.026
organonitrogen compound metabolic process GO:1901564 318 0.026
Fly
positive regulation of catalytic activity GO:0043085 118 0.026
embryonic development via the syncytial blastoderm GO:0001700 148 0.026
positive regulation of immune response GO:0050778 63 0.026
Fly
regulation of innate immune response GO:0045088 71 0.025
Fly
regulation of peptidoglycan recognition protein signaling pathway GO:0061058 4 0.025
regionalization GO:0003002 416 0.025
Fly
regulation of phosphorus metabolic process GO:0051174 210 0.024
gene silencing GO:0016458 138 0.024
regulation of phosphorylation GO:0042325 147 0.024
cell growth GO:0016049 108 0.024
response to sterol GO:0036314 34 0.024
protein modification process GO:0036211 438 0.023
dorsal appendage formation GO:0046843 47 0.023
antimicrobial humoral response GO:0019730 99 0.023
Fly
immune system development GO:0002520 57 0.023
cellular response to arsenic containing substance GO:0071243 6 0.022
mating behavior GO:0007617 106 0.022
cell cell junction assembly GO:0007043 38 0.022
programmed cell death GO:0012501 257 0.022
cellular response to lipopolysaccharide GO:0071222 3 0.022
defense response to other organism GO:0098542 225 0.021
Fly
cell motility GO:0048870 251 0.021
negative regulation of protein processing GO:0010955 31 0.021
negative regulation of response to stimulus GO:0048585 258 0.021
organelle fission GO:0048285 340 0.021
glycerolipid metabolic process GO:0046486 34 0.021
pattern recognition receptor signaling pathway GO:0002221 2 0.021
cuticle pigmentation GO:0048067 22 0.021
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.020
compound eye morphogenesis GO:0001745 249 0.020
regulation of proteolysis GO:0030162 87 0.020
regulation of melanization defense response GO:0035007 6 0.020
Fly
acid secretion GO:0046717 1 0.020
response to oxygen containing compound GO:1901700 200 0.020
transcription from rna polymerase ii promoter GO:0006366 368 0.020
lipopolysaccharide mediated signaling pathway GO:0031663 1 0.020
developmental growth involved in morphogenesis GO:0060560 65 0.019
regulation of neuron projection development GO:0010975 69 0.019
peptidoglycan metabolic process GO:0000270 3 0.019
positive regulation of molecular function GO:0044093 136 0.019
response to alcohol GO:0097305 95 0.019
positive regulation of phosphorus metabolic process GO:0010562 139 0.019
cell death GO:0008219 279 0.019
camera type eye development GO:0043010 4 0.019
regulation of localization GO:0032879 275 0.019
positive regulation of intracellular signal transduction GO:1902533 116 0.019
positive regulation of nucleic acid templated transcription GO:1903508 266 0.019
regulation of protein metabolic process GO:0051246 256 0.019
androgen metabolic process GO:0008209 1 0.018
muscle cell differentiation GO:0042692 103 0.018
secretion GO:0046903 109 0.018
death GO:0016265 284 0.018
positive regulation of macromolecule metabolic process GO:0010604 405 0.018
determination of dorsal ventral asymmetry GO:0048262 3 0.018
negative regulation of neurogenesis GO:0050768 53 0.018
small gtpase mediated signal transduction GO:0007264 88 0.018
regulation of apoptotic process GO:0042981 130 0.018
regulation of anatomical structure size GO:0090066 163 0.018
neutral lipid metabolic process GO:0006638 12 0.018
salivary gland development GO:0007431 162 0.018
cellular response to endogenous stimulus GO:0071495 80 0.018
antibacterial humoral response GO:0019731 44 0.018
Fly
cell projection assembly GO:0030031 94 0.018
cholesterol transport GO:0030301 2 0.018
negative regulation of proteolysis GO:0045861 31 0.018
neurotransmitter catabolic process GO:0042135 1 0.017
extracellular matrix organization GO:0030198 32 0.017
forebrain development GO:0030900 2 0.017
negative regulation of biosynthetic process GO:0009890 277 0.017
response to organic substance GO:0010033 284 0.017
cellular response to nitrogen compound GO:1901699 51 0.017
central nervous system development GO:0007417 201 0.017
thermotaxis GO:0043052 16 0.017
response to uv GO:0009411 24 0.017
negative regulation of signal transduction GO:0009968 206 0.017
zygotic determination of anterior posterior axis embryo GO:0007354 27 0.017
protein phosphorylation GO:0006468 169 0.017
extracellular structure organization GO:0043062 46 0.017
ras protein signal transduction GO:0007265 88 0.017
hemolymph coagulation GO:0042381 10 0.017
histolysis GO:0007559 102 0.016
positive regulation of antimicrobial humoral response GO:0002760 28 0.016
Fly
negative regulation of rna biosynthetic process GO:1902679 240 0.016
regulation of transport GO:0051049 181 0.016
connective tissue development GO:0061448 3 0.016
benzene containing compound metabolic process GO:0042537 3 0.016
regulation of protein processing GO:0070613 32 0.016
regeneration GO:0031099 16 0.016
anatomical structure homeostasis GO:0060249 97 0.016
regulation of protein phosphorylation GO:0001932 64 0.016
ovarian follicle cell development GO:0030707 248 0.016
salivary gland morphogenesis GO:0007435 145 0.016
blastoderm segmentation GO:0007350 159 0.016
positive regulation of production of molecular mediator of immune response GO:0002702 28 0.016
Fly
regulation of antimicrobial peptide production GO:0002784 44 0.016
Fly
extracellular matrix disassembly GO:0022617 4 0.015
tissue morphogenesis GO:0048729 297 0.015
positive regulation of multi organism process GO:0043902 40 0.015
Fly
positive regulation of transcription dna templated GO:0045893 266 0.015
regulation of cell cycle process GO:0010564 181 0.015
amide biosynthetic process GO:0043604 42 0.015
Fly
single organism carbohydrate metabolic process GO:0044723 72 0.015
ovarian follicle cell migration GO:0007297 121 0.015
chitin based cuticle sclerotization GO:0007593 19 0.015
endomembrane system organization GO:0010256 119 0.015
organonitrogen compound biosynthetic process GO:1901566 117 0.015
Fly
regulation of cell cycle GO:0051726 291 0.015
cellular amine metabolic process GO:0044106 12 0.015
regulation of antimicrobial peptide biosynthetic process GO:0002805 38 0.015
Fly
ion transport GO:0006811 145 0.015
eggshell formation GO:0030703 105 0.015
regulation of gene expression epigenetic GO:0040029 128 0.015
regulation of mitotic cell cycle GO:0007346 190 0.015
intracellular signal transduction GO:0035556 300 0.014
negative regulation of transcription dna templated GO:0045892 237 0.014
negative regulation of defense response GO:0031348 35 0.014
positive regulation of response to biotic stimulus GO:0002833 31 0.014
Fly
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.014
positive regulation of protein kinase activity GO:0045860 25 0.014
regulation of cellular ketone metabolic process GO:0010565 3 0.014
positive regulation of antifungal peptide biosynthetic process GO:0006967 5 0.014
regulation of cell substrate adhesion GO:0010810 2 0.014
regulation of mapk cascade GO:0043408 92 0.014
signal transduction by phosphorylation GO:0023014 107 0.013
regulation of nuclear division GO:0051783 58 0.013
immune response regulating signaling pathway GO:0002764 2 0.013
cellular response to peptide hormone stimulus GO:0071375 28 0.013
fatty acid homeostasis GO:0055089 2 0.013
epiboly involved in wound healing GO:0090505 2 0.013
apoptotic process GO:0006915 159 0.013
regulation of cellular component biogenesis GO:0044087 201 0.013
regulation of insulin receptor signaling pathway GO:0046626 17 0.013
mesoderm development GO:0007498 78 0.013
cellular amino acid metabolic process GO:0006520 61 0.013
amine metabolic process GO:0009308 12 0.013
jak stat cascade GO:0007259 49 0.013
response to temperature stimulus GO:0009266 106 0.013
eye development GO:0001654 323 0.013
imaginal disc derived wing vein morphogenesis GO:0008586 44 0.013
mitotic spindle organization GO:0007052 220 0.013
exocrine system development GO:0035272 162 0.013
epithelial cell development GO:0002064 274 0.013
catabolic process GO:0009056 409 0.013
cellular response to oxygen containing compound GO:1901701 79 0.013
nuclear dna replication GO:0033260 1 0.013
cellular response to biotic stimulus GO:0071216 4 0.013
organelle localization GO:0051640 148 0.013
cellular lipid metabolic process GO:0044255 83 0.013
regulation of secretion GO:0051046 44 0.013
negative regulation of cellular biosynthetic process GO:0031327 277 0.013
neural retina development GO:0003407 4 0.012
dendrite development GO:0016358 204 0.012
organic acid metabolic process GO:0006082 103 0.012
regulation of phosphate metabolic process GO:0019220 210 0.012
positive regulation of antibacterial peptide biosynthetic process GO:0006963 20 0.012
Fly
regulation of notch signaling pathway GO:0008593 100 0.012
peptidyl amino acid modification GO:0018193 105 0.012
localization of cell GO:0051674 257 0.012
spindle organization GO:0007051 253 0.012
negative regulation of chromosome organization GO:2001251 19 0.012
rrna processing GO:0006364 3 0.012
compound eye photoreceptor cell differentiation GO:0001751 140 0.012
hematopoietic or lymphoid organ development GO:0048534 57 0.012
negative regulation of protein maturation GO:1903318 31 0.012
biological adhesion GO:0022610 138 0.012
regulation of cell proliferation GO:0042127 163 0.012
regulation of humoral immune response GO:0002920 51 0.011
Fly
regulation of developmental growth GO:0048638 174 0.011
regulation of biosynthetic process of antibacterial peptides active against gram negative bacteria GO:0002813 14 0.011
Fly
basement membrane organization GO:0071711 10 0.011
cation transport GO:0006812 110 0.011
cell migration GO:0016477 238 0.011
regulation of cell division GO:0051302 72 0.011
positive regulation of protein metabolic process GO:0051247 128 0.011
epiboly GO:0090504 2 0.011
negative regulation of cell differentiation GO:0045596 143 0.011
metal ion transport GO:0030001 74 0.011
regulation of adult chitin containing cuticle pigmentation GO:0048082 13 0.011
regulation of cell projection organization GO:0031344 92 0.011
positive regulation of rna biosynthetic process GO:1902680 266 0.011
cellular response to molecule of bacterial origin GO:0071219 3 0.011
olfactory behavior GO:0042048 97 0.011
regulation of immune effector process GO:0002697 52 0.011
Fly
cell adhesion GO:0007155 136 0.011
regulation of cellular amine metabolic process GO:0033238 3 0.011
posttranscriptional regulation of gene expression GO:0010608 145 0.011
body morphogenesis GO:0010171 2 0.011
golgi organization GO:0007030 66 0.011
negative regulation of nervous system development GO:0051961 92 0.011
development of primary sexual characteristics GO:0045137 50 0.011
immune effector process GO:0002252 98 0.011
Fly
taxis GO:0042330 304 0.011
triglyceride biosynthetic process GO:0019432 2 0.011
regulation of map kinase activity GO:0043405 17 0.011
regulation of bmp signaling pathway GO:0030510 23 0.011
cellular ketone metabolic process GO:0042180 24 0.011
chorion containing eggshell formation GO:0007304 105 0.011
lipid modification GO:0030258 24 0.011
carbohydrate derivative metabolic process GO:1901135 217 0.011
positive regulation of innate immune response GO:0045089 38 0.010
Fly
mesodermal cell differentiation GO:0048333 7 0.010
chromosome segregation GO:0007059 157 0.010
actin filament based process GO:0030029 220 0.010
trachea development GO:0060438 29 0.010

MP1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.020
congenital heart disease DOID:1682 0 0.016
heart disease DOID:114 0 0.016
cardiovascular system disease DOID:1287 0 0.016