Drosophila melanogaster

31 known processes

GRHR (Dmel_CG11325)

Gonadotropin-releasing hormone receptor

(Aliases: DGRHR,AKHR,Akhr,DAKHR,BEST:GH19447,CG11325,GnRHR,GRHR/CG11325,Dmel\CG11325,DAKHR-1)

GRHR biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
acylglycerol catabolic process GO:0046464 3 0.779
regulation of lipid storage GO:0010883 22 0.542
triglyceride catabolic process GO:0019433 3 0.476
lipid catabolic process GO:0016042 21 0.309
chemical homeostasis GO:0048878 92 0.219
triglyceride metabolic process GO:0006641 12 0.198
neutral lipid biosynthetic process GO:0046460 2 0.182
lipid homeostasis GO:0055088 33 0.181
acylglycerol biosynthetic process GO:0046463 2 0.166
positive regulation of lipid storage GO:0010884 4 0.156
regulation of sequestering of triglyceride GO:0010889 3 0.154
acylglycerol metabolic process GO:0006639 12 0.154
lipid metabolic process GO:0006629 121 0.137
imaginal disc derived wing morphogenesis GO:0007476 337 0.133
imaginal disc derived appendage morphogenesis GO:0035114 395 0.128
triglyceride biosynthetic process GO:0019432 2 0.128
neutral lipid catabolic process GO:0046461 3 0.127
cellular catabolic process GO:0044248 372 0.120
glycerolipid catabolic process GO:0046503 3 0.114
neuropeptide signaling pathway GO:0007218 45 0.113
Fly
organic substance transport GO:0071702 257 0.101
maintenance of location GO:0051235 73 0.100
cellular lipid metabolic process GO:0044255 83 0.097
wing disc morphogenesis GO:0007472 344 0.094
neutral lipid metabolic process GO:0006638 12 0.094
glycerolipid metabolic process GO:0046486 34 0.090
response to starvation GO:0042594 97 0.087
protein localization GO:0008104 284 0.087
regulation of localization GO:0032879 275 0.086
post embryonic appendage morphogenesis GO:0035120 385 0.080
imaginal disc derived appendage development GO:0048737 399 0.079
small molecule metabolic process GO:0044281 305 0.078
positive regulation of lipid metabolic process GO:0045834 4 0.077
lipid storage GO:0019915 38 0.076
lipid localization GO:0010876 54 0.075
appendage morphogenesis GO:0035107 397 0.071
programmed cell death GO:0012501 257 0.063
cellular lipid catabolic process GO:0044242 16 0.060
salivary gland morphogenesis GO:0007435 145 0.059
cellular protein localization GO:0034613 160 0.057
homeostatic process GO:0042592 199 0.056
aging GO:0007568 143 0.056
cellular metal ion homeostasis GO:0006875 31 0.054
sterol homeostasis GO:0055092 4 0.051
salivary gland development GO:0007431 162 0.050
exocrine system development GO:0035272 162 0.048
appendage development GO:0048736 401 0.047
tissue death GO:0016271 102 0.046
developmental programmed cell death GO:0010623 138 0.045
single organism catabolic process GO:0044712 228 0.044
death GO:0016265 284 0.043
cation homeostasis GO:0055080 51 0.042
anion homeostasis GO:0055081 3 0.040
gland development GO:0048732 191 0.040
regulation of mitotic cell cycle GO:0007346 190 0.039
cholesterol homeostasis GO:0042632 3 0.038
response to abiotic stimulus GO:0009628 341 0.038
regulation of cell cycle GO:0051726 291 0.038
response to alcohol GO:0097305 95 0.037
Fly
cellular cation homeostasis GO:0030003 38 0.037
cellular protein modification process GO:0006464 438 0.037
cell death GO:0008219 279 0.037
divalent inorganic cation homeostasis GO:0072507 29 0.037
lipid biosynthetic process GO:0008610 46 0.036
oxoacid metabolic process GO:0043436 103 0.036
organic substance catabolic process GO:1901575 308 0.036
cellular response to lipopolysaccharide GO:0071222 3 0.035
autophagic cell death GO:0048102 83 0.035
negative regulation of cellular biosynthetic process GO:0031327 277 0.032
cellular divalent inorganic cation homeostasis GO:0072503 23 0.032
response to nutrient levels GO:0031667 114 0.031
negative regulation of nucleic acid templated transcription GO:1903507 240 0.031
macromolecular complex assembly GO:0065003 256 0.031
response to organic substance GO:0010033 284 0.031
Zebrafish Fly
organic acid metabolic process GO:0006082 103 0.031
regulation of cell differentiation GO:0045595 302 0.030
cellular ion homeostasis GO:0006873 39 0.030
phospholipid homeostasis GO:0055091 1 0.029
response to biotic stimulus GO:0009607 294 0.029
triglyceride homeostasis GO:0070328 18 0.029
fat soluble vitamin biosynthetic process GO:0042362 1 0.029
endocytosis GO:0006897 310 0.029
lipid modification GO:0030258 24 0.028
response to lipopolysaccharide GO:0032496 4 0.028
metal ion homeostasis GO:0055065 44 0.028
taxis GO:0042330 304 0.028
catabolic process GO:0009056 409 0.027
multicellular organismal aging GO:0010259 140 0.027
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.027
salivary gland histolysis GO:0035070 88 0.027
positive regulation of signaling GO:0023056 243 0.027
establishment of localization in cell GO:0051649 402 0.027
regulation of lipid metabolic process GO:0019216 15 0.027
developmental growth GO:0048589 280 0.026
nitrogen compound transport GO:0071705 85 0.026
positive regulation of cellular catabolic process GO:0031331 95 0.026
immune system process GO:0002376 347 0.026
positive regulation of lipid catabolic process GO:0050996 1 0.026
defense response to bacterium GO:0042742 178 0.026
sensory perception GO:0007600 196 0.026
organonitrogen compound metabolic process GO:1901564 318 0.025
cell recognition GO:0008037 102 0.025
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.024
response to extracellular stimulus GO:0009991 116 0.024
g protein coupled receptor signaling pathway GO:0007186 136 0.024
single organism biosynthetic process GO:0044711 206 0.024
spermatogenesis GO:0007283 200 0.024
cellular macromolecule localization GO:0070727 220 0.024
determination of adult lifespan GO:0008340 137 0.024
telencephalon development GO:0021537 2 0.024
chemosensory behavior GO:0007635 106 0.023
regulation of cell death GO:0010941 173 0.023
cholesterol transport GO:0030301 2 0.023
apoptotic process GO:0006915 159 0.023
negative regulation of rna metabolic process GO:0051253 251 0.023
cellular response to chemical stimulus GO:0070887 199 0.023
Zebrafish Fly
histolysis GO:0007559 102 0.023
open tracheal system development GO:0007424 204 0.023
negative regulation of biosynthetic process GO:0009890 277 0.023
oxidation reduction process GO:0055114 123 0.023
forebrain development GO:0030900 2 0.022
positive regulation of cell communication GO:0010647 250 0.022
regulation of catabolic process GO:0009894 170 0.022
cellular homeostasis GO:0019725 80 0.022
transcription from rna polymerase ii promoter GO:0006366 368 0.022
mitochondrion organization GO:0007005 65 0.022
acetylcholine metabolic process GO:0008291 2 0.022
phagocytosis GO:0006909 215 0.021
cellular calcium ion homeostasis GO:0006874 21 0.021
regulation of molecular function GO:0065009 217 0.021
alcohol metabolic process GO:0006066 25 0.021
connective tissue development GO:0061448 3 0.021
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.021
regulation of organelle organization GO:0033043 196 0.021
cellular ketone metabolic process GO:0042180 24 0.021
response to wounding GO:0009611 94 0.021
defense response to other organism GO:0098542 225 0.021
salivary gland cell autophagic cell death GO:0035071 83 0.020
organophosphate metabolic process GO:0019637 195 0.020
regulation of protein metabolic process GO:0051246 256 0.020
establishment of protein localization GO:0045184 163 0.020
calcium ion homeostasis GO:0055074 23 0.020
response to light stimulus GO:0009416 124 0.020
regulation of cellular ketone metabolic process GO:0010565 3 0.019
cellular response to biotic stimulus GO:0071216 4 0.019
regulation of multicellular organismal development GO:2000026 414 0.019
cellular amine metabolic process GO:0044106 12 0.019
antimicrobial humoral response GO:0019730 99 0.019
cellular response to heat GO:0034605 24 0.019
carboxylic acid metabolic process GO:0019752 92 0.019
positive regulation of gene expression GO:0010628 290 0.019
protein complex assembly GO:0006461 200 0.019
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 4 0.019
body morphogenesis GO:0010171 2 0.019
defense response GO:0006952 300 0.019
vesicle mediated transport GO:0016192 381 0.018
cellular response to oxygen containing compound GO:1901701 79 0.018
Zebrafish Fly
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.018
protein modification process GO:0036211 438 0.018
eye photoreceptor cell development GO:0042462 81 0.018
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.018
positive regulation of nucleic acid templated transcription GO:1903508 266 0.018
lipid particle organization GO:0034389 7 0.018
regulation of tube architecture open tracheal system GO:0035152 68 0.018
immune response GO:0006955 246 0.018
cellular response to starvation GO:0009267 61 0.018
choline catabolic process GO:0042426 1 0.018
response to monosaccharide GO:0034284 4 0.018
positive regulation of apoptotic signaling pathway GO:2001235 4 0.018
regulation of transport GO:0051049 181 0.017
choline metabolic process GO:0019695 1 0.017
positive regulation of signal transduction GO:0009967 223 0.017
acetylcholine catabolic process GO:0006581 1 0.017
regulation of cellular amine metabolic process GO:0033238 3 0.017
extrinsic apoptotic signaling pathway GO:0097191 1 0.017
gland morphogenesis GO:0022612 145 0.017
regulation of cellular catabolic process GO:0031329 157 0.017
response to oxygen containing compound GO:1901700 200 0.016
Zebrafish Fly
positive regulation of rna biosynthetic process GO:1902680 266 0.016
nucleobase containing small molecule metabolic process GO:0055086 174 0.016
regulation of microtubule cytoskeleton organization GO:0070507 41 0.016
dorsal ventral pattern formation GO:0009953 133 0.016
cellular response to organic substance GO:0071310 132 0.016
Zebrafish Fly
response to radiation GO:0009314 155 0.016
response to glucose GO:0009749 2 0.016
wnt signaling pathway GO:0016055 98 0.016
protein transport GO:0015031 155 0.016
regulation of catalytic activity GO:0050790 185 0.016
response to external biotic stimulus GO:0043207 293 0.015
response to other organism GO:0051707 293 0.015
cellular response to molecule of bacterial origin GO:0071219 3 0.015
response to desiccation GO:0009269 3 0.015
adult behavior GO:0030534 137 0.015
Fly
ion homeostasis GO:0050801 55 0.015
eye development GO:0001654 323 0.015
regulation of epithelial cell differentiation GO:0030856 4 0.015
positive regulation of molecular function GO:0044093 136 0.015
positive regulation of multicellular organismal process GO:0051240 143 0.015
positive regulation of cell death GO:0010942 69 0.015
detection of stimulus GO:0051606 156 0.015
positive regulation of cell migration GO:0030335 2 0.015
tissue morphogenesis GO:0048729 297 0.015
response to water deprivation GO:0009414 4 0.015
respiratory system development GO:0060541 213 0.015
response to sterol GO:0036314 34 0.015
single organism behavior GO:0044708 391 0.015
Fly
negative regulation of developmental process GO:0051093 201 0.015
defense response to gram negative bacterium GO:0050829 94 0.014
positive regulation of programmed cell death GO:0043068 62 0.014
carbohydrate derivative metabolic process GO:1901135 217 0.014
cellular response to nutrient levels GO:0031669 62 0.014
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.014
phosphatidic acid metabolic process GO:0046473 1 0.014
eye pigment metabolic process GO:0042441 33 0.014
wound healing GO:0042060 75 0.014
positive regulation of response to stimulus GO:0048584 323 0.014
response to organic cyclic compound GO:0014070 89 0.014
regulation of cellular amino acid metabolic process GO:0006521 0 0.014
adult locomotory behavior GO:0008344 76 0.014
negative regulation of gene expression GO:0010629 387 0.014
vitamin metabolic process GO:0006766 2 0.014
regulation of cell cycle phase transition GO:1901987 130 0.014
mesenchymal cell development GO:0014031 1 0.014
positive regulation of developmental process GO:0051094 143 0.014
cell maturation GO:0048469 144 0.014
neurotransmitter catabolic process GO:0042135 1 0.014
single organism intracellular transport GO:1902582 207 0.014
cellular response to hormone stimulus GO:0032870 44 0.013
Zebrafish
camera type eye development GO:0043010 4 0.013
cell cycle phase transition GO:0044770 140 0.013
organelle assembly GO:0070925 198 0.013
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.013
chromosome organization GO:0051276 360 0.013
acylglycerol homeostasis GO:0055090 19 0.013
regionalization GO:0003002 416 0.013
positive regulation of catalytic activity GO:0043085 118 0.013
central nervous system development GO:0007417 201 0.013
negative regulation of cell differentiation GO:0045596 143 0.013
ethanolamine containing compound metabolic process GO:0042439 4 0.013
cellular response to radiation GO:0071478 52 0.013
androgen metabolic process GO:0008209 1 0.013
heart process GO:0003015 37 0.013
larval midgut histolysis GO:0035069 22 0.013
negative regulation of cell death GO:0060548 81 0.013
growth GO:0040007 359 0.013
biological adhesion GO:0022610 138 0.013
fatty acid beta oxidation GO:0006635 6 0.013
neuron projection guidance GO:0097485 241 0.013
actin cytoskeleton organization GO:0030036 206 0.012
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.012
detection of chemical stimulus GO:0009593 93 0.012
leg disc morphogenesis GO:0007478 80 0.012
cell motility GO:0048870 251 0.012
hematopoietic or lymphoid organ development GO:0048534 57 0.012
cellular response to abiotic stimulus GO:0071214 58 0.012
compound eye photoreceptor cell differentiation GO:0001751 140 0.012
protein complex biogenesis GO:0070271 201 0.012
regulation of programmed cell death GO:0043067 152 0.012
positive regulation of cell motility GO:2000147 3 0.012
mesenchymal cell differentiation GO:0048762 1 0.012
response to organophosphorus GO:0046683 2 0.012
detection of visible light GO:0009584 38 0.012
amine metabolic process GO:0009308 12 0.012
negative regulation of response to stimulus GO:0048585 258 0.012
negative regulation of rna biosynthetic process GO:1902679 240 0.012
positive regulation of catabolic process GO:0009896 105 0.012
fat soluble vitamin metabolic process GO:0006775 1 0.012
positive regulation of rna metabolic process GO:0051254 271 0.012
response to hexose GO:0009746 3 0.012
protein import GO:0017038 55 0.012
ovarian follicle cell development GO:0030707 248 0.012
non sensory hair organization GO:0035316 47 0.012
neurotransmitter metabolic process GO:0042133 2 0.012
monocarboxylic acid transport GO:0015718 3 0.012
retina development in camera type eye GO:0060041 4 0.011
phototaxis GO:0042331 21 0.011
regulation of epithelial cell proliferation GO:0050678 4 0.011
compound eye photoreceptor development GO:0042051 78 0.011
negative regulation of cell communication GO:0010648 223 0.011
negative regulation of growth GO:0045926 84 0.011
regulation of mitotic cell cycle phase transition GO:1901990 130 0.011
negative regulation of mitotic cell cycle GO:0045930 109 0.011
negative regulation of cellular metabolic process GO:0031324 382 0.011
cellular response to endogenous stimulus GO:0071495 80 0.011
Zebrafish
positive regulation of cell differentiation GO:0045597 64 0.011
regulation of anatomical structure morphogenesis GO:0022603 242 0.011
ribonucleotide metabolic process GO:0009259 145 0.011
positive regulation of transcription dna templated GO:0045893 266 0.011
pigment biosynthetic process GO:0046148 36 0.011
compound eye development GO:0048749 307 0.011
regulation of gene expression epigenetic GO:0040029 128 0.011
imaginal disc derived leg morphogenesis GO:0007480 80 0.011
response to oxidative stress GO:0006979 86 0.011
response to hypoxia GO:0001666 53 0.011
detection of abiotic stimulus GO:0009582 66 0.011
peripheral nervous system development GO:0007422 52 0.011
cellular chemical homeostasis GO:0055082 40 0.011
energy taxis GO:0009453 21 0.011
nucleoside phosphate metabolic process GO:0006753 162 0.011
mitotic spindle organization GO:0007052 220 0.011
anatomical structure homeostasis GO:0060249 97 0.011
rna processing GO:0006396 147 0.011
regulation of i kappab kinase nf kappab signaling GO:0043122 2 0.011
neuromuscular synaptic transmission GO:0007274 67 0.011
response to bacterium GO:0009617 198 0.010
heart development GO:0007507 82 0.010
organic acid catabolic process GO:0016054 16 0.010
imaginal disc pattern formation GO:0007447 91 0.010
regulation of hydrolase activity GO:0051336 97 0.010
cellular response to lipid GO:0071396 20 0.010
response to endogenous stimulus GO:0009719 119 0.010
Zebrafish
cellular component assembly involved in morphogenesis GO:0010927 151 0.010
single organism carbohydrate metabolic process GO:0044723 72 0.010
positive regulation of biosynthetic process GO:0009891 316 0.010
dendrite development GO:0016358 204 0.010
regulation of anatomical structure size GO:0090066 163 0.010
synaptic target recognition GO:0008039 45 0.010
lateral inhibition GO:0046331 206 0.010
epithelial cell differentiation GO:0030855 322 0.010
smoothened signaling pathway GO:0007224 49 0.010

GRHR disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.043
acquired metabolic disease DOID:0060158 0 0.043
disease of anatomical entity DOID:7 0 0.043
carbohydrate metabolism disease DOID:0050013 0 0.027
glucose metabolism disease DOID:4194 0 0.027
familial hypertriglyceridemia DOID:0050527 0 0.020
lipid metabolism disorder DOID:3146 0 0.020
inherited metabolic disorder DOID:655 0 0.020
musculoskeletal system disease DOID:17 0 0.020
nervous system disease DOID:863 0 0.018
diabetes mellitus DOID:9351 0 0.018
type 2 diabetes mellitus DOID:9352 0 0.018
hair disease DOID:421 0 0.016
integumentary system disease DOID:16 0 0.016
hypotrichosis DOID:4535 0 0.016
amyloidosis DOID:9120 0 0.011
familial visceral amyloidosis DOID:0050636 0 0.011
bone disease DOID:0080001 0 0.011
connective tissue disease DOID:65 0 0.011