Drosophila melanogaster

160 known processes

pygo (Dmel_CG11518)

pygopus

(Aliases: pyg,Dmel\CG11518,anon-WO02077023.1,BEST:LD21971,gam,pypo,CG11518,pNB5.2,dPygo,Pygo)

pygo biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of cell cycle GO:0051726 291 0.842
chromosome organization GO:0051276 360 0.836
protein modification process GO:0036211 438 0.806
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.774
axon development GO:0061564 297 0.705
cellular protein modification process GO:0006464 438 0.623
establishment of organelle localization GO:0051656 122 0.595
negative regulation of cell communication GO:0010648 223 0.557
imaginal disc derived leg morphogenesis GO:0007480 80 0.555
appendage development GO:0048736 401 0.523
regulation of neurogenesis GO:0050767 158 0.493
regulation of wnt signaling pathway GO:0030111 68 0.492
post embryonic appendage morphogenesis GO:0035120 385 0.490
negative regulation of rna metabolic process GO:0051253 251 0.410
positive regulation of rna metabolic process GO:0051254 271 0.407
imaginal disc derived appendage development GO:0048737 399 0.401
negative regulation of signal transduction GO:0009968 206 0.390
wing disc morphogenesis GO:0007472 344 0.361
negative regulation of response to stimulus GO:0048585 258 0.358
negative regulation of nucleic acid templated transcription GO:1903507 240 0.350
transcription from rna polymerase ii promoter GO:0006366 368 0.349
chromatin organization GO:0006325 207 0.342
rna processing GO:0006396 147 0.314
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.312
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.305
positive regulation of nucleic acid templated transcription GO:1903508 266 0.297
eye development GO:0001654 323 0.296
intracellular transport GO:0046907 228 0.282
regulation of anatomical structure morphogenesis GO:0022603 242 0.279
imaginal disc derived appendage morphogenesis GO:0035114 395 0.277
regionalization GO:0003002 416 0.273
imaginal disc derived wing margin morphogenesis GO:0008587 41 0.268
stem cell development GO:0048864 79 0.263
regulation of multicellular organismal development GO:2000026 414 0.255
axonogenesis GO:0007409 290 0.243
regulation of developmental pigmentation GO:0048070 24 0.241
establishment of localization in cell GO:0051649 402 0.237
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.229
single organism cellular localization GO:1902580 180 0.226
periodic partitioning GO:0007365 29 0.223
blastoderm segmentation GO:0007350 159 0.219
regulation of nervous system development GO:0051960 248 0.210
negative regulation of biosynthetic process GO:0009890 277 0.209
cellular response to dna damage stimulus GO:0006974 223 0.207
anterior posterior pattern specification GO:0009952 136 0.206
axon guidance GO:0007411 233 0.202
leg disc morphogenesis GO:0007478 80 0.202
organelle localization GO:0051640 148 0.201
appendage morphogenesis GO:0035107 397 0.196
cell cycle phase transition GO:0044770 140 0.192
segmentation GO:0035282 207 0.181
regulation of mitotic cell cycle phase transition GO:1901990 130 0.180
regulation of programmed cell death GO:0043067 152 0.178
negative regulation of signaling GO:0023057 219 0.177
negative regulation of wnt signaling pathway GO:0030178 28 0.159
response to nitrogen compound GO:1901698 90 0.158
positive regulation of response to stimulus GO:0048584 323 0.157
circulatory system development GO:0072359 82 0.156
segment polarity determination GO:0007367 25 0.153
posttranscriptional regulation of gene expression GO:0010608 145 0.152
leg disc development GO:0035218 92 0.147
forebrain development GO:0030900 2 0.145
peptidyl amino acid modification GO:0018193 105 0.143
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.142
negative regulation of cellular metabolic process GO:0031324 382 0.139
regulation of protein modification process GO:0031399 112 0.137
negative regulation of cellular biosynthetic process GO:0031327 277 0.125
covalent chromatin modification GO:0016569 106 0.123
g2 dna damage checkpoint GO:0031572 69 0.121
positive regulation of protein metabolic process GO:0051247 128 0.121
regulation of protein transport GO:0051223 57 0.121
cardiovascular system development GO:0072358 82 0.120
mitotic cell cycle phase transition GO:0044772 138 0.118
regulation of cellular localization GO:0060341 136 0.117
cell motility GO:0048870 251 0.116
imaginal disc pattern formation GO:0007447 91 0.114
positive regulation of rna biosynthetic process GO:1902680 266 0.112
endocytosis GO:0006897 310 0.111
protein modification by small protein conjugation or removal GO:0070647 106 0.111
regulation of eye pigmentation GO:0048073 7 0.111
neuron projection guidance GO:0097485 241 0.110
regulation of mitotic cell cycle GO:0007346 190 0.107
protein localization GO:0008104 284 0.106
body morphogenesis GO:0010171 2 0.105
positive regulation of transcription dna templated GO:0045893 266 0.105
cell proliferation GO:0008283 299 0.102
telencephalon development GO:0021537 2 0.102
regulation of cellular amine metabolic process GO:0033238 3 0.101
regulation of neuron differentiation GO:0045664 103 0.101
modification dependent macromolecule catabolic process GO:0043632 79 0.100
negative regulation of rna biosynthetic process GO:1902679 240 0.100
embryo development ending in birth or egg hatching GO:0009792 152 0.098
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.097
neuroblast proliferation GO:0007405 74 0.096
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.095
hindbrain development GO:0030902 2 0.092
embryonic pattern specification GO:0009880 174 0.090
appendage segmentation GO:0035285 26 0.089
cuticle development GO:0042335 86 0.089
chromatin modification GO:0016568 147 0.088
developmental growth GO:0048589 280 0.086
regulation of phosphorylation GO:0042325 147 0.086
histone modification GO:0016570 106 0.086
actin filament based process GO:0030029 220 0.085
regulation of cell proliferation GO:0042127 163 0.084
regulation of cell death GO:0010941 173 0.084
regulation of cellular ketone metabolic process GO:0010565 3 0.083
positive regulation of macromolecule metabolic process GO:0010604 405 0.082
regulation of organelle organization GO:0033043 196 0.081
protein phosphorylation GO:0006468 169 0.080
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.080
proteolysis GO:0006508 192 0.080
protein ubiquitination GO:0016567 70 0.078
negative regulation of cytoskeleton organization GO:0051494 30 0.078
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.076
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.075
limb morphogenesis GO:0035108 1 0.075
stem cell differentiation GO:0048863 117 0.075
central nervous system development GO:0007417 201 0.072
regulation of cell development GO:0060284 215 0.072
organic acid metabolic process GO:0006082 103 0.071
tube development GO:0035295 244 0.071
positive regulation of signal transduction GO:0009967 223 0.070
larval development GO:0002164 104 0.068
epithelial tube morphogenesis GO:0060562 88 0.068
gene silencing by rna GO:0031047 57 0.067
proteasomal protein catabolic process GO:0010498 59 0.067
developmental growth involved in morphogenesis GO:0060560 65 0.067
positive regulation of gene expression GO:0010628 290 0.067
regulation of cell cycle phase transition GO:1901987 130 0.066
stem cell maintenance GO:0019827 67 0.064
negative regulation of epithelial cell proliferation GO:0050680 4 0.064
cell migration GO:0016477 238 0.064
negative regulation of developmental process GO:0051093 201 0.062
actin cytoskeleton organization GO:0030036 206 0.062
tissue morphogenesis GO:0048729 297 0.062
regulation of compound eye pigmentation GO:0048076 7 0.061
regulation of cellular amino acid metabolic process GO:0006521 0 0.060
regulation of developmental growth GO:0048638 174 0.060
compound eye development GO:0048749 307 0.060
single organism intracellular transport GO:1902582 207 0.059
spindle organization GO:0007051 253 0.059
positive regulation of cellular component organization GO:0051130 156 0.058
positive regulation of biosynthetic process GO:0009891 316 0.058
trachea development GO:0060438 29 0.058
phosphorylation GO:0016310 294 0.057
cellular protein localization GO:0034613 160 0.056
respiratory system development GO:0060541 213 0.055
single organism behavior GO:0044708 391 0.055
canonical wnt signaling pathway GO:0060070 21 0.054
homeostatic process GO:0042592 199 0.052
regulation of intracellular transport GO:0032386 64 0.052
non canonical wnt signaling pathway GO:0035567 8 0.052
oxoacid metabolic process GO:0043436 103 0.051
ubiquitin dependent protein catabolic process GO:0006511 78 0.051
digestive tract development GO:0048565 149 0.051
maintenance of protein location in cell GO:0032507 26 0.050
cellular amine metabolic process GO:0044106 12 0.049
branching morphogenesis of an epithelial tube GO:0048754 45 0.049
protein modification by small protein conjugation GO:0032446 79 0.049
brain development GO:0007420 120 0.048
imaginal disc derived wing morphogenesis GO:0007476 337 0.048
regulation of cytoplasmic transport GO:1903649 47 0.046
smoothened signaling pathway GO:0007224 49 0.045
regulation of cellular protein metabolic process GO:0032268 243 0.045
positive regulation of hh target transcription factor activity GO:0007228 5 0.044
posttranscriptional gene silencing by rna GO:0035194 45 0.043
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.043
intracellular signal transduction GO:0035556 300 0.043
cellular amino acid metabolic process GO:0006520 61 0.043
establishment of spindle localization GO:0051293 22 0.042
single organism membrane organization GO:0044802 93 0.042
regulation of cell cycle process GO:0010564 181 0.041
protein localization to organelle GO:0033365 82 0.040
synapse organization GO:0050808 196 0.039
cellular ketone metabolic process GO:0042180 24 0.039
regulation of transport GO:0051049 181 0.039
convergent extension GO:0060026 2 0.039
regulation of epithelial cell proliferation GO:0050678 4 0.038
positive regulation of molecular function GO:0044093 136 0.038
response to external biotic stimulus GO:0043207 293 0.037
immune system process GO:0002376 347 0.037
tube morphogenesis GO:0035239 191 0.037
regulation of cell differentiation GO:0045595 302 0.037
regulation of intracellular signal transduction GO:1902531 236 0.036
imaginal disc derived wing vein morphogenesis GO:0008586 44 0.036
positive regulation of wnt signaling pathway GO:0030177 25 0.036
apoptotic process GO:0006915 159 0.036
developmental pigmentation GO:0048066 68 0.035
regulation of catabolic process GO:0009894 170 0.035
regulation of ras protein signal transduction GO:0046578 93 0.035
mitotic g2 dna damage checkpoint GO:0007095 69 0.035
cellular protein catabolic process GO:0044257 83 0.035
regulation of protein metabolic process GO:0051246 256 0.035
adult behavior GO:0030534 137 0.034
signal transduction downstream of smoothened GO:0007227 5 0.034
regulation of apoptotic process GO:0042981 130 0.034
wnt signaling pathway GO:0016055 98 0.034
death GO:0016265 284 0.033
protein transport GO:0015031 155 0.033
morphogenesis of an epithelium GO:0002009 276 0.032
wing disc dorsal ventral pattern formation GO:0048190 47 0.032
intraciliary transport GO:0042073 8 0.031
embryonic development via the syncytial blastoderm GO:0001700 148 0.031
programmed cell death GO:0012501 257 0.030
limb development GO:0060173 1 0.030
negative regulation of g1 s transition of mitotic cell cycle GO:2000134 13 0.030
negative regulation of cell cycle GO:0045786 116 0.030
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.030
cell cycle g1 s phase transition GO:0044843 31 0.029
positive regulation of signaling GO:0023056 243 0.029
response to organonitrogen compound GO:0010243 75 0.029
organonitrogen compound metabolic process GO:1901564 318 0.029
positive regulation of phosphorylation GO:0042327 87 0.029
regulation of phosphorus metabolic process GO:0051174 210 0.029
macromolecular complex assembly GO:0065003 256 0.029
anatomical structure homeostasis GO:0060249 97 0.029
response to nutrient levels GO:0031667 114 0.029
defense response GO:0006952 300 0.029
eye photoreceptor cell differentiation GO:0001754 145 0.028
phagocytosis GO:0006909 215 0.028
pigmentation GO:0043473 75 0.028
regulation of growth GO:0040008 233 0.028
protein catabolic process GO:0030163 101 0.028
negative regulation of cellular protein metabolic process GO:0032269 85 0.028
vesicle localization GO:0051648 55 0.028
single organism catabolic process GO:0044712 228 0.027
regulation of proteolysis GO:0030162 87 0.027
regulation of microtubule based process GO:0032886 49 0.027
reproductive structure development GO:0048608 74 0.027
protein targeting to nucleus GO:0044744 51 0.027
membrane organization GO:0061024 112 0.026
retina development in camera type eye GO:0060041 4 0.026
negative regulation of gene expression GO:0010629 387 0.026
regulation of cellular protein catabolic process GO:1903362 44 0.026
amine metabolic process GO:0009308 12 0.026
cell death GO:0008219 279 0.025
regulation of protein catabolic process GO:0042176 55 0.025
atp dependent chromatin remodeling GO:0043044 22 0.025
regulation of cytoskeleton organization GO:0051493 89 0.025
posttranscriptional gene silencing GO:0016441 46 0.024
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.024
spindle localization GO:0051653 22 0.024
asymmetric cell division GO:0008356 37 0.024
peptidyl threonine phosphorylation GO:0018107 2 0.024
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 44 0.024
positive regulation of phosphorus metabolic process GO:0010562 139 0.024
regulation of phosphate metabolic process GO:0019220 210 0.024
establishment of cell polarity GO:0030010 40 0.023
localization of cell GO:0051674 257 0.023
regulation of cell morphogenesis GO:0022604 163 0.023
notch signaling pathway GO:0007219 120 0.023
renal system development GO:0072001 72 0.023
response to other organism GO:0051707 293 0.023
vesicle mediated transport GO:0016192 381 0.023
negative regulation of cell death GO:0060548 81 0.023
neural precursor cell proliferation GO:0061351 75 0.023
response to organic cyclic compound GO:0014070 89 0.023
reproductive system development GO:0061458 74 0.023
cuticle pattern formation GO:0035017 27 0.022
small molecule metabolic process GO:0044281 305 0.022
dorsal ventral pattern formation GO:0009953 133 0.022
heart development GO:0007507 82 0.022
dna templated transcription elongation GO:0006354 18 0.022
response to organic substance GO:0010033 284 0.022
regulation of viral genome replication GO:0045069 4 0.022
catabolic process GO:0009056 409 0.022
positive regulation of proteolysis GO:0045862 52 0.022
centrosome organization GO:0051297 163 0.021
morphogenesis of a branching epithelium GO:0061138 45 0.021
chaeta development GO:0022416 97 0.021
connective tissue development GO:0061448 3 0.021
mesenchymal cell differentiation GO:0048762 1 0.021
nuclear import GO:0051170 51 0.021
peptide metabolic process GO:0006518 80 0.020
sensory organ morphogenesis GO:0090596 260 0.020
ras protein signal transduction GO:0007265 88 0.020
synaptic transmission GO:0007268 288 0.020
sister chromatid segregation GO:0000819 92 0.020
central nervous system neuron differentiation GO:0021953 8 0.020
compound eye pigmentation GO:0048072 17 0.020
regulation of compound eye photoreceptor development GO:0045314 12 0.020
establishment of protein localization GO:0045184 163 0.020
digestive system development GO:0055123 149 0.020
dna damage checkpoint GO:0000077 78 0.019
establishment of vesicle localization GO:0051650 51 0.019
male gamete generation GO:0048232 201 0.019
neuroblast differentiation GO:0014016 29 0.019
wing disc pattern formation GO:0035222 66 0.019
protein targeting to lysosome GO:0006622 5 0.019
regulation of proteasomal protein catabolic process GO:0061136 39 0.019
regulation of intracellular protein transport GO:0033157 46 0.019
regulation of neuroblast proliferation GO:1902692 34 0.018
cellular response to endogenous stimulus GO:0071495 80 0.018
regulation of localization GO:0032879 275 0.018
growth GO:0040007 359 0.018
blood circulation GO:0008015 26 0.018
carboxylic acid metabolic process GO:0019752 92 0.018
developmental programmed cell death GO:0010623 138 0.018
gland morphogenesis GO:0022612 145 0.018
cellular macromolecule localization GO:0070727 220 0.017
camera type eye development GO:0043010 4 0.017
establishment or maintenance of cell polarity GO:0007163 167 0.017
taxis GO:0042330 304 0.017
regulation of hemocyte proliferation GO:0035206 37 0.017
response to oxygen containing compound GO:1901700 200 0.017
stem cell proliferation GO:0072089 88 0.017
cardiac cell fate commitment GO:0060911 17 0.016
mrna processing GO:0006397 104 0.016
muscle structure development GO:0061061 224 0.016
compound eye photoreceptor development GO:0042051 78 0.016
regulation of cellular component biogenesis GO:0044087 201 0.016
cellular macromolecule catabolic process GO:0044265 136 0.016
establishment of planar polarity GO:0001736 87 0.016
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 73 0.016
response to radiation GO:0009314 155 0.016
intracellular protein transport GO:0006886 104 0.016
cytoplasmic transport GO:0016482 130 0.016
regulation of sister chromatid segregation GO:0033045 28 0.016
multicellular organism growth GO:0035264 46 0.016
response to biotic stimulus GO:0009607 294 0.016
mapk cascade GO:0000165 107 0.016
ion transport GO:0006811 145 0.016
regulation of heart morphogenesis GO:2000826 3 0.016
negative regulation of cell proliferation GO:0008285 69 0.015
negative regulation of molecular function GO:0044092 51 0.015
regulation of catalytic activity GO:0050790 185 0.015
signal transduction by phosphorylation GO:0023014 107 0.015
negative regulation of protein metabolic process GO:0051248 85 0.015
negative regulation of organelle organization GO:0010639 56 0.015
positive regulation of cellular amine metabolic process GO:0033240 0 0.015
positive regulation of neurogenesis GO:0050769 41 0.015
gland development GO:0048732 191 0.015
regulation of actin filament based process GO:0032970 42 0.015
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.015
regulation of microtubule depolymerization GO:0031114 24 0.015
regulation of eye photoreceptor cell development GO:0042478 13 0.015
nucleocytoplasmic transport GO:0006913 72 0.014
dorsal ventral pattern formation imaginal disc GO:0007450 51 0.014
positive regulation of cellular component biogenesis GO:0044089 80 0.014
positive regulation of protein phosphorylation GO:0001934 34 0.014
regulation of cell cycle g1 s phase transition GO:1902806 23 0.014
head development GO:0060322 135 0.014
morphogenesis of a branching structure GO:0001763 45 0.014
negative regulation of microtubule depolymerization GO:0007026 21 0.014
regulation of neuron projection development GO:0010975 69 0.013
establishment of protein localization to organelle GO:0072594 62 0.013
positive regulation of intracellular signal transduction GO:1902533 116 0.013
regulation of notch signaling pathway GO:0008593 100 0.013
positive regulation of catalytic activity GO:0043085 118 0.013
negative regulation of cyclin dependent protein serine threonine kinase activity GO:0045736 1 0.013
sex differentiation GO:0007548 81 0.013
axis specification GO:0009798 167 0.013
positive regulation of cell communication GO:0010647 250 0.013
adult locomotory behavior GO:0008344 76 0.013
regulation of transferase activity GO:0051338 58 0.013
mrna metabolic process GO:0016071 124 0.013
organic substance catabolic process GO:1901575 308 0.013
positive regulation of cell death GO:0010942 69 0.013
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 3 0.013
multi organism behavior GO:0051705 175 0.013
multi multicellular organism process GO:0044706 123 0.013
regulation of establishment of protein localization GO:0070201 61 0.012
regulation of smoothened signaling pathway GO:0008589 28 0.012
positive regulation of multicellular organismal process GO:0051240 143 0.012
positive regulation of protein transport GO:0051222 37 0.012
photoreceptor cell differentiation GO:0046530 170 0.012
dna integrity checkpoint GO:0031570 81 0.012
cellular homeostasis GO:0019725 80 0.012
somatic stem cell maintenance GO:0035019 14 0.012
spermatogenesis GO:0007283 200 0.012
protein polymerization GO:0051258 42 0.012
compound eye photoreceptor cell differentiation GO:0001751 140 0.012
mitotic nuclear division GO:0007067 213 0.012
organic substance transport GO:0071702 257 0.012
negative regulation of neuroblast proliferation GO:0007406 27 0.012
locomotory behavior GO:0007626 176 0.012
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.011
maintenance of gastrointestinal epithelium GO:0030277 3 0.011
tissue death GO:0016271 102 0.011
canonical wnt signaling pathway involved in heart development GO:0061316 3 0.011
small gtpase mediated signal transduction GO:0007264 88 0.011
heart morphogenesis GO:0003007 32 0.011
protein targeting GO:0006605 64 0.011
regulation of reproductive process GO:2000241 54 0.011
organelle inheritance GO:0048308 2 0.011
regulation of phosphatase activity GO:0010921 3 0.011
protein processing GO:0016485 68 0.011
centrosome duplication GO:0051298 121 0.011
chaeta morphogenesis GO:0008407 42 0.011
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 19 0.011
determination of adult lifespan GO:0008340 137 0.010
ameboidal type cell migration GO:0001667 151 0.010
regulation of nucleocytoplasmic transport GO:0046822 35 0.010
positive regulation of mitotic cell cycle GO:0045931 34 0.010
imaginal disc derived leg segmentation GO:0036011 26 0.010
organelle assembly GO:0070925 198 0.010
camera type eye morphogenesis GO:0048593 2 0.010
protein import into nucleus GO:0006606 51 0.010
positive regulation of phosphate metabolic process GO:0045937 139 0.010
negative regulation of nervous system development GO:0051961 92 0.010
multicellular organismal aging GO:0010259 140 0.010
regulation of molecular function GO:0065009 217 0.010
cellular catabolic process GO:0044248 372 0.010
negative regulation of multicellular organismal process GO:0051241 142 0.010
regulation of g2 m transition of mitotic cell cycle GO:0010389 15 0.010

pygo disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.052
disease of cellular proliferation DOID:14566 0 0.028
cancer DOID:162 0 0.010
organ system cancer DOID:0050686 0 0.010