Drosophila melanogaster

157 known processes

smo (Dmel_CG11561)

smoothened

(Aliases: SMO,Smo,dSmo,Dmel\CG11561,CG11561)

smo biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
negative regulation of cell communication GO:0010648 223 0.978
forebrain development GO:0030900 2 0.975
Zebrafish Mouse
tube morphogenesis GO:0035239 191 0.973
Zebrafish Mouse
post embryonic appendage morphogenesis GO:0035120 385 0.972
epithelial cell differentiation GO:0030855 322 0.967
negative regulation of wnt signaling pathway GO:0030178 28 0.954
wing disc morphogenesis GO:0007472 344 0.954
gastrulation GO:0007369 70 0.954
appendage morphogenesis GO:0035107 397 0.953
Zebrafish
cellular protein modification process GO:0006464 438 0.937
ameboidal type cell migration GO:0001667 151 0.916
Mouse
meiotic cell cycle process GO:1903046 132 0.907
imaginal disc derived wing morphogenesis GO:0007476 337 0.900
negative regulation of response to stimulus GO:0048585 258 0.887
negative regulation of signal transduction GO:0009968 206 0.826
nuclear division GO:0000280 332 0.825
negative regulation of developmental growth GO:0048640 64 0.823
negative regulation of cellular metabolic process GO:0031324 382 0.820
Mouse
regulation of ras gtpase activity GO:0032318 38 0.817
convergent extension GO:0060026 2 0.802
regulation of developmental growth GO:0048638 174 0.764
heart development GO:0007507 82 0.747
Zebrafish Mouse
open tracheal system development GO:0007424 204 0.741
respiratory system development GO:0060541 213 0.737
muscle structure development GO:0061061 224 0.719
Zebrafish Mouse
negative regulation of multicellular organismal process GO:0051241 142 0.714
Mouse
digestive tract development GO:0048565 149 0.711
Zebrafish Mouse
head development GO:0060322 135 0.711
Zebrafish Mouse
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 44 0.694
programmed cell death GO:0012501 257 0.690
meiotic cell cycle GO:0051321 171 0.685
cell motility GO:0048870 251 0.679
Zebrafish Mouse
morphogenesis of a branching structure GO:0001763 45 0.676
Mouse
columnar cuboidal epithelial cell development GO:0002066 249 0.663
muscle cell differentiation GO:0042692 103 0.663
Zebrafish Mouse
negative regulation of cell differentiation GO:0045596 143 0.660
endodermal cell fate commitment GO:0001711 3 0.648
tissue migration GO:0090130 155 0.642
digestive system development GO:0055123 149 0.626
Zebrafish Mouse
regionalization GO:0003002 416 0.622
regulation of catabolic process GO:0009894 170 0.619
localization of cell GO:0051674 257 0.612
Zebrafish Mouse
meiotic nuclear division GO:0007126 151 0.610
endocytosis GO:0006897 310 0.607
peripheral nervous system development GO:0007422 52 0.601
proteolysis GO:0006508 192 0.592
intracellular transport GO:0046907 228 0.591
Mouse
regulation of neurogenesis GO:0050767 158 0.589
Mouse
regulation of cell cycle g1 s phase transition GO:1902806 23 0.588
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.585
regulation of multicellular organismal development GO:2000026 414 0.576
Mouse
protein localization to nucleus GO:0034504 55 0.573
Mouse
epithelial tube morphogenesis GO:0060562 88 0.571
Zebrafish Mouse
regulation of cell proliferation GO:0042127 163 0.559
Mouse
negative regulation of developmental process GO:0051093 201 0.556
sulfur compound metabolic process GO:0006790 59 0.540
protein modification process GO:0036211 438 0.533
retinal ganglion cell axon guidance GO:0031290 12 0.531
Zebrafish
muscle tissue development GO:0060537 30 0.519
Zebrafish Mouse
regulation of cellular catabolic process GO:0031329 157 0.519
appendage development GO:0048736 401 0.518
Zebrafish
imaginal disc pattern formation GO:0007447 91 0.510
ovarian follicle cell migration GO:0007297 121 0.493
imaginal disc derived appendage morphogenesis GO:0035114 395 0.489
central nervous system development GO:0007417 201 0.486
Zebrafish Mouse Rat
cell division GO:0051301 248 0.482
ubiquitin dependent protein catabolic process GO:0006511 78 0.480
regulation of cytoskeleton organization GO:0051493 89 0.471
muscle organ development GO:0007517 127 0.460
Zebrafish Mouse
gliogenesis GO:0042063 80 0.458
Zebrafish Mouse
sensory organ morphogenesis GO:0090596 260 0.456
regulation of protein catabolic process GO:0042176 55 0.446
cardiovascular system development GO:0072358 82 0.443
Zebrafish Mouse
protein catabolic process GO:0030163 101 0.441
skeletal muscle organ development GO:0060538 48 0.440
Zebrafish Mouse
ovarian follicle cell development GO:0030707 248 0.438
homeostatic process GO:0042592 199 0.437
Mouse
positive regulation of developmental process GO:0051094 143 0.430
Mouse
gland development GO:0048732 191 0.429
Zebrafish Mouse
negative regulation of signaling GO:0023057 219 0.423
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.416
Mouse
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.415
Mouse
striated muscle tissue development GO:0014706 27 0.409
Zebrafish Mouse
multi organism behavior GO:0051705 175 0.403
brain development GO:0007420 120 0.390
Zebrafish Mouse
eye development GO:0001654 323 0.385
organelle fission GO:0048285 340 0.382
epithelial cell development GO:0002064 274 0.376
regulation of mitotic cell cycle GO:0007346 190 0.373
regulation of immune system process GO:0002682 176 0.370
positive regulation of molecular function GO:0044093 136 0.364
Mouse
regulation of muscle organ development GO:0048634 13 0.363
posttranscriptional regulation of gene expression GO:0010608 145 0.362
Mouse
immune system process GO:0002376 347 0.359
cellular protein catabolic process GO:0044257 83 0.358
embryonic morphogenesis GO:0048598 206 0.351
Zebrafish Mouse
taxis GO:0042330 304 0.348
Zebrafish Rat
intracellular signal transduction GO:0035556 300 0.346
Mouse
actin filament bundle organization GO:0061572 28 0.341
positive regulation of pathway restricted smad protein phosphorylation GO:0010862 1 0.340
epithelium migration GO:0090132 148 0.332
imaginal disc derived appendage development GO:0048737 399 0.328
regulation of intracellular signal transduction GO:1902531 236 0.327
regulation of pathway restricted smad protein phosphorylation GO:0060393 1 0.326
multicellular organismal reproductive behavior GO:0033057 110 0.322
single organism intracellular transport GO:1902582 207 0.319
Mouse
regulation of wnt signaling pathway GO:0030111 68 0.314
regulation of microtubule based process GO:0032886 49 0.314
regulation of epithelial cell proliferation GO:0050678 4 0.311
Mouse
cytoplasmic transport GO:0016482 130 0.310
Mouse
tissue morphogenesis GO:0048729 297 0.310
Zebrafish Mouse
negative regulation of cellular biosynthetic process GO:0031327 277 0.308
Mouse
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.303
neuroblast proliferation GO:0007405 74 0.300
Mouse
regulation of growth GO:0040008 233 0.298
modification dependent macromolecule catabolic process GO:0043632 79 0.294
morphogenesis of an epithelium GO:0002009 276 0.294
Zebrafish Mouse
lipid metabolic process GO:0006629 121 0.290
imaginal disc derived wing vein morphogenesis GO:0008586 44 0.283
mesenchymal cell differentiation GO:0048762 1 0.281
Zebrafish Mouse
developmental growth GO:0048589 280 0.279
Mouse Rat
negative regulation of g1 s transition of mitotic cell cycle GO:2000134 13 0.272
regulation of phosphorus metabolic process GO:0051174 210 0.267
compound eye photoreceptor cell differentiation GO:0001751 140 0.264
epithelial cell migration GO:0010631 148 0.264
regulation of nervous system development GO:0051960 248 0.259
Mouse
striated muscle cell differentiation GO:0051146 90 0.252
Zebrafish Mouse
regulation of protein metabolic process GO:0051246 256 0.249
organic acid metabolic process GO:0006082 103 0.247
camera type eye development GO:0043010 4 0.244
Zebrafish
axon development GO:0061564 297 0.232
Zebrafish Rat
wing disc pattern formation GO:0035222 66 0.231
cell migration involved in gastrulation GO:0042074 9 0.231
gtp metabolic process GO:0046039 72 0.231
positive regulation of gtp catabolic process GO:0033126 43 0.230
death GO:0016265 284 0.229
positive regulation of catalytic activity GO:0043085 118 0.227
epidermal cell differentiation GO:0009913 51 0.226
regulation of synaptic growth at neuromuscular junction GO:0008582 89 0.223
protein modification by small protein conjugation or removal GO:0070647 106 0.223
imaginal disc derived wing vein specification GO:0007474 48 0.222
growth GO:0040007 359 0.219
Mouse Rat
camera type eye morphogenesis GO:0048593 2 0.216
guanosine containing compound catabolic process GO:1901069 74 0.216
proteoglycan biosynthetic process GO:0030166 10 0.216
response to external biotic stimulus GO:0043207 293 0.206
ectodermal placode formation GO:0060788 4 0.205
regulation of anatomical structure morphogenesis GO:0022603 242 0.198
Mouse
positive regulation of cellular component biogenesis GO:0044089 80 0.196
multi multicellular organism process GO:0044706 123 0.195
synaptic growth at neuromuscular junction GO:0051124 119 0.194
positive regulation of macromolecule metabolic process GO:0010604 405 0.192
Mouse
organ growth GO:0035265 56 0.192
neuromuscular junction development GO:0007528 149 0.185
apoptotic process GO:0006915 159 0.183
protein targeting GO:0006605 64 0.181
Mouse
regulation of cellular protein catabolic process GO:1903362 44 0.181
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.180
negative regulation of nervous system development GO:0051961 92 0.180
organic substance transport GO:0071702 257 0.175
Mouse
spindle organization GO:0007051 253 0.170
cell fate commitment involved in formation of primary germ layer GO:0060795 10 0.170
stem cell differentiation GO:0048863 117 0.169
positive regulation of gtpase activity GO:0043547 43 0.167
circulatory system development GO:0072359 82 0.167
Zebrafish Mouse
axis specification GO:0009798 167 0.163
leg disc development GO:0035218 92 0.163
imaginal disc derived leg morphogenesis GO:0007480 80 0.159
positive regulation of protein metabolic process GO:0051247 128 0.157
epithelial cell proliferation GO:0050673 15 0.156
Mouse
actin filament based process GO:0030029 220 0.156
Zebrafish
cell proliferation GO:0008283 299 0.155
Mouse Rat
mitotic nuclear division GO:0007067 213 0.155
regulation of smoothened signaling pathway GO:0008589 28 0.154
Zebrafish Mouse
oxoacid metabolic process GO:0043436 103 0.152
glial cell differentiation GO:0010001 35 0.151
Zebrafish Mouse
response to wounding GO:0009611 94 0.149
Rat
vesicle mediated transport GO:0016192 381 0.146
dorsal ventral pattern formation GO:0009953 133 0.145
Zebrafish Mouse
positive regulation of developmental growth GO:0048639 62 0.143
nucleocytoplasmic transport GO:0006913 72 0.143
Mouse
heart morphogenesis GO:0003007 32 0.143
Zebrafish Mouse
cell migration GO:0016477 238 0.140
Zebrafish Mouse
skin development GO:0043588 65 0.140
Mouse
regulation of cell substrate adhesion GO:0010810 2 0.137
positive regulation of nucleoside metabolic process GO:0045979 47 0.137
tube development GO:0035295 244 0.136
Zebrafish Mouse
retina development in camera type eye GO:0060041 4 0.135
Zebrafish
mesoderm formation GO:0001707 21 0.134
negative regulation of epithelial cell proliferation GO:0050680 4 0.133
limb morphogenesis GO:0035108 1 0.133
morphogenesis of a branching epithelium GO:0061138 45 0.133
Mouse
positive regulation of cellular biosynthetic process GO:0031328 316 0.133
Mouse
positive regulation of signaling GO:0023056 243 0.132
Zebrafish Mouse
establishment of localization in cell GO:0051649 402 0.131
Mouse
negative regulation of biosynthetic process GO:0009890 277 0.129
Mouse
regulation of organ morphogenesis GO:2000027 78 0.127
Mouse
response to other organism GO:0051707 293 0.126
reproductive behavior GO:0019098 122 0.124
determination of dorsal ventral asymmetry GO:0048262 3 0.124
proteasomal protein catabolic process GO:0010498 59 0.123
modification dependent protein catabolic process GO:0019941 78 0.122
negative regulation of neurogenesis GO:0050768 53 0.122
spermatid differentiation GO:0048515 114 0.120
regulation of cellular protein metabolic process GO:0032268 243 0.120
positive regulation of cellular protein metabolic process GO:0032270 118 0.118
axonogenesis GO:0007409 290 0.118
Zebrafish Rat
extracellular structure organization GO:0043062 46 0.117
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.115
Mouse
heparan sulfate proteoglycan metabolic process GO:0030201 10 0.114
regulation of cell cycle phase transition GO:1901987 130 0.114
blastoderm segmentation GO:0007350 159 0.113
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.112
single organismal cell cell adhesion GO:0016337 45 0.111
small gtpase mediated signal transduction GO:0007264 88 0.111
positive regulation of ras gtpase activity GO:0032320 36 0.110
regulation of protein serine threonine kinase activity GO:0071900 25 0.109
positive regulation of phosphorus metabolic process GO:0010562 139 0.108
somatic stem cell maintenance GO:0035019 14 0.107
negative regulation of growth GO:0045926 84 0.106
enzyme linked receptor protein signaling pathway GO:0007167 179 0.106
cell junction assembly GO:0034329 42 0.105
hematopoietic or lymphoid organ development GO:0048534 57 0.104
formation of primary germ layer GO:0001704 24 0.103
regulation of glial cell differentiation GO:0045685 1 0.101
gtp catabolic process GO:0006184 72 0.100
cell elongation involved in imaginal disc derived wing morphogenesis GO:0090254 5 0.099
cell fate specification GO:0001708 71 0.099
Zebrafish Mouse
digestive tract morphogenesis GO:0048546 127 0.098
Zebrafish
cell adhesion GO:0007155 136 0.097
regulation of nucleoside metabolic process GO:0009118 50 0.097
positive regulation of signal transduction GO:0009967 223 0.096
Zebrafish Mouse
multi organism reproductive behavior GO:0044705 121 0.096
imaginal disc growth GO:0007446 37 0.094
cellular macromolecule catabolic process GO:0044265 136 0.093
response to biotic stimulus GO:0009607 294 0.093
Human
negative regulation of nucleic acid templated transcription GO:1903507 240 0.092
Mouse
female meiotic division GO:0007143 70 0.092
sensory organ precursor cell division GO:0045035 10 0.091
single organism biosynthetic process GO:0044711 206 0.091
negative regulation of cellular protein metabolic process GO:0032269 85 0.090
protein import into nucleus GO:0006606 51 0.090
Mouse
regulation of proteolysis GO:0030162 87 0.089
neuron projection guidance GO:0097485 241 0.089
Zebrafish Rat
positive regulation of mitotic cell cycle GO:0045931 34 0.088
positive regulation of ribosome biogenesis GO:0090070 3 0.087
convergent extension involved in gastrulation GO:0060027 2 0.087
catabolic process GO:0009056 409 0.086
cellular protein localization GO:0034613 160 0.086
embryonic foregut morphogenesis GO:0048617 3 0.085
organic substance catabolic process GO:1901575 308 0.084
cation homeostasis GO:0055080 51 0.083
endodermal cell differentiation GO:0035987 3 0.082
regulation of microtubule cytoskeleton organization GO:0070507 41 0.082
positive regulation of response to stimulus GO:0048584 323 0.082
Zebrafish Mouse
membrane protein ectodomain proteolysis GO:0006509 5 0.082
protein import GO:0017038 55 0.082
Mouse
single organism nuclear import GO:1902593 51 0.081
Mouse
wnt signaling pathway GO:0016055 98 0.080
stem cell maintenance GO:0019827 67 0.080
protein localization GO:0008104 284 0.078
regulation of ras protein signal transduction GO:0046578 93 0.078
notch signaling pathway GO:0007219 120 0.078
cellular catabolic process GO:0044248 372 0.078
specification of symmetry GO:0009799 13 0.078
Zebrafish Mouse
germ cell migration GO:0008354 43 0.077
canonical wnt signaling pathway involved in heart development GO:0061316 3 0.077
regulation of g1 s transition of mitotic cell cycle GO:2000045 23 0.076
skeletal muscle tissue development GO:0007519 13 0.076
Zebrafish Mouse
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 37 0.076
hemopoiesis GO:0030097 46 0.074
cellular hormone metabolic process GO:0034754 23 0.074
regulation of epidermal growth factor receptor signaling pathway GO:0042058 42 0.073
actin cytoskeleton organization GO:0030036 206 0.072
Zebrafish
regulation of catalytic activity GO:0050790 185 0.072
positive regulation of phosphate metabolic process GO:0045937 139 0.070
negative regulation of intracellular signal transduction GO:1902532 57 0.070
epidermis development GO:0008544 65 0.070
Mouse
neuron recognition GO:0008038 101 0.069
regulation of dna metabolic process GO:0051052 34 0.069
regulation of cell differentiation GO:0045595 302 0.069
determination of ventral identity GO:0048264 1 0.069
regulation of organelle organization GO:0033043 196 0.069
positive regulation of fibroblast growth factor receptor signaling pathway GO:0045743 5 0.069
regulation of map kinase activity GO:0043405 17 0.068
cellular chemical homeostasis GO:0055082 40 0.068
positive regulation of catabolic process GO:0009896 105 0.068
adherens junction organization GO:0034332 27 0.067
axon guidance GO:0007411 233 0.067
Zebrafish Rat
regulation of tube architecture open tracheal system GO:0035152 68 0.066
macromolecule catabolic process GO:0009057 161 0.066
chromosome segregation GO:0007059 157 0.066
ribonucleoside triphosphate metabolic process GO:0009199 119 0.066
regulation of phosphate metabolic process GO:0019220 210 0.066
eye antennal disc development GO:0035214 60 0.066
positive regulation of cell adhesion GO:0045785 10 0.066
neural precursor cell proliferation GO:0061351 75 0.064
Mouse
positive regulation of rna biosynthetic process GO:1902680 266 0.063
Mouse
cell fate determination GO:0001709 91 0.063
biological adhesion GO:0022610 138 0.063
eye morphogenesis GO:0048592 260 0.063
negative regulation of catabolic process GO:0009895 36 0.062
positive regulation of cell communication GO:0010647 250 0.061
Zebrafish Mouse
protein targeting to nucleus GO:0044744 51 0.061
Mouse
guanosine containing compound metabolic process GO:1901068 74 0.061
imaginal disc derived wing hair organization GO:0035317 45 0.061
negative regulation of protein metabolic process GO:0051248 85 0.061
positive regulation of nucleic acid templated transcription GO:1903508 266 0.061
Mouse
enteroendocrine cell differentiation GO:0035883 1 0.060
Mouse
sex determination GO:0007530 18 0.059
carbohydrate derivative biosynthetic process GO:1901137 85 0.057
regulation of defense response GO:0031347 102 0.057
regulation of synapse structure and activity GO:0050803 128 0.056
negative regulation of rna metabolic process GO:0051253 251 0.055
Mouse
stem cell division GO:0017145 69 0.054
smoothened signaling pathway involved in ventral spinal cord patterning GO:0021910 0 0.054
Mouse
regulation of proteasomal protein catabolic process GO:0061136 39 0.053
i kappab phosphorylation GO:0007252 3 0.053
negative regulation of nucleotide metabolic process GO:0045980 4 0.053
mushroom body development GO:0016319 70 0.053
protein palmitoylation GO:0018345 2 0.052
hindbrain development GO:0030902 2 0.051
Zebrafish Mouse
amine metabolic process GO:0009308 12 0.051
dna integration GO:0015074 1 0.051
limb development GO:0060173 1 0.051
compound eye development GO:0048749 307 0.051
regulation of sister chromatid cohesion GO:0007063 2 0.050
salivary gland development GO:0007431 162 0.050
neurological system process GO:0050877 358 0.049
protein complex biogenesis GO:0070271 201 0.049
protein localization to organelle GO:0033365 82 0.049
Mouse
regulation of gliogenesis GO:0014013 11 0.048
cellular homeostasis GO:0019725 80 0.048
anterior posterior pattern specification GO:0009952 136 0.048
Zebrafish Mouse
positive regulation of multicellular organism growth GO:0040018 21 0.047
regulation of rho protein signal transduction GO:0035023 20 0.046
chemical homeostasis GO:0048878 92 0.046
mitotic sister chromatid segregation GO:0000070 87 0.046
segmentation GO:0035282 207 0.045
spinal cord dorsal ventral patterning GO:0021513 1 0.045
Mouse
single organism carbohydrate metabolic process GO:0044723 72 0.045
regulation of immune response GO:0050776 118 0.045
compound eye morphogenesis GO:0001745 249 0.045
glycoprotein biosynthetic process GO:0009101 41 0.044
dorsal closure leading edge cell differentiation GO:0046663 2 0.044
wnt signaling pathway involved in heart development GO:0003306 3 0.044
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 24 0.043
proteoglycan metabolic process GO:0006029 10 0.043
protein modification by small protein conjugation GO:0032446 79 0.043
germarium derived female germ line cyst formation GO:0030727 42 0.043
chemotaxis GO:0006935 249 0.043
Zebrafish Rat
branching involved in open tracheal system development GO:0060446 45 0.042
heparan sulfate proteoglycan biosynthetic process polysaccharide chain biosynthetic process GO:0015014 5 0.042
carbohydrate metabolic process GO:0005975 82 0.042
positive regulation of transcription dna templated GO:0045893 266 0.042
Mouse
metal ion homeostasis GO:0055065 44 0.042
negative regulation of cell cycle g1 s phase transition GO:1902807 13 0.041
positive regulation of nucleotide metabolic process GO:0045981 55 0.041
positive regulation of cellular catabolic process GO:0031331 95 0.041
positive regulation of rho gtpase activity GO:0032321 19 0.041
associative learning GO:0008306 65 0.041
protein ubiquitination GO:0016567 70 0.041
maintenance of protein location in cell GO:0032507 26 0.041
oocyte morphogenesis GO:0048601 3 0.041
establishment or maintenance of cell polarity GO:0007163 167 0.040
regulation of neuron differentiation GO:0045664 103 0.040
cellular lipid metabolic process GO:0044255 83 0.040
positive regulation of protein catabolic process GO:0045732 34 0.040
regulation of gtpase activity GO:0043087 44 0.039
endoderm formation GO:0001706 3 0.039
cell junction organization GO:0034330 57 0.038
synapse organization GO:0050808 196 0.038
single organism cellular localization GO:1902580 180 0.038
regulation of synapse organization GO:0050807 110 0.037
rho protein signal transduction GO:0007266 14 0.037
regulation of organ growth GO:0046620 42 0.037
regulation of cell cycle GO:0051726 291 0.037
transcription from rna polymerase ii promoter GO:0006366 368 0.037
Mouse
cellular macromolecule localization GO:0070727 220 0.037
small molecule metabolic process GO:0044281 305 0.036
regulation of cell morphogenesis involved in differentiation GO:0010769 61 0.036
negative regulation of transcription dna templated GO:0045892 237 0.036
Mouse
telencephalon development GO:0021537 2 0.036
Zebrafish Mouse
regulation of imaginal disc growth GO:0045570 26 0.036
phagocytosis GO:0006909 215 0.036
ribonucleoside catabolic process GO:0042454 112 0.035
retina morphogenesis in camera type eye GO:0060042 2 0.035
smoothened signaling pathway GO:0007224 49 0.035
regulation of gtp catabolic process GO:0033124 44 0.034
positive regulation of purine nucleotide catabolic process GO:0033123 46 0.034
regulation of mapk cascade GO:0043408 92 0.034
unidimensional cell growth GO:0009826 15 0.034
ras protein signal transduction GO:0007265 88 0.034
defense response to gram negative bacterium GO:0050829 94 0.034
maintenance of location in cell GO:0051651 28 0.034
germ line cyst formation GO:0048134 44 0.034
positive regulation of nervous system development GO:0051962 69 0.034
Mouse
regulation of mitosis GO:0007088 56 0.033
negative regulation of cellular catabolic process GO:0031330 34 0.033
regulation of gene expression epigenetic GO:0040029 128 0.033
regulation of intracellular protein transport GO:0033157 46 0.033
Mouse
regulation of synapse assembly GO:0051963 94 0.033
response to bacterium GO:0009617 198 0.033
spinal cord development GO:0021510 1 0.033
Zebrafish Mouse
regulation of molecular function GO:0065009 217 0.033
Mouse
carbohydrate biosynthetic process GO:0016051 17 0.032
regulation of apoptotic process GO:0042981 130 0.032
embryonic pattern specification GO:0009880 174 0.032
epithelial cell migration open tracheal system GO:0007427 32 0.032
germarium derived egg chamber formation GO:0007293 101 0.032
positive regulation of mitotic cell cycle phase transition GO:1901992 20 0.032
negative regulation of synaptic growth at neuromuscular junction GO:0045886 39 0.032
organonitrogen compound metabolic process GO:1901564 318 0.032
glial cell migration GO:0008347 31 0.032
wound healing GO:0042060 75 0.031
protein phosphorylation GO:0006468 169 0.031
regulation of protein import into nucleus GO:0042306 28 0.031
Mouse
heart field specification GO:0003128 0 0.031
synapse assembly GO:0007416 143 0.031
positive regulation of kinase activity GO:0033674 25 0.031
chromosome separation GO:0051304 42 0.030
sister chromatid segregation GO:0000819 92 0.030
positive regulation of intracellular signal transduction GO:1902533 116 0.030
maternal determination of dorsal ventral axis ovarian follicular epithelium soma encoded GO:0008071 1 0.030
regulation of phosphorylation GO:0042325 147 0.030
positive regulation of cell proliferation GO:0008284 47 0.030
Mouse
cortical cytoskeleton organization GO:0030865 29 0.030
protein transport GO:0015031 155 0.030
Mouse
defense response to other organism GO:0098542 225 0.030
regeneration GO:0031099 16 0.030
Rat
mating GO:0007618 120 0.029
purine nucleoside metabolic process GO:0042278 127 0.029
positive regulation of protein phosphorylation GO:0001934 34 0.029
canonical wnt signaling pathway GO:0060070 21 0.029
cellular response to chemical stimulus GO:0070887 199 0.029
Mouse
negative regulation of protein modification process GO:0031400 29 0.029
phosphorylation GO:0016310 294 0.028
establishment of protein localization to organelle GO:0072594 62 0.028
Mouse
positive regulation of nucleotide catabolic process GO:0030813 46 0.028
dorsal closure GO:0007391 79 0.028
regulation of mitotic cell cycle phase transition GO:1901990 130 0.028
epidermal growth factor receptor signaling pathway GO:0007173 58 0.028
cation transport GO:0006812 110 0.028
jak stat cascade GO:0007259 49 0.028
defense response to bacterium GO:0042742 178 0.028
regulation of cell division GO:0051302 72 0.027
organelle assembly GO:0070925 198 0.027
Zebrafish
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.027
Mouse
negative regulation of phosphate metabolic process GO:0045936 45 0.027
receptor mediated endocytosis GO:0006898 21 0.027
multicellular organism growth GO:0035264 46 0.027
Mouse
renal system development GO:0072001 72 0.026
Human Mouse
malpighian tubule development GO:0072002 64 0.026
negative regulation of peptidyl tyrosine phosphorylation GO:0050732 6 0.026
maintenance of location GO:0051235 73 0.026
learning or memory GO:0007611 141 0.026
imaginal disc derived wing margin morphogenesis GO:0008587 41 0.026
regulation of transmembrane transport GO:0034762 27 0.026
branching morphogenesis of an epithelial tube GO:0048754 45 0.026
Mouse
regulation of stem cell proliferation GO:0072091 40 0.026
Mouse
response to red or far red light GO:0009639 2 0.026
peptidyl amino acid modification GO:0018193 105 0.026
sensory perception GO:0007600 196 0.026
regulation of protein localization to nucleus GO:1900180 29 0.026
Mouse
regulation of notch signaling pathway GO:0008593 100 0.026
leg disc morphogenesis GO:0007478 80 0.026
regulation of epithelial cell migration GO:0010632 12 0.025
purine ribonucleotide catabolic process GO:0009154 109 0.025
cell cycle g1 s phase transition GO:0044843 31 0.025
activation of anaphase promoting complex activity GO:0051488 1 0.025
regulation of mitotic sister chromatid segregation GO:0033047 28 0.025
stem cell proliferation GO:0072089 88 0.025
Mouse
regulation of innate immune response GO:0045088 71 0.024
negative regulation of synapse assembly GO:0051964 39 0.024
negative regulation of gene expression GO:0010629 387 0.024
Mouse
aging GO:0007568 143 0.024
muscle cell development GO:0055001 50 0.024
Zebrafish Mouse
muscle cell fate specification GO:0042694 7 0.024
positive regulation of proteasomal protein catabolic process GO:1901800 20 0.024
cell cycle phase transition GO:0044770 140 0.023
regulation of nuclear division GO:0051783 58 0.023
organelle localization GO:0051640 148 0.023
dendrite regeneration GO:0031104 2 0.023

smo disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.137
disease of cellular proliferation DOID:14566 0 0.137
organ system cancer DOID:0050686 0 0.137
disease of anatomical entity DOID:7 0 0.098
musculoskeletal system disease DOID:17 0 0.098
large intestine cancer DOID:5672 0 0.056
gastrointestinal system cancer DOID:3119 0 0.056
intestinal cancer DOID:10155 0 0.056
colorectal cancer DOID:9256 0 0.056
colon cancer DOID:219 0 0.031
artery disease DOID:0050828 0 0.030
aortic aneurysm DOID:3627 0 0.030
vascular disease DOID:178 0 0.030
cardiovascular system disease DOID:1287 0 0.030
aortic disease DOID:520 0 0.030
connective tissue disease DOID:65 0 0.029