Drosophila melanogaster

13 known processes

Rpn2 (Dmel_CG11888)

CG11888 gene product from transcript CG11888-RA

(Aliases: dRpn2,11888,p110,Dmel\CG11888,CG11888)

Rpn2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
proteolysis GO:0006508 192 0.916
modification dependent macromolecule catabolic process GO:0043632 79 0.903
Yeast
catabolic process GO:0009056 409 0.657
Yeast
cellular catabolic process GO:0044248 372 0.605
Yeast
cell death GO:0008219 279 0.580
Worm
determination of adult lifespan GO:0008340 137 0.580
Worm
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.571
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.549
Yeast
multicellular organismal aging GO:0010259 140 0.537
Worm
autophagy GO:0006914 108 0.520
ubiquitin dependent protein catabolic process GO:0006511 78 0.487
Yeast
larval development GO:0002164 104 0.477
Worm
death GO:0016265 284 0.461
Worm
embryo development ending in birth or egg hatching GO:0009792 152 0.415
Worm
mitotic spindle elongation GO:0000022 81 0.413
modification dependent protein catabolic process GO:0019941 78 0.385
Yeast
proteasomal protein catabolic process GO:0010498 59 0.378
spindle elongation GO:0051231 83 0.373
protein catabolic process GO:0030163 101 0.352
Yeast
programmed cell death GO:0012501 257 0.335
Worm
apoptotic process GO:0006915 159 0.330
Worm
positive regulation of multicellular organismal process GO:0051240 143 0.291
body morphogenesis GO:0010171 2 0.267
cellular macromolecule catabolic process GO:0044265 136 0.262
Yeast
organic substance transport GO:0071702 257 0.258
regulation of cellular protein metabolic process GO:0032268 243 0.230
cellular response to dna damage stimulus GO:0006974 223 0.213
macroautophagy GO:0016236 42 0.208
protein modification by small protein conjugation or removal GO:0070647 106 0.193
cellular protein catabolic process GO:0044257 83 0.191
Yeast
regulation of catabolic process GO:0009894 170 0.186
aging GO:0007568 143 0.178
Worm
macromolecule catabolic process GO:0009057 161 0.168
Yeast
regulation of immune system process GO:0002682 176 0.165
organic substance catabolic process GO:1901575 308 0.164
Yeast
cellular response to extracellular stimulus GO:0031668 64 0.152
organonitrogen compound metabolic process GO:1901564 318 0.147
larval midgut histolysis GO:0035069 22 0.147
positive regulation of rna metabolic process GO:0051254 271 0.144
regulation of cellular component biogenesis GO:0044087 201 0.144
positive regulation of gene expression GO:0010628 290 0.138
positive regulation of cellular biosynthetic process GO:0031328 316 0.136
single organism catabolic process GO:0044712 228 0.132
embryonic morphogenesis GO:0048598 206 0.130
transcription from rna polymerase ii promoter GO:0006366 368 0.129
cellular protein modification process GO:0006464 438 0.129
positive regulation of macromolecule metabolic process GO:0010604 405 0.129
nucleus organization GO:0006997 45 0.128
cell proliferation GO:0008283 299 0.120
microtubule organizing center organization GO:0031023 168 0.119
regulation of protein metabolic process GO:0051246 256 0.114
protein dna complex assembly GO:0065004 63 0.109
protein complex assembly GO:0006461 200 0.109
Yeast
negative regulation of cell communication GO:0010648 223 0.103
vesicle mediated transport GO:0016192 381 0.100
stem cell differentiation GO:0048863 117 0.099
centrosome organization GO:0051297 163 0.097
positive regulation of developmental process GO:0051094 143 0.096
er associated ubiquitin dependent protein catabolic process GO:0030433 3 0.095
protein phosphorylation GO:0006468 169 0.092
endocytosis GO:0006897 310 0.092
developmental programmed cell death GO:0010623 138 0.091
cellular response to starvation GO:0009267 61 0.090
regulation of immune response GO:0050776 118 0.086
protein import into nucleus GO:0006606 51 0.086
macromolecular complex assembly GO:0065003 256 0.081
Yeast
appendage development GO:0048736 401 0.080
cellular macromolecular complex assembly GO:0034622 153 0.078
Yeast
homeostatic process GO:0042592 199 0.077
anatomical structure homeostasis GO:0060249 97 0.074
negative regulation of cellular metabolic process GO:0031324 382 0.073
protein ubiquitination GO:0016567 70 0.073
positive regulation of rna biosynthetic process GO:1902680 266 0.072
protein modification process GO:0036211 438 0.072
protein modification by small protein conjugation GO:0032446 79 0.068
regulation of catalytic activity GO:0050790 185 0.066
cytoplasmic transport GO:0016482 130 0.065
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 37 0.064
mitotic spindle organization GO:0007052 220 0.060
positive regulation of nucleic acid templated transcription GO:1903508 266 0.059
cellular protein complex assembly GO:0043623 71 0.059
Yeast
positive regulation of lipid storage GO:0010884 4 0.058
regulation of protein modification process GO:0031399 112 0.058
regulation of multicellular organismal development GO:2000026 414 0.058
establishment of protein localization GO:0045184 163 0.057
spindle organization GO:0007051 253 0.056
dna templated transcription elongation GO:0006354 18 0.056
positive regulation of cellular protein metabolic process GO:0032270 118 0.055
positive regulation of biosynthetic process GO:0009891 316 0.054
larval midgut cell programmed cell death GO:0035096 19 0.053
negative regulation of response to stimulus GO:0048585 258 0.053
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.053
response to external biotic stimulus GO:0043207 293 0.053
developmental growth GO:0048589 280 0.053
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.052
autophagic vacuole fusion GO:0000046 15 0.051
regulation of cellular catabolic process GO:0031329 157 0.051
digestive tract development GO:0048565 149 0.051
regulation of cell differentiation GO:0045595 302 0.050
immune response GO:0006955 246 0.050
nucleocytoplasmic transport GO:0006913 72 0.049
response to abiotic stimulus GO:0009628 341 0.048
organelle membrane fusion GO:0090174 16 0.048
cell migration GO:0016477 238 0.047
negative regulation of signal transduction GO:0009968 206 0.046
protein targeting to nucleus GO:0044744 51 0.046
positive regulation of cellular component biogenesis GO:0044089 80 0.046
single organism biosynthetic process GO:0044711 206 0.044
small molecule metabolic process GO:0044281 305 0.044
regulation of protein transport GO:0051223 57 0.043
antimicrobial peptide production GO:0002775 46 0.043
tube development GO:0035295 244 0.043
single organism cellular localization GO:1902580 180 0.042
regulation of protein complex assembly GO:0043254 42 0.041
negative regulation of cellular biosynthetic process GO:0031327 277 0.041
cellular response to external stimulus GO:0071496 66 0.040
rna localization GO:0006403 115 0.039
regulation of production of molecular mediator of immune response GO:0002700 44 0.039
response to organonitrogen compound GO:0010243 75 0.039
protein transport GO:0015031 155 0.039
centrosome duplication GO:0051298 121 0.038
regulation of dna templated transcription elongation GO:0032784 17 0.038
establishment of localization in cell GO:0051649 402 0.038
positive regulation of protein metabolic process GO:0051247 128 0.037
nucleobase containing compound catabolic process GO:0034655 165 0.037
response to endogenous stimulus GO:0009719 119 0.037
negative regulation of signaling GO:0023057 219 0.037
production of molecular mediator of immune response GO:0002440 46 0.037
cell division GO:0051301 248 0.037
response to other organism GO:0051707 293 0.036
regulation of localization GO:0032879 275 0.036
response to organic substance GO:0010033 284 0.036
positive regulation of protein complex assembly GO:0031334 22 0.035
negative regulation of gene expression GO:0010629 387 0.035
negative regulation of cell cycle process GO:0010948 109 0.035
intracellular transport GO:0046907 228 0.035
cellular response to nutrient levels GO:0031669 62 0.035
response to oxidative stress GO:0006979 86 0.034
lipid localization GO:0010876 54 0.034
regulation of cellular localization GO:0060341 136 0.034
nuclear import GO:0051170 51 0.034
response to extracellular stimulus GO:0009991 116 0.034
stem cell development GO:0048864 79 0.034
growth GO:0040007 359 0.034
nuclear envelope organization GO:0006998 7 0.033
intracellular signal transduction GO:0035556 300 0.033
organonitrogen compound biosynthetic process GO:1901566 117 0.033
regulation of growth GO:0040008 233 0.032
regulation of immune effector process GO:0002697 52 0.032
positive regulation of endopeptidase activity GO:0010950 26 0.032
wing disc morphogenesis GO:0007472 344 0.032
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.031
centrosome cycle GO:0007098 137 0.031
protein secretion GO:0009306 45 0.031
histolysis GO:0007559 102 0.031
regulation of response to external stimulus GO:0032101 115 0.031
enzyme linked receptor protein signaling pathway GO:0007167 179 0.030
phosphorylation GO:0016310 294 0.030
cellular homeostasis GO:0019725 80 0.030
carboxylic acid metabolic process GO:0019752 92 0.029
regulation of molecular function GO:0065009 217 0.029
multi multicellular organism process GO:0044706 123 0.029
aromatic compound catabolic process GO:0019439 166 0.028
protein complex biogenesis GO:0070271 201 0.028
Yeast
dna metabolic process GO:0006259 227 0.028
lipid biosynthetic process GO:0008610 46 0.027
regulation of antimicrobial humoral response GO:0002759 50 0.027
exocrine system development GO:0035272 162 0.026
immune effector process GO:0002252 98 0.026
digestive system development GO:0055123 149 0.026
cell maturation GO:0048469 144 0.026
nuclear pore organization GO:0006999 1 0.025
phagocytosis GO:0006909 215 0.025
proteasome assembly GO:0043248 2 0.025
Yeast
regulation of developmental growth GO:0048638 174 0.025
regionalization GO:0003002 416 0.025
regulation of response to biotic stimulus GO:0002831 63 0.025
endomembrane system organization GO:0010256 119 0.025
regulation of mitosis GO:0007088 56 0.024
regulation of cellular ketone metabolic process GO:0010565 3 0.024
negative regulation of peptidoglycan recognition protein signaling pathway GO:0061060 3 0.024
organic acid metabolic process GO:0006082 103 0.024
regulation of cell cycle GO:0051726 291 0.024
positive regulation of peptidase activity GO:0010952 29 0.024
embryonic development via the syncytial blastoderm GO:0001700 148 0.023
dna repair GO:0006281 54 0.023
regulation of response to stress GO:0080134 200 0.023
tube morphogenesis GO:0035239 191 0.023
regulation of protein modification by small protein conjugation or removal GO:1903320 25 0.022
response to starvation GO:0042594 97 0.022
connective tissue development GO:0061448 3 0.022
regulation of establishment of protein localization GO:0070201 61 0.022
regulation of organelle organization GO:0033043 196 0.022
single organism intracellular transport GO:1902582 207 0.022
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 24 0.022
transcription initiation from rna polymerase ii promoter GO:0006367 25 0.022
nucleoside phosphate metabolic process GO:0006753 162 0.021
eggshell formation GO:0030703 105 0.021
organelle fission GO:0048285 340 0.021
regulation of transport GO:0051049 181 0.021
mitotic cell cycle phase transition GO:0044772 138 0.021
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.021
positive regulation of cell development GO:0010720 61 0.021
regulation of cell development GO:0060284 215 0.021
epithelial cell differentiation GO:0030855 322 0.021
positive regulation of catabolic process GO:0009896 105 0.021
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 65 0.021
lipid storage GO:0019915 38 0.021
protein deubiquitination GO:0016579 17 0.021
axis specification GO:0009798 167 0.021
inositol lipid mediated signaling GO:0048017 4 0.021
regulation of proteolysis GO:0030162 87 0.020
negative regulation of cell death GO:0060548 81 0.020
positive regulation of developmental growth GO:0048639 62 0.020
oxoacid metabolic process GO:0043436 103 0.020
positive regulation of proteasomal protein catabolic process GO:1901800 20 0.020
positive regulation of transcription dna templated GO:0045893 266 0.020
negative regulation of cellular protein metabolic process GO:0032269 85 0.020
heterocycle catabolic process GO:0046700 166 0.020
ribonucleoside triphosphate metabolic process GO:0009199 119 0.020
gland development GO:0048732 191 0.020
guanosine containing compound metabolic process GO:1901068 74 0.019
nucleoside metabolic process GO:0009116 127 0.019
posttranscriptional regulation of gene expression GO:0010608 145 0.019
regulation of i kappab kinase nf kappab signaling GO:0043122 2 0.019
negative regulation of multicellular organismal process GO:0051241 142 0.019
purine nucleoside catabolic process GO:0006152 112 0.019
nitrogen compound transport GO:0071705 85 0.019
autophagic vacuole assembly GO:0000045 2 0.019
organophosphate metabolic process GO:0019637 195 0.018
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.018
cellular ketone metabolic process GO:0042180 24 0.018
secretion by cell GO:0032940 101 0.018
mesenchymal cell development GO:0014031 1 0.018
cellular amino acid metabolic process GO:0006520 61 0.018
transcription elongation from rna polymerase ii promoter GO:0006368 18 0.018
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.018
establishment or maintenance of cytoskeleton polarity GO:0030952 44 0.018
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 38 0.018
glycerolipid metabolic process GO:0046486 34 0.018
immune system process GO:0002376 347 0.018
divalent inorganic cation homeostasis GO:0072507 29 0.017
developmental maturation GO:0021700 172 0.017
regulation of defense response GO:0031347 102 0.017
tissue morphogenesis GO:0048729 297 0.017
negative regulation of cell proliferation GO:0008285 69 0.017
cell motility GO:0048870 251 0.017
appendage morphogenesis GO:0035107 397 0.017
protein localization GO:0008104 284 0.017
regulation of transcription regulatory region dna binding GO:2000677 3 0.017
regulation of phosphorus metabolic process GO:0051174 210 0.017
compound eye morphogenesis GO:0001745 249 0.017
rna polyadenylation GO:0043631 12 0.017
regulation of nf kappab import into nucleus GO:0042345 1 0.017
ovarian follicle cell development GO:0030707 248 0.017
negative regulation of protein metabolic process GO:0051248 85 0.017
mesenchymal cell differentiation GO:0048762 1 0.017
tissue death GO:0016271 102 0.017
regulation of apoptotic process GO:0042981 130 0.016
urogenital system development GO:0001655 72 0.016
positive regulation of proteolysis GO:0045862 52 0.016
imaginal disc derived wing morphogenesis GO:0007476 337 0.016
purine nucleotide metabolic process GO:0006163 146 0.016
regulation of autophagy GO:0010506 62 0.016
cellular response to lipopolysaccharide GO:0071222 3 0.016
chemotaxis GO:0006935 249 0.015
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.015
response to biotic stimulus GO:0009607 294 0.015
phosphatidylinositol mediated signaling GO:0048015 4 0.015
cellular nitrogen compound catabolic process GO:0044270 165 0.015
response to nutrient levels GO:0031667 114 0.015
positive regulation of signal transduction GO:0009967 223 0.015
purine ribonucleoside metabolic process GO:0046128 127 0.014
single organism nuclear import GO:1902593 51 0.014
rna catabolic process GO:0006401 37 0.014
nuclear transport GO:0051169 72 0.014
regulation of hydrolase activity GO:0051336 97 0.014
multi organism behavior GO:0051705 175 0.014
regulation of antimicrobial peptide biosynthetic process GO:0002805 38 0.014
positive regulation of molecular function GO:0044093 136 0.014
regulation of protein ubiquitination GO:0031396 22 0.014
hemopoiesis GO:0030097 46 0.014
smad protein import into nucleus GO:0007184 11 0.014
positive regulation of catalytic activity GO:0043085 118 0.014
purine nucleoside metabolic process GO:0042278 127 0.014
localization of cell GO:0051674 257 0.014
regulation of programmed cell death GO:0043067 152 0.014
regulation of cell proliferation GO:0042127 163 0.013
anterior posterior axis specification GO:0009948 109 0.013
columnar cuboidal epithelial cell development GO:0002066 249 0.013
cellular amide metabolic process GO:0043603 80 0.013
positive regulation of response to stimulus GO:0048584 323 0.013
forebrain development GO:0030900 2 0.013
positive regulation of protein modification process GO:0031401 58 0.013
rna polymerase ii transcriptional preinitiation complex assembly GO:0051123 20 0.013
compound eye development GO:0048749 307 0.013
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.013
amide biosynthetic process GO:0043604 42 0.013
apoptotic signaling pathway GO:0097190 27 0.013
hematopoietic or lymphoid organ development GO:0048534 57 0.012
negative regulation of phosphatidylinositol 3 kinase signaling GO:0014067 4 0.012
negative regulation of programmed cell death GO:0043069 72 0.012
regulation of cellular amino acid metabolic process GO:0006521 0 0.012
protein modification by small protein removal GO:0070646 28 0.012
maintenance of location GO:0051235 73 0.012
positive regulation of immune system process GO:0002684 68 0.012
positive regulation of phosphate metabolic process GO:0045937 139 0.012
protein import GO:0017038 55 0.012
mitotic g2 m transition checkpoint GO:0044818 70 0.012
regulation of translation GO:0006417 56 0.012
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 19 0.012
mitotic nuclear division GO:0007067 213 0.012
mrna polyadenylation GO:0006378 11 0.012
cellular response to abiotic stimulus GO:0071214 58 0.012
rna 3 end processing GO:0031123 45 0.011
regulation of mitotic cell cycle GO:0007346 190 0.011
regulation of cellular amine metabolic process GO:0033238 3 0.011
compound eye photoreceptor development GO:0042051 78 0.011
organophosphate catabolic process GO:0046434 112 0.011
protein localization to organelle GO:0033365 82 0.011
eye development GO:0001654 323 0.011
regulation of antimicrobial peptide production GO:0002784 44 0.011
regulation of cellular response to growth factor stimulus GO:0090287 13 0.011
regulation of cellular amide metabolic process GO:0034248 39 0.011
morphogenesis of an epithelium GO:0002009 276 0.011
regulation of cell division GO:0051302 72 0.011
phosphatidylinositol 3 kinase signaling GO:0014065 4 0.011
regulation of cytoplasmic transport GO:1903649 47 0.011
ethanolamine containing compound metabolic process GO:0042439 4 0.011
secretion GO:0046903 109 0.011
negative regulation of immune system process GO:0002683 50 0.010
tissue homeostasis GO:0001894 36 0.010
negative regulation of nucleic acid templated transcription GO:1903507 240 0.010
regulation of intracellular signal transduction GO:1902531 236 0.010
defense response to bacterium GO:0042742 178 0.010
hematopoietic progenitor cell differentiation GO:0002244 1 0.010
regulation of humoral immune response GO:0002920 51 0.010

Rpn2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.029