Drosophila melanogaster

196 known processes

tgo (Dmel_CG11987)

tango

(Aliases: Dmel\CG11987,DARNT,dTgo,Arnt,CG11987,Hif1,ARNT,darnt,HIF-1,Tango,HIF1b,bHLHe4,dARNT,arnt,HIF-1beta,prd7,Tgo,TGO)

tgo biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of neurogenesis GO:0050767 158 0.995
tube morphogenesis GO:0035239 191 0.987
tube development GO:0035295 244 0.985
neuron projection guidance GO:0097485 241 0.984
Zebrafish
axon guidance GO:0007411 233 0.971
Zebrafish
regulation of neuron differentiation GO:0045664 103 0.963
regulation of multicellular organismal development GO:2000026 414 0.962
cell motility GO:0048870 251 0.956
respiratory system development GO:0060541 213 0.943
digestive system development GO:0055123 149 0.942
tissue morphogenesis GO:0048729 297 0.935
morphogenesis of an epithelium GO:0002009 276 0.893
cell migration GO:0016477 238 0.887
taxis GO:0042330 304 0.882
Zebrafish
establishment of localization in cell GO:0051649 402 0.850
retinal ganglion cell axon guidance GO:0031290 12 0.837
axon development GO:0061564 297 0.825
Zebrafish
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.801
positive regulation of transcription dna templated GO:0045893 266 0.760
central nervous system development GO:0007417 201 0.754
embryonic morphogenesis GO:0048598 206 0.748
morphogenesis of a branching epithelium GO:0061138 45 0.697
axonogenesis GO:0007409 290 0.676
Zebrafish
response to biotic stimulus GO:0009607 294 0.669
transcription from rna polymerase ii promoter GO:0006366 368 0.668
regulation of nervous system development GO:0051960 248 0.660
branching involved in open tracheal system development GO:0060446 45 0.648
regionalization GO:0003002 416 0.635
localization of cell GO:0051674 257 0.628
chemotaxis GO:0006935 249 0.627
Zebrafish
cellular protein modification process GO:0006464 438 0.607
Mouse
regulation of cell proliferation GO:0042127 163 0.560
Rat
regulation of synapse organization GO:0050807 110 0.552
branching morphogenesis of an epithelial tube GO:0048754 45 0.544
positive regulation of macromolecule metabolic process GO:0010604 405 0.542
gliogenesis GO:0042063 80 0.517
response to external biotic stimulus GO:0043207 293 0.507
ameboidal type cell migration GO:0001667 151 0.483
morphogenesis of a branching structure GO:0001763 45 0.481
imaginal disc derived appendage development GO:0048737 399 0.481
muscle structure development GO:0061061 224 0.480
regulation of cell development GO:0060284 215 0.468
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.463
developmental growth GO:0048589 280 0.450
appendage development GO:0048736 401 0.428
regulation of cell differentiation GO:0045595 302 0.412
larval development GO:0002164 104 0.401
cell recognition GO:0008037 102 0.390
wnt signaling pathway GO:0016055 98 0.382
eye morphogenesis GO:0048592 260 0.372
response to other organism GO:0051707 293 0.365
digestive tract development GO:0048565 149 0.361
protein modification process GO:0036211 438 0.355
Mouse
head development GO:0060322 135 0.349
body morphogenesis GO:0010171 2 0.303
Worm
multi multicellular organism process GO:0044706 123 0.300
positive regulation of rna metabolic process GO:0051254 271 0.296
defense response to other organism GO:0098542 225 0.296
negative regulation of rna biosynthetic process GO:1902679 240 0.286
appendage morphogenesis GO:0035107 397 0.283
muscle cell differentiation GO:0042692 103 0.279
multicellular organismal reproductive behavior GO:0033057 110 0.269
neurological system process GO:0050877 358 0.267
organonitrogen compound metabolic process GO:1901564 318 0.259
vesicle mediated transport GO:0016192 381 0.251
telencephalon development GO:0021537 2 0.248
kidney epithelium development GO:0072073 3 0.248
gland development GO:0048732 191 0.244
Zebrafish
cellular component assembly involved in morphogenesis GO:0010927 151 0.244
circulatory system development GO:0072359 82 0.243
Zebrafish
negative regulation of neurogenesis GO:0050768 53 0.216
epithelial cell migration GO:0010631 148 0.214
forebrain development GO:0030900 2 0.203
Zebrafish
cellular response to endogenous stimulus GO:0071495 80 0.192
growth GO:0040007 359 0.188
negative regulation of nervous system development GO:0051961 92 0.183
negative regulation of developmental process GO:0051093 201 0.173
defense response GO:0006952 300 0.169
negative regulation of cell communication GO:0010648 223 0.167
intracellular transport GO:0046907 228 0.166
glial cell differentiation GO:0010001 35 0.162
axon choice point recognition GO:0016198 26 0.161
positive regulation of signaling GO:0023056 243 0.158
columnar cuboidal epithelial cell development GO:0002066 249 0.156
regulation of epithelial cell proliferation GO:0050678 4 0.154
epithelial tube morphogenesis GO:0060562 88 0.148
blastoderm segmentation GO:0007350 159 0.148
epithelial cell differentiation GO:0030855 322 0.147
defense response to fungus GO:0050832 48 0.144
morphogenesis of embryonic epithelium GO:0016331 94 0.143
response to bacterium GO:0009617 198 0.142
negative regulation of signal transduction GO:0009968 206 0.141
regulation of synapse structure and activity GO:0050803 128 0.137
axon midline choice point recognition GO:0016199 26 0.135
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.135
regulation of anatomical structure morphogenesis GO:0022603 242 0.134
embryonic organ development GO:0048568 50 0.133
Mouse
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.132
positive regulation of response to stimulus GO:0048584 323 0.128
post embryonic appendage morphogenesis GO:0035120 385 0.127
open tracheal system development GO:0007424 204 0.125
synapse assembly GO:0007416 143 0.124
regulation of wnt signaling pathway GO:0030111 68 0.122
cell cell signaling involved in cell fate commitment GO:0045168 210 0.120
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.119
gastrulation GO:0007369 70 0.116
negative regulation of cellular metabolic process GO:0031324 382 0.114
negative regulation of cell proliferation GO:0008285 69 0.114
glial cell migration GO:0008347 31 0.110
tissue migration GO:0090130 155 0.107
reproductive system development GO:0061458 74 0.106
Mouse
negative regulation of response to stimulus GO:0048585 258 0.100
endocytosis GO:0006897 310 0.097
oxoacid metabolic process GO:0043436 103 0.097
positive regulation of cellular biosynthetic process GO:0031328 316 0.094
cell migration involved in gastrulation GO:0042074 9 0.092
single organism intracellular transport GO:1902582 207 0.091
organ growth GO:0035265 56 0.091
positive regulation of cell differentiation GO:0045597 64 0.090
positive regulation of nervous system development GO:0051962 69 0.090
positive regulation of gene expression GO:0010628 290 0.089
cellular response to peptide GO:1901653 28 0.089
positive regulation of cell communication GO:0010647 250 0.085
negative regulation of rna metabolic process GO:0051253 251 0.084
brain development GO:0007420 120 0.084
nephron development GO:0072006 3 0.084
wing disc morphogenesis GO:0007472 344 0.083
digestive tract morphogenesis GO:0048546 127 0.081
regulation of photoreceptor cell axon guidance GO:2000289 5 0.080
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.077
small molecule metabolic process GO:0044281 305 0.077
cellular response to growth factor stimulus GO:0071363 30 0.077
positive regulation of nucleic acid templated transcription GO:1903508 266 0.076
positive regulation of rna biosynthetic process GO:1902680 266 0.076
regulation of protein modification process GO:0031399 112 0.075
Mouse
olfactory bulb axon guidance GO:0071678 3 0.075
organelle localization GO:0051640 148 0.074
regulation of cell morphogenesis GO:0022604 163 0.072
mushroom body development GO:0016319 70 0.070
lateral inhibition GO:0046331 206 0.070
establishment or maintenance of cell polarity GO:0007163 167 0.070
sex differentiation GO:0007548 81 0.070
neural precursor cell proliferation GO:0061351 75 0.069
regulation of axon extension involved in axon guidance GO:0048841 4 0.068
regulation of cell morphogenesis involved in differentiation GO:0010769 61 0.065
ovarian follicle cell migration GO:0007297 121 0.064
kidney development GO:0001822 3 0.063
single organism behavior GO:0044708 391 0.063
Fly
regulation of axonogenesis GO:0050770 32 0.063
regulation of localization GO:0032879 275 0.061
intracellular signal transduction GO:0035556 300 0.061
negative regulation of response to external stimulus GO:0032102 22 0.059
positive regulation of nucleoside metabolic process GO:0045979 47 0.058
chemosensory behavior GO:0007635 106 0.057
heart morphogenesis GO:0003007 32 0.057
Zebrafish
regulation of cell cycle GO:0051726 291 0.057
compound eye photoreceptor development GO:0042051 78 0.056
negative regulation of signaling GO:0023057 219 0.056
negative regulation of protein phosphorylation GO:0001933 17 0.054
regulation of tube architecture open tracheal system GO:0035152 68 0.054
reproductive structure development GO:0048608 74 0.052
Mouse
response to wounding GO:0009611 94 0.051
negative regulation of cell differentiation GO:0045596 143 0.051
single organism cell adhesion GO:0098602 47 0.051
Zebrafish
regulation of phosphorus metabolic process GO:0051174 210 0.051
protein localization GO:0008104 284 0.051
imaginal disc derived wing margin morphogenesis GO:0008587 41 0.050
cellular macromolecule localization GO:0070727 220 0.050
stem cell development GO:0048864 79 0.049
specification of symmetry GO:0009799 13 0.049
anterior posterior pattern specification GO:0009952 136 0.048
death GO:0016265 284 0.047
Rat
embryonic pattern specification GO:0009880 174 0.047
epithelial cell development GO:0002064 274 0.047
positive regulation of signal transduction GO:0009967 223 0.047
negative regulation of cell development GO:0010721 62 0.046
oocyte differentiation GO:0009994 145 0.046
regulation of cell migration GO:0030334 22 0.046
regulation of cell cycle process GO:0010564 181 0.046
gonad development GO:0008406 50 0.046
axis specification GO:0009798 167 0.045
dorsal trunk growth open tracheal system GO:0035001 7 0.045
regulation of cellular response to growth factor stimulus GO:0090287 13 0.045
substrate dependent cell migration GO:0006929 3 0.044
axon extension involved in axon guidance GO:0048846 10 0.044
nuclear transport GO:0051169 72 0.043
regulation of meiosis GO:0040020 3 0.043
regulation of chemotaxis GO:0050920 12 0.043
embryonic axis specification GO:0000578 107 0.042
cellular macromolecular complex assembly GO:0034622 153 0.042
multi organism reproductive behavior GO:0044705 121 0.042
stem cell differentiation GO:0048863 117 0.042
cell junction organization GO:0034330 57 0.041
negative regulation of transcription dna templated GO:0045892 237 0.041
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.040
lymph gland development GO:0048542 28 0.040
regulation of apoptotic process GO:0042981 130 0.040
Rat
regulation of phosphate metabolic process GO:0019220 210 0.039
cellular response to oxygen containing compound GO:1901701 79 0.039
photoreceptor cell differentiation GO:0046530 170 0.039
neuron recognition GO:0008038 101 0.038
response to fungus GO:0009620 50 0.038
heart development GO:0007507 82 0.038
Zebrafish
regulation of epithelial cell migration GO:0010632 12 0.036
striated muscle cell differentiation GO:0051146 90 0.036
regulation of hemocyte proliferation GO:0035206 37 0.035
negative regulation of cellular component organization GO:0051129 108 0.035
branch fusion open tracheal system GO:0035147 17 0.035
enzyme linked receptor protein signaling pathway GO:0007167 179 0.035
ribonucleoside triphosphate metabolic process GO:0009199 119 0.034
segmentation GO:0035282 207 0.034
macromolecular complex assembly GO:0065003 256 0.034
actin cytoskeleton organization GO:0030036 206 0.034
cell adhesion GO:0007155 136 0.033
Zebrafish
r7 cell differentiation GO:0045466 43 0.033
cellular response to chemical stimulus GO:0070887 199 0.033
cellular response to nitrogen compound GO:1901699 51 0.032
regulation of cell motility GO:2000145 23 0.031
mesenchymal cell differentiation GO:0048762 1 0.031
carboxylic acid metabolic process GO:0019752 92 0.031
oviposition GO:0018991 19 0.030
regulation of response to external stimulus GO:0032101 115 0.030
developmental growth involved in morphogenesis GO:0060560 65 0.030
blood circulation GO:0008015 26 0.030
oocyte development GO:0048599 124 0.030
regulation of cell division GO:0051302 72 0.029
photoreceptor cell axon guidance GO:0072499 23 0.029
regulation of response to stress GO:0080134 200 0.029
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.028
positive regulation of multicellular organismal process GO:0051240 143 0.028
Human
imaginal disc derived wing morphogenesis GO:0007476 337 0.028
regulation of protein metabolic process GO:0051246 256 0.028
Mouse
embryonic hemopoiesis GO:0035162 26 0.027
synapse organization GO:0050808 196 0.027
motor neuron axon guidance GO:0008045 58 0.027
negative regulation of nucleic acid templated transcription GO:1903507 240 0.027
endosomal transport GO:0016197 44 0.027
long term memory GO:0007616 62 0.027
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.027
phagocytosis GO:0006909 215 0.026
negative regulation of gene expression GO:0010629 387 0.026
positive regulation of ribosome biogenesis GO:0090070 3 0.026
imaginal disc growth GO:0007446 37 0.026
eye photoreceptor cell development GO:0042462 81 0.026
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.026
positive regulation of biosynthetic process GO:0009891 316 0.026
imaginal disc derived wing vein morphogenesis GO:0008586 44 0.025
wound healing GO:0042060 75 0.025
endomembrane system organization GO:0010256 119 0.025
carbohydrate derivative metabolic process GO:1901135 217 0.024
regulation of behavior GO:0050795 75 0.024
Fly
membrane organization GO:0061024 112 0.024
hindgut development GO:0061525 58 0.024
actin filament based process GO:0030029 220 0.024
negative regulation of multicellular organismal process GO:0051241 142 0.024
establishment of tissue polarity GO:0007164 87 0.024
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.024
defense response to bacterium GO:0042742 178 0.023
connective tissue development GO:0061448 3 0.023
mesoderm development GO:0007498 78 0.023
negative regulation of nucleotide catabolic process GO:0030812 1 0.023
regulation of embryonic development GO:0045995 68 0.023
regulation of cell adhesion GO:0030155 27 0.023
regulation of axon guidance GO:1902667 10 0.022
negative regulation of epithelial cell migration GO:0010633 1 0.022
histone h3 k9 modification GO:0061647 12 0.022
regulation of cellular ketone metabolic process GO:0010565 3 0.022
development of primary sexual characteristics GO:0045137 50 0.022
response to organic substance GO:0010033 284 0.022
regulation of epithelial cell migration open tracheal system GO:2000274 11 0.021
small gtpase mediated signal transduction GO:0007264 88 0.021
regulation of striated muscle contraction GO:0006942 2 0.021
homeostatic process GO:0042592 199 0.021
regulation of immune system process GO:0002682 176 0.021
retina morphogenesis in camera type eye GO:0060042 2 0.021
programmed cell death GO:0012501 257 0.021
Rat
receptor mediated endocytosis GO:0006898 21 0.021
photoreceptor cell development GO:0042461 96 0.021
negative regulation of phosphate metabolic process GO:0045936 45 0.021
phosphorylation GO:0016310 294 0.021
single organism catabolic process GO:0044712 228 0.021
male sex differentiation GO:0046661 25 0.021
negative regulation of protein metabolic process GO:0051248 85 0.020
retina development in camera type eye GO:0060041 4 0.020
diterpenoid biosynthetic process GO:0016102 1 0.020
icosanoid biosynthetic process GO:0046456 1 0.020
negative regulation of phosphorus metabolic process GO:0010563 45 0.020
regulation of organelle organization GO:0033043 196 0.020
tripartite regional subdivision GO:0007351 103 0.019
camera type eye morphogenesis GO:0048593 2 0.019
convergent extension GO:0060026 2 0.018
negative regulation of phosphorylation GO:0042326 35 0.018
positive regulation of cellular amine metabolic process GO:0033240 0 0.018
adult locomotory behavior GO:0008344 76 0.018
organelle assembly GO:0070925 198 0.018
dendrite guidance GO:0070983 21 0.018
multicellular organismal aging GO:0010259 140 0.018
cellular ketone metabolic process GO:0042180 24 0.018
cellular response to organonitrogen compound GO:0071417 36 0.018
positive regulation of protein modification process GO:0031401 58 0.017
Mouse
neuromuscular process GO:0050905 21 0.017
rubidium ion transport GO:0035826 1 0.017
negative regulation of molecular function GO:0044092 51 0.017
cellular amino acid metabolic process GO:0006520 61 0.017
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.017
regulation of catalytic activity GO:0050790 185 0.017
regulation of cellular component movement GO:0051270 42 0.017
positive regulation of axonogenesis GO:0050772 2 0.017
positive regulation of cell migration GO:0030335 2 0.017
hemopoiesis GO:0030097 46 0.016
organonitrogen compound catabolic process GO:1901565 128 0.016
urogenital system development GO:0001655 72 0.016
negative regulation of biosynthetic process GO:0009890 277 0.016
oocyte morphogenesis GO:0048601 3 0.016
regulation of cellular amino acid metabolic process GO:0006521 0 0.015
regulation of molecular function GO:0065009 217 0.015
positive regulation of cellular component organization GO:0051130 156 0.015
multi organism behavior GO:0051705 175 0.015
Worm
endoderm formation GO:0001706 3 0.015
semaphorin plexin signaling pathway involved in regulation of photoreceptor cell axon guidance GO:2000305 2 0.015
single organismal cell cell adhesion GO:0016337 45 0.015
Zebrafish
cellular response to organic substance GO:0071310 132 0.015
limb morphogenesis GO:0035108 1 0.015
regulation of nuclear division GO:0051783 58 0.015
establishment of protein localization GO:0045184 163 0.015
hindbrain development GO:0030902 2 0.014
dorsal ventral axon guidance GO:0033563 2 0.014
regulation of locomotion GO:0040012 42 0.014
compound eye photoreceptor cell differentiation GO:0001751 140 0.014
regulation of mitotic cell cycle GO:0007346 190 0.014
positive regulation of developmental process GO:0051094 143 0.013
embryo development ending in birth or egg hatching GO:0009792 152 0.013
Mouse
regulation of synapse assembly GO:0051963 94 0.013
organelle fission GO:0048285 340 0.013
camera type eye development GO:0043010 4 0.013
nephron epithelium development GO:0072009 3 0.013
regulation of epidermal growth factor receptor signaling pathway GO:0042058 42 0.013
regulation of cellular amine metabolic process GO:0033238 3 0.013
purine ribonucleoside catabolic process GO:0046130 112 0.013
protein complex assembly GO:0006461 200 0.013
negative regulation of protein modification process GO:0031400 29 0.013
nucleotide catabolic process GO:0009166 109 0.013
cellular response to nutrient GO:0031670 1 0.013
positive regulation of immune response GO:0050778 63 0.013
response to hormone GO:0009725 45 0.012
cell death GO:0008219 279 0.012
Rat
regulation of mitotic spindle checkpoint GO:1903504 1 0.012
genital disc morphogenesis GO:0007483 16 0.012
central nervous system projection neuron axonogenesis GO:0021952 6 0.012
response to peptide GO:1901652 29 0.012
arp2 3 complex mediated actin nucleation GO:0034314 3 0.012
anterior head segmentation GO:0035288 3 0.012
negative regulation of epithelial cell proliferation GO:0050680 4 0.012
amine metabolic process GO:0009308 12 0.012
cell fate specification GO:0001708 71 0.012
Worm
negative regulation of gtpase activity GO:0034260 1 0.012
mitochondrial membrane organization GO:0007006 3 0.012
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 1 0.012
biological adhesion GO:0022610 138 0.012
Zebrafish
regulation of cell proliferation involved in compound eye morphogenesis GO:2000495 2 0.012
dorsal ventral pattern formation GO:0009953 133 0.011
meiotic nuclear envelope disassembly GO:0051078 2 0.011
regulation of cellular protein metabolic process GO:0032268 243 0.011
Mouse
positive regulation of immune system process GO:0002684 68 0.011
protein phosphorylation GO:0006468 169 0.011
hindgut morphogenesis GO:0007442 58 0.011
positive regulation of cell motility GO:2000147 3 0.011
cellular response to peptide hormone stimulus GO:0071375 28 0.011
regulation of intracellular signal transduction GO:1902531 236 0.011
regulation of nucleoside metabolic process GO:0009118 50 0.011
dna catabolic process endonucleolytic GO:0000737 6 0.011
anterior posterior axis specification GO:0009948 109 0.011
spinal cord development GO:0021510 1 0.011
positive regulation of transport GO:0051050 92 0.011
dendrite morphogenesis GO:0048813 199 0.011
epithelial cell migration open tracheal system GO:0007427 32 0.011
nucleoside triphosphate catabolic process GO:0009143 108 0.011
negative regulation of nucleotide metabolic process GO:0045980 4 0.010
establishment of protein localization to organelle GO:0072594 62 0.010
heart process GO:0003015 37 0.010
neuroblast proliferation GO:0007405 74 0.010
regulation of growth GO:0040008 233 0.010
positive regulation of catalytic activity GO:0043085 118 0.010
positive regulation of hydrolase activity GO:0051345 78 0.010

tgo disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.036
nervous system disease DOID:863 0 0.036
musculoskeletal system disease DOID:17 0 0.018
cancer DOID:162 0 0.015
disease of cellular proliferation DOID:14566 0 0.015
artery disease DOID:0050828 0 0.010
aortic aneurysm DOID:3627 0 0.010
vascular disease DOID:178 0 0.010
cardiovascular system disease DOID:1287 0 0.010
aortic disease DOID:520 0 0.010