Drosophila melanogaster

390 known processes

Cdc42 (Dmel_CG12530)

CG12530 gene product from transcript CG12530-RA

(Aliases: DCDC42,DCdc42,CG12530,Dm Cdc42,DmCDC42,Dcdc42,Dmcdc42,Cdc42Dm,D-Cdc42,cdc42,D-CDC42,Dmel\CG12530,D-cdc42,CDC42)

Cdc42 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
germarium derived egg chamber formation GO:0007293 101 1.000
imaginal disc derived wing hair site selection GO:0035320 4 1.000
Fly
female germ line cyst formation GO:0048135 42 0.999
oocyte axis specification GO:0007309 108 0.999
Fly
pole plasm rna localization GO:0007316 52 0.998
Fly
oocyte differentiation GO:0009994 145 0.998
Fly
initiation of dorsal closure GO:0007392 12 0.998
Fly
pole plasm assembly GO:0007315 61 0.997
Fly
pole plasm oskar mrna localization GO:0045451 46 0.996
Fly
regulation of dendrite morphogenesis GO:0048814 28 0.995
Fly
morphogenesis of an epithelium GO:0002009 276 0.995
axonogenesis GO:0007409 290 0.994
germarium derived female germ line cyst formation GO:0030727 42 0.994
spermatogenesis GO:0007283 200 0.994
oocyte construction GO:0007308 112 0.993
Fly
establishment or maintenance of cell polarity GO:0007163 167 0.993
germ line cyst formation GO:0048134 44 0.992
oocyte development GO:0048599 124 0.989
Fly
spermatid differentiation GO:0048515 114 0.989
tissue morphogenesis GO:0048729 297 0.985
oocyte microtubule cytoskeleton organization GO:0016325 35 0.983
Fly
oocyte microtubule cytoskeleton polarization GO:0008103 22 0.978
Fly
immune system process GO:0002376 347 0.976
dorsal appendage formation GO:0046843 47 0.975
neurological system process GO:0050877 358 0.974
dendrite development GO:0016358 204 0.971
actin cytoskeleton reorganization GO:0031532 22 0.969
epithelial cell differentiation GO:0030855 322 0.968
renal filtration GO:0097205 7 0.966
hemocyte migration GO:0035099 19 0.964
regulation of filopodium assembly GO:0051489 24 0.962
establishment of proximal distal cell polarity GO:0022606 4 0.962
Fly
chorion containing eggshell formation GO:0007304 105 0.958
cell competition in a multicellular organism GO:0035212 10 0.957
Fly
cell projection assembly GO:0030031 94 0.957
spermatid development GO:0007286 98 0.956
ovarian follicle cell development GO:0030707 248 0.955
compound eye development GO:0048749 307 0.954
Fly
axon guidance GO:0007411 233 0.949
axon development GO:0061564 297 0.947
epithelial cell migration GO:0010631 148 0.942
Fly
regulation of phosphatidylinositol 3 kinase activity GO:0043551 2 0.940
Mouse
morphogenesis of a polarized epithelium GO:0001738 93 0.940
Fly
cell adhesion GO:0007155 136 0.938
Human Mouse
establishment of neuroblast polarity GO:0045200 2 0.931
neuron recognition GO:0008038 101 0.928
Fly
embryonic ectodermal digestive tract morphogenesis GO:0048613 4 0.924
Fly
establishment or maintenance of cytoskeleton polarity GO:0030952 44 0.924
Fly
axonal fasciculation GO:0007413 12 0.923
Fly
imaginal disc derived wing hair outgrowth GO:0035318 1 0.918
single organismal cell cell adhesion GO:0016337 45 0.916
Mouse
immune response GO:0006955 246 0.912
respiratory system development GO:0060541 213 0.911
cellular macromolecule localization GO:0070727 220 0.907
Human Yeast Mouse Rat Fly
border follicle cell migration GO:0007298 113 0.906
Fly
regulation of actin cytoskeleton organization GO:0032956 42 0.898
maintenance of cell polarity GO:0030011 18 0.896
regulation of synaptic growth at neuromuscular junction GO:0008582 89 0.893
filopodium assembly GO:0046847 33 0.889
synaptic transmission GO:0007268 288 0.886
establishment of protein localization GO:0045184 163 0.882
Rat
organelle localization GO:0051640 148 0.880
Mouse Rat Worm
actin filament bundle organization GO:0061572 28 0.879
Mouse Fly
embryonic ectodermal digestive tract development GO:0048611 4 0.878
Fly
single organism cell adhesion GO:0098602 47 0.872
Human Mouse
actin filament bundle assembly GO:0051017 26 0.869
Mouse Fly
sensory perception GO:0007600 196 0.869
organelle fission GO:0048285 340 0.868
Yeast Mouse
organelle assembly GO:0070925 198 0.865
response to radiation GO:0009314 155 0.861
biological adhesion GO:0022610 138 0.859
Human Mouse
positive regulation of macromolecule metabolic process GO:0010604 405 0.858
melanization defense response GO:0035006 45 0.856
single organism cellular localization GO:1902580 180 0.850
Worm Fly
synapse assembly GO:0007416 143 0.850
cell migration GO:0016477 238 0.843
eye morphogenesis GO:0048592 260 0.838
Fly
positive regulation of lamellipodium assembly GO:0010592 7 0.836
regulation of localization GO:0032879 275 0.829
Human Yeast Rat Fly
regulation of phosphorylation GO:0042325 147 0.829
open tracheal system development GO:0007424 204 0.828
regulation of cellular component biogenesis GO:0044087 201 0.827
male gamete generation GO:0048232 201 0.815
phosphorylation GO:0016310 294 0.813
regulation of actin filament polymerization GO:0030833 25 0.810
cell motility GO:0048870 251 0.800
establishment of ommatidial planar polarity GO:0042067 49 0.796
Fly
oocyte anterior posterior axis specification GO:0007314 72 0.790
Fly
regulation of synapse structure and activity GO:0050803 128 0.781
establishment or maintenance of neuroblast polarity GO:0045196 8 0.780
establishment of nucleus localization GO:0040023 26 0.762
Mouse
morphogenesis of embryonic epithelium GO:0016331 94 0.758
sensory organ morphogenesis GO:0090596 260 0.753
Fly
regulation of protein phosphorylation GO:0001932 64 0.750
dorsal closure GO:0007391 79 0.747
female meiotic division GO:0007143 70 0.736
cellularization GO:0007349 90 0.734
anterior posterior axis specification embryo GO:0008595 103 0.734
Fly
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.729
actin polymerization or depolymerization GO:0008154 31 0.723
regulation of synaptic transmission GO:0050804 69 0.720
sensory perception of touch GO:0050975 11 0.716
protein modification process GO:0036211 438 0.715
regulation of anatomical structure morphogenesis GO:0022603 242 0.711
neuromuscular junction development GO:0007528 149 0.711
negative regulation of cellular metabolic process GO:0031324 382 0.711
cytoskeleton dependent cytokinesis GO:0061640 81 0.706
tissue migration GO:0090130 155 0.700
Fly
actin cytoskeleton organization GO:0030036 206 0.699
intracellular signal transduction GO:0035556 300 0.689
dendrite morphogenesis GO:0048813 199 0.688
ovarian follicle cell migration GO:0007297 121 0.687
Fly
gland development GO:0048732 191 0.683
Rat Fly
actin filament organization GO:0007015 126 0.681
regulation of tube architecture open tracheal system GO:0035152 68 0.673
eggshell chorion assembly GO:0007306 66 0.670
negative regulation of signaling GO:0023057 219 0.670
mapk cascade GO:0000165 107 0.666
Mouse Rat Fly
actomyosin structure organization GO:0031032 56 0.661
regulation of cell projection organization GO:0031344 92 0.660
embryonic development via the syncytial blastoderm GO:0001700 148 0.658
regulation of actin filament length GO:0030832 27 0.658
cytoplasmic transport nurse cell to oocyte GO:0007303 12 0.657
nucleus localization GO:0051647 34 0.651
Mouse
regulation of neuron projection development GO:0010975 69 0.644
regulation of lamellipodium assembly GO:0010591 15 0.642
regulation of wnt signaling pathway GO:0030111 68 0.639
regulation of cell cell adhesion GO:0022407 21 0.633
neuron projection guidance GO:0097485 241 0.631
cytokinesis GO:0000910 90 0.630
Human Worm
positive regulation of actin filament polymerization GO:0030838 11 0.628
regulation of actin filament based process GO:0032970 42 0.626
eye development GO:0001654 323 0.625
Fly
eye photoreceptor cell differentiation GO:0001754 145 0.624
Fly
macromolecular complex assembly GO:0065003 256 0.623
regulation of anatomical structure size GO:0090066 163 0.619
regulation of cell projection assembly GO:0060491 30 0.619
melanin metabolic process GO:0006582 47 0.615
anterior midgut ectodermal morphogenesis GO:0007441 4 0.610
Fly
dendrite self avoidance GO:0070593 8 0.607
skin development GO:0043588 65 0.606
regulation of cellular localization GO:0060341 136 0.605
Human Yeast Rat
developmental maturation GO:0021700 172 0.603
Fly
regulation of protein metabolic process GO:0051246 256 0.600
epidermal cell differentiation GO:0009913 51 0.598
neuromuscular synaptic transmission GO:0007274 67 0.597
pole plasm mrna localization GO:0019094 49 0.597
Fly
post embryonic appendage morphogenesis GO:0035120 385 0.596
tube development GO:0035295 244 0.595
dorsal closure spreading of leading edge cells GO:0007395 4 0.585
positive regulation of filopodium assembly GO:0051491 15 0.583
positive regulation of cell adhesion GO:0045785 10 0.581
Human
regulation of actin polymerization or depolymerization GO:0008064 27 0.576
cellular protein modification process GO:0006464 438 0.571
regulation of multicellular organismal development GO:2000026 414 0.556
establishment or maintenance of bipolar cell polarity GO:0061245 34 0.555
Mouse
r3 r4 cell fate commitment GO:0007464 10 0.551
branching involved in open tracheal system development GO:0060446 45 0.544
determination of digestive tract left right asymmetry GO:0071907 6 0.542
Fly
regulation of nervous system development GO:0051960 248 0.531
wnt signaling pathway planar cell polarity pathway GO:0060071 6 0.531
positive regulation of protein metabolic process GO:0051247 128 0.530
semaphorin plexin signaling pathway GO:0071526 4 0.528
organic substance transport GO:0071702 257 0.523
Rat
regulation of cytoskeleton organization GO:0051493 89 0.523
positive regulation of cellular component biogenesis GO:0044089 80 0.522
urogenital system development GO:0001655 72 0.521
signal transduction by phosphorylation GO:0023014 107 0.521
Mouse Rat Fly
secondary metabolic process GO:0019748 75 0.520
circulatory system development GO:0072359 82 0.518
Mouse Rat
regulation of synapse assembly GO:0051963 94 0.517
vesicle mediated transport GO:0016192 381 0.515
cell maturation GO:0048469 144 0.512
Fly
synaptic growth at neuromuscular junction GO:0051124 119 0.507
establishment of tissue polarity GO:0007164 87 0.503
Fly
cellular response to chemical stimulus GO:0070887 199 0.498
Yeast
regulation of cell development GO:0060284 215 0.495
meiotic nuclear division GO:0007126 151 0.494
negative regulation of developmental process GO:0051093 201 0.494
Worm
response to organic substance GO:0010033 284 0.494
Yeast
positive regulation of response to wounding GO:1903036 15 0.489
establishment of planar polarity GO:0001736 87 0.484
Fly
regulation of protein serine threonine kinase activity GO:0071900 25 0.481
Fly
pseudocleavage involved in syncytial blastoderm formation GO:0030589 9 0.480
positive regulation of wound healing GO:0090303 12 0.476
striated muscle cell differentiation GO:0051146 90 0.476
Fly
encapsulation of foreign target GO:0035010 38 0.463
digestive system development GO:0055123 149 0.460
Zebrafish Fly
regulation of neurogenesis GO:0050767 158 0.456
negative regulation of cell communication GO:0010648 223 0.453
response to metal ion GO:0010038 23 0.447
hemocyte development GO:0007516 7 0.434
Fly
regulation of organ morphogenesis GO:2000027 78 0.420
establishment or maintenance of apical basal cell polarity GO:0035088 34 0.412
Mouse
tube morphogenesis GO:0035239 191 0.410
regulation of phosphate metabolic process GO:0019220 210 0.408
melanotic encapsulation of foreign target GO:0035011 30 0.406
myoblast proliferation GO:0051450 3 0.402
Fly
positive regulation of response to stimulus GO:0048584 323 0.399
germarium derived oocyte fate determination GO:0007294 26 0.397
regulation of cell differentiation GO:0045595 302 0.393
growth GO:0040007 359 0.392
phagocytosis GO:0006909 215 0.391
epidermis development GO:0008544 65 0.385
dorsal closure amnioserosa morphology change GO:0046664 7 0.384
Fly
cognition GO:0050890 141 0.379
innate immune response GO:0045087 144 0.378
negative regulation of immune system process GO:0002683 50 0.374
embryonic morphogenesis GO:0048598 206 0.367
cortical actin cytoskeleton organization GO:0030866 24 0.366
ras protein signal transduction GO:0007265 88 0.364
single organism behavior GO:0044708 391 0.358
segmentation GO:0035282 207 0.358
Fly
localization of cell GO:0051674 257 0.358
neuromuscular process GO:0050905 21 0.349
meiotic chromosome segregation GO:0045132 59 0.348
salivary gland development GO:0007431 162 0.346
Rat Fly
establishment of localization in cell GO:0051649 402 0.345
Yeast Mouse Rat Worm
compound eye photoreceptor development GO:0042051 78 0.342
Fly
apoptotic cell clearance GO:0043277 14 0.336
nuclear division GO:0000280 332 0.335
Yeast Mouse
maintenance of protein location GO:0045185 28 0.335
asymmetric protein localization GO:0008105 33 0.334
pigment metabolic process GO:0042440 84 0.332
dorsal closure elongation of leading edge cells GO:0007394 10 0.332
Fly
membrane organization GO:0061024 112 0.329
Yeast
compound eye photoreceptor cell differentiation GO:0001751 140 0.327
Fly
cell substrate adhesion GO:0031589 10 0.324
Human
protein complex biogenesis GO:0070271 201 0.317
regulation of cell proliferation GO:0042127 163 0.315
Mouse
regulation of neuron differentiation GO:0045664 103 0.313
intracellular protein transport GO:0006886 104 0.312
Rat
cellular response to organic substance GO:0071310 132 0.311
Yeast
wing disc morphogenesis GO:0007472 344 0.309
regulation of establishment of protein localization GO:0070201 61 0.307
Rat
regulation of hemocyte differentiation GO:0045610 22 0.305
Fly
regulation of cell shape GO:0008360 113 0.304
cytoplasm organization GO:0007028 64 0.287
Fly
multi organism behavior GO:0051705 175 0.285
Fly
regulation of establishment of planar polarity GO:0090175 22 0.284
response to abiotic stimulus GO:0009628 341 0.284
taxis GO:0042330 304 0.281
meiotic cell cycle process GO:1903046 132 0.281
regulation of cell morphogenesis GO:0022604 163 0.277
regulation of cell cycle GO:0051726 291 0.274
Human Yeast Mouse Fly
negative regulation of apoptotic signaling pathway GO:2001234 5 0.274
response to organonitrogen compound GO:0010243 75 0.274
microtubule based transport GO:0010970 42 0.273
Rat
synapse organization GO:0050808 196 0.272
imaginal disc derived wing hair organization GO:0035317 45 0.271
regulation of dendrite development GO:0050773 37 0.268
Fly
photoreceptor cell differentiation GO:0046530 170 0.266
Fly
cellular lipid metabolic process GO:0044255 83 0.265
Mouse
response to other organism GO:0051707 293 0.265
Fly
regulation of axonogenesis GO:0050770 32 0.265
cell junction assembly GO:0034329 42 0.264
meiotic cell cycle GO:0051321 171 0.260
protein phosphorylation GO:0006468 169 0.255
adherens junction organization GO:0034332 27 0.255
Mouse Fly
exocrine system development GO:0035272 162 0.254
Rat Fly
phenol containing compound metabolic process GO:0018958 57 0.254
defense response GO:0006952 300 0.253
sensory perception of mechanical stimulus GO:0050954 72 0.253
purine ribonucleoside catabolic process GO:0046130 112 0.252
epithelial cell development GO:0002064 274 0.251
small gtpase mediated signal transduction GO:0007264 88 0.250
regulation of tube length open tracheal system GO:0035159 24 0.249
tracheal outgrowth open tracheal system GO:0007426 18 0.245
Fly
cellular protein localization GO:0034613 160 0.244
Human Yeast Mouse Rat
proteolysis GO:0006508 192 0.244
positive regulation of cellular protein metabolic process GO:0032270 118 0.243
multicellular organismal reproductive behavior GO:0033057 110 0.242
actin filament based process GO:0030029 220 0.236
single organism membrane organization GO:0044802 93 0.235
Yeast
r7 cell differentiation GO:0045466 43 0.234
maternal determination of anterior posterior axis embryo GO:0008358 74 0.234
Fly
peptidyl amino acid modification GO:0018193 105 0.234
Mouse
dorsal ventral axon guidance GO:0033563 2 0.233
protein localization to organelle GO:0033365 82 0.230
asymmetric neuroblast division GO:0055059 33 0.230
regulation of notch signaling pathway GO:0008593 100 0.229
reproductive behavior GO:0019098 122 0.229
Fly
regulation of actin filament bundle assembly GO:0032231 8 0.225
regulation of cell substrate adhesion GO:0010810 2 0.225
Human
positive regulation of cellular component organization GO:0051130 156 0.224
head development GO:0060322 135 0.222
Human
anterior posterior pattern specification GO:0009952 136 0.220
Fly
actin filament polymerization GO:0030041 27 0.216
regulation of protein kinase activity GO:0045859 51 0.214
single organism intracellular transport GO:1902582 207 0.214
Rat
regulation of embryonic development GO:0045995 68 0.213
Fly
negative regulation of protein metabolic process GO:0051248 85 0.211
muscle cell differentiation GO:0042692 103 0.211
Fly
hair cell differentiation GO:0035315 47 0.208
negative regulation of heart induction by canonical wnt signaling pathway GO:0003136 3 0.208
digestive tract morphogenesis GO:0048546 127 0.207
Zebrafish Fly
substrate dependent cell migration cell extension GO:0006930 3 0.207
wnt signaling pathway GO:0016055 98 0.207
Mouse
regulation of tube size open tracheal system GO:0035151 43 0.204
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.203
r3 r4 cell differentiation GO:0048056 12 0.201
regionalization GO:0003002 416 0.201
Fly
establishment of monopolar cell polarity GO:0061162 15 0.197
Fly
regulation of vesicle mediated transport GO:0060627 59 0.196
Yeast
chorion containing eggshell pattern formation GO:0030381 11 0.196
regulation of map kinase activity GO:0043405 17 0.196
stem cell proliferation GO:0072089 88 0.195
multi organism reproductive behavior GO:0044705 121 0.195
Fly
chemotaxis GO:0006935 249 0.194
regulation of substrate adhesion dependent cell spreading GO:1900024 1 0.194
Human
embryonic axis specification GO:0000578 107 0.192
Fly
ribonucleotide metabolic process GO:0009259 145 0.190
hemocyte differentiation GO:0042386 38 0.189
Fly
response to endogenous stimulus GO:0009719 119 0.189
cellular response to oxygen containing compound GO:1901701 79 0.188
protein localization GO:0008104 284 0.188
negative regulation of phosphate metabolic process GO:0045936 45 0.187
negative regulation of insulin receptor signaling pathway GO:0046627 11 0.186
appendage development GO:0048736 401 0.186
organic substance catabolic process GO:1901575 308 0.185
blastoderm segmentation GO:0007350 159 0.183
Fly
muscle structure development GO:0061061 224 0.181
Fly
establishment of imaginal disc derived wing hair orientation GO:0001737 24 0.179
Fly
protein transport GO:0015031 155 0.176
Rat
cell recognition GO:0008037 102 0.175
Fly
phagocytosis engulfment GO:0006911 11 0.175
striated muscle cell development GO:0055002 50 0.172
Fly
ameboidal type cell migration GO:0001667 151 0.171
Zebrafish Fly
cell proliferation GO:0008283 299 0.171
regulation of protein complex assembly GO:0043254 42 0.170
substrate dependent cell migration GO:0006929 3 0.170
negative regulation of response to stimulus GO:0048585 258 0.168
purine ribonucleotide catabolic process GO:0009154 109 0.168
cellular component assembly involved in morphogenesis GO:0010927 151 0.167
regulation of cellular protein metabolic process GO:0032268 243 0.166
regulation of mapk cascade GO:0043408 92 0.166
Mouse Rat
positive regulation of protein localization to plasma membrane GO:1903078 3 0.165
imaginal disc derived wing morphogenesis GO:0007476 337 0.164
tripartite regional subdivision GO:0007351 103 0.163
Fly
negative regulation of phosphorus metabolic process GO:0010563 45 0.163
regulation of endocytosis GO:0030100 37 0.161
outflow tract morphogenesis GO:0003151 4 0.161
rna localization GO:0006403 115 0.159
Fly
regulation of cell adhesion GO:0030155 27 0.158
Human
regulation of growth GO:0040008 233 0.158
neuroblast division GO:0055057 35 0.158
regulation of transport GO:0051049 181 0.158
Yeast Rat
cellular response to peptide GO:1901653 28 0.157
positive regulation of cell development GO:0010720 61 0.155
Human
regulation of immune system process GO:0002682 176 0.155
Fly
developmental growth GO:0048589 280 0.154
cell growth GO:0016049 108 0.154
Yeast Fly
axis specification GO:0009798 167 0.153
Fly
stem cell fate commitment GO:0048865 25 0.153
small molecule metabolic process GO:0044281 305 0.153
compound eye morphogenesis GO:0001745 249 0.153
Fly
epithelial cell morphogenesis GO:0003382 25 0.152
spindle organization GO:0007051 253 0.152
lamellipodium organization GO:0097581 21 0.149
axon regeneration GO:0031103 8 0.148
cell cell adhesion GO:0098609 26 0.147
body morphogenesis GO:0010171 2 0.145
Worm
stem cell differentiation GO:0048863 117 0.144
regulation of protein modification process GO:0031399 112 0.144
determination of adult lifespan GO:0008340 137 0.143
establishment of organelle localization GO:0051656 122 0.141
Mouse Rat Worm
organic acid metabolic process GO:0006082 103 0.141
membrane invagination GO:0010324 11 0.140
intracellular mrna localization GO:0008298 66 0.140
Fly
mating behavior GO:0007617 106 0.139
Fly
compound eye retinal cell programmed cell death GO:0046667 23 0.137
developmental programmed cell death GO:0010623 138 0.137
forebrain development GO:0030900 2 0.136
positive regulation of cell migration GO:0030335 2 0.135
cellular response to endogenous stimulus GO:0071495 80 0.134
intracellular mrna localization involved in pattern specification process GO:0060810 56 0.134
Fly
negative regulation of signal transduction GO:0009968 206 0.133
response to biotic stimulus GO:0009607 294 0.132
Fly
establishment or maintenance of monopolar cell polarity GO:0061339 15 0.132
Fly
imaginal disc derived appendage morphogenesis GO:0035114 395 0.132
response to external biotic stimulus GO:0043207 293 0.131
Fly
regulation of synapse organization GO:0050807 110 0.131
macromolecule catabolic process GO:0009057 161 0.130
Mouse Worm
cardiovascular system development GO:0072358 82 0.130
Mouse Rat
developmental growth involved in morphogenesis GO:0060560 65 0.130
Fly
cell type specific apoptotic process GO:0097285 38 0.129
Rat
imaginal disc derived wing vein specification GO:0007474 48 0.129
notch signaling pathway GO:0007219 120 0.129
anterior posterior axis specification GO:0009948 109 0.128
Fly
embryonic digestive tract development GO:0048566 5 0.126
Fly
negative regulation of cell development GO:0010721 62 0.126
epithelial cell cell adhesion GO:0090136 6 0.125
Mouse
cell fate determination GO:0001709 91 0.124
Mouse
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 6 0.124
cell cell junction organization GO:0045216 55 0.124
Mouse Fly
regulation of cell morphogenesis involved in differentiation GO:0010769 61 0.122
asymmetric stem cell division GO:0098722 49 0.120
stem cell development GO:0048864 79 0.120
embryonic heart tube development GO:0035050 22 0.119
collateral sprouting GO:0048668 3 0.119
cuticle pattern formation GO:0035017 27 0.119
appendage morphogenesis GO:0035107 397 0.118
myofibril assembly GO:0030239 36 0.117
regulation of protein polymerization GO:0032271 28 0.117
mitochondrion organization GO:0007005 65 0.117
mitotic spindle organization GO:0007052 220 0.116
embryonic pattern specification GO:0009880 174 0.116
Fly
negative regulation of protein modification process GO:0031400 29 0.114
homeostatic process GO:0042592 199 0.114
response to hydrogen peroxide GO:0042542 11 0.113
engulfment of apoptotic cell GO:0043652 6 0.113
protein localization to plasma membrane GO:0072659 13 0.112
apoptotic signaling pathway GO:0097190 27 0.112
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.112
brain development GO:0007420 120 0.111
Human
response to wounding GO:0009611 94 0.111
negative regulation of cellular protein metabolic process GO:0032269 85 0.110
establishment of protein localization to plasma membrane GO:0090002 9 0.110
regulation of jnk cascade GO:0046328 40 0.110
Rat
endomembrane system organization GO:0010256 119 0.107
Rat
larval behavior GO:0030537 42 0.106
imaginal disc derived appendage development GO:0048737 399 0.105
epithelial tube morphogenesis GO:0060562 88 0.104
regulation of epidermal growth factor receptor signaling pathway GO:0042058 42 0.103
myotube differentiation GO:0014902 46 0.103
Fly
determination of bilateral symmetry GO:0009855 13 0.103
Fly
response to hormone GO:0009725 45 0.102
negative regulation of compound eye retinal cell programmed cell death GO:0046673 7 0.101
negative regulation of heart induction GO:1901320 3 0.101
positive regulation of locomotion GO:0040017 8 0.101
micropyle formation GO:0046844 4 0.101
epithelium migration GO:0090132 148 0.101
Fly
intracellular transport GO:0046907 228 0.101
Rat
ribonucleoside metabolic process GO:0009119 127 0.100
positive regulation of cell motility GO:2000147 3 0.098
negative regulation of nervous system development GO:0051961 92 0.098
specification of axis polarity GO:0065001 6 0.098
circulatory system process GO:0003013 37 0.097
Mouse
formation of anatomical boundary GO:0048859 37 0.094
positive regulation of peptidase activity GO:0010952 29 0.092
cell cell junction assembly GO:0007043 38 0.092
cell matrix adhesion GO:0007160 6 0.092
regulation of lipid kinase activity GO:0043550 2 0.091
Mouse
stress fiber assembly GO:0043149 6 0.091
eye photoreceptor cell fate commitment GO:0042706 37 0.091
centrosome cycle GO:0007098 137 0.090
negative regulation of synaptic growth at neuromuscular junction GO:0045886 39 0.090
regulation of intracellular transport GO:0032386 64 0.090
Rat
cell junction organization GO:0034330 57 0.090
Mouse Fly
ovarian fusome organization GO:0030723 11 0.089
organophosphate metabolic process GO:0019637 195 0.089
regulation of multi organism process GO:0043900 131 0.088
Yeast
axon choice point recognition GO:0016198 26 0.088
Fly
epithelial cell migration open tracheal system GO:0007427 32 0.087
stress activated mapk cascade GO:0051403 52 0.086
Rat Fly
canonical wnt signaling pathway involved in heart development GO:0061316 3 0.086
positive regulation of cell differentiation GO:0045597 64 0.086
Human
cytoplasmic transport GO:0016482 130 0.086
regulation of embryonic cell shape GO:0016476 30 0.085
Fly
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 41 0.084
Fly
cell junction maintenance GO:0034331 10 0.084
Fly
centrosome organization GO:0051297 163 0.083
response to inorganic substance GO:0010035 44 0.083
regulation of cellular component size GO:0032535 98 0.082
microtubule based movement GO:0007018 51 0.082
Rat
nucleoside phosphate metabolic process GO:0006753 162 0.081
eggshell formation GO:0030703 105 0.081
salivary gland morphogenesis GO:0007435 145 0.081
Rat Fly
guanosine containing compound metabolic process GO:1901068 74 0.081
axon extension GO:0048675 32 0.080
Fly
positive regulation of phosphorylation GO:0042327 87 0.080
chaeta morphogenesis GO:0008407 42 0.080
delamination GO:0060232 8 0.080
columnar cuboidal epithelial cell development GO:0002066 249 0.080
branching morphogenesis of an epithelial tube GO:0048754 45 0.080
wound healing GO:0042060 75 0.080
positive regulation of mapk cascade GO:0043410 63 0.079
Mouse Rat
regulation of apoptotic process GO:0042981 130 0.079
Rat
cellular homeostasis GO:0019725 80 0.079
sperm individualization GO:0007291 48 0.078
retinal cell programmed cell death GO:0046666 25 0.078
regulation of cellular ketone metabolic process GO:0010565 3 0.078
negative regulation of small gtpase mediated signal transduction GO:0051058 13 0.078
ribonucleoside catabolic process GO:0042454 112 0.077
oocyte fate determination GO:0030716 27 0.077
adherens junction assembly GO:0034333 11 0.077
negative regulation of molecular function GO:0044092 51 0.077
myotube cell development GO:0014904 3 0.076
transmembrane transport GO:0055085 139 0.076
response to gravity GO:0009629 26 0.075
maintenance of apical basal cell polarity GO:0035090 8 0.075
digestive tract development GO:0048565 149 0.074
Zebrafish Fly
startle response GO:0001964 16 0.074
positive regulation of protein serine threonine kinase activity GO:0071902 15 0.074
Fly
establishment of cell polarity GO:0030010 40 0.073

Cdc42 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
muscular disease DOID:0080000 0 0.090
disease of anatomical entity DOID:7 0 0.090
musculoskeletal system disease DOID:17 0 0.090
muscle tissue disease DOID:66 0 0.090