Drosophila melanogaster

7 known processes

sle (Dmel_CG12819)

slender lobes

(Aliases: CG12819,Dmel\CG12819,CG12819-PA)

sle biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
organelle fission GO:0048285 340 0.975
brain development GO:0007420 120 0.899
mushroom body development GO:0016319 70 0.867
central nervous system development GO:0007417 201 0.723
head development GO:0060322 135 0.691
neural precursor cell proliferation GO:0061351 75 0.542
negative regulation of biosynthetic process GO:0009890 277 0.542
macromolecular complex assembly GO:0065003 256 0.433
cell proliferation GO:0008283 299 0.418
ribonucleoside monophosphate catabolic process GO:0009158 39 0.410
atp metabolic process GO:0046034 49 0.403
asymmetric neuroblast division GO:0055059 33 0.388
dna metabolic process GO:0006259 227 0.376
mitotic nuclear division GO:0007067 213 0.375
purine ribonucleoside monophosphate catabolic process GO:0009169 38 0.373
chromosome segregation GO:0007059 157 0.297
chromosome organization GO:0051276 360 0.289
aging GO:0007568 143 0.272
nucleosome organization GO:0034728 59 0.265
purine nucleoside monophosphate catabolic process GO:0009128 38 0.230
regulation of chromosome segregation GO:0051983 32 0.227
negative regulation of cellular metabolic process GO:0031324 382 0.194
cell death GO:0008219 279 0.192
nucleoside phosphate metabolic process GO:0006753 162 0.187
ribonucleoside monophosphate metabolic process GO:0009161 51 0.177
mitotic cell cycle phase transition GO:0044772 138 0.169
multicellular organismal aging GO:0010259 140 0.163
glycosyl compound metabolic process GO:1901657 127 0.163
regulation of cellular component biogenesis GO:0044087 201 0.151
dna repair GO:0006281 54 0.142
purine ribonucleoside monophosphate metabolic process GO:0009167 50 0.141
nucleobase containing small molecule metabolic process GO:0055086 174 0.138
mitotic cell cycle checkpoint GO:0007093 88 0.133
spindle organization GO:0007051 253 0.130
protein modification process GO:0036211 438 0.127
chromatin assembly GO:0031497 48 0.127
mitotic spindle organization GO:0007052 220 0.127
programmed cell death GO:0012501 257 0.125
cellular protein modification process GO:0006464 438 0.122
carbohydrate derivative metabolic process GO:1901135 217 0.120
response to oxygen containing compound GO:1901700 200 0.120
regulation of apoptotic process GO:0042981 130 0.119
organelle assembly GO:0070925 198 0.119
mitotic sister chromatid segregation GO:0000070 87 0.118
glycosyl compound catabolic process GO:1901658 112 0.118
nucleoside monophosphate catabolic process GO:0009125 39 0.114
chromosome separation GO:0051304 42 0.113
death GO:0016265 284 0.112
determination of adult lifespan GO:0008340 137 0.112
nucleoside catabolic process GO:0009164 112 0.110
organonitrogen compound metabolic process GO:1901564 318 0.109
male gamete generation GO:0048232 201 0.109
purine nucleoside monophosphate metabolic process GO:0009126 50 0.108
sister chromatid segregation GO:0000819 92 0.104
ribonucleoside metabolic process GO:0009119 127 0.101
regulation of cell cycle phase transition GO:1901987 130 0.099
purine nucleoside catabolic process GO:0006152 112 0.094
ribonucleotide metabolic process GO:0009259 145 0.094
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.091
vesicle mediated transport GO:0016192 381 0.090
negative regulation of gene expression GO:0010629 387 0.089
response to light stimulus GO:0009416 124 0.086
protein localization GO:0008104 284 0.085
cellular catabolic process GO:0044248 372 0.083
ribonucleoside triphosphate catabolic process GO:0009203 108 0.083
nucleoside phosphate catabolic process GO:1901292 110 0.083
small molecule metabolic process GO:0044281 305 0.082
response to radiation GO:0009314 155 0.077
organonitrogen compound catabolic process GO:1901565 128 0.075
maintenance of protein location GO:0045185 28 0.073
regulation of mitotic cell cycle GO:0007346 190 0.072
embryo development ending in birth or egg hatching GO:0009792 152 0.072
cellular protein complex assembly GO:0043623 71 0.070
nucleus organization GO:0006997 45 0.069
maintenance of protein location in cell GO:0032507 26 0.068
cellular response to dna damage stimulus GO:0006974 223 0.068
maintenance of location in cell GO:0051651 28 0.068
ribonucleoside catabolic process GO:0042454 112 0.067
negative regulation of mitotic cell cycle GO:0045930 109 0.066
rna processing GO:0006396 147 0.065
centrosome cycle GO:0007098 137 0.065
nucleoside triphosphate catabolic process GO:0009143 108 0.062
organophosphate metabolic process GO:0019637 195 0.061
response to abiotic stimulus GO:0009628 341 0.059
mitotic g2 dna damage checkpoint GO:0007095 69 0.059
carbohydrate derivative catabolic process GO:1901136 118 0.059
development of primary sexual characteristics GO:0045137 50 0.059
cellular nitrogen compound catabolic process GO:0044270 165 0.059
regulation of cell death GO:0010941 173 0.058
regulation of cell cycle GO:0051726 291 0.058
imaginal disc derived appendage morphogenesis GO:0035114 395 0.058
purine nucleotide metabolic process GO:0006163 146 0.057
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.057
forebrain development GO:0030900 2 0.057
purine nucleoside triphosphate catabolic process GO:0009146 108 0.056
dna integrity checkpoint GO:0031570 81 0.056
cell division GO:0051301 248 0.056
nucleoside metabolic process GO:0009116 127 0.055
ubiquitin dependent protein catabolic process GO:0006511 78 0.055
apoptotic process GO:0006915 159 0.054
chromatin remodeling GO:0006338 72 0.054
cellular macromolecule localization GO:0070727 220 0.054
regulation of mitotic sister chromatid segregation GO:0033047 28 0.053
cell cycle checkpoint GO:0000075 95 0.053
cellular macromolecular complex assembly GO:0034622 153 0.053
meiotic cell cycle GO:0051321 171 0.053
catabolic process GO:0009056 409 0.053
multi organism behavior GO:0051705 175 0.053
localization of cell GO:0051674 257 0.053
endocytosis GO:0006897 310 0.052
nucleotide catabolic process GO:0009166 109 0.051
positive regulation of multicellular organismal process GO:0051240 143 0.051
purine nucleoside metabolic process GO:0042278 127 0.050
purine ribonucleotide metabolic process GO:0009150 145 0.050
heterocycle catabolic process GO:0046700 166 0.050
organic substance catabolic process GO:1901575 308 0.050
stem cell proliferation GO:0072089 88 0.049
morphogenesis of an epithelium GO:0002009 276 0.049
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.048
response to temperature stimulus GO:0009266 106 0.047
maintenance of location GO:0051235 73 0.045
nucleocytoplasmic transport GO:0006913 72 0.044
regulation of sister chromatid segregation GO:0033045 28 0.044
response to organic substance GO:0010033 284 0.044
body morphogenesis GO:0010171 2 0.043
multi multicellular organism process GO:0044706 123 0.043
imaginal disc derived appendage development GO:0048737 399 0.042
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.041
positive regulation of cell death GO:0010942 69 0.041
nuclear division GO:0000280 332 0.040
metaphase anaphase transition of mitotic cell cycle GO:0007091 28 0.040
mitotic g2 m transition checkpoint GO:0044818 70 0.040
regulation of chromosome organization GO:0033044 64 0.039
retina development in camera type eye GO:0060041 4 0.039
spindle assembly checkpoint GO:0071173 11 0.039
negative regulation of protein metabolic process GO:0051248 85 0.038
single organism catabolic process GO:0044712 228 0.037
purine ribonucleoside catabolic process GO:0046130 112 0.037
regulation of localization GO:0032879 275 0.036
axon development GO:0061564 297 0.036
nucleoside monophosphate metabolic process GO:0009123 52 0.036
nucleoside triphosphate metabolic process GO:0009141 120 0.035
purine nucleoside triphosphate metabolic process GO:0009144 119 0.035
regulation of hydrolase activity GO:0051336 97 0.034
ribose phosphate metabolic process GO:0019693 145 0.034
sex differentiation GO:0007548 81 0.034
ribonucleotide catabolic process GO:0009261 109 0.034
mating GO:0007618 120 0.034
aromatic compound catabolic process GO:0019439 166 0.033
regulation of protein metabolic process GO:0051246 256 0.033
chromatin assembly or disassembly GO:0006333 52 0.032
positive regulation of programmed cell death GO:0043068 62 0.032
regulation of programmed cell death GO:0043067 152 0.032
response to organic cyclic compound GO:0014070 89 0.032
protein import into nucleus GO:0006606 51 0.032
nucleosome positioning GO:0016584 3 0.032
mitotic dna integrity checkpoint GO:0044774 75 0.032
regulation of metaphase anaphase transition of cell cycle GO:1902099 26 0.031
protein complex biogenesis GO:0070271 201 0.031
single organism nuclear import GO:1902593 51 0.031
ribonucleoside triphosphate metabolic process GO:0009199 119 0.031
reproductive system development GO:0061458 74 0.031
cellular protein localization GO:0034613 160 0.030
protein complex assembly GO:0006461 200 0.030
cellular component disassembly GO:0022411 46 0.030
nuclear body organization GO:0030575 6 0.030
camera type eye development GO:0043010 4 0.029
asymmetric stem cell division GO:0098722 49 0.029
regulation of organelle organization GO:0033043 196 0.029
regulation of phosphorus metabolic process GO:0051174 210 0.029
organophosphate catabolic process GO:0046434 112 0.029
response to external biotic stimulus GO:0043207 293 0.029
eye development GO:0001654 323 0.028
dna conformation change GO:0071103 105 0.028
negative regulation of cellular biosynthetic process GO:0031327 277 0.028
regulation of protein localization GO:0032880 76 0.028
cytoplasmic microtubule organization GO:0031122 22 0.028
protein processing GO:0016485 68 0.028
microtubule cytoskeleton organization involved in mitosis GO:1902850 52 0.028
mitotic dna damage checkpoint GO:0044773 74 0.027
purine nucleotide catabolic process GO:0006195 109 0.027
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process GO:0031145 30 0.027
cellular response to chemical stimulus GO:0070887 199 0.026
negative regulation of proteolysis GO:0045861 31 0.026
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.026
positive regulation of rna biosynthetic process GO:1902680 266 0.026
purine containing compound catabolic process GO:0072523 112 0.025
reproductive behavior GO:0019098 122 0.025
protein localization to nucleus GO:0034504 55 0.025
dna damage checkpoint GO:0000077 78 0.025
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.024
regulation of protein complex assembly GO:0043254 42 0.024
purine ribonucleotide catabolic process GO:0009154 109 0.023
mitotic sister chromatid separation GO:0051306 30 0.023
negative regulation of cellular component organization GO:0051129 108 0.023
centrosome organization GO:0051297 163 0.023
cell migration GO:0016477 238 0.023
negative regulation of response to external stimulus GO:0032102 22 0.022
regulation of mitotic metaphase anaphase transition GO:0030071 26 0.022
neuronal stem cell division GO:0036445 35 0.021
metaphase anaphase transition of cell cycle GO:0044784 28 0.020
modification dependent protein catabolic process GO:0019941 78 0.020
organic cyclic compound catabolic process GO:1901361 168 0.020
atp catabolic process GO:0006200 38 0.019
negative regulation of mitotic sister chromatid separation GO:2000816 13 0.019
negative regulation of cellular protein metabolic process GO:0032269 85 0.019
ribonucleoprotein complex assembly GO:0022618 23 0.019
nuclear transport GO:0051169 72 0.019
negative regulation of proteasomal protein catabolic process GO:1901799 16 0.019
phagocytosis GO:0006909 215 0.019
positive regulation of cellular biosynthetic process GO:0031328 316 0.018
exocrine system development GO:0035272 162 0.018
regulation of protein processing GO:0070613 32 0.018
intracellular protein transport GO:0006886 104 0.018
nucleotide metabolic process GO:0009117 161 0.017
negative regulation of cell death GO:0060548 81 0.017
regulation of nuclear division GO:0051783 58 0.017
negative regulation of cell differentiation GO:0045596 143 0.017
cellular response to nitrogen compound GO:1901699 51 0.017
positive regulation of cell development GO:0010720 61 0.017
cell motility GO:0048870 251 0.017
homeostatic process GO:0042592 199 0.017
protein import GO:0017038 55 0.016
regulation of establishment of protein localization GO:0070201 61 0.016
negative regulation of developmental process GO:0051093 201 0.016
microtubule bundle formation GO:0001578 27 0.016
response to uv GO:0009411 24 0.016
positive regulation of developmental process GO:0051094 143 0.016
protein transport GO:0015031 155 0.016
negative regulation of neuron death GO:1901215 18 0.016
regulation of cellular response to stress GO:0080135 89 0.016
double strand break repair GO:0006302 26 0.016
gonad development GO:0008406 50 0.015
purine ribonucleoside metabolic process GO:0046128 127 0.015
spermatogenesis GO:0007283 200 0.015
dna packaging GO:0006323 91 0.015
negative regulation of organelle organization GO:0010639 56 0.015
proteolysis GO:0006508 192 0.015
centrosome duplication GO:0051298 121 0.015
salivary gland development GO:0007431 162 0.015
asymmetric cell division GO:0008356 37 0.014
chemotaxis GO:0006935 249 0.014
positive regulation of cell proliferation GO:0008284 47 0.014
dna duplex unwinding GO:0032508 16 0.014
negative regulation of cell cycle GO:0045786 116 0.014
regulation of multi organism process GO:0043900 131 0.014
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.014
multi organism reproductive behavior GO:0044705 121 0.013
protein dna complex subunit organization GO:0071824 86 0.013
salivary gland morphogenesis GO:0007435 145 0.013
establishment of localization in cell GO:0051649 402 0.013
enzyme linked receptor protein signaling pathway GO:0007167 179 0.013
tissue morphogenesis GO:0048729 297 0.012
response to biotic stimulus GO:0009607 294 0.012
response to other organism GO:0051707 293 0.012
reproductive structure development GO:0048608 74 0.012
regulation of meiosis GO:0040020 3 0.012
spindle assembly GO:0051225 80 0.012
somatic stem cell division GO:0048103 37 0.012
negative regulation of chromosome segregation GO:0051985 14 0.012
cell aging GO:0007569 2 0.012
negative regulation of proteolysis involved in cellular protein catabolic process GO:1903051 17 0.012
regulation of cell cycle process GO:0010564 181 0.012
post embryonic appendage morphogenesis GO:0035120 385 0.012
nucleobase containing compound catabolic process GO:0034655 165 0.012
regulation of neuron differentiation GO:0045664 103 0.012
chromatin modification GO:0016568 147 0.012
centriole replication GO:0007099 24 0.012
negative regulation of programmed cell death GO:0043069 72 0.012
cytoplasmic transport GO:0016482 130 0.011
regulation of cell differentiation GO:0045595 302 0.011
developmental programmed cell death GO:0010623 138 0.011
stem cell division GO:0017145 69 0.011
regulation of cell development GO:0060284 215 0.011
positive regulation of phosphate metabolic process GO:0045937 139 0.011
multicellular organismal reproductive behavior GO:0033057 110 0.011
rna splicing GO:0008380 83 0.011
negative regulation of nucleic acid templated transcription GO:1903507 240 0.011
regulation of cellular catabolic process GO:0031329 157 0.011
protein phosphorylation GO:0006468 169 0.011
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.011
chromatin organization GO:0006325 207 0.011
negative regulation of protein maturation GO:1903318 31 0.011
regulation of molecular function GO:0065009 217 0.010
protein ubiquitination GO:0016567 70 0.010
purine containing compound metabolic process GO:0072521 155 0.010
cellular macromolecule catabolic process GO:0044265 136 0.010
regulation of catabolic process GO:0009894 170 0.010
regulation of response to stress GO:0080134 200 0.010
negative regulation of rna metabolic process GO:0051253 251 0.010
regulation of proteolysis GO:0030162 87 0.010
positive regulation of binding GO:0051099 4 0.010
negative regulation of catabolic process GO:0009895 36 0.010
nuclear import GO:0051170 51 0.010

sle disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.012
disease of cellular proliferation DOID:14566 0 0.012
organ system cancer DOID:0050686 0 0.010