Drosophila melanogaster

139 known processes

Topors (Dmel_CG15104)

Topoisomerase I-interacting protein

(Aliases: dTopors,dtopors,CG15104,Dmel\CG15104)

Topors biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
organelle localization GO:0051640 148 0.468
protein complex assembly GO:0006461 200 0.324
macromolecular complex assembly GO:0065003 256 0.318
protein complex biogenesis GO:0070271 201 0.308
transcription from rna polymerase ii promoter GO:0006366 368 0.289
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.247
Mouse
chromosome organization GO:0051276 360 0.213
cellular protein modification process GO:0006464 438 0.162
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.159
Mouse
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.155
dna metabolic process GO:0006259 227 0.151
developmental programmed cell death GO:0010623 138 0.137
organelle fission GO:0048285 340 0.136
establishment of localization in cell GO:0051649 402 0.119
protein modification process GO:0036211 438 0.115
positive regulation of macromolecule metabolic process GO:0010604 405 0.114
Human Mouse
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.107
spindle organization GO:0007051 253 0.099
organelle assembly GO:0070925 198 0.087
determination of adult lifespan GO:0008340 137 0.087
transcription initiation from rna polymerase ii promoter GO:0006367 25 0.076
rna polymerase ii transcriptional preinitiation complex assembly GO:0051123 20 0.075
cellular macromolecular complex assembly GO:0034622 153 0.072
protein dna complex assembly GO:0065004 63 0.071
phosphorylation GO:0016310 294 0.067
cellular catabolic process GO:0044248 372 0.065
dna templated transcriptional preinitiation complex assembly GO:0070897 20 0.065
protein dna complex subunit organization GO:0071824 86 0.065
histolysis GO:0007559 102 0.065
cell proliferation GO:0008283 299 0.064
Mouse
negative regulation of gene expression GO:0010629 387 0.063
photoreceptor cell differentiation GO:0046530 170 0.063
single organism intracellular transport GO:1902582 207 0.061
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.061
regulation of anatomical structure morphogenesis GO:0022603 242 0.060
dna templated transcription initiation GO:0006352 25 0.054
tissue death GO:0016271 102 0.054
positive regulation of cellular catabolic process GO:0031331 95 0.052
positive regulation of canonical wnt signaling pathway GO:0090263 7 0.051
nuclear division GO:0000280 332 0.050
cytoplasmic transport GO:0016482 130 0.046
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.045
regulation of protein phosphorylation GO:0001932 64 0.044
spermatid differentiation GO:0048515 114 0.043
positive regulation of cellular component organization GO:0051130 156 0.042
cellular protein localization GO:0034613 160 0.041
Human
intracellular transport GO:0046907 228 0.040
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.039
covalent chromatin modification GO:0016569 106 0.038
regulation of dna replication GO:0006275 13 0.038
histone modification GO:0016570 106 0.037
catabolic process GO:0009056 409 0.037
negative regulation of biosynthetic process GO:0009890 277 0.037
single organism cellular localization GO:1902580 180 0.037
centrosome cycle GO:0007098 137 0.035
establishment of organelle localization GO:0051656 122 0.035
regulation of protein metabolic process GO:0051246 256 0.035
Human
positive regulation of biosynthetic process GO:0009891 316 0.035
Mouse
sister chromatid segregation GO:0000819 92 0.034
mitotic spindle organization GO:0007052 220 0.033
death GO:0016265 284 0.032
Human Mouse
nucleoside phosphate catabolic process GO:1901292 110 0.032
meiotic cell cycle process GO:1903046 132 0.032
axis specification GO:0009798 167 0.032
regulation of protein modification process GO:0031399 112 0.032
Human
positive regulation of organelle organization GO:0010638 65 0.032
nucleotide metabolic process GO:0009117 161 0.031
cellular macromolecule localization GO:0070727 220 0.031
Human
intracellular signal transduction GO:0035556 300 0.030
Human Mouse
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.030
positive regulation of phosphorus metabolic process GO:0010562 139 0.030
negative regulation of transcription dna templated GO:0045892 237 0.030
negative regulation of rna metabolic process GO:0051253 251 0.030
spermatogenesis GO:0007283 200 0.029
mitotic nuclear division GO:0007067 213 0.029
regulation of multicellular organismal development GO:2000026 414 0.029
chromatin modification GO:0016568 147 0.029
vesicle mediated transport GO:0016192 381 0.029
regulation of proteasomal protein catabolic process GO:0061136 39 0.028
dorsal closure GO:0007391 79 0.028
dna replication GO:0006260 48 0.028
positive regulation of phosphate metabolic process GO:0045937 139 0.028
protein phosphorylation GO:0006468 169 0.028
regulation of cellular component biogenesis GO:0044087 201 0.027
organonitrogen compound metabolic process GO:1901564 318 0.027
cellular macromolecule catabolic process GO:0044265 136 0.027
organic substance catabolic process GO:1901575 308 0.026
chromatin organization GO:0006325 207 0.026
protein transport GO:0015031 155 0.026
cellular nitrogen compound catabolic process GO:0044270 165 0.026
mitotic spindle elongation GO:0000022 81 0.026
positive regulation of cellular component biogenesis GO:0044089 80 0.025
purine ribonucleotide catabolic process GO:0009154 109 0.025
eye development GO:0001654 323 0.024
regulation of cell development GO:0060284 215 0.023
salivary gland morphogenesis GO:0007435 145 0.023
cellular amino acid metabolic process GO:0006520 61 0.023
positive regulation of catabolic process GO:0009896 105 0.023
localization of cell GO:0051674 257 0.023
purine nucleoside metabolic process GO:0042278 127 0.022
regulation of catabolic process GO:0009894 170 0.022
gland development GO:0048732 191 0.022
cellular response to chemical stimulus GO:0070887 199 0.022
organic substance transport GO:0071702 257 0.022
intracellular protein transport GO:0006886 104 0.021
glycosyl compound catabolic process GO:1901658 112 0.021
meiotic nuclear division GO:0007126 151 0.021
regulation of cellular protein metabolic process GO:0032268 243 0.021
Human
positive regulation of multicellular organismal process GO:0051240 143 0.021
ribonucleoside triphosphate metabolic process GO:0009199 119 0.021
purine nucleoside triphosphate catabolic process GO:0009146 108 0.021
meiotic cell cycle GO:0051321 171 0.021
spindle assembly involved in mitosis GO:0090307 50 0.021
aromatic compound catabolic process GO:0019439 166 0.020
regulation of nervous system development GO:0051960 248 0.020
cellular response to dna damage stimulus GO:0006974 223 0.020
regulation of phosphate metabolic process GO:0019220 210 0.020
negative regulation of nucleic acid templated transcription GO:1903507 240 0.020
ribose phosphate metabolic process GO:0019693 145 0.020
regulation of cellular catabolic process GO:0031329 157 0.019
regulation of phosphorus metabolic process GO:0051174 210 0.019
multicellular organismal aging GO:0010259 140 0.019
nucleoside triphosphate metabolic process GO:0009141 120 0.019
regulation of intracellular signal transduction GO:1902531 236 0.019
nuclear transport GO:0051169 72 0.018
actin filament organization GO:0007015 126 0.018
regulation of cell differentiation GO:0045595 302 0.018
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.018
Human
dorsal ventral axis specification GO:0009950 66 0.018
male gamete generation GO:0048232 201 0.018
body morphogenesis GO:0010171 2 0.018
centrosome organization GO:0051297 163 0.018
organophosphate metabolic process GO:0019637 195 0.017
response to organic cyclic compound GO:0014070 89 0.017
sensory organ morphogenesis GO:0090596 260 0.017
dorsal ventral pattern formation GO:0009953 133 0.017
negative regulation of rna biosynthetic process GO:1902679 240 0.017
macromolecule catabolic process GO:0009057 161 0.017
ras protein signal transduction GO:0007265 88 0.016
nucleobase containing small molecule metabolic process GO:0055086 174 0.016
regulation of cell morphogenesis GO:0022604 163 0.016
negative regulation of cell cycle GO:0045786 116 0.016
protein localization GO:0008104 284 0.016
Human
cell death GO:0008219 279 0.016
Human Mouse
regulation of protein complex assembly GO:0043254 42 0.016
salivary gland development GO:0007431 162 0.016
actin cytoskeleton organization GO:0030036 206 0.016
positive regulation of cellular biosynthetic process GO:0031328 316 0.016
Mouse
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.016
Mouse
regulation of ras protein signal transduction GO:0046578 93 0.016
regulation of mitotic cell cycle GO:0007346 190 0.016
purine nucleoside triphosphate metabolic process GO:0009144 119 0.015
eye morphogenesis GO:0048592 260 0.015
regulation of dna metabolic process GO:0051052 34 0.015
respiratory system development GO:0060541 213 0.015
nucleus localization GO:0051647 34 0.015
salivary gland cell autophagic cell death GO:0035071 83 0.015
organic cyclic compound catabolic process GO:1901361 168 0.015
negative regulation of neurogenesis GO:0050768 53 0.015
kinetochore organization GO:0051383 9 0.015
mitotic cell cycle checkpoint GO:0007093 88 0.015
nucleoside catabolic process GO:0009164 112 0.015
positive regulation of protein modification process GO:0031401 58 0.015
Human
positive regulation of response to stimulus GO:0048584 323 0.015
establishment or maintenance of cell polarity GO:0007163 167 0.014
fertilization GO:0009566 26 0.014
regulation of cell cycle phase transition GO:1901987 130 0.014
mitochondrion localization GO:0051646 17 0.014
establishment of protein localization GO:0045184 163 0.014
regulation of cellular amino acid metabolic process GO:0006521 0 0.014
regulation of cellular ketone metabolic process GO:0010565 3 0.014
regulation of cytoskeleton organization GO:0051493 89 0.014
regulation of neuron differentiation GO:0045664 103 0.014
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.014
positive regulation of rna biosynthetic process GO:1902680 266 0.014
Mouse
mitotic sister chromatid segregation GO:0000070 87 0.014
centriole replication GO:0007099 24 0.013
embryonic morphogenesis GO:0048598 206 0.013
imaginal disc derived appendage development GO:0048737 399 0.013
spermatid development GO:0007286 98 0.013
nucleocytoplasmic transport GO:0006913 72 0.013
meiotic chromosome segregation GO:0045132 59 0.013
cellular protein complex assembly GO:0043623 71 0.013
proteasomal protein catabolic process GO:0010498 59 0.013
Human
regulation of transferase activity GO:0051338 58 0.013
Human
single organism catabolic process GO:0044712 228 0.013
regulation of kinase activity GO:0043549 53 0.013
nucleobase containing compound catabolic process GO:0034655 165 0.013
ribonucleotide metabolic process GO:0009259 145 0.013
autophagic cell death GO:0048102 83 0.012
golgi vesicle transport GO:0048193 27 0.012
leg disc morphogenesis GO:0007478 80 0.012
ribonucleoside triphosphate catabolic process GO:0009203 108 0.012
molting cycle GO:0042303 56 0.012
sperm motility GO:0030317 12 0.012
multi multicellular organism process GO:0044706 123 0.012
regionalization GO:0003002 416 0.012
aging GO:0007568 143 0.012
cell cycle comprising mitosis without cytokinesis GO:0033301 25 0.012
female meiotic division GO:0007143 70 0.012
positive regulation of protein complex assembly GO:0031334 22 0.012
heterocycle catabolic process GO:0046700 166 0.012
negative regulation of cell differentiation GO:0045596 143 0.012
carbohydrate derivative catabolic process GO:1901136 118 0.012
regulation of neurogenesis GO:0050767 158 0.011
negative regulation of cellular biosynthetic process GO:0031327 277 0.011
membrane organization GO:0061024 112 0.011
digestive system development GO:0055123 149 0.011
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.011
establishment or maintenance of cytoskeleton polarity GO:0030952 44 0.011
embryo development ending in birth or egg hatching GO:0009792 152 0.011
synaptic vesicle endocytosis GO:0048488 28 0.011
purine nucleotide metabolic process GO:0006163 146 0.011
negative regulation of cellular metabolic process GO:0031324 382 0.011
homeostatic process GO:0042592 199 0.011
negative regulation of cellular component organization GO:0051129 108 0.011
regulation of cytoplasmic transport GO:1903649 47 0.011
purine ribonucleotide metabolic process GO:0009150 145 0.011
nucleoside triphosphate catabolic process GO:0009143 108 0.011
regulation of multi organism process GO:0043900 131 0.011
regulation of cellular amine metabolic process GO:0033238 3 0.011
microtubule organizing center organization GO:0031023 168 0.011
dna packaging GO:0006323 91 0.010
exocrine system development GO:0035272 162 0.010
ribonucleoside metabolic process GO:0009119 127 0.010
regulation of establishment of protein localization GO:0070201 61 0.010
purine ribonucleoside catabolic process GO:0046130 112 0.010
regulation of response to external stimulus GO:0032101 115 0.010
positive regulation of cellular amine metabolic process GO:0033240 0 0.010
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.010

Topors disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.015
cancer DOID:162 0 0.012
organ system cancer DOID:0050686 0 0.012
disease of anatomical entity DOID:7 0 0.010
Human