Drosophila melanogaster

32 known processes

MESK2 (Dmel_CG15669)

Misexpression suppressor of KSR 2

(Aliases: mesk2,Mesk2,CG15668,BcDNA:GH12032,BcDNA:RH10174,CG15669,Dmel\CG15669,BcDNA:LD27504,l(2)01467)

MESK2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
negative regulation of signaling GO:0023057 219 0.572
Mouse
chemosensory behavior GO:0007635 106 0.533
response to abiotic stimulus GO:0009628 341 0.465
negative regulation of cell communication GO:0010648 223 0.395
Mouse
endocytosis GO:0006897 310 0.390
vesicle mediated transport GO:0016192 381 0.361
learning or memory GO:0007611 141 0.356
ion transmembrane transport GO:0034220 122 0.348
locomotory behavior GO:0007626 176 0.327
response to mechanical stimulus GO:0009612 28 0.268
rhythmic process GO:0048511 106 0.254
cognition GO:0050890 141 0.234
associative learning GO:0008306 65 0.218
sleep GO:0030431 49 0.217
synaptic transmission GO:0007268 288 0.209
learning GO:0007612 75 0.187
olfactory learning GO:0008355 56 0.160
phosphorylation GO:0016310 294 0.157
Mouse
olfactory behavior GO:0042048 97 0.130
rhythmic behavior GO:0007622 76 0.127
wing disc morphogenesis GO:0007472 344 0.126
regulation of synaptic transmission GO:0050804 69 0.125
phagocytosis GO:0006909 215 0.118
taxis GO:0042330 304 0.113
response to light stimulus GO:0009416 124 0.112
regulation of circadian rhythm GO:0042752 49 0.111
inter male aggressive behavior GO:0002121 60 0.110
negative regulation of response to stimulus GO:0048585 258 0.108
Mouse
ion transport GO:0006811 145 0.108
homeostatic process GO:0042592 199 0.107
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.106
inorganic ion transmembrane transport GO:0098660 73 0.103
imaginal disc derived wing morphogenesis GO:0007476 337 0.095
response to external biotic stimulus GO:0043207 293 0.094
protein complex biogenesis GO:0070271 201 0.087
negative regulation of developmental process GO:0051093 201 0.087
regulation of behavior GO:0050795 75 0.086
circadian sleep wake cycle GO:0042745 28 0.086
organophosphate metabolic process GO:0019637 195 0.085
eye development GO:0001654 323 0.084
neurological system process GO:0050877 358 0.082
small molecule metabolic process GO:0044281 305 0.080
positive regulation of cellular biosynthetic process GO:0031328 316 0.080
organonitrogen compound metabolic process GO:1901564 318 0.079
appendage morphogenesis GO:0035107 397 0.077
cell death GO:0008219 279 0.077
regulation of circadian sleep wake cycle GO:0042749 25 0.076
regulation of multicellular organismal development GO:2000026 414 0.074
Rat
programmed cell death GO:0012501 257 0.074
transcription from rna polymerase ii promoter GO:0006366 368 0.072
regulation of intracellular signal transduction GO:1902531 236 0.070
multi organism behavior GO:0051705 175 0.069
localization of cell GO:0051674 257 0.068
cellular response to radiation GO:0071478 52 0.068
protein complex assembly GO:0006461 200 0.067
establishment of localization in cell GO:0051649 402 0.063
single organism behavior GO:0044708 391 0.061
imaginal disc derived appendage development GO:0048737 399 0.060
macromolecular complex assembly GO:0065003 256 0.060
cellular protein modification process GO:0006464 438 0.059
negative regulation of biosynthetic process GO:0009890 277 0.059
single organism intracellular transport GO:1902582 207 0.059
regulation of immune system process GO:0002682 176 0.058
intracellular signal transduction GO:0035556 300 0.058
cellular response to light stimulus GO:0071482 37 0.058
defense response GO:0006952 300 0.054
regulation of cell proliferation GO:0042127 163 0.053
Mouse
immune system process GO:0002376 347 0.051
response to other organism GO:0051707 293 0.051
axonogenesis GO:0007409 290 0.051
negative regulation of multicellular organismal process GO:0051241 142 0.050
Mouse
positive regulation of macromolecule metabolic process GO:0010604 405 0.048
response to biotic stimulus GO:0009607 294 0.047
organic substance transport GO:0071702 257 0.045
aggressive behavior GO:0002118 63 0.045
regulation of localization GO:0032879 275 0.045
nucleoside phosphate metabolic process GO:0006753 162 0.045
transmembrane transport GO:0055085 139 0.044
death GO:0016265 284 0.044
cellular catabolic process GO:0044248 372 0.044
post embryonic appendage morphogenesis GO:0035120 385 0.044
nucleotide metabolic process GO:0009117 161 0.044
regulation of cell development GO:0060284 215 0.044
Rat
imaginal disc derived appendage morphogenesis GO:0035114 395 0.044
regulation of transport GO:0051049 181 0.043
catabolic process GO:0009056 409 0.043
ribose phosphate metabolic process GO:0019693 145 0.043
defense response to other organism GO:0098542 225 0.041
detection of light stimulus GO:0009583 58 0.041
protein modification process GO:0036211 438 0.040
single organism catabolic process GO:0044712 228 0.040
regulation of catalytic activity GO:0050790 185 0.040
positive regulation of response to stimulus GO:0048584 323 0.039
kidney development GO:0001822 3 0.039
negative regulation of gene expression GO:0010629 387 0.039
axon guidance GO:0007411 233 0.039
negative regulation of cellular component organization GO:0051129 108 0.038
immune response GO:0006955 246 0.037
regulation of cell cycle GO:0051726 291 0.036
appendage development GO:0048736 401 0.036
nucleoside triphosphate metabolic process GO:0009141 120 0.036
response to drug GO:0042493 17 0.035
regulation of molecular function GO:0065009 217 0.035
intracellular transport GO:0046907 228 0.034
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.034
negative regulation of cellular metabolic process GO:0031324 382 0.034
Mouse
negative regulation of programmed cell death GO:0043069 72 0.034
cell proliferation GO:0008283 299 0.033
Mouse
regulation of cellular component biogenesis GO:0044087 201 0.033
purine ribonucleotide metabolic process GO:0009150 145 0.033
tissue morphogenesis GO:0048729 297 0.033
response to radiation GO:0009314 155 0.032
developmental maturation GO:0021700 172 0.032
regulation of cell differentiation GO:0045595 302 0.032
Rat
anion transport GO:0006820 41 0.031
positive regulation of gene expression GO:0010628 290 0.031
regionalization GO:0003002 416 0.031
ribonucleotide metabolic process GO:0009259 145 0.031
morphogenesis of an epithelium GO:0002009 276 0.030
positive regulation of cell communication GO:0010647 250 0.030
enzyme linked receptor protein signaling pathway GO:0007167 179 0.030
acetylcholine metabolic process GO:0008291 2 0.029
regulation of protein metabolic process GO:0051246 256 0.029
camera type eye development GO:0043010 4 0.029
apoptotic process GO:0006915 159 0.028
chloride transport GO:0006821 10 0.028
single organism biosynthetic process GO:0044711 206 0.028
cellular response to chemical stimulus GO:0070887 199 0.028
response to organic substance GO:0010033 284 0.027
purine nucleotide catabolic process GO:0006195 109 0.027
cell maturation GO:0048469 144 0.027
negative regulation of cellular biosynthetic process GO:0031327 277 0.027
mapk cascade GO:0000165 107 0.027
Mouse
axon development GO:0061564 297 0.027
positive regulation of biosynthetic process GO:0009891 316 0.027
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.027
protein phosphorylation GO:0006468 169 0.027
cell migration GO:0016477 238 0.026
developmental programmed cell death GO:0010623 138 0.026
ras protein signal transduction GO:0007265 88 0.026
growth GO:0040007 359 0.026
negative regulation of protein metabolic process GO:0051248 85 0.025
positive regulation of phosphate metabolic process GO:0045937 139 0.025
regulation of ras protein signal transduction GO:0046578 93 0.025
establishment or maintenance of cell polarity GO:0007163 167 0.025
regulation of phosphorus metabolic process GO:0051174 210 0.025
Mouse
protein transport GO:0015031 155 0.025
response to temperature stimulus GO:0009266 106 0.024
glycosyl compound metabolic process GO:1901657 127 0.024
regulation of programmed cell death GO:0043067 152 0.024
nucleobase containing small molecule metabolic process GO:0055086 174 0.024
tube development GO:0035295 244 0.024
cation transport GO:0006812 110 0.024
metal ion transport GO:0030001 74 0.024
chemical homeostasis GO:0048878 92 0.023
purine containing compound metabolic process GO:0072521 155 0.023
neuromuscular junction development GO:0007528 149 0.023
proteolysis GO:0006508 192 0.023
cell motility GO:0048870 251 0.023
negative regulation of signal transduction GO:0009968 206 0.023
Mouse
cellular response to abiotic stimulus GO:0071214 58 0.023
negative regulation of cell death GO:0060548 81 0.023
anion transmembrane transport GO:0098656 26 0.023
regulation of olfactory learning GO:0090328 8 0.023
cytoplasmic transport GO:0016482 130 0.022
negative regulation of immune system process GO:0002683 50 0.022
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.022
phototransduction GO:0007602 52 0.022
negative regulation of nucleic acid templated transcription GO:1903507 240 0.022
regulation of cellular ketone metabolic process GO:0010565 3 0.022
dendrite development GO:0016358 204 0.022
negative regulation of synaptic transmission GO:0050805 12 0.022
organic substance catabolic process GO:1901575 308 0.022
regulation of i kappab kinase nf kappab signaling GO:0043122 2 0.021
protein complex disassembly GO:0043241 36 0.021
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.021
small gtpase mediated signal transduction GO:0007264 88 0.021
response to bacterium GO:0009617 198 0.021
chemotaxis GO:0006935 249 0.021
regulation of defense response GO:0031347 102 0.021
regulation of mitotic cell cycle GO:0007346 190 0.021
regulation of phosphate metabolic process GO:0019220 210 0.021
Mouse
male mating behavior GO:0060179 70 0.021
cellular nitrogen compound catabolic process GO:0044270 165 0.021
adult behavior GO:0030534 137 0.020
organelle localization GO:0051640 148 0.020
sensory organ morphogenesis GO:0090596 260 0.020
salivary gland morphogenesis GO:0007435 145 0.020
negative regulation of nervous system development GO:0051961 92 0.020
carbohydrate derivative metabolic process GO:1901135 217 0.020
positive regulation of signaling GO:0023056 243 0.020
salivary gland development GO:0007431 162 0.020
cellular macromolecule catabolic process GO:0044265 136 0.020
imaginal disc growth GO:0007446 37 0.020
aromatic compound catabolic process GO:0019439 166 0.020
organic hydroxy compound metabolic process GO:1901615 83 0.020
gland morphogenesis GO:0022612 145 0.019
axis specification GO:0009798 167 0.019
regulation of phosphorylation GO:0042325 147 0.019
Mouse
purine ribonucleotide catabolic process GO:0009154 109 0.019
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.019
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.019
notch signaling pathway GO:0007219 120 0.019
response to lipopolysaccharide GO:0032496 4 0.019
negative regulation of rna biosynthetic process GO:1902679 240 0.019
eye morphogenesis GO:0048592 260 0.019
oocyte dorsal ventral axis specification GO:0007310 34 0.019
regulation of multi organism process GO:0043900 131 0.019
positive regulation of molecular function GO:0044093 136 0.019
epithelial cell differentiation GO:0030855 322 0.019
morphogenesis of a branching structure GO:0001763 45 0.018
positive regulation of signal transduction GO:0009967 223 0.018
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.018
positive regulation of catalytic activity GO:0043085 118 0.018
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.018
nitrogen compound transport GO:0071705 85 0.018
regulation of organelle organization GO:0033043 196 0.018
actin cytoskeleton organization GO:0030036 206 0.018
compound eye development GO:0048749 307 0.018
positive regulation of rna biosynthetic process GO:1902680 266 0.017
regulation of anatomical structure morphogenesis GO:0022603 242 0.017
regulation of nervous system development GO:0051960 248 0.017
Rat
signal transduction by phosphorylation GO:0023014 107 0.017
Mouse
compound eye morphogenesis GO:0001745 249 0.017
amine metabolic process GO:0009308 12 0.017
negative regulation of transcription dna templated GO:0045892 237 0.017
negative regulation of cellular protein metabolic process GO:0032269 85 0.017
rna processing GO:0006396 147 0.017
nucleobase containing compound catabolic process GO:0034655 165 0.017
response to alcohol GO:0097305 95 0.017
mitotic cell cycle phase transition GO:0044772 138 0.017
multicellular organismal aging GO:0010259 140 0.017
forebrain development GO:0030900 2 0.016
detection of stimulus GO:0051606 156 0.016
regulation of synapse structure and activity GO:0050803 128 0.016
nucleotide catabolic process GO:0009166 109 0.016
purine ribonucleoside catabolic process GO:0046130 112 0.016
regulation of cellular localization GO:0060341 136 0.016
ribonucleoside metabolic process GO:0009119 127 0.016
regulation of cellular amine metabolic process GO:0033238 3 0.016
establishment of protein localization GO:0045184 163 0.016
heterocycle catabolic process GO:0046700 166 0.016
neuron projection guidance GO:0097485 241 0.016
embryonic development via the syncytial blastoderm GO:0001700 148 0.016
nucleoside phosphate catabolic process GO:1901292 110 0.016
anatomical structure homeostasis GO:0060249 97 0.016
nucleoside metabolic process GO:0009116 127 0.015
negative regulation of rna metabolic process GO:0051253 251 0.015
cellular ketone metabolic process GO:0042180 24 0.015
protein catabolic process GO:0030163 101 0.015
adult locomotory behavior GO:0008344 76 0.015
regulation of cellular amino acid metabolic process GO:0006521 0 0.015
tissue death GO:0016271 102 0.015
neural precursor cell proliferation GO:0061351 75 0.015
positive regulation of exocytosis GO:0045921 4 0.015
connective tissue development GO:0061448 3 0.015
dendrite morphogenesis GO:0048813 199 0.015
regulation of neurological system process GO:0031644 8 0.015
regulation of response to stress GO:0080134 200 0.015
organic acid metabolic process GO:0006082 103 0.015
macromolecule catabolic process GO:0009057 161 0.015
cellular response to organic substance GO:0071310 132 0.015
regulation of cell death GO:0010941 173 0.015
ameboidal type cell migration GO:0001667 151 0.014
ribonucleoside triphosphate catabolic process GO:0009203 108 0.014
cell cycle phase transition GO:0044770 140 0.014
positive regulation of intracellular signal transduction GO:1902533 116 0.014
innate immune response GO:0045087 144 0.014
detection of abiotic stimulus GO:0009582 66 0.014
nuclear transport GO:0051169 72 0.014
dna metabolic process GO:0006259 227 0.014
regulation of reproductive process GO:2000241 54 0.014
respiratory system development GO:0060541 213 0.014
positive regulation of transcription dna templated GO:0045893 266 0.014
regulation of rna splicing GO:0043484 69 0.014
posttranscriptional regulation of gene expression GO:0010608 145 0.014
dorsal ventral pattern formation GO:0009953 133 0.014
regulation of apoptotic process GO:0042981 130 0.014
body morphogenesis GO:0010171 2 0.014
response to nutrient levels GO:0031667 114 0.014
protein processing GO:0016485 68 0.014
single organism cellular localization GO:1902580 180 0.014
purine nucleoside triphosphate catabolic process GO:0009146 108 0.014
synapse organization GO:0050808 196 0.013
tissue migration GO:0090130 155 0.013
cellular protein catabolic process GO:0044257 83 0.013
positive regulation of protein metabolic process GO:0051247 128 0.013
purine nucleoside metabolic process GO:0042278 127 0.013
regulation of anatomical structure size GO:0090066 163 0.013
response to decreased oxygen levels GO:0036293 58 0.013
retina development in camera type eye GO:0060041 4 0.013
regulation of notch signaling pathway GO:0008593 100 0.013
intracellular protein transport GO:0006886 104 0.013
exocrine system development GO:0035272 162 0.013
wing disc pattern formation GO:0035222 66 0.013
camera type eye morphogenesis GO:0048593 2 0.013
regulation of cellular protein metabolic process GO:0032268 243 0.013
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.013
positive regulation of catabolic process GO:0009896 105 0.013
regulation of secretion by cell GO:1903530 39 0.013
regulation of organ morphogenesis GO:2000027 78 0.013
positive regulation of phosphorus metabolic process GO:0010562 139 0.013
epithelium migration GO:0090132 148 0.013
regulation of small gtpase mediated signal transduction GO:0051056 93 0.013
negative regulation of cell differentiation GO:0045596 143 0.013
signal release GO:0023061 49 0.013
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.013
regulation of purine nucleotide metabolic process GO:1900542 62 0.013
erbb signaling pathway GO:0038127 58 0.013
developmental growth GO:0048589 280 0.013
ribonucleotide catabolic process GO:0009261 109 0.013
oxoacid metabolic process GO:0043436 103 0.013
regulation of innate immune response GO:0045088 71 0.012
tube morphogenesis GO:0035239 191 0.012
positive regulation of developmental process GO:0051094 143 0.012
Rat
oocyte differentiation GO:0009994 145 0.012
spindle organization GO:0007051 253 0.012
regulation of mitotic cell cycle phase transition GO:1901990 130 0.012
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.012
organonitrogen compound biosynthetic process GO:1901566 117 0.012
reproductive system development GO:0061458 74 0.012
regulation of response to external stimulus GO:0032101 115 0.012
regulation of protein modification process GO:0031399 112 0.012
protein localization GO:0008104 284 0.012
protein modification by small protein conjugation GO:0032446 79 0.012
regulation of nucleotide metabolic process GO:0006140 62 0.012
branching morphogenesis of an epithelial tube GO:0048754 45 0.012
negative regulation of apoptotic process GO:0043066 63 0.012
defense response to bacterium GO:0042742 178 0.012
regulation of vesicle mediated transport GO:0060627 59 0.012
negative regulation of organelle organization GO:0010639 56 0.012
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.012
cell cycle arrest GO:0007050 4 0.012
smoothened signaling pathway GO:0007224 49 0.012
nucleoside triphosphate catabolic process GO:0009143 108 0.012
microtubule polymerization or depolymerization GO:0031109 39 0.012
positive regulation of multicellular organismal process GO:0051240 143 0.012
Rat
response to oxygen levels GO:0070482 59 0.012
secretion by cell GO:0032940 101 0.012
regulation of hydrolase activity GO:0051336 97 0.012
imaginal disc derived wing vein morphogenesis GO:0008586 44 0.012
actin filament based process GO:0030029 220 0.012
purine nucleoside catabolic process GO:0006152 112 0.012
regulation of growth GO:0040008 233 0.011
neuromuscular synaptic transmission GO:0007274 67 0.011
nucleocytoplasmic transport GO:0006913 72 0.011
embryonic morphogenesis GO:0048598 206 0.011
organophosphate catabolic process GO:0046434 112 0.011
rrna processing GO:0006364 3 0.011
epidermal growth factor receptor signaling pathway GO:0007173 58 0.011
purine nucleoside triphosphate metabolic process GO:0009144 119 0.011
ribonucleoside triphosphate metabolic process GO:0009199 119 0.011
cellular amino acid metabolic process GO:0006520 61 0.011
gland development GO:0048732 191 0.011
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.011
nucleoside catabolic process GO:0009164 112 0.011
g protein coupled receptor signaling pathway GO:0007186 136 0.011
negative regulation of phosphate metabolic process GO:0045936 45 0.011
Mouse
chromatin modification GO:0016568 147 0.011
endomembrane system organization GO:0010256 119 0.011
regulation of protein localization GO:0032880 76 0.011
nephron development GO:0072006 3 0.011
cellular carbohydrate metabolic process GO:0044262 22 0.011
secretion GO:0046903 109 0.011
purine nucleotide metabolic process GO:0006163 146 0.011
negative regulation of neurogenesis GO:0050768 53 0.011
regulation of protein phosphorylation GO:0001932 64 0.011
cranial nerve development GO:0021545 1 0.011
myotube cell development GO:0014904 3 0.011
synaptic growth at neuromuscular junction GO:0051124 119 0.011
cellular homeostasis GO:0019725 80 0.011
cell cell signaling involved in cell fate commitment GO:0045168 210 0.011
macromolecular complex disassembly GO:0032984 37 0.011
organelle fission GO:0048285 340 0.011
skin development GO:0043588 65 0.011
muscle structure development GO:0061061 224 0.011
cellular amine metabolic process GO:0044106 12 0.011
skeletal muscle fiber development GO:0048741 3 0.011
regulation of wnt signaling pathway GO:0030111 68 0.011
nucleus organization GO:0006997 45 0.011
actin polymerization or depolymerization GO:0008154 31 0.010
response to extracellular stimulus GO:0009991 116 0.010
organonitrogen compound catabolic process GO:1901565 128 0.010
detection of external stimulus GO:0009581 66 0.010
response to wounding GO:0009611 94 0.010
salivary gland cell autophagic cell death GO:0035071 83 0.010
regulation of locomotion GO:0040012 42 0.010
positive regulation of transport GO:0051050 92 0.010
intrinsic apoptotic signaling pathway GO:0097193 16 0.010
establishment of organelle localization GO:0051656 122 0.010
negative regulation of phosphorus metabolic process GO:0010563 45 0.010
Mouse
neuroblast proliferation GO:0007405 74 0.010
cyclic nucleotide metabolic process GO:0009187 28 0.010
neuronal stem cell division GO:0036445 35 0.010
gtp metabolic process GO:0046039 72 0.010
establishment of planar polarity GO:0001736 87 0.010
dna integrity checkpoint GO:0031570 81 0.010
negative regulation of catalytic activity GO:0043086 42 0.010
ovarian follicle cell development GO:0030707 248 0.010

MESK2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.066
musculoskeletal system disease DOID:17 0 0.019
nervous system disease DOID:863 0 0.017
disease of cellular proliferation DOID:14566 0 0.014
bone disease DOID:0080001 0 0.013
connective tissue disease DOID:65 0 0.013
cardiovascular system disease DOID:1287 0 0.011
disease of metabolism DOID:0014667 0 0.011
inherited metabolic disorder DOID:655 0 0.010