Drosophila melanogaster

27 known processes

Gcn2 (Dmel_CG1609)

CG1609 gene product from transcript CG1609-RA

(Aliases: EIF2,dGCN2,CG1609,GCN2,Dmel\CG1609,DGCN2)

Gcn2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
defense response to bacterium GO:0042742 178 0.292
immune system process GO:0002376 347 0.220
protein modification process GO:0036211 438 0.202
regionalization GO:0003002 416 0.186
positive regulation of macromolecule metabolic process GO:0010604 405 0.180
response to biotic stimulus GO:0009607 294 0.177
negative regulation of gene expression GO:0010629 387 0.167
Mouse
intracellular signal transduction GO:0035556 300 0.156
response to external biotic stimulus GO:0043207 293 0.155
cuticle development GO:0042335 86 0.146
regulation of catabolic process GO:0009894 170 0.145
negative regulation of cellular metabolic process GO:0031324 382 0.142
Mouse
positive regulation of protein metabolic process GO:0051247 128 0.132
transcription from rna polymerase ii promoter GO:0006366 368 0.128
catabolic process GO:0009056 409 0.123
defense response GO:0006952 300 0.121
response to other organism GO:0051707 293 0.119
chromosome organization GO:0051276 360 0.112
organonitrogen compound metabolic process GO:1901564 318 0.107
Yeast
cell proliferation GO:0008283 299 0.104
cellular protein modification process GO:0006464 438 0.099
innate immune response GO:0045087 144 0.099
regulation of cell cycle process GO:0010564 181 0.098
positive regulation of catabolic process GO:0009896 105 0.098
response to abiotic stimulus GO:0009628 341 0.093
response to bacterium GO:0009617 198 0.091
regulation of chitin based cuticle tanning GO:0007564 14 0.088
negative regulation of signal transduction GO:0009968 206 0.087
negative regulation of response to stimulus GO:0048585 258 0.086
regulation of molecular function GO:0065009 217 0.085
cell cell signaling involved in cell fate commitment GO:0045168 210 0.083
positive regulation of biosynthetic process GO:0009891 316 0.082
organic substance catabolic process GO:1901575 308 0.082
cellular catabolic process GO:0044248 372 0.081
dorsal ventral pattern formation GO:0009953 133 0.080
pigmentation GO:0043473 75 0.079
trna aminoacylation GO:0043039 2 0.078
purine containing compound catabolic process GO:0072523 112 0.078
vesicle mediated transport GO:0016192 381 0.078
regulation of small gtpase mediated signal transduction GO:0051056 93 0.078
posttranscriptional regulation of gene expression GO:0010608 145 0.075
Yeast Mouse
proteolysis GO:0006508 192 0.073
imaginal disc derived appendage morphogenesis GO:0035114 395 0.073
phagocytosis GO:0006909 215 0.073
regulation of intracellular signal transduction GO:1902531 236 0.072
regulation of catalytic activity GO:0050790 185 0.072
negative regulation of biosynthetic process GO:0009890 277 0.071
Mouse
regulation of hydrolase activity GO:0051336 97 0.071
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.069
molting cycle chitin based cuticle GO:0007591 56 0.068
localization of cell GO:0051674 257 0.066
positive regulation of hydrolase activity GO:0051345 78 0.063
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.063
lateral inhibition GO:0046331 206 0.062
response to organic substance GO:0010033 284 0.062
Mouse
molting cycle GO:0042303 56 0.061
chromatin assembly or disassembly GO:0006333 52 0.061
positive regulation of molecular function GO:0044093 136 0.061
regulation of protein metabolic process GO:0051246 256 0.061
Yeast Mouse
mapk cascade GO:0000165 107 0.060
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.060
regulation of transport GO:0051049 181 0.060
regulation of phosphate metabolic process GO:0019220 210 0.059
negative regulation of developmental process GO:0051093 201 0.058
ribonucleotide catabolic process GO:0009261 109 0.058
regulation of ras protein signal transduction GO:0046578 93 0.058
regulation of cell cycle GO:0051726 291 0.056
positive regulation of phosphate metabolic process GO:0045937 139 0.056
positive regulation of cellular catabolic process GO:0031331 95 0.055
dna damage checkpoint GO:0000077 78 0.055
Yeast
regulation of phosphorus metabolic process GO:0051174 210 0.055
response to lipopolysaccharide GO:0032496 4 0.055
organelle fission GO:0048285 340 0.055
phosphorylation GO:0016310 294 0.054
negative regulation of cellular biosynthetic process GO:0031327 277 0.054
Mouse
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.054
Mouse
positive regulation of catalytic activity GO:0043085 118 0.053
macromolecule catabolic process GO:0009057 161 0.053
regulation of mitotic cell cycle GO:0007346 190 0.052
male gamete generation GO:0048232 201 0.052
organic acid metabolic process GO:0006082 103 0.051
Yeast
ribonucleoside catabolic process GO:0042454 112 0.051
regulation of defense response to virus by host GO:0050691 10 0.051
negative regulation of kinase activity GO:0033673 16 0.050
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.049
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.049
Mouse
appendage morphogenesis GO:0035107 397 0.048
regulation of localization GO:0032879 275 0.047
negative regulation of multicellular organismal process GO:0051241 142 0.047
imaginal disc derived appendage development GO:0048737 399 0.047
cell death GO:0008219 279 0.047
purine ribonucleotide catabolic process GO:0009154 109 0.047
positive regulation of cell communication GO:0010647 250 0.047
immune response GO:0006955 246 0.046
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.046
regulation of mapk cascade GO:0043408 92 0.046
organic cyclic compound catabolic process GO:1901361 168 0.046
endocytosis GO:0006897 310 0.045
dna integrity checkpoint GO:0031570 81 0.045
Yeast
protein import GO:0017038 55 0.045
appendage development GO:0048736 401 0.044
response to oxidative stress GO:0006979 86 0.044
protein phosphorylation GO:0006468 169 0.043
positive regulation of immune response GO:0050778 63 0.043
cell fate determination GO:0001709 91 0.043
regulation of cell differentiation GO:0045595 302 0.042
camera type eye development GO:0043010 4 0.042
heterochromatin organization GO:0070828 25 0.041
connective tissue development GO:0061448 3 0.041
establishment of localization in cell GO:0051649 402 0.041
ras protein signal transduction GO:0007265 88 0.041
heterocycle catabolic process GO:0046700 166 0.041
positive regulation of cellular protein metabolic process GO:0032270 118 0.040
gene silencing by rna GO:0031047 57 0.039
death GO:0016265 284 0.039
chromatin modification GO:0016568 147 0.039
single organism nuclear import GO:1902593 51 0.038
wing disc morphogenesis GO:0007472 344 0.038
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070059 4 0.037
negative regulation of rna biosynthetic process GO:1902679 240 0.037
regulation of cellular catabolic process GO:0031329 157 0.037
developmental pigmentation GO:0048066 68 0.037
negative regulation of signaling GO:0023057 219 0.037
regulation of gene expression epigenetic GO:0040029 128 0.036
growth GO:0040007 359 0.036
ion transport GO:0006811 145 0.036
programmed cell death GO:0012501 257 0.035
covalent chromatin modification GO:0016569 106 0.035
membrane fusion GO:0061025 42 0.035
positive regulation of gene expression GO:0010628 290 0.035
gene silencing GO:0016458 138 0.035
positive regulation of cellular biosynthetic process GO:0031328 316 0.035
regulation of cytoplasmic transport GO:1903649 47 0.034
posttranscriptional gene silencing by rna GO:0035194 45 0.034
defense response to other organism GO:0098542 225 0.034
regulation of nucleocytoplasmic transport GO:0046822 35 0.034
trna aminoacylation for protein translation GO:0006418 2 0.034
necrotic cell death GO:0070265 1 0.034
positive regulation of defense response GO:0031349 59 0.033
single organism biosynthetic process GO:0044711 206 0.033
Yeast
positive regulation of nucleic acid templated transcription GO:1903508 266 0.033
positive regulation of response to stimulus GO:0048584 323 0.033
nucleoside triphosphate metabolic process GO:0009141 120 0.032
positive regulation of defense response to virus by host GO:0002230 10 0.032
small molecule metabolic process GO:0044281 305 0.032
Yeast
positive regulation of signaling GO:0023056 243 0.032
purine nucleoside catabolic process GO:0006152 112 0.032
small gtpase mediated signal transduction GO:0007264 88 0.032
adult chitin containing cuticle pigmentation GO:0048085 16 0.031
positive regulation of jun kinase activity GO:0043507 4 0.031
nucleobase containing small molecule metabolic process GO:0055086 174 0.031
regulation of organelle organization GO:0033043 196 0.030
regulation of cellular protein metabolic process GO:0032268 243 0.030
Yeast Mouse
regulation of nuclear division GO:0051783 58 0.030
regulation of developmental pigmentation GO:0048070 24 0.029
cellular response to abiotic stimulus GO:0071214 58 0.029
protein catabolic process GO:0030163 101 0.029
positive regulation of proteolysis GO:0045862 52 0.029
single organism membrane fusion GO:0044801 42 0.029
regulation of developmental growth GO:0048638 174 0.029
regulation of i kappab kinase nf kappab signaling GO:0043122 2 0.028
central nervous system development GO:0007417 201 0.028
mucosal immune response GO:0002385 10 0.028
spindle assembly GO:0051225 80 0.028
positive regulation of intracellular signal transduction GO:1902533 116 0.028
antimicrobial humoral response GO:0019730 99 0.028
regulation of growth GO:0040008 233 0.028
cellular amino acid metabolic process GO:0006520 61 0.027
Yeast
glycosyl compound catabolic process GO:1901658 112 0.027
cellular response to chemical stimulus GO:0070887 199 0.027
Mouse
regulation of establishment of protein localization GO:0070201 61 0.027
immune response regulating signaling pathway GO:0002764 2 0.027
spermatogenesis GO:0007283 200 0.027
dna repair GO:0006281 54 0.027
nuclear division GO:0000280 332 0.026
epithelial cell differentiation GO:0030855 322 0.026
defense response to gram negative bacterium GO:0050829 94 0.026
regulation of proteolysis GO:0030162 87 0.026
positive regulation of peptidase activity GO:0010952 29 0.026
glycosyl compound metabolic process GO:1901657 127 0.026
regulation of defense response GO:0031347 102 0.026
organelle assembly GO:0070925 198 0.026
carbohydrate metabolic process GO:0005975 82 0.025
mitotic dna integrity checkpoint GO:0044774 75 0.025
imaginal disc derived wing morphogenesis GO:0007476 337 0.025
cellular response to organic substance GO:0071310 132 0.025
Mouse
positive regulation of transcription dna templated GO:0045893 266 0.025
regulation of protein transport GO:0051223 57 0.025
regulation of multicellular organismal development GO:2000026 414 0.025
regulation of map kinase activity GO:0043405 17 0.025
cellular nitrogen compound catabolic process GO:0044270 165 0.025
regulation of intracellular transport GO:0032386 64 0.024
positive regulation of mapk cascade GO:0043410 63 0.024
mitotic nuclear division GO:0007067 213 0.024
humoral immune response GO:0006959 117 0.024
intracellular transport GO:0046907 228 0.024
negative regulation of transcription dna templated GO:0045892 237 0.024
single organism catabolic process GO:0044712 228 0.024
protein transport GO:0015031 155 0.023
positive regulation of rna metabolic process GO:0051254 271 0.023
ribonucleoside triphosphate metabolic process GO:0009199 119 0.023
purine ribonucleoside catabolic process GO:0046130 112 0.023
purine ribonucleoside monophosphate catabolic process GO:0009169 38 0.023
anatomical structure homeostasis GO:0060249 97 0.023
chromatin organization GO:0006325 207 0.023
dna metabolic process GO:0006259 227 0.023
protein localization to nucleus GO:0034504 55 0.023
regulation of innate immune response GO:0045088 71 0.023
macromolecular complex assembly GO:0065003 256 0.023
carbohydrate derivative catabolic process GO:1901136 118 0.023
imaginal disc pattern formation GO:0007447 91 0.023
negative regulation of cell cycle phase transition GO:1901988 103 0.023
protein complex biogenesis GO:0070271 201 0.023
positive regulation of apoptotic signaling pathway GO:2001235 4 0.023
regulation of adult chitin containing cuticle pigmentation GO:0048082 13 0.023
carbohydrate derivative metabolic process GO:1901135 217 0.023
positive regulation of phosphorus metabolic process GO:0010562 139 0.022
nucleoside catabolic process GO:0009164 112 0.022
membrane organization GO:0061024 112 0.022
positive regulation of transport GO:0051050 92 0.022
regulation of jun kinase activity GO:0043506 8 0.022
establishment of protein localization GO:0045184 163 0.022
jak stat cascade GO:0007259 49 0.022
regulation of mitosis GO:0007088 56 0.021
response to starvation GO:0042594 97 0.021
Mouse
organophosphate metabolic process GO:0019637 195 0.021
posttranscriptional gene silencing GO:0016441 46 0.021
heart development GO:0007507 82 0.021
negative regulation of cell communication GO:0010648 223 0.021
regulation of multi organism process GO:0043900 131 0.021
negative regulation of rna metabolic process GO:0051253 251 0.021
nucleotide catabolic process GO:0009166 109 0.021
protein targeting to nucleus GO:0044744 51 0.021
positive regulation of signal transduction GO:0009967 223 0.021
regulation of intracellular protein transport GO:0033157 46 0.021
regulation of response to stress GO:0080134 200 0.021
regulation of cell cycle phase transition GO:1901987 130 0.020
post embryonic appendage morphogenesis GO:0035120 385 0.020
response to light stimulus GO:0009416 124 0.020
regulation of dna metabolic process GO:0051052 34 0.020
mrna metabolic process GO:0016071 124 0.020
protein targeting GO:0006605 64 0.020
regulation of protein modification process GO:0031399 112 0.020
eye development GO:0001654 323 0.020
aromatic compound catabolic process GO:0019439 166 0.020
skin development GO:0043588 65 0.020
positive regulation of protein transport GO:0051222 37 0.020
ribonucleotide metabolic process GO:0009259 145 0.019
cellular response to dsrna GO:0071359 15 0.019
protein modification by small protein conjugation GO:0032446 79 0.019
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.019
homeostatic process GO:0042592 199 0.019
negative regulation of nucleic acid templated transcription GO:1903507 240 0.019
nucleoside phosphate catabolic process GO:1901292 110 0.019
regulation of cell development GO:0060284 215 0.019
aging GO:0007568 143 0.019
Yeast
single organism carbohydrate metabolic process GO:0044723 72 0.019
sensory organ morphogenesis GO:0090596 260 0.018
ribonucleoside triphosphate catabolic process GO:0009203 108 0.018
response to organic cyclic compound GO:0014070 89 0.018
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.018
atp catabolic process GO:0006200 38 0.018
nucleoside metabolic process GO:0009116 127 0.018
organonitrogen compound catabolic process GO:1901565 128 0.017
response to organophosphorus GO:0046683 2 0.017
purine ribonucleotide metabolic process GO:0009150 145 0.017
telencephalon development GO:0021537 2 0.017
regulation of immune system process GO:0002682 176 0.017
protein import into nucleus GO:0006606 51 0.017
nucleoside triphosphate catabolic process GO:0009143 108 0.017
nucleotide metabolic process GO:0009117 161 0.017
positive regulation of nucleoside metabolic process GO:0045979 47 0.017
negative regulation of nervous system development GO:0051961 92 0.017
regulation of cellular localization GO:0060341 136 0.017
response to radiation GO:0009314 155 0.017
cation transmembrane transport GO:0098655 88 0.017
chitin based cuticle sclerotization GO:0007593 19 0.017
cell division GO:0051301 248 0.017
detection of stimulus GO:0051606 156 0.017
positive regulation of cell death GO:0010942 69 0.017
purine nucleoside triphosphate metabolic process GO:0009144 119 0.016
negative regulation of cellular protein metabolic process GO:0032269 85 0.016
Mouse
cellular response to unfolded protein GO:0034620 9 0.016
Mouse
cellular macromolecule catabolic process GO:0044265 136 0.016
cellular hyperosmotic salinity response GO:0071475 1 0.016
response to copper ion GO:0046688 4 0.016
regulation of cuticle pigmentation GO:0048079 16 0.016
germ line stem cell maintenance GO:0030718 50 0.016
regulation of protein catabolic process GO:0042176 55 0.016
ensheathment of neurons GO:0007272 10 0.016
cation homeostasis GO:0055080 51 0.016
negative regulation of growth GO:0045926 84 0.016
dorsal ventral pattern formation imaginal disc GO:0007450 51 0.016
response to temperature stimulus GO:0009266 106 0.016
positive regulation of cellular component biogenesis GO:0044089 80 0.016
purine nucleotide catabolic process GO:0006195 109 0.016
regulation of purine nucleotide catabolic process GO:0033121 48 0.016
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.016
organophosphate catabolic process GO:0046434 112 0.015
regulation of response to external stimulus GO:0032101 115 0.015
cellular response to biotic stimulus GO:0071216 4 0.015
negative regulation of epidermal growth factor receptor signaling pathway GO:0042059 29 0.015
cell migration GO:0016477 238 0.015
negative regulation of developmental growth GO:0048640 64 0.015
regulation of programmed cell death GO:0043067 152 0.015
skeletal muscle fiber development GO:0048741 3 0.015
antennal development GO:0007469 25 0.015
autophagy GO:0006914 108 0.015
response to alcohol GO:0097305 95 0.015
regulation of membrane potential GO:0042391 35 0.015
regulation of protein import into nucleus GO:0042306 28 0.015
ribonucleoside metabolic process GO:0009119 127 0.015
organ or tissue specific immune response GO:0002251 10 0.015
hair cell differentiation GO:0035315 47 0.014
response to endoplasmic reticulum stress GO:0034976 28 0.014
Mouse
organic substance transport GO:0071702 257 0.014
defense response to gram positive bacterium GO:0050830 41 0.014
limb development GO:0060173 1 0.014
positive regulation of multicellular organismal process GO:0051240 143 0.014
antimicrobial peptide production GO:0002775 46 0.014
immune response activating signal transduction GO:0002757 2 0.014
oxoacid metabolic process GO:0043436 103 0.014
Yeast
spindle organization GO:0007051 253 0.014
forebrain development GO:0030900 2 0.014
rna processing GO:0006396 147 0.014
cellular response to dna damage stimulus GO:0006974 223 0.014
Yeast
stem cell maintenance GO:0019827 67 0.014
ribonucleoside monophosphate catabolic process GO:0009158 39 0.014
regulation of sequestering of calcium ion GO:0051282 3 0.014
regulation of cellular component biogenesis GO:0044087 201 0.013
neuronal action potential GO:0019228 10 0.013
regulation of nucleotide metabolic process GO:0006140 62 0.013
axon ensheathment GO:0008366 10 0.013
positive regulation of phosphorylation GO:0042327 87 0.013
negative regulation of cell cycle process GO:0010948 109 0.013
carboxylic acid metabolic process GO:0019752 92 0.013
Yeast
hindbrain development GO:0030902 2 0.013
epithelial cell development GO:0002064 274 0.013
amino acid activation GO:0043038 3 0.013
response to nitrogen compound GO:1901698 90 0.013
response to decreased oxygen levels GO:0036293 58 0.013
wnt signaling pathway GO:0016055 98 0.013
body morphogenesis GO:0010171 2 0.012
regulation of nucleoside metabolic process GO:0009118 50 0.012
regulation of cellular amine metabolic process GO:0033238 3 0.012
glycoprotein metabolic process GO:0009100 41 0.012
regulation of immune response GO:0050776 118 0.012
protein localization GO:0008104 284 0.012
regulation of apoptotic process GO:0042981 130 0.012
cytoplasmic translation GO:0002181 0 0.012
nuclear transport GO:0051169 72 0.012
regulation of response to oxidative stress GO:1902882 4 0.012
purine containing compound metabolic process GO:0072521 155 0.012
positive regulation of ras gtpase activity GO:0032320 36 0.012
gastrulation with mouth forming first GO:0001703 36 0.012
regulation of mrna metabolic process GO:1903311 72 0.012
dna conformation change GO:0071103 105 0.012
regulation of protein phosphorylation GO:0001932 64 0.012
cellular macromolecular complex assembly GO:0034622 153 0.012
taxis GO:0042330 304 0.012
regulation of phosphorylation GO:0042325 147 0.012
nucleoside monophosphate catabolic process GO:0009125 39 0.012
inositol lipid mediated signaling GO:0048017 4 0.012
endosomal transport GO:0016197 44 0.012
response to hexose GO:0009746 3 0.012
single organism intracellular transport GO:1902582 207 0.012
purine nucleoside metabolic process GO:0042278 127 0.011
regulation of protein localization GO:0032880 76 0.011
immune effector process GO:0002252 98 0.011
apoptotic process GO:0006915 159 0.011
purine nucleotide metabolic process GO:0006163 146 0.011
purine nucleoside monophosphate catabolic process GO:0009128 38 0.011
nucleocytoplasmic transport GO:0006913 72 0.011
response to topologically incorrect protein GO:0035966 10 0.011
Mouse
cation transport GO:0006812 110 0.011
regulation of epithelial cell differentiation GO:0030856 4 0.011
positive regulation of exocytosis GO:0045921 4 0.011
i kappab phosphorylation GO:0007252 3 0.011
production of small rna involved in gene silencing by rna GO:0070918 15 0.011
regulation of cellular component size GO:0032535 98 0.011
positive regulation of reactive oxygen species metabolic process GO:2000379 0 0.011
ribonucleoside monophosphate metabolic process GO:0009161 51 0.011
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.011
regulation of gtpase activity GO:0043087 44 0.011
single organism membrane organization GO:0044802 93 0.010
cellular homeostasis GO:0019725 80 0.010
regulation of gtp catabolic process GO:0033124 44 0.010
response to organonitrogen compound GO:0010243 75 0.010
regulation of rab gtpase activity GO:0032313 7 0.010
ribose phosphate metabolic process GO:0019693 145 0.010
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 4 0.010
extrinsic apoptotic signaling pathway GO:0097191 1 0.010
regulation of mitotic cell cycle phase transition GO:1901990 130 0.010
negative regulation of homeostatic process GO:0032845 2 0.010
cellular response to lipopolysaccharide GO:0071222 3 0.010
detection of stimulus involved in sensory perception GO:0050906 92 0.010
positive regulation of ion transmembrane transporter activity GO:0032414 4 0.010
guanosine containing compound catabolic process GO:1901069 74 0.010
eye antennal disc development GO:0035214 60 0.010
xenobiotic transport GO:0042908 1 0.010

Gcn2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.053
disease of metabolism DOID:0014667 0 0.019
nervous system disease DOID:863 0 0.018
disease of cellular proliferation DOID:14566 0 0.017
cancer DOID:162 0 0.017
organ system cancer DOID:0050686 0 0.017
inherited metabolic disorder DOID:655 0 0.015
central nervous system disease DOID:331 0 0.013