Drosophila melanogaster

78 known processes

Eps-15 (Dmel_CG16932)

Epidermal growth factor receptor pathway substrate clone 15

(Aliases: Eps15,EH1,i31,eps15,anon-WO0118547.85,CG16932,Dmel\CG16932,eps-15,EPS-15)

Eps-15 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of nervous system development GO:0051960 248 0.982
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.952
regulation of multicellular organismal development GO:2000026 414 0.938
neuromuscular junction development GO:0007528 149 0.880
determination of adult lifespan GO:0008340 137 0.710
protein modification by small protein conjugation or removal GO:0070647 106 0.695
negative regulation of nervous system development GO:0051961 92 0.694
multicellular organismal aging GO:0010259 140 0.632
intracellular signal transduction GO:0035556 300 0.608
regulation of synapse assembly GO:0051963 94 0.596
regulation of synaptic growth at neuromuscular junction GO:0008582 89 0.594
aging GO:0007568 143 0.582
establishment of localization in cell GO:0051649 402 0.569
cellular component disassembly GO:0022411 46 0.530
body morphogenesis GO:0010171 2 0.527
regulation of cellular component biogenesis GO:0044087 201 0.525
embryo development ending in birth or egg hatching GO:0009792 152 0.514
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.490
regulation of cell differentiation GO:0045595 302 0.441
Fly
transcription from rna polymerase ii promoter GO:0006366 368 0.430
synaptic transmission GO:0007268 288 0.424
regulation of developmental growth GO:0048638 174 0.408
tissue morphogenesis GO:0048729 297 0.406
negative regulation of multicellular organismal process GO:0051241 142 0.405
actomyosin contractile ring organization GO:0044837 10 0.376
organelle localization GO:0051640 148 0.358
synaptic vesicle recycling GO:0036465 28 0.354
regulation of growth GO:0040008 233 0.313
negative regulation of synapse assembly GO:0051964 39 0.312
central nervous system development GO:0007417 201 0.305
imaginal disc derived wing vein morphogenesis GO:0008586 44 0.298
endocytosis GO:0006897 310 0.292
dna metabolic process GO:0006259 227 0.292
notch signaling pathway GO:0007219 120 0.278
protein modification process GO:0036211 438 0.273
Fly
regulation of synapse organization GO:0050807 110 0.255
cell projection assembly GO:0030031 94 0.255
macromolecular complex disassembly GO:0032984 37 0.254
negative regulation of cellular component organization GO:0051129 108 0.254
small molecule metabolic process GO:0044281 305 0.252
developmental growth GO:0048589 280 0.251
cellular catabolic process GO:0044248 372 0.236
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.228
eye morphogenesis GO:0048592 260 0.221
negative regulation of developmental process GO:0051093 201 0.220
negative regulation of cellular biosynthetic process GO:0031327 277 0.212
synapse organization GO:0050808 196 0.209
organonitrogen compound metabolic process GO:1901564 318 0.204
regulation of cell development GO:0060284 215 0.204
Fly
cellular lipid metabolic process GO:0044255 83 0.201
positive regulation of cell communication GO:0010647 250 0.199
vesicle mediated transport GO:0016192 381 0.188
protein phosphorylation GO:0006468 169 0.186
Fly
oocyte differentiation GO:0009994 145 0.182
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.180
cellular protein modification process GO:0006464 438 0.178
Fly
oocyte microtubule cytoskeleton organization GO:0016325 35 0.174
spermatid differentiation GO:0048515 114 0.173
homeostatic process GO:0042592 199 0.171
compound eye development GO:0048749 307 0.168
neuroblast proliferation GO:0007405 74 0.166
Fly
spermatid development GO:0007286 98 0.163
negative regulation of rna metabolic process GO:0051253 251 0.155
positive regulation of cellular component organization GO:0051130 156 0.151
establishment of organelle localization GO:0051656 122 0.146
sensory organ morphogenesis GO:0090596 260 0.144
ribonucleotide metabolic process GO:0009259 145 0.144
protein localization GO:0008104 284 0.139
Fly
axonogenesis GO:0007409 290 0.135
positive regulation of signal transduction GO:0009967 223 0.135
dna templated transcription elongation GO:0006354 18 0.135
compound eye morphogenesis GO:0001745 249 0.135
secretion by cell GO:0032940 101 0.130
regulation of catabolic process GO:0009894 170 0.129
negative regulation of gene expression GO:0010629 387 0.128
enzyme linked receptor protein signaling pathway GO:0007167 179 0.127
chaeta development GO:0022416 97 0.127
purine nucleoside catabolic process GO:0006152 112 0.126
regulation of mitotic cell cycle GO:0007346 190 0.121
chemotaxis GO:0006935 249 0.113
protein modification by small protein removal GO:0070646 28 0.112
imaginal disc growth GO:0007446 37 0.111
cilium organization GO:0044782 41 0.111
positive regulation of rna biosynthetic process GO:1902680 266 0.110
cell proliferation GO:0008283 299 0.109
Fly
negative regulation of cellular metabolic process GO:0031324 382 0.108
g protein coupled receptor signaling pathway GO:0007186 136 0.107
carbohydrate derivative catabolic process GO:1901136 118 0.106
regulation of organelle organization GO:0033043 196 0.106
negative regulation of biosynthetic process GO:0009890 277 0.105
response to ecdysone GO:0035075 34 0.105
circulatory system development GO:0072359 82 0.104
morphogenesis of an epithelium GO:0002009 276 0.101
appendage development GO:0048736 401 0.100
wing disc morphogenesis GO:0007472 344 0.099
eye development GO:0001654 323 0.099
mitotic cell cycle phase transition GO:0044772 138 0.099
positive regulation of developmental process GO:0051094 143 0.098
Fly
cellular component assembly involved in morphogenesis GO:0010927 151 0.097
neuron projection guidance GO:0097485 241 0.093
actomyosin contractile ring assembly GO:0000915 10 0.093
negative regulation of transcription dna templated GO:0045892 237 0.092
establishment of mitochondrion localization GO:0051654 7 0.091
positive regulation of catalytic activity GO:0043085 118 0.090
Fly
mesoderm development GO:0007498 78 0.090
negative regulation of rna biosynthetic process GO:1902679 240 0.090
positive regulation of transcription dna templated GO:0045893 266 0.090
regulation of phosphate metabolic process GO:0019220 210 0.089
Fly
glial cell development GO:0021782 27 0.089
positive regulation of biosynthetic process GO:0009891 316 0.089
ovarian follicle cell development GO:0030707 248 0.088
protein ubiquitination GO:0016567 70 0.088
neural precursor cell proliferation GO:0061351 75 0.088
Fly
cell death GO:0008219 279 0.086
glial cell differentiation GO:0010001 35 0.085
regulation of neurogenesis GO:0050767 158 0.084
Fly
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.083
lipid metabolic process GO:0006629 121 0.082
oocyte development GO:0048599 124 0.082
organophosphate catabolic process GO:0046434 112 0.082
secretion GO:0046903 109 0.081
regulation of molecular function GO:0065009 217 0.080
Fly
protein modification by small protein conjugation GO:0032446 79 0.080
catabolic process GO:0009056 409 0.080
membrane organization GO:0061024 112 0.080
Human
negative regulation of cell proliferation GO:0008285 69 0.078
synaptic vesicle endocytosis GO:0048488 28 0.077
phosphorylation GO:0016310 294 0.077
Fly
regulation of phosphorus metabolic process GO:0051174 210 0.077
Fly
embryonic organ development GO:0048568 50 0.076
negative regulation of mitotic cell cycle GO:0045930 109 0.076
regulation of cellular response to stress GO:0080135 89 0.075
synaptic growth at neuromuscular junction GO:0051124 119 0.075
organelle assembly GO:0070925 198 0.075
positive regulation of nervous system development GO:0051962 69 0.074
Fly
multi multicellular organism process GO:0044706 123 0.074
sex differentiation GO:0007548 81 0.073
defense response to other organism GO:0098542 225 0.073
regulation of response to stress GO:0080134 200 0.073
small gtpase mediated signal transduction GO:0007264 88 0.072
single organism catabolic process GO:0044712 228 0.070
regulation of intracellular signal transduction GO:1902531 236 0.070
phagocytosis GO:0006909 215 0.070
leg disc morphogenesis GO:0007478 80 0.069
multicellular organismal reproductive behavior GO:0033057 110 0.068
synapse assembly GO:0007416 143 0.068
hematopoietic or lymphoid organ development GO:0048534 57 0.068
protein deubiquitination GO:0016579 17 0.066
heart development GO:0007507 82 0.065
establishment of spindle localization GO:0051293 22 0.064
positive regulation of response to stimulus GO:0048584 323 0.064
programmed cell death GO:0012501 257 0.063
purine containing compound metabolic process GO:0072521 155 0.063
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.061
nuclear dna replication GO:0033260 1 0.061
nuclear division GO:0000280 332 0.061
macromolecular complex assembly GO:0065003 256 0.061
Human
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.059
regulation of protein modification process GO:0031399 112 0.059
Fly
dendrite morphogenesis GO:0048813 199 0.058
imaginal disc derived leg morphogenesis GO:0007480 80 0.058
malpighian tubule tip cell differentiation GO:0061382 9 0.058
cardiovascular system development GO:0072358 82 0.057
regulation of catalytic activity GO:0050790 185 0.057
Fly
hemopoiesis GO:0030097 46 0.057
mesoderm morphogenesis GO:0048332 22 0.056
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.056
cortical actin cytoskeleton organization GO:0030866 24 0.056
regulation of protein metabolic process GO:0051246 256 0.055
Fly
regulation of dna templated transcription elongation GO:0032784 17 0.055
purine ribonucleotide metabolic process GO:0009150 145 0.055
cell maturation GO:0048469 144 0.054
positive regulation of cellular catabolic process GO:0031331 95 0.054
purine nucleotide catabolic process GO:0006195 109 0.054
negative regulation of cell differentiation GO:0045596 143 0.053
positive regulation of phosphorus metabolic process GO:0010562 139 0.053
Fly
protein depolymerization GO:0051261 31 0.053
positive regulation of neurogenesis GO:0050769 41 0.053
Fly
cellular protein complex disassembly GO:0043624 35 0.052
purine ribonucleoside catabolic process GO:0046130 112 0.052
purine nucleotide metabolic process GO:0006163 146 0.052
imaginal disc derived appendage morphogenesis GO:0035114 395 0.051
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.050
reproductive structure development GO:0048608 74 0.050
synaptic vesicle localization GO:0097479 53 0.050
response to organic substance GO:0010033 284 0.050
establishment of synaptic vesicle localization GO:0097480 50 0.050
organic acid metabolic process GO:0006082 103 0.049
defense response to bacterium GO:0042742 178 0.048
regulation of neural precursor cell proliferation GO:2000177 35 0.048
Fly
purine nucleoside triphosphate catabolic process GO:0009146 108 0.048
regulation of kinase activity GO:0043549 53 0.048
Fly
peptidyl lysine methylation GO:0018022 16 0.048
regulation of cell cycle process GO:0010564 181 0.048
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.048
response to external biotic stimulus GO:0043207 293 0.047
single organism membrane organization GO:0044802 93 0.047
nucleoside phosphate metabolic process GO:0006753 162 0.047
methylation GO:0032259 47 0.047
regulation of neuroblast proliferation GO:1902692 34 0.047
Fly
positive regulation of macromolecule metabolic process GO:0010604 405 0.046
Fly
actin filament based process GO:0030029 220 0.046
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.046
negative regulation of developmental growth GO:0048640 64 0.045
negative regulation of nucleic acid templated transcription GO:1903507 240 0.045
development of primary sexual characteristics GO:0045137 50 0.045
positive regulation of signaling GO:0023056 243 0.045
positive regulation of axon guidance GO:1902669 1 0.045
imaginal disc derived wing morphogenesis GO:0007476 337 0.045
regulation of stem cell proliferation GO:0072091 40 0.045
Fly
regulation of synapse structure and activity GO:0050803 128 0.044
ribonucleoside catabolic process GO:0042454 112 0.043
lipid modification GO:0030258 24 0.043
cellular nitrogen compound catabolic process GO:0044270 165 0.043
regulation of cellular catabolic process GO:0031329 157 0.043
oxoacid metabolic process GO:0043436 103 0.043
positive regulation of multicellular organismal process GO:0051240 143 0.042
Fly
positive regulation of cell differentiation GO:0045597 64 0.042
Fly
negative regulation of cell cycle process GO:0010948 109 0.042
nucleotide catabolic process GO:0009166 109 0.041
nucleobase containing small molecule metabolic process GO:0055086 174 0.041
positive regulation of cellular amine metabolic process GO:0033240 0 0.041
regulation of localization GO:0032879 275 0.041
epithelial cell development GO:0002064 274 0.041
ribose phosphate metabolic process GO:0019693 145 0.040
appendage morphogenesis GO:0035107 397 0.040
guanosine containing compound catabolic process GO:1901069 74 0.039
regulation of purine nucleotide metabolic process GO:1900542 62 0.039
immune system development GO:0002520 57 0.039
establishment or maintenance of cytoskeleton polarity GO:0030952 44 0.038
nucleoside metabolic process GO:0009116 127 0.038
establishment of vesicle localization GO:0051650 51 0.038
regulation of cell cycle phase transition GO:1901987 130 0.038
forebrain development GO:0030900 2 0.038
cellular response to sterol depletion GO:0071501 3 0.038
regulation of protein phosphorylation GO:0001932 64 0.038
Fly
cytokinesis GO:0000910 90 0.038
endoplasmic reticulum organization GO:0007029 13 0.037
epidermis development GO:0008544 65 0.037
negative regulation of programmed cell death GO:0043069 72 0.037
negative regulation of growth GO:0045926 84 0.037
positive regulation of organelle organization GO:0010638 65 0.037
regulation of synaptic transmission GO:0050804 69 0.036
positive regulation of protein deacetylation GO:0090312 2 0.036
positive regulation of cellular component biogenesis GO:0044089 80 0.036
positive regulation of cell development GO:0010720 61 0.036
Fly
locomotory behavior GO:0007626 176 0.036
axon development GO:0061564 297 0.035
growth GO:0040007 359 0.035
assembly of actomyosin apparatus involved in cytokinesis GO:0000912 11 0.035
camera type eye morphogenesis GO:0048593 2 0.035
positive regulation of rna metabolic process GO:0051254 271 0.035
cytoskeleton dependent cytokinesis GO:0061640 81 0.035
ribonucleoside metabolic process GO:0009119 127 0.034
organelle fission GO:0048285 340 0.034
positive regulation of nucleotide metabolic process GO:0045981 55 0.034
dendrite development GO:0016358 204 0.034
neuromuscular synaptic transmission GO:0007274 67 0.034
negative regulation of signal transduction GO:0009968 206 0.034
protein complex assembly GO:0006461 200 0.034
Human
formation of anatomical boundary GO:0048859 37 0.033
cilium assembly GO:0042384 38 0.033
cellular macromolecule localization GO:0070727 220 0.033
meiotic spindle organization GO:0000212 36 0.033
regulation of cytoskeleton organization GO:0051493 89 0.032
localization of cell GO:0051674 257 0.032
epithelial cell differentiation GO:0030855 322 0.031
mesenchymal cell differentiation GO:0048762 1 0.031
gliogenesis GO:0042063 80 0.031
actin cytoskeleton organization GO:0030036 206 0.031
regulation of protein stability GO:0031647 43 0.031
organic cyclic compound catabolic process GO:1901361 168 0.031
single organism biosynthetic process GO:0044711 206 0.031
multi organism reproductive behavior GO:0044705 121 0.030
negative regulation of synaptic growth at neuromuscular junction GO:0045886 39 0.030
regulation of hydrolase activity GO:0051336 97 0.030
columnar cuboidal epithelial cell development GO:0002066 249 0.030
positive regulation of gene expression GO:0010628 290 0.030
purine nucleoside metabolic process GO:0042278 127 0.030
tube development GO:0035295 244 0.030
immune system process GO:0002376 347 0.030
germarium derived oocyte fate determination GO:0007294 26 0.029
regulation of metaphase anaphase transition of cell cycle GO:1902099 26 0.029
organic substance catabolic process GO:1901575 308 0.029
ecdysone receptor mediated signaling pathway GO:0035076 11 0.029
ribonucleoside triphosphate catabolic process GO:0009203 108 0.029
regulation of endocytosis GO:0030100 37 0.029
endomembrane system organization GO:0010256 119 0.029
regulation of nucleotide metabolic process GO:0006140 62 0.029
cell cycle phase transition GO:0044770 140 0.028
transcription elongation from rna polymerase ii promoter GO:0006368 18 0.028
developmental maturation GO:0021700 172 0.028
meiotic nuclear division GO:0007126 151 0.028
regulation of gene silencing GO:0060968 63 0.028
regulation of cellular protein metabolic process GO:0032268 243 0.028
Fly
stem cell development GO:0048864 79 0.028
cellular response to chemical stimulus GO:0070887 199 0.028
protein alkylation GO:0008213 43 0.028
cellular response to dna damage stimulus GO:0006974 223 0.028
regulation of actin polymerization or depolymerization GO:0008064 27 0.027
defense response GO:0006952 300 0.027
male gamete generation GO:0048232 201 0.027
gonad development GO:0008406 50 0.027
histolysis GO:0007559 102 0.027
regulation of nurse cell apoptotic process GO:0045477 9 0.027
ovarian follicle cell migration GO:0007297 121 0.027
establishment of protein localization GO:0045184 163 0.027
actomyosin structure organization GO:0031032 56 0.027
heterocycle catabolic process GO:0046700 166 0.027
positive regulation of nucleic acid templated transcription GO:1903508 266 0.027
organonitrogen compound biosynthetic process GO:1901566 117 0.026
nucleoside catabolic process GO:0009164 112 0.026
imaginal disc derived appendage development GO:0048737 399 0.026
positive regulation of phosphate metabolic process GO:0045937 139 0.026
Fly
leg disc development GO:0035218 92 0.026
regulation of cell morphogenesis GO:0022604 163 0.026
nucleus organization GO:0006997 45 0.026
positive regulation of purine nucleotide metabolic process GO:1900544 55 0.026
single organism intracellular transport GO:1902582 207 0.026
Human
cortical cytoskeleton organization GO:0030865 29 0.026
regulation of cell shape GO:0008360 113 0.025
regulation of actin filament length GO:0030832 27 0.025
mitotic cell cycle checkpoint GO:0007093 88 0.025
regulation of cellular component size GO:0032535 98 0.025
carbohydrate derivative metabolic process GO:1901135 217 0.025
telencephalon development GO:0021537 2 0.025
oocyte microtubule cytoskeleton polarization GO:0008103 22 0.025
nucleotide metabolic process GO:0009117 161 0.024
regulation of programmed cell death GO:0043067 152 0.024
establishment of mitochondrion localization microtubule mediated GO:0034643 6 0.024
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.024
segmentation GO:0035282 207 0.024
actin polymerization or depolymerization GO:0008154 31 0.024
larval development GO:0002164 104 0.024
single organism cellular localization GO:1902580 180 0.024
negative regulation of g1 s transition of mitotic cell cycle GO:2000134 13 0.023
regulation of cellular ketone metabolic process GO:0010565 3 0.023
macromolecule methylation GO:0043414 45 0.023
regulation of protein deacetylation GO:0090311 2 0.023
negative regulation of cell cycle GO:0045786 116 0.023
outflow tract morphogenesis GO:0003151 4 0.023
gtp catabolic process GO:0006184 72 0.022
macromolecule catabolic process GO:0009057 161 0.022
nucleobase containing compound catabolic process GO:0034655 165 0.022
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.022
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 41 0.022
positive regulation of nucleoside metabolic process GO:0045979 47 0.022
positive regulation of synaptic growth at neuromuscular junction GO:0045887 26 0.022
cellular homeostasis GO:0019725 80 0.021
dna conformation change GO:0071103 105 0.021
regulation of mitotic cell cycle phase transition GO:1901990 130 0.021
negative regulation of cell cycle phase transition GO:1901988 103 0.021
cytokinetic cell separation GO:0000920 1 0.021
developmental programmed cell death GO:0010623 138 0.020
asymmetric protein localization GO:0008105 33 0.020
purine containing compound catabolic process GO:0072523 112 0.020
regulation of nucleoside metabolic process GO:0009118 50 0.020
digestive system development GO:0055123 149 0.020
multi organism behavior GO:0051705 175 0.020
response to organic cyclic compound GO:0014070 89 0.020
endoderm formation GO:0001706 3 0.020
histone lysine methylation GO:0034968 32 0.020
proteolysis GO:0006508 192 0.020
positive regulation of organ growth GO:0046622 12 0.020
regulation of nucleotide catabolic process GO:0030811 48 0.019
spermatogenesis GO:0007283 200 0.019
response to bacterium GO:0009617 198 0.019
cell fate determination involved in pattern specification GO:0060582 19 0.019
histone methylation GO:0016571 40 0.019
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.019
negative regulation of organelle organization GO:0010639 56 0.019
response to endoplasmic reticulum stress GO:0034976 28 0.019
male meiosis cytokinesis GO:0007112 26 0.019
defense response to gram negative bacterium GO:0050829 94 0.019
meiotic cell cycle GO:0051321 171 0.019
reproductive system development GO:0061458 74 0.019
positive regulation of cellular biosynthetic process GO:0031328 316 0.019
regulation of g protein coupled receptor protein signaling pathway GO:0008277 23 0.019
aromatic compound catabolic process GO:0019439 166 0.019
mitotic dna damage checkpoint GO:0044773 74 0.019
positive regulation of catabolic process GO:0009896 105 0.018
cell fate determination GO:0001709 91 0.018
camera type eye development GO:0043010 4 0.018
negative regulation of neural precursor cell proliferation GO:2000178 27 0.018
death GO:0016265 284 0.018
protein transport GO:0015031 155 0.018
response to alcohol GO:0097305 95 0.018
intrinsic apoptotic signaling pathway GO:0097193 16 0.018
cellular protein localization GO:0034613 160 0.018
regulation of cellular amino acid metabolic process GO:0006521 0 0.018
stem cell differentiation GO:0048863 117 0.018
carboxylic acid metabolic process GO:0019752 92 0.018
negative regulation of cell cycle g1 s phase transition GO:1902807 13 0.018
organophosphate metabolic process GO:0019637 195 0.018
dorsal ventral axis specification ovarian follicular epithelium GO:0008069 13 0.018
positive regulation of cell morphogenesis involved in differentiation GO:0010770 12 0.017
negative regulation of phosphorus metabolic process GO:0010563 45 0.017
purine ribonucleotide catabolic process GO:0009154 109 0.017
nucleoside phosphate catabolic process GO:1901292 110 0.017
mitotic g2 dna damage checkpoint GO:0007095 69 0.017
regulation of lipid metabolic process GO:0019216 15 0.017
nucleoside triphosphate metabolic process GO:0009141 120 0.017
oocyte anterior posterior axis specification GO:0007314 72 0.017
regulation of imaginal disc growth GO:0045570 26 0.017
regulation of transport GO:0051049 181 0.017
regulation of cellular localization GO:0060341 136 0.017
transmission of nerve impulse GO:0019226 12 0.017
regulation of chromosome segregation GO:0051983 32 0.017
glycerolipid metabolic process GO:0046486 34 0.017
rac protein signal transduction GO:0016601 3 0.017
regulation of cellular amine metabolic process GO:0033238 3 0.017
axis specification GO:0009798 167 0.017
organic substance transport GO:0071702 257 0.017
negative regulation of epithelial cell proliferation GO:0050680 4 0.016
regulation of phosphorylation GO:0042325 147 0.016
Fly
regulation of organ growth GO:0046620 42 0.016
negative regulation of gene expression epigenetic GO:0045814 77 0.016
dna repair GO:0006281 54 0.016
negative regulation of neuroblast proliferation GO:0007406 27 0.016
dorsal closure GO:0007391 79 0.016
digestive tract development GO:0048565 149 0.016
mitotic nuclear division GO:0007067 213 0.016
positive regulation of hydrolase activity GO:0051345 78 0.016
embryonic heart tube development GO:0035050 22 0.016
regulation of mitosis GO:0007088 56 0.016
cellular response to nutrient levels GO:0031669 62 0.015
positive regulation of gtpase activity GO:0043547 43 0.015
mesenchymal cell development GO:0014031 1 0.015
regulation of ras protein signal transduction GO:0046578 93 0.015
purine nucleoside triphosphate metabolic process GO:0009144 119 0.015
regulation of gene expression epigenetic GO:0040029 128 0.015
muscle structure development GO:0061061 224 0.015
regulation of gtpase activity GO:0043087 44 0.015
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.015
cellular amino acid metabolic process GO:0006520 61 0.015
gtp metabolic process GO:0046039 72 0.014
positive regulation of developmental growth GO:0048639 62 0.014
neuron maturation GO:0042551 31 0.014
response to oxygen containing compound GO:1901700 200 0.014
lamellipodium assembly GO:0030032 21 0.014
posttranscriptional regulation of gene expression GO:0010608 145 0.014
regulation of erbb signaling pathway GO:1901184 42 0.014
negative regulation of signaling GO:0023057 219 0.014
regulation of transcription elongation from rna polymerase ii promoter GO:0034243 15 0.014
glycosyl compound metabolic process GO:1901657 127 0.014
head development GO:0060322 135 0.014
positive regulation of notch signaling pathway GO:0045747 34 0.014
muscle cell differentiation GO:0042692 103 0.014
guanosine containing compound metabolic process GO:1901068 74 0.014
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070059 4 0.014
peripheral nervous system development GO:0007422 52 0.014
regulation of vesicle mediated transport GO:0060627 59 0.014
nucleus localization GO:0051647 34 0.014
morphogenesis of a branching structure GO:0001763 45 0.014
response to other organism GO:0051707 293 0.014
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 11 0.014
fatty acid homeostasis GO:0055089 2 0.014
regulation of neuron apoptotic process GO:0043523 16 0.014
actin filament polymerization GO:0030041 27 0.014
endosomal transport GO:0016197 44 0.014
Human
response to radiation GO:0009314 155 0.014
purine ribonucleoside metabolic process GO:0046128 127 0.014
establishment or maintenance of polarity of follicular epithelium GO:0016334 26 0.014
intracellular protein transport GO:0006886 104 0.014
regulation of dna metabolic process GO:0051052 34 0.013
adherens junction organization GO:0034332 27 0.013
nucleoside triphosphate catabolic process GO:0009143 108 0.013
cytoplasmic transport GO:0016482 130 0.013
Human
regulation of cellular response to hypoxia GO:1900037 3 0.013
regulation of notch signaling pathway GO:0008593 100 0.013
embryonic morphogenesis GO:0048598 206 0.013
peptide biosynthetic process GO:0043043 42 0.013
oocyte axis specification GO:0007309 108 0.013
mitotic dna integrity checkpoint GO:0044774 75 0.013
positive regulation of stem cell proliferation GO:2000648 8 0.013
Fly
chromatin modification GO:0016568 147 0.013
regulation of cell projection organization GO:0031344 92 0.013
dna replication GO:0006260 48 0.013
cytokinetic process GO:0032506 27 0.013
single organism behavior GO:0044708 391 0.013
oocyte construction GO:0007308 112 0.013
regulation of ras gtpase activity GO:0032318 38 0.013

Eps-15 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.073
nervous system disease DOID:863 0 0.059
neurodegenerative disease DOID:1289 0 0.059
central nervous system disease DOID:331 0 0.059
motor neuron disease DOID:231 0 0.059
charcot marie tooth disease DOID:10595 0 0.048
neuropathy DOID:870 0 0.048
neuromuscular disease DOID:440 0 0.048
disease of cellular proliferation DOID:14566 0 0.035
cancer DOID:162 0 0.033
organ system cancer DOID:0050686 0 0.025
musculoskeletal system cancer DOID:0060100 0 0.013
connective tissue cancer DOID:201 0 0.013
amyotrophic lateral sclerosis DOID:332 0 0.013