Drosophila melanogaster

227 known processes

skpA (Dmel_CG16983)

CG16983 gene product from transcript CG16983-RD

(Aliases: CG16983,l(1)G0037,Skp,dSkp-1,Skp1,l(1)G0058,l(1)G0109,Dmel\CG16983,dskpA,dSkpA,l(1)G0389,anon-WO03040301.238,SkpA,anon-WO03040301.236,anon-WO03040301.234,EG:115C2.4,spkA)

skpA biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
negative regulation of cell cycle GO:0045786 116 0.995
cellular response to dna damage stimulus GO:0006974 223 0.991
protein modification by small protein conjugation or removal GO:0070647 106 0.989
Human
synapse organization GO:0050808 196 0.982
negative regulation of neuroblast proliferation GO:0007406 27 0.973
dna integrity checkpoint GO:0031570 81 0.967
regulation of cell cycle phase transition GO:1901987 130 0.967
protein ubiquitination GO:0016567 70 0.963
Human
organelle fission GO:0048285 340 0.956
dna replication GO:0006260 48 0.946
negative regulation of cell cycle phase transition GO:1901988 103 0.943
developmental maturation GO:0021700 172 0.931
vesicle mediated transport GO:0016192 381 0.929
Worm
mitotic g2 dna damage checkpoint GO:0007095 69 0.913
regulation of cellular component biogenesis GO:0044087 201 0.907
meiotic cell cycle GO:0051321 171 0.903
Worm
apoptotic process GO:0006915 159 0.886
single organism intracellular transport GO:1902582 207 0.883
cell cycle phase transition GO:0044770 140 0.882
cell maturation GO:0048469 144 0.871
negative regulation of synaptic growth at neuromuscular junction GO:0045886 39 0.861
mitotic cell cycle phase transition GO:0044772 138 0.861
mitotic cell cycle checkpoint GO:0007093 88 0.855
regulation of phosphate metabolic process GO:0019220 210 0.854
regulation of protein stability GO:0031647 43 0.839
regulation of response to stress GO:0080134 200 0.839
negative regulation of neural precursor cell proliferation GO:2000178 27 0.837
negative regulation of nervous system development GO:0051961 92 0.828
dna conformation change GO:0071103 105 0.800
dna packaging GO:0006323 91 0.784
negative regulation of cell cycle process GO:0010948 109 0.778
jnk cascade GO:0007254 50 0.774
death GO:0016265 284 0.769
intracellular transport GO:0046907 228 0.752
axonogenesis GO:0007409 290 0.750
cellular protein modification process GO:0006464 438 0.741
Human
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.740
protein catabolic process GO:0030163 101 0.739
Human
regulation of mitotic cell cycle phase transition GO:1901990 130 0.729
mitotic dna integrity checkpoint GO:0044774 75 0.721
neuron remodeling GO:0016322 29 0.719
dna damage checkpoint GO:0000077 78 0.702
regulation of cell cycle process GO:0010564 181 0.697
negative regulation of response to stimulus GO:0048585 258 0.688
modification dependent protein catabolic process GO:0019941 78 0.685
Human
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.675
Human
stress activated mapk cascade GO:0051403 52 0.663
chromosome organization GO:0051276 360 0.658
regulation of cytoskeleton organization GO:0051493 89 0.653
regulation of cellular response to stress GO:0080135 89 0.652
negative regulation of mitotic cell cycle GO:0045930 109 0.616
programmed cell death GO:0012501 257 0.567
developmental growth GO:0048589 280 0.553
cell death GO:0008219 279 0.535
positive regulation of cellular biosynthetic process GO:0031328 316 0.508
negative regulation of developmental process GO:0051093 201 0.488
response to organonitrogen compound GO:0010243 75 0.486
stress activated protein kinase signaling cascade GO:0031098 55 0.477
synaptic growth at neuromuscular junction GO:0051124 119 0.472
cellular protein catabolic process GO:0044257 83 0.469
Human
neuromuscular junction development GO:0007528 149 0.468
regulation of synaptic growth at neuromuscular junction GO:0008582 89 0.456
cellular response to endogenous stimulus GO:0071495 80 0.441
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.434
growth GO:0040007 359 0.433
endocytosis GO:0006897 310 0.422
Worm
regulation of cellular protein metabolic process GO:0032268 243 0.411
response to endogenous stimulus GO:0009719 119 0.409
cellular macromolecule catabolic process GO:0044265 136 0.401
Human
regulation of synapse assembly GO:0051963 94 0.399
regulation of stress activated protein kinase signaling cascade GO:0070302 42 0.398
regulation of jnk cascade GO:0046328 40 0.396
meiotic nuclear division GO:0007126 151 0.393
Worm
regulation of cell death GO:0010941 173 0.386
positive regulation of response to stimulus GO:0048584 323 0.373
negative regulation of multicellular organismal process GO:0051241 142 0.372
cellular response to chemical stimulus GO:0070887 199 0.370
dna repair GO:0006281 54 0.364
regionalization GO:0003002 416 0.353
negative regulation of programmed cell death GO:0043069 72 0.343
posttranscriptional regulation of gene expression GO:0010608 145 0.338
chromatin assembly or disassembly GO:0006333 52 0.335
defense response to gram negative bacterium GO:0050829 94 0.326
Worm
regulation of protein modification process GO:0031399 112 0.318
protein modification by small protein conjugation GO:0032446 79 0.313
Human
regulation of developmental growth GO:0048638 174 0.307
neuron maturation GO:0042551 31 0.298
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.290
Human
centrosome duplication GO:0051298 121 0.284
segmentation GO:0035282 207 0.282
mitotic dna damage checkpoint GO:0044773 74 0.276
negative regulation of signal transduction GO:0009968 206 0.270
modification dependent macromolecule catabolic process GO:0043632 79 0.262
Human
negative regulation of stem cell proliferation GO:2000647 30 0.257
response to external biotic stimulus GO:0043207 293 0.251
Worm
response to other organism GO:0051707 293 0.248
Worm
regulation of innate immune response GO:0045088 71 0.240
regulation of programmed cell death GO:0043067 152 0.239
regulation of mapk cascade GO:0043408 92 0.239
response to bacterium GO:0009617 198 0.231
Worm
regulation of stem cell proliferation GO:0072091 40 0.225
regulation of synapse organization GO:0050807 110 0.224
ubiquitin dependent protein catabolic process GO:0006511 78 0.223
Human
negative regulation of synapse assembly GO:0051964 39 0.220
phagocytosis GO:0006909 215 0.220
columnar cuboidal epithelial cell development GO:0002066 249 0.219
axon guidance GO:0007411 233 0.206
macromolecular complex assembly GO:0065003 256 0.203
negative regulation of stress activated protein kinase signaling cascade GO:0070303 20 0.198
embryonic pattern specification GO:0009880 174 0.197
regulation of mitotic cell cycle GO:0007346 190 0.191
positive regulation of macromolecule metabolic process GO:0010604 405 0.186
cytoplasmic transport GO:0016482 130 0.182
protein localization to plasma membrane GO:0072659 13 0.180
protein modification process GO:0036211 438 0.178
Human
axis specification GO:0009798 167 0.168
response to biotic stimulus GO:0009607 294 0.166
Worm
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.161
macromolecule catabolic process GO:0009057 161 0.156
Human
larval development GO:0002164 104 0.152
Worm
regulation of protein modification by small protein conjugation or removal GO:1903320 25 0.152
cellular response to insulin stimulus GO:0032869 28 0.151
organic substance catabolic process GO:1901575 308 0.150
Human
transcription from rna polymerase ii promoter GO:0006366 368 0.149
negative regulation of phosphorus metabolic process GO:0010563 45 0.149
negative regulation of cell death GO:0060548 81 0.137
tissue migration GO:0090130 155 0.136
nuclear division GO:0000280 332 0.130
establishment of localization in cell GO:0051649 402 0.127
Worm
regulation of cysteine type endopeptidase activity GO:2000116 27 0.124
spermatogenesis GO:0007283 200 0.117
synapse assembly GO:0007416 143 0.116
negative regulation of apoptotic process GO:0043066 63 0.113
regulation of phosphorus metabolic process GO:0051174 210 0.111
response to nitrogen compound GO:1901698 90 0.110
cellular response to organic substance GO:0071310 132 0.109
regulation of cell cycle GO:0051726 291 0.108
histone h4 k20 methylation GO:0034770 4 0.107
response to organic substance GO:0010033 284 0.106
axon development GO:0061564 297 0.106
male gamete generation GO:0048232 201 0.106
mitochondrion organization GO:0007005 65 0.106
spindle organization GO:0007051 253 0.104
negative regulation of cell communication GO:0010648 223 0.103
histone modification GO:0016570 106 0.102
Human
muscle structure development GO:0061061 224 0.099
negative regulation of cellular metabolic process GO:0031324 382 0.099
positive regulation of signal transduction GO:0009967 223 0.097
protein acylation GO:0043543 42 0.096
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.095
salivary gland morphogenesis GO:0007435 145 0.090
regulation of multicellular organismal development GO:2000026 414 0.088
insulin receptor signaling pathway GO:0008286 25 0.088
ncrna metabolic process GO:0034660 43 0.087
cellular amine metabolic process GO:0044106 12 0.086
gland morphogenesis GO:0022612 145 0.085
positive regulation of rna metabolic process GO:0051254 271 0.084
regulation of neuroblast proliferation GO:1902692 34 0.082
nuclear transport GO:0051169 72 0.082
signal transduction by phosphorylation GO:0023014 107 0.081
intracellular signal transduction GO:0035556 300 0.081
regulation of apoptotic process GO:0042981 130 0.081
tissue death GO:0016271 102 0.079
regulation of stress activated mapk cascade GO:0032872 41 0.078
regulation of catalytic activity GO:0050790 185 0.077
nucleocytoplasmic transport GO:0006913 72 0.076
scf dependent proteasomal ubiquitin dependent protein catabolic process GO:0031146 1 0.076
Human
positive regulation of cellular protein metabolic process GO:0032270 118 0.076
positive regulation of biosynthetic process GO:0009891 316 0.076
negative regulation of phosphate metabolic process GO:0045936 45 0.076
cellular protein localization GO:0034613 160 0.074
regulation of defense response GO:0031347 102 0.074
cell cycle dna replication GO:0044786 23 0.073
cellular macromolecular complex assembly GO:0034622 153 0.071
dna metabolic process GO:0006259 227 0.071
maintenance of location GO:0051235 73 0.070
salivary gland cell autophagic cell death GO:0035071 83 0.069
cellular macromolecule localization GO:0070727 220 0.067
regulation of notch signaling pathway GO:0008593 100 0.067
response to peptide GO:1901652 29 0.067
anterior posterior pattern specification GO:0009952 136 0.066
cell division GO:0051301 248 0.065
positive regulation of immune response GO:0050778 63 0.064
circulatory system development GO:0072359 82 0.064
organophosphate metabolic process GO:0019637 195 0.064
positive regulation of cell cycle GO:0045787 43 0.061
neuron projection guidance GO:0097485 241 0.061
developmental programmed cell death GO:0010623 138 0.060
catabolic process GO:0009056 409 0.059
Human
exocrine system development GO:0035272 162 0.058
response to oxygen containing compound GO:1901700 200 0.057
dna endoreduplication GO:0042023 22 0.056
regulation of transferase activity GO:0051338 58 0.055
cellular amide metabolic process GO:0043603 80 0.054
mitotic g2 m transition checkpoint GO:0044818 70 0.054
negative regulation of signaling GO:0023057 219 0.053
cell cycle checkpoint GO:0000075 95 0.053
negative regulation of developmental growth GO:0048640 64 0.053
taxis GO:0042330 304 0.053
regulation of nervous system development GO:0051960 248 0.051
defense response to bacterium GO:0042742 178 0.051
Worm
cellular response to peptide GO:1901653 28 0.051
cytokinesis GO:0000910 90 0.050
transmembrane transport GO:0055085 139 0.049
mitotic nuclear division GO:0007067 213 0.047
regulation of wnt signaling pathway GO:0030111 68 0.047
regulation of production of molecular mediator of immune response GO:0002700 44 0.046
trna modification GO:0006400 2 0.046
regulation of cellular localization GO:0060341 136 0.044
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.044
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 19 0.043
salivary gland development GO:0007431 162 0.042
wnt signaling pathway GO:0016055 98 0.042
proteasomal protein catabolic process GO:0010498 59 0.042
Human
enzyme linked receptor protein signaling pathway GO:0007167 179 0.042
cell motility GO:0048870 251 0.039
Worm
positive regulation of defense response GO:0031349 59 0.039
covalent chromatin modification GO:0016569 106 0.038
Human
body morphogenesis GO:0010171 2 0.038
regulation of proteolysis GO:0030162 87 0.038
immune response GO:0006955 246 0.038
Worm
rna processing GO:0006396 147 0.036
negative regulation of phosphorylation GO:0042326 35 0.035
cell migration GO:0016477 238 0.035
Worm
stem cell differentiation GO:0048863 117 0.035
embryo development ending in birth or egg hatching GO:0009792 152 0.034
Worm
regulation of growth GO:0040008 233 0.034
negative regulation of cellular component organization GO:0051129 108 0.033
appendage development GO:0048736 401 0.033
regulation of cell proliferation GO:0042127 163 0.033
Worm
receptor mediated endocytosis GO:0006898 21 0.033
Worm
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 24 0.033
protein maturation GO:0051604 71 0.033
mapk cascade GO:0000165 107 0.032
development of primary sexual characteristics GO:0045137 50 0.032
Worm
sensory organ precursor cell division GO:0045035 10 0.031
aging GO:0007568 143 0.031
Worm
lipid localization GO:0010876 54 0.031
negative regulation of neurogenesis GO:0050768 53 0.031
positive regulation of cell communication GO:0010647 250 0.031
ovarian follicle cell development GO:0030707 248 0.030
positive regulation of protein metabolic process GO:0051247 128 0.029
regulation of protein ubiquitination GO:0031396 22 0.029
epithelial cell differentiation GO:0030855 322 0.029
establishment of oocyte nucleus localization involved in oocyte dorsal ventral axis specification GO:0030722 6 0.029
regulation of microtubule based process GO:0032886 49 0.029
regulation of synapse structure and activity GO:0050803 128 0.029
regulation of molecular function GO:0065009 217 0.028
pigment metabolic process GO:0042440 84 0.028
protein processing GO:0016485 68 0.028
positive regulation of proteasomal protein catabolic process GO:1901800 20 0.028
centrosome cycle GO:0007098 137 0.028
negative regulation of proteolysis GO:0045861 31 0.027
organic substance transport GO:0071702 257 0.027
ribosomal large subunit biogenesis GO:0042273 1 0.027
positive regulation of rna biosynthetic process GO:1902680 266 0.026
autophagic cell death GO:0048102 83 0.026
dorsal ventral pattern formation GO:0009953 133 0.026
negative regulation of defense response GO:0031348 35 0.025
regulation of response to external stimulus GO:0032101 115 0.025
chromosome segregation GO:0007059 157 0.025
Worm
neural precursor cell proliferation GO:0061351 75 0.025
dendrite development GO:0016358 204 0.025
regulation of organelle organization GO:0033043 196 0.024
positive regulation of multi organism process GO:0043902 40 0.024
regulation of nucleocytoplasmic transport GO:0046822 35 0.024
protein localization to membrane GO:0072657 19 0.024
regulation of gene silencing GO:0060968 63 0.023
positive regulation of phosphorus metabolic process GO:0010562 139 0.023
phosphorylation GO:0016310 294 0.023
chromatin modification GO:0016568 147 0.023
Human
cellular response to hormone stimulus GO:0032870 44 0.023
negative regulation of protein processing GO:0010955 31 0.022
positive regulation of phosphate metabolic process GO:0045937 139 0.022
regulation of multi organism process GO:0043900 131 0.022
positive regulation of nucleic acid templated transcription GO:1903508 266 0.022
mitotic spindle organization GO:0007052 220 0.022
blastoderm segmentation GO:0007350 159 0.022
membrane organization GO:0061024 112 0.022
regulation of neural precursor cell proliferation GO:2000177 35 0.021
autophagic vacuole assembly GO:0000045 2 0.021
telomere capping GO:0016233 11 0.021
metal ion transport GO:0030001 74 0.020
positive regulation of signaling GO:0023056 243 0.020
regulation of cellular amine metabolic process GO:0033238 3 0.020
regulation of hemocyte proliferation GO:0035206 37 0.020
positive regulation of response to external stimulus GO:0032103 44 0.020
imaginal disc fusion GO:0046528 19 0.019
positive regulation of heterochromatin assembly GO:0031453 5 0.019
regulation of protein catabolic process GO:0042176 55 0.019
positive regulation of cell size GO:0045793 21 0.019
positive regulation of wnt signaling pathway GO:0030177 25 0.019
skeletal muscle tissue development GO:0007519 13 0.019
ribosome biogenesis GO:0042254 8 0.019
pigmentation GO:0043473 75 0.018
positive regulation of gene expression GO:0010628 290 0.018
epithelial cell proliferation GO:0050673 15 0.018
oocyte differentiation GO:0009994 145 0.018
positive regulation of protein modification process GO:0031401 58 0.018
negative regulation of protein maturation GO:1903318 31 0.018
positive regulation of transcription dna templated GO:0045893 266 0.018
cell proliferation GO:0008283 299 0.017
Worm
tripartite regional subdivision GO:0007351 103 0.017
female meiotic division GO:0007143 70 0.017
dorsal ventral axis specification GO:0009950 66 0.017
protein phosphorylation GO:0006468 169 0.017
regulation of anatomical structure size GO:0090066 163 0.017
response to radiation GO:0009314 155 0.016
appendage morphogenesis GO:0035107 397 0.016
cellular response to nitrogen compound GO:1901699 51 0.016
regulation of heterochromatin assembly GO:0031445 8 0.016
chromatin organization GO:0006325 207 0.016
Human
oocyte development GO:0048599 124 0.016
immune effector process GO:0002252 98 0.016
cellular response to abiotic stimulus GO:0071214 58 0.016
regulation of intracellular signal transduction GO:1902531 236 0.015
regulation of peptidase activity GO:0052547 39 0.015
single organism behavior GO:0044708 391 0.015
nitric oxide metabolic process GO:0046209 1 0.015
single organism cellular localization GO:1902580 180 0.015
Worm
establishment of protein localization GO:0045184 163 0.015
positive regulation of immune system process GO:0002684 68 0.015
cellular ion homeostasis GO:0006873 39 0.015
positive regulation of intracellular signal transduction GO:1902533 116 0.015
histolysis GO:0007559 102 0.015
regulation of chromatin assembly GO:0010847 9 0.014
gland development GO:0048732 191 0.014
multicellular organismal aging GO:0010259 140 0.014
Worm
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 44 0.014
regulation of immune response GO:0050776 118 0.014
negative regulation of growth GO:0045926 84 0.014
limb development GO:0060173 1 0.014
regulation of cellular ketone metabolic process GO:0010565 3 0.014
instar larval development GO:0002168 55 0.014
negative regulation of peptidase activity GO:0010466 11 0.013
positive regulation of cellular protein catabolic process GO:1903364 24 0.013
ncrna processing GO:0034470 30 0.013
regulation of cytoplasmic transport GO:1903649 47 0.013
melanin metabolic process GO:0006582 47 0.013
notch signaling pathway GO:0007219 120 0.013
regulation of intracellular transport GO:0032386 64 0.013
regulation of catabolic process GO:0009894 170 0.013
regulation of cellular component size GO:0032535 98 0.013
eye development GO:0001654 323 0.013
positive regulation of ribosome biogenesis GO:0090070 3 0.013
negative regulation of protein metabolic process GO:0051248 85 0.013
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 1 0.013
meiotic cytokinesis GO:0033206 33 0.013
nitrogen compound transport GO:0071705 85 0.013
negative regulation of insulin receptor signaling pathway GO:0046627 11 0.013
response to insulin GO:0032868 29 0.013
positive regulation of protein catabolic process GO:0045732 34 0.013
homeostatic process GO:0042592 199 0.013
negative regulation of innate immune response GO:0045824 30 0.013
embryonic axis specification GO:0000578 107 0.013
gonad development GO:0008406 50 0.013
Worm
cell volume homeostasis GO:0006884 1 0.013
negative regulation of molecular function GO:0044092 51 0.012
salivary gland histolysis GO:0035070 88 0.012
response to fungus GO:0009620 50 0.012
regulation of transport GO:0051049 181 0.012
ameboidal type cell migration GO:0001667 151 0.012
divalent inorganic cation transport GO:0072511 30 0.012
synaptic transmission GO:0007268 288 0.011
cellular catabolic process GO:0044248 372 0.011
Human
maintenance of location in cell GO:0051651 28 0.011
lipid metabolic process GO:0006629 121 0.011
regulation of canonical wnt signaling pathway GO:0060828 15 0.011
rna localization GO:0006403 115 0.011
nucleoside phosphate metabolic process GO:0006753 162 0.011
detection of stimulus GO:0051606 156 0.011
regulation of dna metabolic process GO:0051052 34 0.011
epithelial cell migration GO:0010631 148 0.011
regulation of rac protein signal transduction GO:0035020 3 0.011
cell aging GO:0007569 2 0.011
heart development GO:0007507 82 0.011
neuromuscular synaptic transmission GO:0007274 67 0.010
translation GO:0006412 69 0.010
regulation of protein processing GO:0070613 32 0.010

skpA disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.012
nervous system disease DOID:863 0 0.012