Drosophila melanogaster

160 known processes

mad2 (Dmel_CG17498)

CG17498 gene product from transcript CG17498-RA

(Aliases: Mad2,Dmel\CG17498,MAD2,CG17498)

mad2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
negative regulation of cellular metabolic process GO:0031324 382 0.733
meiotic cell cycle process GO:1903046 132 0.634
negative regulation of cell cycle process GO:0010948 109 0.480
organelle fission GO:0048285 340 0.479
mitotic cell cycle phase transition GO:0044772 138 0.451
meiotic nuclear division GO:0007126 151 0.449
meiotic cell cycle GO:0051321 171 0.355
regulation of cell cycle phase transition GO:1901987 130 0.350
cellular response to dna damage stimulus GO:0006974 223 0.344
regulation of mitotic cell cycle GO:0007346 190 0.314
cell cycle phase transition GO:0044770 140 0.312
regulation of mitotic cell cycle phase transition GO:1901990 130 0.270
meiosis i GO:0007127 59 0.258
negative regulation of mitotic cell cycle GO:0045930 109 0.257
negative regulation of gene expression GO:0010629 387 0.237
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.230
negative regulation of chromosome segregation GO:0051985 14 0.215
regulation of cell differentiation GO:0045595 302 0.206
regulation of cellular protein metabolic process GO:0032268 243 0.175
dna metabolic process GO:0006259 227 0.172
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.172
mitotic sister chromatid separation GO:0051306 30 0.160
dna repair GO:0006281 54 0.142
cell division GO:0051301 248 0.132
negative regulation of cell cycle phase transition GO:1901988 103 0.117
regulation of nervous system development GO:0051960 248 0.116
stem cell division GO:0017145 69 0.109
regulation of multicellular organismal development GO:2000026 414 0.104
mitotic cell cycle checkpoint GO:0007093 88 0.100
innate immune response GO:0045087 144 0.090
negative regulation of cell cycle GO:0045786 116 0.081
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.080
organelle assembly GO:0070925 198 0.079
chromosome segregation GO:0007059 157 0.077
mitotic spindle organization GO:0007052 220 0.076
catabolic process GO:0009056 409 0.074
microtubule cytoskeleton organization involved in mitosis GO:1902850 52 0.073
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.067
neuronal stem cell division GO:0036445 35 0.066
cell proliferation GO:0008283 299 0.065
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.065
negative regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032435 16 0.065
cellular protein localization GO:0034613 160 0.064
regulation of phosphate metabolic process GO:0019220 210 0.063
asymmetric neuroblast division GO:0055059 33 0.063
dna conformation change GO:0071103 105 0.063
ribonucleoside triphosphate metabolic process GO:0009199 119 0.062
mitotic dna integrity checkpoint GO:0044774 75 0.062
regulation of mitosis GO:0007088 56 0.061
mrna processing GO:0006397 104 0.060
spindle organization GO:0007051 253 0.058
regulation of cell cycle process GO:0010564 181 0.058
neural precursor cell proliferation GO:0061351 75 0.058
negative regulation of chromosome organization GO:2001251 19 0.057
cytoplasmic transport GO:0016482 130 0.055
spindle assembly involved in mitosis GO:0090307 50 0.055
negative regulation of cellular biosynthetic process GO:0031327 277 0.054
asymmetric stem cell division GO:0098722 49 0.050
establishment or maintenance of cell polarity GO:0007163 167 0.050
proteasomal protein catabolic process GO:0010498 59 0.050
protein localization GO:0008104 284 0.050
spindle checkpoint GO:0031577 11 0.050
ubiquitin dependent protein catabolic process GO:0006511 78 0.047
regulation of cell cycle GO:0051726 291 0.047
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.047
cell cycle g1 s phase transition GO:0044843 31 0.046
positive regulation of macromolecule metabolic process GO:0010604 405 0.046
nuclear transport GO:0051169 72 0.045
cellular macromolecule localization GO:0070727 220 0.044
single organism intracellular transport GO:1902582 207 0.044
olfactory behavior GO:0042048 97 0.044
cellular nitrogen compound catabolic process GO:0044270 165 0.044
organic substance catabolic process GO:1901575 308 0.044
metaphase anaphase transition of cell cycle GO:0044784 28 0.044
negative regulation of mitotic sister chromatid separation GO:2000816 13 0.043
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.042
asymmetric protein localization GO:0008105 33 0.041
dna recombination GO:0006310 32 0.041
mitotic cytokinesis GO:0000281 50 0.041
regulation of cell development GO:0060284 215 0.041
negative regulation of rna metabolic process GO:0051253 251 0.040
body morphogenesis GO:0010171 2 0.039
organic substance transport GO:0071702 257 0.038
spermatogenesis GO:0007283 200 0.038
regulation of organelle organization GO:0033043 196 0.037
ribonucleoside metabolic process GO:0009119 127 0.036
negative regulation of nucleic acid templated transcription GO:1903507 240 0.036
cellular catabolic process GO:0044248 372 0.035
stem cell proliferation GO:0072089 88 0.035
regulation of cell division GO:0051302 72 0.034
purine ribonucleoside metabolic process GO:0046128 127 0.034
appendage morphogenesis GO:0035107 397 0.034
ribonucleotide catabolic process GO:0009261 109 0.034
ribonucleoside catabolic process GO:0042454 112 0.034
regulation of gene silencing GO:0060968 63 0.034
intracellular signal transduction GO:0035556 300 0.034
regulation of phosphorus metabolic process GO:0051174 210 0.033
mitotic g2 dna damage checkpoint GO:0007095 69 0.032
protein processing GO:0016485 68 0.032
regulation of microtubule cytoskeleton organization GO:0070507 41 0.032
negative regulation of biosynthetic process GO:0009890 277 0.031
organelle localization GO:0051640 148 0.031
mitotic g2 m transition checkpoint GO:0044818 70 0.031
organonitrogen compound metabolic process GO:1901564 318 0.031
positive regulation of mitotic cell cycle GO:0045931 34 0.031
regulation of cell death GO:0010941 173 0.031
g1 s transition of mitotic cell cycle GO:0000082 31 0.031
intracellular protein transport GO:0006886 104 0.029
response to organic substance GO:0010033 284 0.029
ribonucleoside triphosphate catabolic process GO:0009203 108 0.029
positive regulation of nucleic acid templated transcription GO:1903508 266 0.028
centrosome cycle GO:0007098 137 0.028
response to external biotic stimulus GO:0043207 293 0.028
protein complex assembly GO:0006461 200 0.028
regulation of triglyceride catabolic process GO:0010896 1 0.027
regulation of proteasomal protein catabolic process GO:0061136 39 0.027
developmental growth GO:0048589 280 0.027
organophosphate metabolic process GO:0019637 195 0.027
neuroblast division GO:0055057 35 0.026
protein transport GO:0015031 155 0.026
post embryonic appendage morphogenesis GO:0035120 385 0.026
regulation of metaphase anaphase transition of cell cycle GO:1902099 26 0.026
negative regulation of sister chromatid segregation GO:0033046 13 0.025
mitotic spindle elongation GO:0000022 81 0.025
dna damage checkpoint GO:0000077 78 0.025
cytoskeleton dependent cytokinesis GO:0061640 81 0.025
positive regulation of cell cycle GO:0045787 43 0.024
purine nucleoside triphosphate catabolic process GO:0009146 108 0.024
negative regulation of stem cell proliferation GO:2000647 30 0.024
gtp metabolic process GO:0046039 72 0.024
cytokinesis GO:0000910 90 0.024
phagocytosis GO:0006909 215 0.024
regulation of cellular protein catabolic process GO:1903362 44 0.023
cell cycle checkpoint GO:0000075 95 0.023
purine nucleotide metabolic process GO:0006163 146 0.023
imaginal disc derived appendage development GO:0048737 399 0.023
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.023
centrosome organization GO:0051297 163 0.023
locomotory behavior GO:0007626 176 0.022
posttranscriptional regulation of gene expression GO:0010608 145 0.022
nuclear migration GO:0007097 20 0.022
purine containing compound metabolic process GO:0072521 155 0.022
leg disc development GO:0035218 92 0.022
mitotic dna damage checkpoint GO:0044773 74 0.022
regulation of sister chromatid cohesion GO:0007063 2 0.022
small gtpase mediated signal transduction GO:0007264 88 0.022
regulation of protein metabolic process GO:0051246 256 0.021
appendage development GO:0048736 401 0.021
response to biotic stimulus GO:0009607 294 0.021
dna replication GO:0006260 48 0.021
nucleotide metabolic process GO:0009117 161 0.021
positive regulation of immune system process GO:0002684 68 0.021
nucleus organization GO:0006997 45 0.021
chromosome condensation GO:0030261 41 0.021
regulation of catalytic activity GO:0050790 185 0.020
single organism behavior GO:0044708 391 0.020
positive regulation of cellular catabolic process GO:0031331 95 0.020
positive regulation of multicellular organismal process GO:0051240 143 0.020
negative regulation of rna biosynthetic process GO:1902679 240 0.020
regulation of protein processing GO:0070613 32 0.020
regulation of neuron differentiation GO:0045664 103 0.020
spindle assembly GO:0051225 80 0.020
regulation of cellular component biogenesis GO:0044087 201 0.020
meiotic chromosome segregation GO:0045132 59 0.019
nuclear body organization GO:0030575 6 0.019
regulation of chromosome organization GO:0033044 64 0.019
histone mrna 3 end processing GO:0006398 8 0.019
regulation of molecular function GO:0065009 217 0.019
negative regulation of cell division GO:0051782 17 0.019
ribonucleotide metabolic process GO:0009259 145 0.019
rna processing GO:0006396 147 0.019
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.018
negative regulation of response to stimulus GO:0048585 258 0.018
heterocycle catabolic process GO:0046700 166 0.018
regulation of neurogenesis GO:0050767 158 0.018
nucleoside phosphate metabolic process GO:0006753 162 0.018
purine nucleoside triphosphate metabolic process GO:0009144 119 0.018
regulation of cellular catabolic process GO:0031329 157 0.018
positive regulation of cell cycle process GO:0090068 28 0.018
female meiotic division GO:0007143 70 0.018
negative regulation of mitotic sister chromatid segregation GO:0033048 13 0.018
cellular protein catabolic process GO:0044257 83 0.018
mrna metabolic process GO:0016071 124 0.018
regulation of dna metabolic process GO:0051052 34 0.017
organophosphate catabolic process GO:0046434 112 0.017
purine ribonucleotide metabolic process GO:0009150 145 0.017
negative regulation of protein metabolic process GO:0051248 85 0.017
genitalia development GO:0048806 26 0.017
negative regulation of intracellular signal transduction GO:1902532 57 0.017
nucleoside phosphate catabolic process GO:1901292 110 0.017
negative regulation of cellular protein metabolic process GO:0032269 85 0.017
phosphorylation GO:0016310 294 0.017
negative regulation of cellular component organization GO:0051129 108 0.016
nucleoside triphosphate catabolic process GO:0009143 108 0.016
nucleoside triphosphate metabolic process GO:0009141 120 0.016
regulation of chromosome segregation GO:0051983 32 0.016
regulation of cell cycle g1 s phase transition GO:1902806 23 0.016
positive regulation of catalytic activity GO:0043085 118 0.016
proteolysis GO:0006508 192 0.016
nucleocytoplasmic transport GO:0006913 72 0.016
translation GO:0006412 69 0.016
germ line cyst formation GO:0048134 44 0.016
gene silencing GO:0016458 138 0.016
gonad development GO:0008406 50 0.016
positive regulation of biosynthetic process GO:0009891 316 0.015
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.015
cell cycle dna replication GO:0044786 23 0.015
response to abiotic stimulus GO:0009628 341 0.015
nucleobase containing small molecule metabolic process GO:0055086 174 0.015
asymmetric protein localization involved in cell fate determination GO:0045167 9 0.015
ion transport GO:0006811 145 0.015
regulation of nucleoside metabolic process GO:0009118 50 0.015
ras protein signal transduction GO:0007265 88 0.015
regulation of g1 s transition of mitotic cell cycle GO:2000045 23 0.015
mitotic nuclear division GO:0007067 213 0.015
negative regulation of cell communication GO:0010648 223 0.015
positive regulation of developmental process GO:0051094 143 0.015
positive regulation of cell development GO:0010720 61 0.015
mitotic spindle checkpoint GO:0071174 11 0.015
dna packaging GO:0006323 91 0.015
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 44 0.015
imaginal disc derived leg morphogenesis GO:0007480 80 0.015
nucleotide catabolic process GO:0009166 109 0.015
establishment of localization in cell GO:0051649 402 0.015
negative regulation of proteolysis GO:0045861 31 0.014
nuclear export GO:0051168 24 0.014
defense response to gram negative bacterium GO:0050829 94 0.014
single organism biosynthetic process GO:0044711 206 0.014
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.014
regulation of cytoskeleton organization GO:0051493 89 0.014
zymogen activation GO:0031638 20 0.014
regulation of protein catabolic process GO:0042176 55 0.014
modification dependent macromolecule catabolic process GO:0043632 79 0.014
eye photoreceptor cell differentiation GO:0001754 145 0.014
carbohydrate derivative catabolic process GO:1901136 118 0.013
regulation of microtubule based process GO:0032886 49 0.013
spindle assembly checkpoint GO:0071173 11 0.013
development of primary sexual characteristics GO:0045137 50 0.013
negative regulation of transcription dna templated GO:0045892 237 0.013
regulation of proteolysis GO:0030162 87 0.013
response to other organism GO:0051707 293 0.013
protein complex biogenesis GO:0070271 201 0.013
negative regulation of cell death GO:0060548 81 0.013
positive regulation of molecular function GO:0044093 136 0.013
regulation of catabolic process GO:0009894 170 0.013
positive regulation of phosphorus metabolic process GO:0010562 139 0.013
rna localization GO:0006403 115 0.013
response to copper ion GO:0046688 4 0.012
reproductive structure development GO:0048608 74 0.012
single organism catabolic process GO:0044712 228 0.012
positive regulation of mitotic cell cycle phase transition GO:1901992 20 0.012
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.012
response to uv GO:0009411 24 0.012
protein localization to organelle GO:0033365 82 0.012
purine ribonucleotide catabolic process GO:0009154 109 0.012
purine nucleoside catabolic process GO:0006152 112 0.012
nucleobase containing compound catabolic process GO:0034655 165 0.012
olfactory learning GO:0008355 56 0.012
nuclear dna replication GO:0033260 1 0.012
female germ line cyst formation GO:0048135 42 0.012
brain development GO:0007420 120 0.012
regulation of innate immune response GO:0045088 71 0.012
nucleoside catabolic process GO:0009164 112 0.012
negative regulation of proteasomal protein catabolic process GO:1901799 16 0.012
establishment of nucleus localization GO:0040023 26 0.011
regulation of sister chromatid segregation GO:0033045 28 0.011
establishment of protein localization GO:0045184 163 0.011
embryo development ending in birth or egg hatching GO:0009792 152 0.011
regulation of cell projection organization GO:0031344 92 0.011
establishment of organelle localization GO:0051656 122 0.011
positive regulation of neurogenesis GO:0050769 41 0.011
nuclear division GO:0000280 332 0.011
nucleoside metabolic process GO:0009116 127 0.011
chromatin assembly or disassembly GO:0006333 52 0.011
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process GO:0031145 30 0.011
atp dependent chromatin remodeling GO:0043044 22 0.011
ribose phosphate metabolic process GO:0019693 145 0.011
regulation of hemocyte proliferation GO:0035206 37 0.011
sister chromatid segregation GO:0000819 92 0.011
regulation of ras protein signal transduction GO:0046578 93 0.011
meiotic dna double strand break formation GO:0042138 1 0.011
positive regulation of cell differentiation GO:0045597 64 0.011
centrosome duplication GO:0051298 121 0.011
regulation of gene expression epigenetic GO:0040029 128 0.011
mitotic spindle assembly checkpoint GO:0007094 11 0.010
negative regulation of multicellular organismal process GO:0051241 142 0.010
mrna 3 end processing GO:0031124 28 0.010
defense response to bacterium GO:0042742 178 0.010
response to wounding GO:0009611 94 0.010

mad2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.024
cancer DOID:162 0 0.018
disease of cellular proliferation DOID:14566 0 0.018
nervous system disease DOID:863 0 0.011