Drosophila melanogaster

60 known processes

ASPP (Dmel_CG18375)

Ankyrin-repeat, SH3-domain, and Proline-rich-region containing Protein

(Aliases: dASPP,Dmel\CG18375,CG18375)

ASPP biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of multicellular organismal development GO:2000026 414 0.232
compound eye morphogenesis GO:0001745 249 0.217
photoreceptor cell differentiation GO:0046530 170 0.185
intracellular signal transduction GO:0035556 300 0.184
Human
ovarian follicle cell development GO:0030707 248 0.180
notch signaling pathway GO:0007219 120 0.174
positive regulation of response to stimulus GO:0048584 323 0.173
epithelial cell differentiation GO:0030855 322 0.138
eye development GO:0001654 323 0.133
sensory organ morphogenesis GO:0090596 260 0.131
regulation of nervous system development GO:0051960 248 0.127
regulation of apoptotic process GO:0042981 130 0.121
enzyme linked receptor protein signaling pathway GO:0007167 179 0.111
immune system process GO:0002376 347 0.108
negative regulation of developmental process GO:0051093 201 0.104
forebrain development GO:0030900 2 0.101
negative regulation of cell communication GO:0010648 223 0.099
open tracheal system development GO:0007424 204 0.097
growth GO:0040007 359 0.096
multi organism behavior GO:0051705 175 0.096
appendage development GO:0048736 401 0.094
negative regulation of response to stimulus GO:0048585 258 0.092
eye morphogenesis GO:0048592 260 0.092
regulation of gene expression epigenetic GO:0040029 128 0.091
store operated calcium entry GO:0002115 3 0.089
imaginal disc derived appendage development GO:0048737 399 0.085
compound eye development GO:0048749 307 0.084
tube morphogenesis GO:0035239 191 0.082
regulation of programmed cell death GO:0043067 152 0.081
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.078
organelle fission GO:0048285 340 0.074
protein modification by small protein conjugation GO:0032446 79 0.072
nuclear division GO:0000280 332 0.071
programmed cell death GO:0012501 257 0.068
Human
protein modification by small protein conjugation or removal GO:0070647 106 0.067
ommatidial rotation GO:0016318 20 0.067
negative regulation of multicellular organismal process GO:0051241 142 0.067
regulation of neurogenesis GO:0050767 158 0.067
cellular protein modification process GO:0006464 438 0.066
synapse organization GO:0050808 196 0.066
post embryonic appendage morphogenesis GO:0035120 385 0.065
negative regulation of signaling GO:0023057 219 0.065
columnar cuboidal epithelial cell development GO:0002066 249 0.064
apoptotic process GO:0006915 159 0.064
Human
lateral inhibition GO:0046331 206 0.064
positive regulation of signaling GO:0023056 243 0.064
regulation of catalytic activity GO:0050790 185 0.062
negative regulation of signal transduction GO:0009968 206 0.061
negative regulation of apoptotic process GO:0043066 63 0.060
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.059
wing disc morphogenesis GO:0007472 344 0.059
organonitrogen compound metabolic process GO:1901564 318 0.057
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.057
regulation of notch signaling pathway GO:0008593 100 0.057
establishment of planar polarity GO:0001736 87 0.056
negative regulation of programmed cell death GO:0043069 72 0.056
modification dependent macromolecule catabolic process GO:0043632 79 0.056
epithelial cell development GO:0002064 274 0.056
behavioral response to ethanol GO:0048149 49 0.054
single organism behavior GO:0044708 391 0.052
regulation of mitotic cell cycle GO:0007346 190 0.052
tissue morphogenesis GO:0048729 297 0.051
developmental growth GO:0048589 280 0.051
regulation of cell death GO:0010941 173 0.050
regulation of protein metabolic process GO:0051246 256 0.050
regulation of response to stress GO:0080134 200 0.050
neurological system process GO:0050877 358 0.049
mitotic nuclear division GO:0007067 213 0.048
protein ubiquitination GO:0016567 70 0.048
compound eye photoreceptor development GO:0042051 78 0.048
regulation of cell differentiation GO:0045595 302 0.046
imaginal disc derived wing morphogenesis GO:0007476 337 0.045
transcription from rna polymerase ii promoter GO:0006366 368 0.044
tube development GO:0035295 244 0.044
proteolysis GO:0006508 192 0.043
cell cell signaling involved in cell fate commitment GO:0045168 210 0.043
regulation of cellular amino acid metabolic process GO:0006521 0 0.042
imaginal disc derived appendage morphogenesis GO:0035114 395 0.041
cellular protein catabolic process GO:0044257 83 0.040
negative regulation of cellular component organization GO:0051129 108 0.039
negative regulation of cell death GO:0060548 81 0.039
negative regulation of cell differentiation GO:0045596 143 0.039
central nervous system development GO:0007417 201 0.039
Mouse
brain development GO:0007420 120 0.038
regulation of intracellular signal transduction GO:1902531 236 0.038
positive regulation of catalytic activity GO:0043085 118 0.038
positive regulation of signal transduction GO:0009967 223 0.037
negative regulation of developmental growth GO:0048640 64 0.037
regulation of localization GO:0032879 275 0.037
ubiquitin dependent protein catabolic process GO:0006511 78 0.037
defense response GO:0006952 300 0.036
cell motility GO:0048870 251 0.036
regulation of phosphate metabolic process GO:0019220 210 0.036
mapk cascade GO:0000165 107 0.035
protein modification process GO:0036211 438 0.035
purine containing compound metabolic process GO:0072521 155 0.035
axon development GO:0061564 297 0.035
negative regulation of nervous system development GO:0051961 92 0.035
negative regulation of gene expression GO:0010629 387 0.034
cytoplasmic transport GO:0016482 130 0.033
cell adhesion GO:0007155 136 0.033
olfactory behavior GO:0042048 97 0.033
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.033
epithelium migration GO:0090132 148 0.033
localization of cell GO:0051674 257 0.033
imaginal disc pattern formation GO:0007447 91 0.032
vesicle mediated transport GO:0016192 381 0.032
negative regulation of neurogenesis GO:0050768 53 0.032
telencephalon development GO:0021537 2 0.032
appendage morphogenesis GO:0035107 397 0.032
regulation of cellular ketone metabolic process GO:0010565 3 0.032
establishment or maintenance of cell polarity GO:0007163 167 0.031
cell fate determination GO:0001709 91 0.031
regulation of molecular function GO:0065009 217 0.031
regionalization GO:0003002 416 0.031
rna processing GO:0006396 147 0.030
single organism intracellular transport GO:1902582 207 0.030
cellular macromolecule catabolic process GO:0044265 136 0.030
innate immune response GO:0045087 144 0.030
modification dependent protein catabolic process GO:0019941 78 0.030
establishment of localization in cell GO:0051649 402 0.030
regulation of epithelial cell proliferation GO:0050678 4 0.030
posttranscriptional regulation of gene expression GO:0010608 145 0.029
biological adhesion GO:0022610 138 0.029
eggshell formation GO:0030703 105 0.029
regulation of cell development GO:0060284 215 0.029
eye photoreceptor cell development GO:0042462 81 0.029
chemotaxis GO:0006935 249 0.029
regulation of cellular component size GO:0032535 98 0.029
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.029
positive regulation of molecular function GO:0044093 136 0.028
positive regulation of cell death GO:0010942 69 0.028
endocytosis GO:0006897 310 0.028
regulation of growth GO:0040008 233 0.028
peptidyl amino acid modification GO:0018193 105 0.027
positive regulation of cell communication GO:0010647 250 0.027
regulation of glial cell differentiation GO:0045685 1 0.027
calcium ion transport GO:0006816 24 0.027
establishment of tissue polarity GO:0007164 87 0.026
nucleotide metabolic process GO:0009117 161 0.026
sensory perception GO:0007600 196 0.026
axonogenesis GO:0007409 290 0.026
eye photoreceptor cell differentiation GO:0001754 145 0.026
photoreceptor cell development GO:0042461 96 0.026
ras protein signal transduction GO:0007265 88 0.025
catabolic process GO:0009056 409 0.025
morphogenesis of a polarized epithelium GO:0001738 93 0.025
cellular component assembly involved in morphogenesis GO:0010927 151 0.025
actin cytoskeleton organization GO:0030036 206 0.025
carbohydrate derivative metabolic process GO:1901135 217 0.025
protein localization GO:0008104 284 0.025
positive regulation of cellular amine metabolic process GO:0033240 0 0.025
positive regulation of nucleic acid templated transcription GO:1903508 266 0.024
multicellular organism growth GO:0035264 46 0.024
regulation of transport GO:0051049 181 0.024
cellular amino acid metabolic process GO:0006520 61 0.023
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.023
cellular macromolecule localization GO:0070727 220 0.023
chemosensory behavior GO:0007635 106 0.023
regulation of phosphorus metabolic process GO:0051174 210 0.023
hindgut morphogenesis GO:0007442 58 0.023
ion transport GO:0006811 145 0.023
positive regulation of protein metabolic process GO:0051247 128 0.023
nephron development GO:0072006 3 0.022
positive regulation of phosphate metabolic process GO:0045937 139 0.022
cell cell adhesion via plasma membrane adhesion molecules GO:0098742 26 0.022
regulation of cell cycle process GO:0010564 181 0.022
organic acid metabolic process GO:0006082 103 0.022
chorion containing eggshell formation GO:0007304 105 0.022
respiratory system development GO:0060541 213 0.022
cognition GO:0050890 141 0.022
imaginal disc derived wing vein morphogenesis GO:0008586 44 0.021
camera type eye development GO:0043010 4 0.021
actin filament based process GO:0030029 220 0.021
imaginal disc derived wing vein specification GO:0007474 48 0.021
regulation of developmental growth GO:0048638 174 0.021
cell migration GO:0016477 238 0.020
larval development GO:0002164 104 0.020
regulation of cellular amine metabolic process GO:0033238 3 0.020
negative regulation of insulin secretion GO:0046676 1 0.020
cellular response to dna damage stimulus GO:0006974 223 0.020
digestive tract morphogenesis GO:0048546 127 0.020
gene silencing by rna GO:0031047 57 0.020
segmentation GO:0035282 207 0.020
macromolecular complex assembly GO:0065003 256 0.020
mitotic sister chromatid segregation GO:0000070 87 0.020
regulation of cellular catabolic process GO:0031329 157 0.019
somatic muscle development GO:0007525 66 0.019
digestive tract development GO:0048565 149 0.019
single organism cellular localization GO:1902580 180 0.019
regulation of immune system process GO:0002682 176 0.019
signal transduction by phosphorylation GO:0023014 107 0.019
cell cell adhesion GO:0098609 26 0.019
regulation of cell division GO:0051302 72 0.019
gene silencing GO:0016458 138 0.018
proteasomal protein catabolic process GO:0010498 59 0.018
small molecule metabolic process GO:0044281 305 0.018
divalent inorganic cation transport GO:0072511 30 0.018
wing disc pattern formation GO:0035222 66 0.018
phagocytosis GO:0006909 215 0.018
organic substance transport GO:0071702 257 0.018
regulation of neuron differentiation GO:0045664 103 0.018
regulation of protein transport GO:0051223 57 0.018
positive regulation of cellular protein metabolic process GO:0032270 118 0.018
organonitrogen compound biosynthetic process GO:1901566 117 0.018
regulation of purine nucleotide metabolic process GO:1900542 62 0.017
death GO:0016265 284 0.017
Human
secretion GO:0046903 109 0.017
head development GO:0060322 135 0.017
immune system development GO:0002520 57 0.017
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.017
regulation of stem cell proliferation GO:0072091 40 0.017
anatomical structure homeostasis GO:0060249 97 0.017
response to other organism GO:0051707 293 0.017
regulation of protein modification process GO:0031399 112 0.017
negative regulation of rna metabolic process GO:0051253 251 0.017
regulation of hydrolase activity GO:0051336 97 0.016
intracellular transport GO:0046907 228 0.016
nucleobase containing small molecule metabolic process GO:0055086 174 0.016
positive regulation of cellular biosynthetic process GO:0031328 316 0.016
response to external biotic stimulus GO:0043207 293 0.016
sex differentiation GO:0007548 81 0.016
regulation of cell cycle GO:0051726 291 0.016
protein transport GO:0015031 155 0.016
smoothened signaling pathway GO:0007224 49 0.016
negative regulation of rna biosynthetic process GO:1902679 240 0.016
purine nucleotide metabolic process GO:0006163 146 0.016
phosphorylation GO:0016310 294 0.016
chromosome segregation GO:0007059 157 0.016
negative regulation of cellular metabolic process GO:0031324 382 0.016
purine ribonucleotide metabolic process GO:0009150 145 0.016
positive regulation of rna metabolic process GO:0051254 271 0.016
digestive system development GO:0055123 149 0.016
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.016
morphogenesis of an epithelium GO:0002009 276 0.015
homeostatic process GO:0042592 199 0.015
regulation of cellular protein metabolic process GO:0032268 243 0.015
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 65 0.015
protein complex assembly GO:0006461 200 0.015
eggshell chorion assembly GO:0007306 66 0.015
macromolecule catabolic process GO:0009057 161 0.015
cell fate specification GO:0001708 71 0.015
positive regulation of hydrolase activity GO:0051345 78 0.015
regulation of meiosis GO:0040020 3 0.015
positive regulation of transport GO:0051050 92 0.015
regulation of protein catabolic process GO:0042176 55 0.015
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.015
response to oxygen containing compound GO:1901700 200 0.015
ribonucleotide metabolic process GO:0009259 145 0.015
embryonic pattern specification GO:0009880 174 0.015
regulation of anatomical structure size GO:0090066 163 0.015
blastoderm segmentation GO:0007350 159 0.015
developmental maturation GO:0021700 172 0.015
mitotic spindle organization GO:0007052 220 0.014
nucleocytoplasmic transport GO:0006913 72 0.014
single organism nuclear import GO:1902593 51 0.014
regulation of multicellular organism growth GO:0040014 40 0.014
neuron projection guidance GO:0097485 241 0.014
erbb signaling pathway GO:0038127 58 0.014
nitrogen compound transport GO:0071705 85 0.014
olfactory learning GO:0008355 56 0.014
response to organic substance GO:0010033 284 0.014
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.014
defense response to gram negative bacterium GO:0050829 94 0.014
genital disc development GO:0035215 44 0.014
mesenchymal cell differentiation GO:0048762 1 0.014
positive regulation of catabolic process GO:0009896 105 0.014
oxoacid metabolic process GO:0043436 103 0.014
glycosyl compound catabolic process GO:1901658 112 0.013
protein catabolic process GO:0030163 101 0.013
organic substance catabolic process GO:1901575 308 0.013
negative regulation of nucleic acid templated transcription GO:1903507 240 0.013
negative regulation of cellular protein metabolic process GO:0032269 85 0.013
cellular protein localization GO:0034613 160 0.013
stem cell division GO:0017145 69 0.013
establishment of ommatidial planar polarity GO:0042067 49 0.013
regulation of cellular component biogenesis GO:0044087 201 0.013
negative regulation of organelle organization GO:0010639 56 0.013
response to endogenous stimulus GO:0009719 119 0.013
regulation of protein localization GO:0032880 76 0.013
gliogenesis GO:0042063 80 0.013
regulation of phosphorylation GO:0042325 147 0.013
neuron fate commitment GO:0048663 50 0.013
kidney development GO:0001822 3 0.012
positive regulation of macromolecule metabolic process GO:0010604 405 0.012
striated muscle cell differentiation GO:0051146 90 0.012
chaeta development GO:0022416 97 0.012
embryo development ending in birth or egg hatching GO:0009792 152 0.012
Mouse
organ growth GO:0035265 56 0.012
positive regulation of phosphorylation GO:0042327 87 0.012
regulation of establishment of protein localization GO:0070201 61 0.012
positive regulation of cell cycle GO:0045787 43 0.012
skeletal muscle fiber development GO:0048741 3 0.012
regulation of embryonic development GO:0045995 68 0.012
negative regulation of cell cycle process GO:0010948 109 0.012
developmental programmed cell death GO:0010623 138 0.012
neuromuscular junction development GO:0007528 149 0.012
compound eye photoreceptor cell differentiation GO:0001751 140 0.012
regulation of defense response GO:0031347 102 0.012
positive regulation of purine nucleotide metabolic process GO:1900544 55 0.012
hematopoietic or lymphoid organ development GO:0048534 57 0.012
regulation of response to external stimulus GO:0032101 115 0.012
protein import into nucleus GO:0006606 51 0.012
single organism catabolic process GO:0044712 228 0.012
wnt signaling pathway GO:0016055 98 0.012
adult behavior GO:0030534 137 0.011
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.011
reproductive behavior GO:0019098 122 0.011
regulation of cell shape GO:0008360 113 0.011
negative regulation of protein metabolic process GO:0051248 85 0.011
muscle tissue development GO:0060537 30 0.011
cellular response to external stimulus GO:0071496 66 0.011
regulation of innate immune response GO:0045088 71 0.011
regulation of catabolic process GO:0009894 170 0.011
multicellular organismal homeostasis GO:0048871 41 0.011
muscle organ development GO:0007517 127 0.011
actin filament organization GO:0007015 126 0.011
hippo signaling GO:0035329 20 0.011
protein complex biogenesis GO:0070271 201 0.011
cell maturation GO:0048469 144 0.011
synaptic target recognition GO:0008039 45 0.011
multi multicellular organism process GO:0044706 123 0.011
spermatogenesis GO:0007283 200 0.011
mesenchymal cell development GO:0014031 1 0.011
locomotory behavior GO:0007626 176 0.011
purine nucleoside metabolic process GO:0042278 127 0.011
cellular catabolic process GO:0044248 372 0.011
actomyosin structure organization GO:0031032 56 0.011
regulation of cell morphogenesis GO:0022604 163 0.011
response to starvation GO:0042594 97 0.011
regulation of cell growth GO:0001558 43 0.011
amine metabolic process GO:0009308 12 0.011
extrinsic apoptotic signaling pathway GO:0097191 1 0.011
regulation of purine nucleotide catabolic process GO:0033121 48 0.011
single organism biosynthetic process GO:0044711 206 0.011
response to wounding GO:0009611 94 0.011
ncrna metabolic process GO:0034660 43 0.011
regulation of nuclear division GO:0051783 58 0.010
regulation of protein modification by small protein conjugation or removal GO:1903320 25 0.010
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 38 0.010
stem cell fate commitment GO:0048865 25 0.010
ameboidal type cell migration GO:0001667 151 0.010
response to nutrient levels GO:0031667 114 0.010
establishment of protein localization to organelle GO:0072594 62 0.010
epidermal growth factor receptor signaling pathway GO:0007173 58 0.010
cation transport GO:0006812 110 0.010
negative regulation of phosphorus metabolic process GO:0010563 45 0.010
inter male aggressive behavior GO:0002121 60 0.010
response to abiotic stimulus GO:0009628 341 0.010
Mouse
cell division GO:0051301 248 0.010
positive regulation of immune response GO:0050778 63 0.010
positive regulation of mapk cascade GO:0043410 63 0.010
positive regulation of phosphorus metabolic process GO:0010562 139 0.010
regulation of small gtpase mediated signal transduction GO:0051056 93 0.010
protein processing GO:0016485 68 0.010
positive regulation of multicellular organismal process GO:0051240 143 0.010
protein maturation GO:0051604 71 0.010
retina homeostasis GO:0001895 13 0.010
regulation of secretion GO:0051046 44 0.010

ASPP disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.056
disease of cellular proliferation DOID:14566 0 0.043
cancer DOID:162 0 0.030
organ system cancer DOID:0050686 0 0.030
nervous system disease DOID:863 0 0.013
cardiovascular system disease DOID:1287 0 0.011