Drosophila melanogaster

137 known processes

ph-p (Dmel_CG18412)

polyhomeotic proximal

(Aliases: Dmel\CG18412,CG18412,PHP,Ph-p,ph,phm,CG18414,PhP,ph[P],ph[p],Ph,ph-P,EG:87B1.5,PH-p,PH,php)

ph-p biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
neuron projection guidance GO:0097485 241 0.991
columnar cuboidal epithelial cell development GO:0002066 249 0.980
ovarian follicle cell development GO:0030707 248 0.959
negative regulation of transcription dna templated GO:0045892 237 0.934
axon guidance GO:0007411 233 0.912
taxis GO:0042330 304 0.899
ovarian follicle cell stalk formation GO:0030713 17 0.893
morphogenesis of follicular epithelium GO:0016333 36 0.861
negative regulation of cellular biosynthetic process GO:0031327 277 0.836
negative regulation of cell differentiation GO:0045596 143 0.822
axonogenesis GO:0007409 290 0.821
negative regulation of signal transduction GO:0009968 206 0.809
chemotaxis GO:0006935 249 0.806
axon development GO:0061564 297 0.798
cell cycle comprising mitosis without cytokinesis GO:0033301 25 0.796
protein modification process GO:0036211 438 0.764
Human
brain development GO:0007420 120 0.748
negative regulation of cell development GO:0010721 62 0.748
central nervous system development GO:0007417 201 0.736
neuron recognition GO:0008038 101 0.702
protein ubiquitination GO:0016567 70 0.684
Human
growth GO:0040007 359 0.635
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.613
regulation of cell differentiation GO:0045595 302 0.579
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.574
regulation of anatomical structure size GO:0090066 163 0.540
dendrite morphogenesis GO:0048813 199 0.529
positive regulation of cysteine type endopeptidase activity GO:2001056 24 0.522
germarium derived egg chamber formation GO:0007293 101 0.505
negative regulation of nucleic acid templated transcription GO:1903507 240 0.487
neuroblast differentiation GO:0014016 29 0.482
dendrite guidance GO:0070983 21 0.462
response to ecdysone GO:0035075 34 0.462
positive regulation of nucleic acid templated transcription GO:1903508 266 0.461
germarium derived female germ line cyst encapsulation GO:0030708 8 0.454
dendrite development GO:0016358 204 0.441
response to alcohol GO:0097305 95 0.422
negative regulation of cell communication GO:0010648 223 0.421
negative regulation of rna biosynthetic process GO:1902679 240 0.417
axon midline choice point recognition GO:0016199 26 0.404
catabolic process GO:0009056 409 0.384
cognition GO:0050890 141 0.371
blastoderm segmentation GO:0007350 159 0.362
proteolysis GO:0006508 192 0.358
immune system process GO:0002376 347 0.338
germ line cyst encapsulation GO:0048138 8 0.337
chromatin mediated maintenance of transcription GO:0048096 7 0.331
meiotic cell cycle process GO:1903046 132 0.329
negative regulation of biosynthetic process GO:0009890 277 0.319
cell recognition GO:0008037 102 0.314
negative regulation of rna metabolic process GO:0051253 251 0.308
intracellular signal transduction GO:0035556 300 0.304
chromatin silencing GO:0006342 76 0.300
transcription from rna polymerase ii promoter GO:0006366 368 0.294
synapse organization GO:0050808 196 0.281
stem cell development GO:0048864 79 0.268
positive regulation of macromolecule metabolic process GO:0010604 405 0.265
negative regulation of neurogenesis GO:0050768 53 0.264
response to organic substance GO:0010033 284 0.257
negative regulation of cellular component organization GO:0051129 108 0.257
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.252
response to abiotic stimulus GO:0009628 341 0.249
single organism behavior GO:0044708 391 0.245
developmental growth GO:0048589 280 0.227
negative regulation of cellular metabolic process GO:0031324 382 0.226
head development GO:0060322 135 0.225
compound eye photoreceptor cell differentiation GO:0001751 140 0.216
negative regulation of signaling GO:0023057 219 0.214
cellular protein modification process GO:0006464 438 0.212
Human
response to oxygen containing compound GO:1901700 200 0.207
photoreceptor cell axon guidance GO:0072499 23 0.204
protein catabolic process GO:0030163 101 0.203
regulation of epithelial cell proliferation GO:0050678 4 0.203
axon choice point recognition GO:0016198 26 0.190
response to organic cyclic compound GO:0014070 89 0.184
male courtship behavior veined wing extension GO:0048065 22 0.181
embryonic development via the syncytial blastoderm GO:0001700 148 0.174
cell maturation GO:0048469 144 0.171
histone modification GO:0016570 106 0.171
Human
covalent chromatin modification GO:0016569 106 0.167
Human
carbohydrate metabolic process GO:0005975 82 0.151
tissue migration GO:0090130 155 0.149
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.147
central nervous system projection neuron axonogenesis GO:0021952 6 0.146
organic substance catabolic process GO:1901575 308 0.143
retina development in camera type eye GO:0060041 4 0.141
ubiquitin dependent protein catabolic process GO:0006511 78 0.141
protein modification by small protein conjugation or removal GO:0070647 106 0.141
Human
forebrain development GO:0030900 2 0.141
negative regulation of multicellular organismal process GO:0051241 142 0.139
neuroblast development GO:0014019 13 0.138
negative regulation of developmental process GO:0051093 201 0.133
dna metabolic process GO:0006259 227 0.131
cellular macromolecule localization GO:0070727 220 0.131
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.130
negative regulation of response to stimulus GO:0048585 258 0.126
single organism biosynthetic process GO:0044711 206 0.124
positive regulation of rna metabolic process GO:0051254 271 0.124
gene silencing GO:0016458 138 0.119
regulation of gene silencing GO:0060968 63 0.116
stem cell proliferation GO:0072089 88 0.116
border follicle cell migration GO:0007298 113 0.115
cell proliferation GO:0008283 299 0.114
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.111
pigmentation GO:0043473 75 0.111
periodic partitioning GO:0007365 29 0.109
positive regulation of proteolysis GO:0045862 52 0.108
organonitrogen compound metabolic process GO:1901564 318 0.107
limb morphogenesis GO:0035108 1 0.105
negative regulation of organelle organization GO:0010639 56 0.104
regionalization GO:0003002 416 0.103
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.099
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.099
response to ketone GO:1901654 34 0.097
developmental maturation GO:0021700 172 0.095
central nervous system neuron development GO:0021954 8 0.092
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.089
meiotic cell cycle GO:0051321 171 0.088
mapk cascade GO:0000165 107 0.088
negative regulation of protein complex disassembly GO:0043242 23 0.088
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.087
regulation of protein depolymerization GO:1901879 27 0.086
phagocytosis GO:0006909 215 0.086
compound eye development GO:0048749 307 0.086
circulatory system development GO:0072359 82 0.085
regulation of synapse organization GO:0050807 110 0.084
regulation of imaginal disc derived wing size GO:0044719 20 0.083
cellular catabolic process GO:0044248 372 0.083
regulation of intracellular signal transduction GO:1902531 236 0.080
multicellular organismal reproductive behavior GO:0033057 110 0.078
meiotic nuclear division GO:0007126 151 0.078
tissue morphogenesis GO:0048729 297 0.078
chromatin organization GO:0006325 207 0.078
Human
chromatin remodeling GO:0006338 72 0.076
regulation of immune system process GO:0002682 176 0.072
response to wounding GO:0009611 94 0.072
meiotic g2 mi transition GO:0008315 3 0.071
maintenance of location in cell GO:0051651 28 0.071
negative regulation of gene expression GO:0010629 387 0.070
hemopoiesis GO:0030097 46 0.068
maintenance of location GO:0051235 73 0.068
cystoblast division GO:0007282 10 0.066
cellular response to chemical stimulus GO:0070887 199 0.066
Mouse
embryonic pattern specification GO:0009880 174 0.064
negative regulation of gene expression epigenetic GO:0045814 77 0.064
amine metabolic process GO:0009308 12 0.063
single organism intracellular transport GO:1902582 207 0.062
development of primary sexual characteristics GO:0045137 50 0.060
cellular response to organic substance GO:0071310 132 0.059
Mouse
stem cell differentiation GO:0048863 117 0.059
sex differentiation GO:0007548 81 0.058
epithelial cell development GO:0002064 274 0.058
eye antennal disc morphogenesis GO:0007455 34 0.057
regulation of ras protein signal transduction GO:0046578 93 0.057
eye morphogenesis GO:0048592 260 0.056
chromatin modification GO:0016568 147 0.055
Human
mitotic cell cycle embryonic GO:0045448 38 0.055
epithelial cell proliferation GO:0050673 15 0.054
regulation of chromatin silencing GO:0031935 36 0.054
positive regulation of transcription dna templated GO:0045893 266 0.053
regulation of protein metabolic process GO:0051246 256 0.052
synaptic target recognition GO:0008039 45 0.051
eye development GO:0001654 323 0.051
positive regulation of nf kappab import into nucleus GO:0042346 1 0.048
positive regulation of molecular function GO:0044093 136 0.047
negative regulation of nervous system development GO:0051961 92 0.046
spermatogenesis GO:0007283 200 0.045
Mouse
protein complex assembly GO:0006461 200 0.045
zygotic determination of anterior posterior axis embryo GO:0007354 27 0.045
positive regulation of catabolic process GO:0009896 105 0.044
learning or memory GO:0007611 141 0.044
small gtpase mediated signal transduction GO:0007264 88 0.044
regulation of catalytic activity GO:0050790 185 0.043
modification dependent protein catabolic process GO:0019941 78 0.043
histone acetylation GO:0016573 38 0.041
maintenance of protein location GO:0045185 28 0.041
cellular protein localization GO:0034613 160 0.041
aging GO:0007568 143 0.040
cell motility GO:0048870 251 0.040
macromolecular complex assembly GO:0065003 256 0.040
female sex differentiation GO:0046660 20 0.039
wnt signaling pathway GO:0016055 98 0.038
terminal region determination GO:0007362 25 0.038
positive regulation of cellular biosynthetic process GO:0031328 316 0.038
germ line cyst formation GO:0048134 44 0.038
protein complex biogenesis GO:0070271 201 0.038
negative regulation of cell cycle GO:0045786 116 0.037
stem cell maintenance GO:0019827 67 0.037
negative regulation of cell proliferation GO:0008285 69 0.037
rna interference GO:0016246 27 0.037
hematopoietic or lymphoid organ development GO:0048534 57 0.037
anterior posterior axis specification GO:0009948 109 0.036
negative regulation of cellular protein metabolic process GO:0032269 85 0.036
camera type eye development GO:0043010 4 0.036
cellular protein catabolic process GO:0044257 83 0.036
rhythmic process GO:0048511 106 0.035
tripartite regional subdivision GO:0007351 103 0.035
immune system development GO:0002520 57 0.035
sensory organ morphogenesis GO:0090596 260 0.035
central nervous system neuron differentiation GO:0021953 8 0.034
compound eye cone cell differentiation GO:0042675 13 0.034
regulation of meiosis GO:0040020 3 0.034
regulation of synapse structure and activity GO:0050803 128 0.033
biological adhesion GO:0022610 138 0.032
mushroom body development GO:0016319 70 0.032
central nervous system neuron axonogenesis GO:0021955 7 0.032
positive regulation of cellular catabolic process GO:0031331 95 0.032
adult locomotory behavior GO:0008344 76 0.032
eye photoreceptor cell development GO:0042462 81 0.031
reproductive structure development GO:0048608 74 0.031
regulation of phosphorus metabolic process GO:0051174 210 0.031
regulation of cellular catabolic process GO:0031329 157 0.030
defense response to other organism GO:0098542 225 0.030
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 25 0.030
negative regulation of cell cycle phase transition GO:1901988 103 0.030
neuron maturation GO:0042551 31 0.029
dorsal ventral pattern formation GO:0009953 133 0.028
negative regulation of multi organism process GO:0043901 29 0.028
chromosome organization GO:0051276 360 0.028
Human
embryonic axis specification GO:0000578 107 0.028
cellular amine metabolic process GO:0044106 12 0.028
regulation of nervous system development GO:0051960 248 0.028
neuroblast fate commitment GO:0014017 19 0.027
protein alkylation GO:0008213 43 0.027
regulation of protein complex assembly GO:0043254 42 0.027
negative regulation of cell cycle process GO:0010948 109 0.027
regulation of wnt signaling pathway GO:0030111 68 0.027
negative regulation of microtubule polymerization or depolymerization GO:0031111 21 0.027
female genitalia development GO:0030540 6 0.027
positive regulation of phosphorus metabolic process GO:0010562 139 0.027
regulation of apoptotic process GO:0042981 130 0.026
skeletal muscle organ development GO:0060538 48 0.026
gonad morphogenesis GO:0035262 7 0.026
segmentation GO:0035282 207 0.026
imaginal disc pattern formation GO:0007447 91 0.026
neurological system process GO:0050877 358 0.026
syncytial blastoderm mitotic cell cycle GO:0035186 21 0.026
regulation of localization GO:0032879 275 0.025
positive regulation of gene expression GO:0010628 290 0.025
vesicle mediated transport GO:0016192 381 0.024
single organism carbohydrate metabolic process GO:0044723 72 0.024
regulation of stress activated protein kinase signaling cascade GO:0070302 42 0.024
segment polarity determination GO:0007367 25 0.024
protein localization to organelle GO:0033365 82 0.024
eye photoreceptor cell differentiation GO:0001754 145 0.024
epithelial cell migration GO:0010631 148 0.024
positive regulation of protein metabolic process GO:0051247 128 0.024
negative regulation of meiotic cell cycle GO:0051447 2 0.024
organic hydroxy compound metabolic process GO:1901615 83 0.024
cell fate determination GO:0001709 91 0.024
negative regulation of intracellular signal transduction GO:1902532 57 0.024
muscle organ development GO:0007517 127 0.023
regulation of catabolic process GO:0009894 170 0.023
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.023
macromolecule catabolic process GO:0009057 161 0.023
regulation of molecular function GO:0065009 217 0.023
actin filament organization GO:0007015 126 0.023
muscle tissue development GO:0060537 30 0.023
cellular response to oxygen containing compound GO:1901701 79 0.023
Mouse
regulation of cellular protein metabolic process GO:0032268 243 0.023
embryo development ending in birth or egg hatching GO:0009792 152 0.022
regulation of protein catabolic process GO:0042176 55 0.022
regulation of cellular amine metabolic process GO:0033238 3 0.022
telencephalon development GO:0021537 2 0.022
regulation of photoreceptor cell differentiation GO:0046532 34 0.022
positive regulation of hydrolase activity GO:0051345 78 0.022
cellular amino acid metabolic process GO:0006520 61 0.022
cellular macromolecule catabolic process GO:0044265 136 0.021
positive regulation of catalytic activity GO:0043085 118 0.021
female germ line cyst encapsulation GO:0048139 8 0.021
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 23 0.021
phosphorylation GO:0016310 294 0.021
retina morphogenesis in camera type eye GO:0060042 2 0.021
organophosphate metabolic process GO:0019637 195 0.021
negative regulation of protein metabolic process GO:0051248 85 0.021
regulation of response to stress GO:0080134 200 0.021
ovarian follicle cell migration GO:0007297 121 0.021
aggressive behavior GO:0002118 63 0.021
r3 r4 cell differentiation GO:0048056 12 0.021
chorion containing eggshell pattern formation GO:0030381 11 0.020
positive regulation of multicellular organismal process GO:0051240 143 0.020
regulation of transport GO:0051049 181 0.019
regulation of cellular component size GO:0032535 98 0.019
death GO:0016265 284 0.019
camera type eye morphogenesis GO:0048593 2 0.019
regulation of neurogenesis GO:0050767 158 0.019
positive regulation of cell migration GO:0030335 2 0.019
dna recombination GO:0006310 32 0.018
trunk segmentation GO:0035290 8 0.018
response to starvation GO:0042594 97 0.018
regulation of tube size GO:0035150 46 0.018
regulation of cell development GO:0060284 215 0.018
humoral immune response GO:0006959 117 0.018
secretion GO:0046903 109 0.018
regulation of multicellular organismal development GO:2000026 414 0.018
male mating behavior GO:0060179 70 0.018
positive regulation of cellular amine metabolic process GO:0033240 0 0.017
nucleoside phosphate catabolic process GO:1901292 110 0.017
stem cell division GO:0017145 69 0.017
regulation of microtubule based process GO:0032886 49 0.017
negative regulation of phosphorus metabolic process GO:0010563 45 0.017
carbohydrate derivative metabolic process GO:1901135 217 0.017
chemical homeostasis GO:0048878 92 0.017
photoreceptor cell differentiation GO:0046530 170 0.017
response to light stimulus GO:0009416 124 0.017
microtubule depolymerization GO:0007019 25 0.017
nucleoside triphosphate catabolic process GO:0009143 108 0.017
positive regulation of biosynthetic process GO:0009891 316 0.017
regulation of hydrolase activity GO:0051336 97 0.017
antimicrobial humoral response GO:0019730 99 0.017
development of primary female sexual characteristics GO:0046545 12 0.016
positive regulation of gene expression epigenetic GO:0045815 16 0.016
female germ line cyst formation GO:0048135 42 0.016
regulation of cell proliferation GO:0042127 163 0.016
axis specification GO:0009798 167 0.016
maintenance of protein location in cell GO:0032507 26 0.016
regulation of multi organism process GO:0043900 131 0.016
leg disc development GO:0035218 92 0.016
response to external biotic stimulus GO:0043207 293 0.016
positive regulation of response to stimulus GO:0048584 323 0.016
determination of dorsal ventral asymmetry GO:0048262 3 0.016
appendage morphogenesis GO:0035107 397 0.016
protein targeting GO:0006605 64 0.016
molting cycle GO:0042303 56 0.016
positive regulation of signaling GO:0023056 243 0.015
localization of cell GO:0051674 257 0.015
response to endogenous stimulus GO:0009719 119 0.015
regulation of mapk cascade GO:0043408 92 0.015
negative regulation of neuroblast proliferation GO:0007406 27 0.015
embryonic hemopoiesis GO:0035162 26 0.015
multicellular organismal aging GO:0010259 140 0.015
segment specification GO:0007379 33 0.015
circadian rhythm GO:0007623 105 0.015
regulation of cell cycle GO:0051726 291 0.015
erbb signaling pathway GO:0038127 58 0.015
regulation of cell death GO:0010941 173 0.015
establishment of protein localization to organelle GO:0072594 62 0.015
negative regulation of neuron differentiation GO:0045665 16 0.015
neuroblast division GO:0055057 35 0.015
appendage development GO:0048736 401 0.015
negative regulation of cell fate commitment GO:0010454 17 0.014
limb development GO:0060173 1 0.014
methylation GO:0032259 47 0.014
negative regulation of immune system process GO:0002683 50 0.014
regulation of protein transport GO:0051223 57 0.014
nucleus localization GO:0051647 34 0.014
positive regulation of cell communication GO:0010647 250 0.014
regulation of insulin receptor signaling pathway GO:0046626 17 0.014
regulation of protein import into nucleus GO:0042306 28 0.014
positive regulation of response to external stimulus GO:0032103 44 0.014
organic hydroxy compound biosynthetic process GO:1901617 21 0.014
regulation of phosphate metabolic process GO:0019220 210 0.013
regulation of protein modification process GO:0031399 112 0.013
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 16 0.013
regulation of endopeptidase activity GO:0052548 36 0.013
inositol lipid mediated signaling GO:0048017 4 0.013
actin cytoskeleton organization GO:0030036 206 0.013
spindle organization GO:0007051 253 0.012
morphogenesis of embryonic epithelium GO:0016331 94 0.012
chromosome segregation GO:0007059 157 0.012
programmed cell death GO:0012501 257 0.012
negative regulation of programmed cell death GO:0043069 72 0.012
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 15 0.012
regulation of protein complex disassembly GO:0043244 29 0.012
photoreceptor cell development GO:0042461 96 0.012
oocyte nucleus localization involved in oocyte dorsal ventral axis specification GO:0051663 12 0.012
extrinsic apoptotic signaling pathway GO:0097191 1 0.012
jak stat cascade GO:0007259 49 0.012
regulation of neuron differentiation GO:0045664 103 0.012
nephron tubule development GO:0072080 3 0.012
cellular response to lipid GO:0071396 20 0.012
Mouse
response to hormone GO:0009725 45 0.012
negative regulation of notch signaling pathway GO:0045746 41 0.012
intracellular protein transport GO:0006886 104 0.011
regulation of cellular component movement GO:0051270 42 0.011
determination of adult lifespan GO:0008340 137 0.011
cellular carbohydrate metabolic process GO:0044262 22 0.011
regulation of jak stat cascade GO:0046425 43 0.011
protein modification by small protein conjugation GO:0032446 79 0.011
Human
locomotor rhythm GO:0045475 56 0.011
anterior posterior pattern specification GO:0009952 136 0.011
organonitrogen compound catabolic process GO:1901565 128 0.011
intrinsic apoptotic signaling pathway GO:0097193 16 0.011
ameboidal type cell migration GO:0001667 151 0.011
eye antennal disc development GO:0035214 60 0.011
positive regulation of cellular component organization GO:0051130 156 0.011
activin receptor signaling pathway GO:0032924 6 0.011
regulation of growth GO:0040008 233 0.011
positive regulation of signal transduction GO:0009967 223 0.011
peptidyl lysine trimethylation GO:0018023 6 0.011
regulation of nucleocytoplasmic transport GO:0046822 35 0.010
organelle fission GO:0048285 340 0.010
epithelium migration GO:0090132 148 0.010
positive regulation of antimicrobial peptide production GO:0002225 28 0.010
regulation of immune response GO:0050776 118 0.010
regulation of jnk cascade GO:0046328 40 0.010
modification dependent macromolecule catabolic process GO:0043632 79 0.010
regulation of dendrite morphogenesis GO:0048814 28 0.010
apoptotic signaling pathway GO:0097190 27 0.010
histone h2a ubiquitination GO:0033522 2 0.010
anterior posterior axis specification embryo GO:0008595 103 0.010
cell death GO:0008219 279 0.010
oxoacid metabolic process GO:0043436 103 0.010
compound eye photoreceptor development GO:0042051 78 0.010

ph-p disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.022
disease of cellular proliferation DOID:14566 0 0.022
organ system cancer DOID:0050686 0 0.022
disease of anatomical entity DOID:7 0 0.017
nervous system disease DOID:863 0 0.012