Drosophila melanogaster

109 known processes

mbt (Dmel_CG18582)

mushroom bodies tiny

(Aliases: CG18582,Ste20,DmMBT,anon-EST:fe1G7,dPAK2,Dmel\CG18582,STE20,Mbt,DmPAK2,Pak2)

mbt biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
head development GO:0060322 135 0.865
imaginal disc derived appendage morphogenesis GO:0035114 395 0.694
mushroom body development GO:0016319 70 0.689
regulation of phosphate metabolic process GO:0019220 210 0.624
actin filament based process GO:0030029 220 0.617
phosphorylation GO:0016310 294 0.551
actin filament organization GO:0007015 126 0.542
eye development GO:0001654 323 0.527
establishment of localization in cell GO:0051649 402 0.516
regulation of cytoskeleton organization GO:0051493 89 0.514
single organism cellular localization GO:1902580 180 0.512
growth GO:0040007 359 0.500
eye photoreceptor cell development GO:0042462 81 0.495
guanosine containing compound metabolic process GO:1901068 74 0.449
nucleotide catabolic process GO:0009166 109 0.441
guanosine containing compound catabolic process GO:1901069 74 0.427
response to abiotic stimulus GO:0009628 341 0.425
ribonucleoside catabolic process GO:0042454 112 0.423
purine nucleoside triphosphate catabolic process GO:0009146 108 0.421
nucleobase containing compound catabolic process GO:0034655 165 0.417
regulation of phosphorylation GO:0042325 147 0.414
regulation of actin cytoskeleton organization GO:0032956 42 0.412
appendage morphogenesis GO:0035107 397 0.394
centrosome organization GO:0051297 163 0.387
regulation of cellular component size GO:0032535 98 0.379
purine ribonucleotide catabolic process GO:0009154 109 0.378
actin cytoskeleton organization GO:0030036 206 0.378
regulation of cell size GO:0008361 63 0.369
purine ribonucleoside catabolic process GO:0046130 112 0.367
signal transduction by phosphorylation GO:0023014 107 0.349
nucleoside triphosphate catabolic process GO:0009143 108 0.337
carbohydrate derivative catabolic process GO:1901136 118 0.336
cellular macromolecule localization GO:0070727 220 0.331
nucleoside catabolic process GO:0009164 112 0.329
ribose phosphate metabolic process GO:0019693 145 0.326
small gtpase mediated signal transduction GO:0007264 88 0.322
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.318
photoreceptor cell differentiation GO:0046530 170 0.315
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.309
regulation of neurogenesis GO:0050767 158 0.303
regulation of small gtpase mediated signal transduction GO:0051056 93 0.303
cell cell signaling involved in cell fate commitment GO:0045168 210 0.300
regulation of protein metabolic process GO:0051246 256 0.299
regulation of growth GO:0040008 233 0.294
imaginal disc derived appendage development GO:0048737 399 0.290
ribonucleoside triphosphate catabolic process GO:0009203 108 0.288
neurological system process GO:0050877 358 0.287
Mouse
ras protein signal transduction GO:0007265 88 0.286
positive regulation of gtp catabolic process GO:0033126 43 0.285
heterocycle catabolic process GO:0046700 166 0.285
aromatic compound catabolic process GO:0019439 166 0.284
negative regulation of response to stimulus GO:0048585 258 0.280
Mouse
cellular protein localization GO:0034613 160 0.279
purine nucleoside catabolic process GO:0006152 112 0.279
appendage development GO:0048736 401 0.268
regulation of developmental growth GO:0048638 174 0.261
nucleobase containing small molecule metabolic process GO:0055086 174 0.256
purine containing compound metabolic process GO:0072521 155 0.256
developmental growth GO:0048589 280 0.255
single organism membrane organization GO:0044802 93 0.254
regulation of catalytic activity GO:0050790 185 0.253
regulation of photoreceptor cell differentiation GO:0046532 34 0.248
gtp catabolic process GO:0006184 72 0.248
glycosyl compound catabolic process GO:1901658 112 0.243
regulation of intracellular signal transduction GO:1902531 236 0.242
morphogenesis of an epithelium GO:0002009 276 0.238
post embryonic appendage morphogenesis GO:0035120 385 0.237
purine nucleotide catabolic process GO:0006195 109 0.233
chromosome organization GO:0051276 360 0.232
nucleoside metabolic process GO:0009116 127 0.232
lateral inhibition GO:0046331 206 0.228
nucleoside triphosphate metabolic process GO:0009141 120 0.225
negative regulation of cell communication GO:0010648 223 0.218
Mouse
single organism intracellular transport GO:1902582 207 0.209
regulation of phosphorus metabolic process GO:0051174 210 0.205
organophosphate metabolic process GO:0019637 195 0.197
nucleoside phosphate metabolic process GO:0006753 162 0.193
regulation of catabolic process GO:0009894 170 0.189
positive regulation of phosphorus metabolic process GO:0010562 139 0.188
nucleoside phosphate catabolic process GO:1901292 110 0.187
nucleotide metabolic process GO:0009117 161 0.183
regulation of organelle organization GO:0033043 196 0.180
positive regulation of phosphate metabolic process GO:0045937 139 0.180
cellular nitrogen compound catabolic process GO:0044270 165 0.179
positive regulation of catalytic activity GO:0043085 118 0.178
purine nucleotide metabolic process GO:0006163 146 0.176
purine ribonucleotide metabolic process GO:0009150 145 0.173
purine ribonucleoside metabolic process GO:0046128 127 0.171
muscle structure development GO:0061061 224 0.169
protein localization GO:0008104 284 0.163
imaginal disc derived wing morphogenesis GO:0007476 337 0.162
organonitrogen compound catabolic process GO:1901565 128 0.159
protein localization to organelle GO:0033365 82 0.159
regulation of cellular component biogenesis GO:0044087 201 0.155
regulation of gtp catabolic process GO:0033124 44 0.153
regulation of anatomical structure size GO:0090066 163 0.153
ribonucleoside triphosphate metabolic process GO:0009199 119 0.150
epithelial cell differentiation GO:0030855 322 0.147
positive regulation of gtpase activity GO:0043547 43 0.146
wing disc morphogenesis GO:0007472 344 0.142
regulation of cell differentiation GO:0045595 302 0.139
positive regulation of cellular protein metabolic process GO:0032270 118 0.139
intracellular signal transduction GO:0035556 300 0.139
transcription from rna polymerase ii promoter GO:0006366 368 0.136
ribonucleotide metabolic process GO:0009259 145 0.136
response to wounding GO:0009611 94 0.134
regulation of ras protein signal transduction GO:0046578 93 0.134
purine containing compound catabolic process GO:0072523 112 0.133
protein modification process GO:0036211 438 0.133
regulation of gtpase activity GO:0043087 44 0.133
cellular protein modification process GO:0006464 438 0.131
multicellular organismal aging GO:0010259 140 0.129
positive regulation of hydrolase activity GO:0051345 78 0.126
actin filament bundle assembly GO:0051017 26 0.126
ribonucleoside metabolic process GO:0009119 127 0.123
regulation of nervous system development GO:0051960 248 0.120
tissue morphogenesis GO:0048729 297 0.119
golgi organization GO:0007030 66 0.116
negative regulation of biosynthetic process GO:0009890 277 0.115
actin filament bundle organization GO:0061572 28 0.113
organonitrogen compound metabolic process GO:1901564 318 0.109
ribonucleotide catabolic process GO:0009261 109 0.107
intracellular transport GO:0046907 228 0.105
sensory organ morphogenesis GO:0090596 260 0.102
regulation of cellular catabolic process GO:0031329 157 0.101
negative regulation of small gtpase mediated signal transduction GO:0051058 13 0.101
positive regulation of nucleoside metabolic process GO:0045979 47 0.100
positive regulation of response to stimulus GO:0048584 323 0.097
positive regulation of purine nucleotide catabolic process GO:0033123 46 0.096
purine nucleoside triphosphate metabolic process GO:0009144 119 0.096
regulation of ras gtpase activity GO:0032318 38 0.096
gtp metabolic process GO:0046039 72 0.094
glycosyl compound metabolic process GO:1901657 127 0.094
endosomal transport GO:0016197 44 0.094
eye morphogenesis GO:0048592 260 0.088
carbohydrate derivative metabolic process GO:1901135 217 0.087
regionalization GO:0003002 416 0.087
regulation of nucleoside metabolic process GO:0009118 50 0.084
regulation of cell development GO:0060284 215 0.083
embryo development ending in birth or egg hatching GO:0009792 152 0.083
catabolic process GO:0009056 409 0.083
cell motility GO:0048870 251 0.083
protein complex disassembly GO:0043241 36 0.082
regulation of hydrolase activity GO:0051336 97 0.082
regulation of proteolysis GO:0030162 87 0.081
compound eye photoreceptor cell differentiation GO:0001751 140 0.081
negative regulation of cellular metabolic process GO:0031324 382 0.080
vesicle mediated transport GO:0016192 381 0.079
cytoplasmic transport GO:0016482 130 0.079
endomembrane system organization GO:0010256 119 0.077
regulation of response to stress GO:0080134 200 0.077
positive regulation of signal transduction GO:0009967 223 0.076
negative regulation of signaling GO:0023057 219 0.076
Mouse
learning GO:0007612 75 0.075
Mouse
regulation of nucleotide catabolic process GO:0030811 48 0.074
cell proliferation GO:0008283 299 0.073
macromolecular complex assembly GO:0065003 256 0.073
central nervous system development GO:0007417 201 0.072
positive regulation of endopeptidase activity GO:0010950 26 0.071
regulation of cellular response to stress GO:0080135 89 0.071
regulation of nucleotide metabolic process GO:0006140 62 0.071
positive regulation of nucleotide catabolic process GO:0030813 46 0.070
rho protein signal transduction GO:0007266 14 0.070
negative regulation of multicellular organismal process GO:0051241 142 0.070
establishment of protein localization GO:0045184 163 0.070
regulation of cellular protein metabolic process GO:0032268 243 0.070
positive regulation of programmed cell death GO:0043068 62 0.067
forebrain development GO:0030900 2 0.067
regulation of endopeptidase activity GO:0052548 36 0.066
photoreceptor cell development GO:0042461 96 0.065
regulation of purine nucleotide metabolic process GO:1900542 62 0.065
regulation of macroautophagy GO:0016241 15 0.064
stress activated protein kinase signaling cascade GO:0031098 55 0.063
neuronal stem cell division GO:0036445 35 0.063
organic cyclic compound catabolic process GO:1901361 168 0.063
positive regulation of nucleotide metabolic process GO:0045981 55 0.062
enzyme linked receptor protein signaling pathway GO:0007167 179 0.062
cell division GO:0051301 248 0.061
regulation of molecular function GO:0065009 217 0.060
organophosphate catabolic process GO:0046434 112 0.060
dendrite development GO:0016358 204 0.058
cellular response to dna damage stimulus GO:0006974 223 0.058
regulation of cysteine type endopeptidase activity GO:2000116 27 0.056
salivary gland development GO:0007431 162 0.053
regulation of neuron differentiation GO:0045664 103 0.052
positive regulation of response to external stimulus GO:0032103 44 0.052
compound eye photoreceptor development GO:0042051 78 0.051
immune system process GO:0002376 347 0.051
positive regulation of cell communication GO:0010647 250 0.051
receptor clustering GO:0043113 3 0.050
negative regulation of organelle organization GO:0010639 56 0.050
cellularization GO:0007349 90 0.049
purine nucleoside metabolic process GO:0042278 127 0.048
exocrine system development GO:0035272 162 0.048
positive regulation of ras gtpase activity GO:0032320 36 0.048
positive regulation of signaling GO:0023056 243 0.047
proteolysis GO:0006508 192 0.047
negative regulation of cellular component organization GO:0051129 108 0.047
skin development GO:0043588 65 0.047
centrosome cycle GO:0007098 137 0.046
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.046
jnk cascade GO:0007254 50 0.046
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.043
regulation of stress activated mapk cascade GO:0032872 41 0.043
regulation of anatomical structure morphogenesis GO:0022603 242 0.042
negative regulation of erk1 and erk2 cascade GO:0070373 3 0.042
multicellular organism growth GO:0035264 46 0.042
small molecule metabolic process GO:0044281 305 0.042
cellular component disassembly GO:0022411 46 0.041
negative regulation of neurogenesis GO:0050768 53 0.041
imaginal disc fusion GO:0046528 19 0.041
regulation of peptidase activity GO:0052547 39 0.041
terminal region determination GO:0007362 25 0.041
dendrite morphogenesis GO:0048813 199 0.040
spermatid differentiation GO:0048515 114 0.040
negative regulation of nervous system development GO:0051961 92 0.039
negative regulation of cellular biosynthetic process GO:0031327 277 0.039
positive regulation of mapk cascade GO:0043410 63 0.038
single organism catabolic process GO:0044712 228 0.038
regulation of cell death GO:0010941 173 0.038
Mouse
negative regulation of gene expression GO:0010629 387 0.037
gland development GO:0048732 191 0.037
spermatogenesis GO:0007283 200 0.037
regulation of purine nucleotide catabolic process GO:0033121 48 0.037
cognition GO:0050890 141 0.037
Mouse
imaginal disc derived wing vein specification GO:0007474 48 0.036
negative regulation of signal transduction GO:0009968 206 0.036
Mouse
regulation of cell morphogenesis GO:0022604 163 0.034
regulation of apoptotic process GO:0042981 130 0.034
Mouse
negative regulation of intracellular signal transduction GO:1902532 57 0.034
microtubule organizing center organization GO:0031023 168 0.033
positive regulation of purine nucleotide metabolic process GO:1900544 55 0.033
protein depolymerization GO:0051261 31 0.033
response to organic substance GO:0010033 284 0.032
regulation of jnk cascade GO:0046328 40 0.032
establishment or maintenance of cell polarity GO:0007163 167 0.032
ameboidal type cell migration GO:0001667 151 0.031
protein transport GO:0015031 155 0.031
cellular catabolic process GO:0044248 372 0.031
negative regulation of cell development GO:0010721 62 0.030
stress activated mapk cascade GO:0051403 52 0.030
regulation of protein complex disassembly GO:0043244 29 0.030
apoptotic process GO:0006915 159 0.030
Mouse
brain development GO:0007420 120 0.030
positive regulation of phosphorylation GO:0042327 87 0.030
compound eye morphogenesis GO:0001745 249 0.029
mitochondrion localization GO:0051646 17 0.029
negative regulation of nucleic acid templated transcription GO:1903507 240 0.028
endocytosis GO:0006897 310 0.028
larval development GO:0002164 104 0.028
cellular amine metabolic process GO:0044106 12 0.027
notch receptor processing GO:0007220 13 0.027
regulation of microtubule cytoskeleton organization GO:0070507 41 0.027
locomotory behavior GO:0007626 176 0.027
Mouse
positive regulation of multicellular organismal process GO:0051240 143 0.027
protein complex assembly GO:0006461 200 0.026
cellular response to oxygen containing compound GO:1901701 79 0.026
organic substance catabolic process GO:1901575 308 0.026
positive regulation of cellular component biogenesis GO:0044089 80 0.026
respiratory system development GO:0060541 213 0.025
embryonic morphogenesis GO:0048598 206 0.025
regulation of synapse structure and activity GO:0050803 128 0.025
epidermis development GO:0008544 65 0.025
nucleocytoplasmic transport GO:0006913 72 0.025
eye photoreceptor cell differentiation GO:0001754 145 0.024
asymmetric stem cell division GO:0098722 49 0.024
regulation of cell shape GO:0008360 113 0.024
cellular response to chemical stimulus GO:0070887 199 0.024
regulation of multi organism process GO:0043900 131 0.024
membrane organization GO:0061024 112 0.023
protein complex biogenesis GO:0070271 201 0.023
chromatin assembly or disassembly GO:0006333 52 0.023
negative regulation of rna metabolic process GO:0051253 251 0.023
positive regulation of cell development GO:0010720 61 0.022
neuron projection extension GO:1990138 32 0.022
defense response GO:0006952 300 0.022
amine metabolic process GO:0009308 12 0.022
male gamete generation GO:0048232 201 0.022
positive regulation of cell projection organization GO:0031346 29 0.022
positive regulation of cell size GO:0045793 21 0.022
cellular component assembly involved in morphogenesis GO:0010927 151 0.021
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.021
positive regulation of molecular function GO:0044093 136 0.021
oocyte development GO:0048599 124 0.021
centrosome duplication GO:0051298 121 0.021
oocyte maturation GO:0001556 3 0.021
regulation of locomotion GO:0040012 42 0.021
negative regulation of photoreceptor cell differentiation GO:0046533 8 0.021
oocyte differentiation GO:0009994 145 0.021
negative regulation of notch signaling pathway GO:0045746 41 0.020
developmental maturation GO:0021700 172 0.020
regulation of mapk cascade GO:0043408 92 0.020
regulation of cellular amine metabolic process GO:0033238 3 0.020
regulation of cell projection organization GO:0031344 92 0.020
positive regulation of catabolic process GO:0009896 105 0.020
regulation of nucleocytoplasmic transport GO:0046822 35 0.020
convergent extension GO:0060026 2 0.020
regulation of stress activated protein kinase signaling cascade GO:0070302 42 0.020
actin polymerization or depolymerization GO:0008154 31 0.020
ommatidial rotation GO:0016318 20 0.019
cellular response to peptide GO:1901653 28 0.019
negative regulation of erbb signaling pathway GO:1901185 29 0.019
negative regulation of ras protein signal transduction GO:0046580 13 0.019
establishment of cell polarity GO:0030010 40 0.019
stem cell division GO:0017145 69 0.019
regulation of response to nutrient levels GO:0032107 18 0.019
non sensory hair organization GO:0035316 47 0.019
death GO:0016265 284 0.018
Mouse
mapk cascade GO:0000165 107 0.018
actomyosin structure organization GO:0031032 56 0.018
establishment of protein localization to organelle GO:0072594 62 0.018
nuclear division GO:0000280 332 0.018
meiotic cell cycle process GO:1903046 132 0.017
lipid metabolic process GO:0006629 121 0.017
regulation of notch signaling pathway GO:0008593 100 0.017
regulation of neuron projection development GO:0010975 69 0.017
cell projection assembly GO:0030031 94 0.017
epithelium migration GO:0090132 148 0.017
reproductive structure development GO:0048608 74 0.017
secondary metabolic process GO:0019748 75 0.017
regulation of protein complex assembly GO:0043254 42 0.016
protein maturation GO:0051604 71 0.016
cell cycle checkpoint GO:0000075 95 0.016
regulation of embryonic development GO:0045995 68 0.016
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 65 0.015
synapse assembly GO:0007416 143 0.015
negative regulation of catalytic activity GO:0043086 42 0.015
germarium derived egg chamber formation GO:0007293 101 0.015
positive regulation of neurogenesis GO:0050769 41 0.015
negative regulation of cell differentiation GO:0045596 143 0.015
regulation of actin polymerization or depolymerization GO:0008064 27 0.015
intracellular protein transport GO:0006886 104 0.015
regulation of actin filament based process GO:0032970 42 0.015
regulation of cellular amino acid metabolic process GO:0006521 0 0.014
imaginal disc derived wing hair organization GO:0035317 45 0.014
negative regulation of meiotic cell cycle GO:0051447 2 0.014
regulation of organ growth GO:0046620 42 0.014
protein dna complex subunit organization GO:0071824 86 0.014
sex differentiation GO:0007548 81 0.014
chaeta development GO:0022416 97 0.014
negative regulation of developmental process GO:0051093 201 0.014
positive regulation of organelle organization GO:0010638 65 0.014
muscle adaptation GO:0043500 1 0.014
positive regulation of kinase activity GO:0033674 25 0.014
negative regulation of phosphate metabolic process GO:0045936 45 0.014
mitotic nuclear division GO:0007067 213 0.014
regulation of axonogenesis GO:0050770 32 0.013
developmental growth involved in morphogenesis GO:0060560 65 0.013
positive regulation of cysteine type endopeptidase activity GO:2001056 24 0.013
establishment of ommatidial planar polarity GO:0042067 49 0.013
nuclear transport GO:0051169 72 0.013
cellular protein complex assembly GO:0043623 71 0.013
macromolecular complex disassembly GO:0032984 37 0.013
positive regulation of developmental process GO:0051094 143 0.013
chromatin organization GO:0006325 207 0.013
phagocytosis GO:0006909 215 0.012
spermatid development GO:0007286 98 0.012
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.012
regulation of endocytosis GO:0030100 37 0.012
macroautophagy GO:0016236 42 0.012
negative regulation of cytoskeleton organization GO:0051494 30 0.012
actin filament polymerization GO:0030041 27 0.012
mitotic spindle organization GO:0007052 220 0.012
transposition rna mediated GO:0032197 3 0.012
protein phosphorylation GO:0006468 169 0.012
regulation of transport GO:0051049 181 0.012
epidermal cell differentiation GO:0009913 51 0.012
wound healing GO:0042060 75 0.012
protein localization to membrane GO:0072657 19 0.012
peptidyl amino acid modification GO:0018193 105 0.012
torso signaling pathway GO:0008293 21 0.012
organelle fission GO:0048285 340 0.012
localization of cell GO:0051674 257 0.012
positive regulation of protein phosphorylation GO:0001934 34 0.012
protein localization to nucleus GO:0034504 55 0.011
synaptic transmission GO:0007268 288 0.011
tube development GO:0035295 244 0.011
cortical actin cytoskeleton organization GO:0030866 24 0.011
synapse organization GO:0050808 196 0.011
nucleus organization GO:0006997 45 0.011
embryonic development via the syncytial blastoderm GO:0001700 148 0.011
response to temperature stimulus GO:0009266 106 0.011
development of primary sexual characteristics GO:0045137 50 0.011
positive regulation of cytoskeleton organization GO:0051495 21 0.011
regulation of immune system process GO:0002682 176 0.011
positive regulation of cellular catabolic process GO:0031331 95 0.011
tube morphogenesis GO:0035239 191 0.011
regulation of mrna metabolic process GO:1903311 72 0.011
regulation of wnt signaling pathway GO:0030111 68 0.011
response to starvation GO:0042594 97 0.011
positive regulation of protein kinase activity GO:0045860 25 0.011
embryonic axis specification GO:0000578 107 0.011
regulation of actin filament bundle assembly GO:0032231 8 0.011
protein import into nucleus GO:0006606 51 0.011
mitotic sister chromatid segregation GO:0000070 87 0.011
regulation of transferase activity GO:0051338 58 0.011
positive regulation of cell death GO:0010942 69 0.011
regulation of localization GO:0032879 275 0.010
axis specification GO:0009798 167 0.010
positive regulation of protein metabolic process GO:0051247 128 0.010
protein targeting to nucleus GO:0044744 51 0.010
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.010
response to other organism GO:0051707 293 0.010
positive regulation of cell motility GO:2000147 3 0.010
anterior posterior axis specification embryo GO:0008595 103 0.010
nuclear import GO:0051170 51 0.010

mbt disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.036
disease of mental health DOID:150 0 0.011
developmental disorder of mental health DOID:0060037 0 0.011