Drosophila melanogaster

173 known processes

R (Dmel_CG1956)

Roughened

(Aliases: rap1,Dras3,Dras62B,l(3)62Bf,DRap,RasIII,RAP1,CG1956,l(3)R,ras3,Dmel\CG1956,BEST:GH18528,ras 3,C-ras3,Ras3,Rap,DRap1,E(faf),Rap1,D-Rap1)

R biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
ovarian follicle cell migration GO:0007297 121 0.984
embryonic development via the syncytial blastoderm GO:0001700 148 0.939
dorsal closure GO:0007391 79 0.914
border follicle cell migration GO:0007298 113 0.882
tissue morphogenesis GO:0048729 297 0.848
wing disc morphogenesis GO:0007472 344 0.755
embryonic hemopoiesis GO:0035162 26 0.735
tissue migration GO:0090130 155 0.726
photoreceptor cell differentiation GO:0046530 170 0.703
epithelium migration GO:0090132 148 0.681
compound eye development GO:0048749 307 0.617
establishment of ommatidial planar polarity GO:0042067 49 0.588
purine ribonucleoside metabolic process GO:0046128 127 0.509
embryonic morphogenesis GO:0048598 206 0.499
compound eye photoreceptor development GO:0042051 78 0.449
epithelial cell migration GO:0010631 148 0.390
negative regulation of cell communication GO:0010648 223 0.349
Mouse
morphogenesis of a polarized epithelium GO:0001738 93 0.335
oocyte differentiation GO:0009994 145 0.329
embryo development ending in birth or egg hatching GO:0009792 152 0.291
imaginal disc derived appendage development GO:0048737 399 0.278
photoreceptor cell development GO:0042461 96 0.257
regulation of phosphate metabolic process GO:0019220 210 0.251
Mouse Rat
eye morphogenesis GO:0048592 260 0.248
morphogenesis of an epithelium GO:0002009 276 0.245
r7 cell differentiation GO:0045466 43 0.244
regulation of catabolic process GO:0009894 170 0.236
Rat
eye photoreceptor cell development GO:0042462 81 0.232
catabolic process GO:0009056 409 0.224
imaginal disc derived wing morphogenesis GO:0007476 337 0.219
organic substance catabolic process GO:1901575 308 0.189
purine nucleoside triphosphate catabolic process GO:0009146 108 0.176
oocyte axis specification GO:0007309 108 0.176
positive regulation of macromolecule metabolic process GO:0010604 405 0.173
Rat
purine nucleoside metabolic process GO:0042278 127 0.173
axis specification GO:0009798 167 0.172
Zebrafish
oocyte construction GO:0007308 112 0.172
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.171
Rat
cellular response to nutrient levels GO:0031669 62 0.170
post embryonic appendage morphogenesis GO:0035120 385 0.165
carbohydrate derivative catabolic process GO:1901136 118 0.165
compound eye photoreceptor cell differentiation GO:0001751 140 0.160
ribonucleoside metabolic process GO:0009119 127 0.157
cation transport GO:0006812 110 0.156
regulation of hemocyte differentiation GO:0045610 22 0.154
response to organic cyclic compound GO:0014070 89 0.152
Human
cell maturation GO:0048469 144 0.144
morphogenesis of follicular epithelium GO:0016333 36 0.143
regulation of cytoskeleton organization GO:0051493 89 0.137
germarium derived egg chamber formation GO:0007293 101 0.136
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.134
head involution GO:0008258 35 0.129
regulation of cell proliferation GO:0042127 163 0.126
gastrulation GO:0007369 70 0.125
gtp metabolic process GO:0046039 72 0.112
cell recognition GO:0008037 102 0.109
regulation of cell differentiation GO:0045595 302 0.108
r7 cell fate commitment GO:0007465 12 0.106
cellular catabolic process GO:0044248 372 0.103
regulation of protein serine threonine kinase activity GO:0071900 25 0.102
homeostatic process GO:0042592 199 0.098
ameboidal type cell migration GO:0001667 151 0.091
regulation of cellular catabolic process GO:0031329 157 0.091
Rat
purine nucleoside catabolic process GO:0006152 112 0.091
membrane invagination GO:0010324 11 0.090
ovarian follicle cell development GO:0030707 248 0.086
digestive tract morphogenesis GO:0048546 127 0.084
signal transduction downstream of smoothened GO:0007227 5 0.083
appendage morphogenesis GO:0035107 397 0.080
second mitotic wave involved in compound eye morphogenesis GO:0016330 7 0.076
purine nucleotide catabolic process GO:0006195 109 0.076
nucleoside triphosphate metabolic process GO:0009141 120 0.075
cellular response to starvation GO:0009267 61 0.074
compound eye morphogenesis GO:0001745 249 0.074
positive regulation of cellular catabolic process GO:0031331 95 0.072
Rat
negative regulation of homeostatic process GO:0032845 2 0.072
phagocytosis engulfment GO:0006911 11 0.071
ovarian follicle cell stalk formation GO:0030713 17 0.071
adherens junction organization GO:0034332 27 0.071
regulation of protein kinase activity GO:0045859 51 0.071
Rat
positive regulation of protein phosphorylation GO:0001934 34 0.069
Rat
gtp catabolic process GO:0006184 72 0.068
rho protein signal transduction GO:0007266 14 0.067
regulation of cell development GO:0060284 215 0.067
Mouse Rat
intracellular signal transduction GO:0035556 300 0.065
ras protein signal transduction GO:0007265 88 0.063
dna replication GO:0006260 48 0.060
hemocyte differentiation GO:0042386 38 0.059
r7 cell development GO:0045467 14 0.058
wound healing GO:0042060 75 0.056
guanosine containing compound catabolic process GO:1901069 74 0.056
regulation of apoptotic process GO:0042981 130 0.055
regulation of tube architecture open tracheal system GO:0035152 68 0.053
regulation of cell morphogenesis GO:0022604 163 0.053
kidney development GO:0001822 3 0.053
regulation of immune system process GO:0002682 176 0.053
compound eye cone cell differentiation GO:0042675 13 0.053
carbohydrate derivative metabolic process GO:1901135 217 0.052
epidermal growth factor receptor signaling pathway GO:0007173 58 0.052
response to nitrogen compound GO:1901698 90 0.052
Human
regulation of phosphorus metabolic process GO:0051174 210 0.051
Mouse Rat
regulation of epidermal growth factor receptor signaling pathway GO:0042058 42 0.050
eye development GO:0001654 323 0.049
regulation of hormone levels GO:0010817 40 0.049
eye photoreceptor cell differentiation GO:0001754 145 0.049
negative regulation of cellular metabolic process GO:0031324 382 0.049
mapk cascade GO:0000165 107 0.046
Mouse Rat
positive regulation of transferase activity GO:0051347 26 0.046
Rat
regulation of transferase activity GO:0051338 58 0.045
Rat
cell division GO:0051301 248 0.045
endodermal cell fate commitment GO:0001711 3 0.045
establishment of planar polarity GO:0001736 87 0.045
hemocyte migration GO:0035099 19 0.044
immune system process GO:0002376 347 0.043
regionalization GO:0003002 416 0.042
Zebrafish
developmental maturation GO:0021700 172 0.041
oocyte localization involved in germarium derived egg chamber formation GO:0030720 12 0.041
regulation of embryonic development GO:0045995 68 0.040
regulation of ras protein signal transduction GO:0046578 93 0.040
Rat
dorsal ventral axis specification ovarian follicular epithelium GO:0008069 13 0.040
micropyle formation GO:0046844 4 0.040
chemical homeostasis GO:0048878 92 0.040
positive regulation of phosphorylation GO:0042327 87 0.039
Mouse Rat
epithelial cell development GO:0002064 274 0.039
Human
small gtpase mediated signal transduction GO:0007264 88 0.039
oocyte development GO:0048599 124 0.038
tube development GO:0035295 244 0.038
cellular nitrogen compound catabolic process GO:0044270 165 0.038
embryonic organ development GO:0048568 50 0.038
anatomical structure homeostasis GO:0060249 97 0.037
open tracheal system development GO:0007424 204 0.037
digestive system development GO:0055123 149 0.037
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 3 0.036
response to other organism GO:0051707 293 0.035
positive regulation of nucleotide metabolic process GO:0045981 55 0.035
Rat
cellular ketone metabolic process GO:0042180 24 0.035
cuticle development GO:0042335 86 0.035
Worm
glycosyl compound metabolic process GO:1901657 127 0.035
gland development GO:0048732 191 0.034
embryonic pattern specification GO:0009880 174 0.034
Zebrafish
ribonucleotide metabolic process GO:0009259 145 0.034
regulation of cellular response to stress GO:0080135 89 0.034
morphogenesis of embryonic epithelium GO:0016331 94 0.034
ommatidial rotation GO:0016318 20 0.034
chitin based embryonic cuticle biosynthetic process GO:0008362 16 0.033
appendage development GO:0048736 401 0.033
purine containing compound metabolic process GO:0072521 155 0.033
purine ribonucleotide metabolic process GO:0009150 145 0.033
regulation of gtpase activity GO:0043087 44 0.033
Rat
compound eye retinal cell programmed cell death GO:0046667 23 0.032
negative regulation of erk1 and erk2 cascade GO:0070373 3 0.032
response to wounding GO:0009611 94 0.032
regulation of map kinase activity GO:0043405 17 0.032
response to endogenous stimulus GO:0009719 119 0.031
Human Rat
protein catabolic process GO:0030163 101 0.031
immune response GO:0006955 246 0.030
jnk cascade GO:0007254 50 0.030
maintenance of protein location in cell GO:0032507 26 0.030
digestive tract development GO:0048565 149 0.029
purine nucleoside triphosphate metabolic process GO:0009144 119 0.029
energy derivation by oxidation of organic compounds GO:0015980 32 0.029
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.029
germarium derived female germ line cyst encapsulation GO:0030708 8 0.028
regulation of kinase activity GO:0043549 53 0.028
Rat
cellular component assembly involved in morphogenesis GO:0010927 151 0.028
ion homeostasis GO:0050801 55 0.027
nucleoside phosphate metabolic process GO:0006753 162 0.027
regulation of mapk cascade GO:0043408 92 0.027
Mouse Rat
regulation of phosphorylation GO:0042325 147 0.027
Mouse Rat
axon development GO:0061564 297 0.026
cellular response to organic substance GO:0071310 132 0.026
Human Rat
cortical actin cytoskeleton organization GO:0030866 24 0.026
imaginal disc derived appendage morphogenesis GO:0035114 395 0.026
establishment of tissue polarity GO:0007164 87 0.026
regulation of developmental growth GO:0048638 174 0.025
regulation of proteasomal protein catabolic process GO:0061136 39 0.025
regulation of rho protein signal transduction GO:0035023 20 0.025
blastoderm segmentation GO:0007350 159 0.025
positive regulation of cell differentiation GO:0045597 64 0.025
Mouse Rat
dephosphorylation GO:0016311 51 0.025
purine ribonucleotide catabolic process GO:0009154 109 0.025
establishment or maintenance of bipolar cell polarity GO:0061245 34 0.025
epithelial cell cell adhesion GO:0090136 6 0.024
negative regulation of protein depolymerization GO:1901880 23 0.024
cuticle pattern formation GO:0035017 27 0.024
eggshell chorion assembly GO:0007306 66 0.024
regulation of protein catabolic process GO:0042176 55 0.023
negative regulation of cellular biosynthetic process GO:0031327 277 0.023
chaeta morphogenesis GO:0008407 42 0.022
columnar cuboidal epithelial cell development GO:0002066 249 0.022
dorsal closure spreading of leading edge cells GO:0007395 4 0.022
regulation of viral genome replication GO:0045069 4 0.022
cellular response to extracellular stimulus GO:0031668 64 0.022
developmental growth GO:0048589 280 0.022
reproductive system development GO:0061458 74 0.021
tube morphogenesis GO:0035239 191 0.021
cellular macromolecule localization GO:0070727 220 0.021
maintenance of apical basal cell polarity GO:0035090 8 0.021
response to abiotic stimulus GO:0009628 341 0.020
cellular homeostasis GO:0019725 80 0.020
regulation of intracellular signal transduction GO:1902531 236 0.020
Mouse Rat
regulation of ras gtpase activity GO:0032318 38 0.020
Rat
negative regulation of cellular protein metabolic process GO:0032269 85 0.020
positive regulation of mitotic cell cycle GO:0045931 34 0.020
regulation of catalytic activity GO:0050790 185 0.019
Rat
epithelial cell differentiation GO:0030855 322 0.019
Human
positive regulation of protein kinase activity GO:0045860 25 0.019
Rat
negative regulation of response to stimulus GO:0048585 258 0.019
heterocycle catabolic process GO:0046700 166 0.019
asymmetric cell division GO:0008356 37 0.019
regulation of rho gtpase activity GO:0032319 20 0.019
positive regulation of catalytic activity GO:0043085 118 0.019
Rat
regulation of cell cycle GO:0051726 291 0.019
sensory organ morphogenesis GO:0090596 260 0.019
negative regulation of epidermal growth factor receptor signaling pathway GO:0042059 29 0.019
regulation of compound eye retinal cell programmed cell death GO:0046669 18 0.019
positive regulation of nervous system development GO:0051962 69 0.019
Mouse Rat
regulation of purine nucleotide catabolic process GO:0033121 48 0.019
Rat
activation of protein kinase activity GO:0032147 12 0.018
regulation of vesicle mediated transport GO:0060627 59 0.018
Mouse
regulation of erk1 and erk2 cascade GO:0070372 39 0.018
Mouse Rat
developmental programmed cell death GO:0010623 138 0.018
negative regulation of wnt signaling pathway GO:0030178 28 0.018
nucleotide catabolic process GO:0009166 109 0.018
organophosphate metabolic process GO:0019637 195 0.018
positive regulation of catabolic process GO:0009896 105 0.017
Rat
guanosine containing compound metabolic process GO:1901068 74 0.017
positive regulation of protein serine threonine kinase activity GO:0071902 15 0.017
organonitrogen compound metabolic process GO:1901564 318 0.017
compound eye photoreceptor fate commitment GO:0001752 36 0.017
peptidyl threonine phosphorylation GO:0018107 2 0.017
eye antennal disc morphogenesis GO:0007455 34 0.017
regulation of protein modification process GO:0031399 112 0.017
Rat
nucleoside phosphate catabolic process GO:1901292 110 0.017
protein phosphorylation GO:0006468 169 0.016
Rat
establishment or maintenance of epithelial cell apical basal polarity GO:0045197 24 0.016
regulation of protein metabolic process GO:0051246 256 0.016
Rat
positive regulation of epithelial cell differentiation GO:0030858 1 0.016
positive regulation of nucleotide catabolic process GO:0030813 46 0.016
Rat
hemopoiesis GO:0030097 46 0.016
positive regulation of signaling GO:0023056 243 0.016
Mouse Rat
negative regulation of signal transduction GO:0009968 206 0.016
negative regulation of rna metabolic process GO:0051253 251 0.016
positive regulation of response to stimulus GO:0048584 323 0.015
Mouse Rat
nucleotide metabolic process GO:0009117 161 0.015
establishment or maintenance of polarity of follicular epithelium GO:0016334 26 0.015
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.015
dorsal appendage formation GO:0046843 47 0.015
regulation of response to external stimulus GO:0032101 115 0.015
nucleoside metabolic process GO:0009116 127 0.015
regulation of cell shape GO:0008360 113 0.015
response to organophosphorus GO:0046683 2 0.015
Human
segmentation GO:0035282 207 0.015
Zebrafish
neuron recognition GO:0008038 101 0.015
regulation of cellular amino acid metabolic process GO:0006521 0 0.015
erk1 and erk2 cascade GO:0070371 39 0.014
Mouse Rat
response to organonitrogen compound GO:0010243 75 0.014
Human
organic cyclic compound catabolic process GO:1901361 168 0.014
regulation of nucleotide catabolic process GO:0030811 48 0.014
Rat
nucleoside catabolic process GO:0009164 112 0.014
negative regulation of protein metabolic process GO:0051248 85 0.014
cell proliferation GO:0008283 299 0.014
Mouse
positive regulation of gene expression GO:0010628 290 0.014
activation of jun kinase activity GO:0007257 3 0.014
purine containing compound catabolic process GO:0072523 112 0.014
negative regulation of signaling GO:0023057 219 0.014
Mouse
oocyte microtubule cytoskeleton polarization GO:0008103 22 0.014
hematopoietic or lymphoid organ development GO:0048534 57 0.013
positive regulation of cell proliferation GO:0008284 47 0.013
germ line cyst formation GO:0048134 44 0.013
positive regulation of intracellular signal transduction GO:1902533 116 0.013
Mouse Rat
establishment or maintenance of apical basal cell polarity GO:0035088 34 0.013
dorsal ventral pattern formation GO:0009953 133 0.013
single organism catabolic process GO:0044712 228 0.013
regulation of notch signaling pathway GO:0008593 100 0.013
positive regulation of r7 cell differentiation GO:0045678 7 0.013
leg disc development GO:0035218 92 0.013
positive regulation of nucleoside metabolic process GO:0045979 47 0.013
Rat
ion transport GO:0006811 145 0.012
negative regulation of autophagy GO:0010507 16 0.012
gastrulation involving germ band extension GO:0010004 36 0.012
translation GO:0006412 69 0.012
regulation of microtubule cytoskeleton organization GO:0070507 41 0.012
negative regulation of signal transduction by p53 class mediator GO:1901797 1 0.012
salivary gland morphogenesis GO:0007435 145 0.012
regulation of nervous system development GO:0051960 248 0.012
Mouse Rat
convergent extension involved in gastrulation GO:0060027 2 0.012
negative regulation of protein phosphorylation GO:0001933 17 0.012
cellular macromolecular complex assembly GO:0034622 153 0.012
ribonucleoside triphosphate catabolic process GO:0009203 108 0.012
adherens junction assembly GO:0034333 11 0.012
cytoplasmic transport GO:0016482 130 0.012
attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation GO:0051316 1 0.012
positive regulation of gtpase activity GO:0043547 43 0.012
Rat
morphogenesis of a branching epithelium GO:0061138 45 0.012
signal transduction by phosphorylation GO:0023014 107 0.012
Mouse Rat
positive regulation of ras gtpase activity GO:0032320 36 0.012
Rat
regulation of transport GO:0051049 181 0.012
Mouse
respiratory system development GO:0060541 213 0.012
cellular macromolecule catabolic process GO:0044265 136 0.012
cell projection assembly GO:0030031 94 0.011
vesicle mediated transport GO:0016192 381 0.011
Mouse
stress activated mapk cascade GO:0051403 52 0.011
regulation of hydrolase activity GO:0051336 97 0.011
Rat
positive regulation of developmental process GO:0051094 143 0.011
Mouse Rat
r3 r4 cell differentiation GO:0048056 12 0.011
erbb signaling pathway GO:0038127 58 0.011
oocyte microtubule cytoskeleton organization GO:0016325 35 0.011
phagocytosis GO:0006909 215 0.011
regulation of intracellular transport GO:0032386 64 0.011
regulation of hemocyte proliferation GO:0035206 37 0.011
neurological system process GO:0050877 358 0.011
purine nucleotide metabolic process GO:0006163 146 0.011
establishment of spindle orientation GO:0051294 18 0.011
positive regulation of cell communication GO:0010647 250 0.010
Mouse Rat
maintenance of location GO:0051235 73 0.010
regulation of anatomical structure size GO:0090066 163 0.010
positive regulation of cellular biosynthetic process GO:0031328 316 0.010
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 44 0.010
regulation of meiosis GO:0040020 3 0.010
response to organic substance GO:0010033 284 0.010
Human Rat
oxidation reduction process GO:0055114 123 0.010
regulation of anatomical structure morphogenesis GO:0022603 242 0.010
torc1 signaling GO:0038202 12 0.010
negative regulation of mapk cascade GO:0043409 23 0.010
r3 r4 cell fate commitment GO:0007464 10 0.010
epithelial cell migration open tracheal system GO:0007427 32 0.010
regulation of cell cycle process GO:0010564 181 0.010
germline stem cell asymmetric division GO:0098728 15 0.010

R disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.038
musculoskeletal system disease DOID:17 0 0.021
connective tissue disease DOID:65 0 0.013