Drosophila melanogaster

214 known processes

Acf1 (Dmel_CG1966)

ATP-dependent chromatin assembly factor large subunit

(Aliases: Acf,p170/p185,ACF1,acf1,Acf-1,ACF/CHRAC,dACF,CHRAC,CHRAC-175,Dmel\CG1966,CG1966,dCHRAC,CAF,ACF)

Acf1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of gene expression epigenetic GO:0040029 128 0.995
gene silencing GO:0016458 138 0.986
chromatin silencing GO:0006342 76 0.967
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.950
negative regulation of gene expression GO:0010629 387 0.904
nuclear division GO:0000280 332 0.900
organelle fission GO:0048285 340 0.854
embryo development ending in birth or egg hatching GO:0009792 152 0.854
negative regulation of rna metabolic process GO:0051253 251 0.847
mitotic nuclear division GO:0007067 213 0.843
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.842
negative regulation of rna biosynthetic process GO:1902679 240 0.777
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.768
negative regulation of nucleic acid templated transcription GO:1903507 240 0.760
negative regulation of transcription dna templated GO:0045892 237 0.727
meiotic nuclear division GO:0007126 151 0.715
eye development GO:0001654 323 0.578
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.542
negative regulation of biosynthetic process GO:0009890 277 0.517
positive regulation of macromolecule metabolic process GO:0010604 405 0.458
cell proliferation GO:0008283 299 0.457
chromosome organization GO:0051276 360 0.433
chromosome separation GO:0051304 42 0.426
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.406
dna conformation change GO:0071103 105 0.373
positive regulation of gene expression GO:0010628 290 0.372
spindle organization GO:0007051 253 0.371
meiotic cell cycle GO:0051321 171 0.359
negative regulation of cell differentiation GO:0045596 143 0.339
negative regulation of cellular biosynthetic process GO:0031327 277 0.300
regulation of cell cycle GO:0051726 291 0.290
mitotic g2 dna damage checkpoint GO:0007095 69 0.288
regulation of mitotic cell cycle GO:0007346 190 0.287
mitotic dna integrity checkpoint GO:0044774 75 0.280
mitotic sister chromatid segregation GO:0000070 87 0.265
regulation of cell cycle process GO:0010564 181 0.258
chromosome segregation GO:0007059 157 0.252
larval development GO:0002164 104 0.241
Worm
mitotic sister chromatid separation GO:0051306 30 0.234
stem cell differentiation GO:0048863 117 0.231
posttranscriptional gene silencing GO:0016441 46 0.229
negative regulation of developmental process GO:0051093 201 0.225
Worm
positive regulation of cellular biosynthetic process GO:0031328 316 0.219
heterochromatin organization GO:0070828 25 0.198
regulation of response to stress GO:0080134 200 0.190
chromatin organization GO:0006325 207 0.186
eye morphogenesis GO:0048592 260 0.186
cellular protein modification process GO:0006464 438 0.183
dna methylation or demethylation GO:0044728 4 0.174
immune response GO:0006955 246 0.173
regulation of cell cycle phase transition GO:1901987 130 0.171
cell cycle phase transition GO:0044770 140 0.170
transcription from rna polymerase ii promoter GO:0006366 368 0.167
regulation of meiosis GO:0040020 3 0.166
imaginal disc derived appendage development GO:0048737 399 0.162
regulation of cell death GO:0010941 173 0.159
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.154
nucleoside metabolic process GO:0009116 127 0.153
regulation of nuclear division GO:0051783 58 0.149
ribose phosphate metabolic process GO:0019693 145 0.149
mitotic cell cycle phase transition GO:0044772 138 0.149
heterochromatin organization involved in chromatin silencing GO:0070868 9 0.140
sensory organ morphogenesis GO:0090596 260 0.137
positive regulation of rna biosynthetic process GO:1902680 266 0.128
appendage development GO:0048736 401 0.125
regulation of cell division GO:0051302 72 0.117
dna metabolic process GO:0006259 227 0.116
negative regulation of gene expression epigenetic GO:0045814 77 0.115
small molecule metabolic process GO:0044281 305 0.114
positive regulation of nucleic acid templated transcription GO:1903508 266 0.109
nucleobase containing compound catabolic process GO:0034655 165 0.107
positive regulation of programmed cell death GO:0043068 62 0.105
glycosyl compound catabolic process GO:1901658 112 0.103
innate immune response GO:0045087 144 0.101
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.098
reproductive system development GO:0061458 74 0.097
negative regulation of cellular metabolic process GO:0031324 382 0.094
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.089
embryonic organ development GO:0048568 50 0.081
apoptotic process GO:0006915 159 0.081
reproductive structure development GO:0048608 74 0.079
organonitrogen compound catabolic process GO:1901565 128 0.078
macromolecular complex assembly GO:0065003 256 0.077
sister chromatid segregation GO:0000819 92 0.077
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.076
regulation of cell proliferation GO:0042127 163 0.075
regulation of mitotic sister chromatid segregation GO:0033047 28 0.072
tube morphogenesis GO:0035239 191 0.071
immune system process GO:0002376 347 0.069
atp metabolic process GO:0046034 49 0.068
regulation of cellular response to stress GO:0080135 89 0.068
positive regulation of biosynthetic process GO:0009891 316 0.067
negative regulation of cell cycle phase transition GO:1901988 103 0.066
immune system development GO:0002520 57 0.065
peptidyl amino acid modification GO:0018193 105 0.065
positive regulation of transcription dna templated GO:0045893 266 0.065
gland development GO:0048732 191 0.064
organonitrogen compound metabolic process GO:1901564 318 0.064
nucleosome organization GO:0034728 59 0.064
compound eye development GO:0048749 307 0.063
purine ribonucleotide metabolic process GO:0009150 145 0.063
photoreceptor cell differentiation GO:0046530 170 0.062
dna methylation GO:0006306 4 0.061
response to other organism GO:0051707 293 0.060
regulation of apoptotic process GO:0042981 130 0.060
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.059
posttranscriptional gene silencing by rna GO:0035194 45 0.058
chromosome condensation GO:0030261 41 0.057
positive regulation of rna metabolic process GO:0051254 271 0.056
nucleoside triphosphate catabolic process GO:0009143 108 0.055
maintenance of protein location in cell GO:0032507 26 0.054
negative regulation of mitotic sister chromatid separation GO:2000816 13 0.054
camera type eye development GO:0043010 4 0.052
dna integrity checkpoint GO:0031570 81 0.052
dna damage checkpoint GO:0000077 78 0.050
response to external biotic stimulus GO:0043207 293 0.050
negative regulation of cell cycle GO:0045786 116 0.049
negative regulation of apoptotic process GO:0043066 63 0.047
regulation of protein metabolic process GO:0051246 256 0.047
regulation of programmed cell death GO:0043067 152 0.047
telomere maintenance GO:0000723 21 0.046
regulation of catabolic process GO:0009894 170 0.044
regulation of chromosome organization GO:0033044 64 0.043
cell cycle checkpoint GO:0000075 95 0.042
regulation of intracellular signal transduction GO:1902531 236 0.042
dendrite development GO:0016358 204 0.042
regulation of chromatin silencing GO:0031935 36 0.041
purine nucleoside triphosphate catabolic process GO:0009146 108 0.040
carbohydrate derivative metabolic process GO:1901135 217 0.040
regulation of cell differentiation GO:0045595 302 0.040
regulation of transcription by chromatin organization GO:0034401 3 0.040
stem cell division GO:0017145 69 0.039
gene silencing by rna GO:0031047 57 0.039
positive regulation of response to stimulus GO:0048584 323 0.038
cellular macromolecular complex assembly GO:0034622 153 0.038
nuclear dna replication GO:0033260 1 0.038
purine ribonucleoside monophosphate metabolic process GO:0009167 50 0.038
anatomical structure homeostasis GO:0060249 97 0.038
meiotic cell cycle process GO:1903046 132 0.037
meiosis i GO:0007127 59 0.037
organic cyclic compound catabolic process GO:1901361 168 0.036
metaphase anaphase transition of cell cycle GO:0044784 28 0.036
ribonucleoside monophosphate catabolic process GO:0009158 39 0.034
development of primary sexual characteristics GO:0045137 50 0.034
compound eye morphogenesis GO:0001745 249 0.034
organic substance catabolic process GO:1901575 308 0.033
salivary gland morphogenesis GO:0007435 145 0.033
negative regulation of chromosome segregation GO:0051985 14 0.032
eye photoreceptor cell differentiation GO:0001754 145 0.032
chromatin modification GO:0016568 147 0.032
mitotic dna damage checkpoint GO:0044773 74 0.032
dna alkylation GO:0006305 4 0.031
receptor mediated endocytosis GO:0006898 21 0.031
organ formation GO:0048645 39 0.030
regulation of mitotic cell cycle phase transition GO:1901990 130 0.030
cellular amino acid metabolic process GO:0006520 61 0.029
positive regulation of cell death GO:0010942 69 0.029
digestive system development GO:0055123 149 0.029
cell cycle dna replication GO:0044786 23 0.029
programmed cell death GO:0012501 257 0.029
purine containing compound metabolic process GO:0072521 155 0.029
gland morphogenesis GO:0022612 145 0.029
vesicle mediated transport GO:0016192 381 0.029
body morphogenesis GO:0010171 2 0.029
epithelial cell differentiation GO:0030855 322 0.029
cellular catabolic process GO:0044248 372 0.029
single organism biosynthetic process GO:0044711 206 0.028
positive regulation of apoptotic process GO:0043065 47 0.028
protein modification process GO:0036211 438 0.028
endocytosis GO:0006897 310 0.028
nucleoside catabolic process GO:0009164 112 0.027
cellular nitrogen compound catabolic process GO:0044270 165 0.027
histone h3 k27 methylation GO:0070734 6 0.027
purine ribonucleotide catabolic process GO:0009154 109 0.027
mitotic cell cycle checkpoint GO:0007093 88 0.026
eggshell chorion gene amplification GO:0007307 9 0.026
nucleobase containing small molecule metabolic process GO:0055086 174 0.026
post embryonic appendage morphogenesis GO:0035120 385 0.026
organic acid metabolic process GO:0006082 103 0.026
regulation of mitosis GO:0007088 56 0.025
nucleotide catabolic process GO:0009166 109 0.025
ribonucleoside catabolic process GO:0042454 112 0.025
cell division GO:0051301 248 0.025
regulation of phosphatase activity GO:0010921 3 0.024
compound eye photoreceptor cell differentiation GO:0001751 140 0.024
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.024
purine nucleotide metabolic process GO:0006163 146 0.024
r7 cell differentiation GO:0045466 43 0.024
purine nucleoside triphosphate metabolic process GO:0009144 119 0.024
positive regulation of multicellular organismal process GO:0051240 143 0.024
purine ribonucleoside catabolic process GO:0046130 112 0.023
regulation of phosphate metabolic process GO:0019220 210 0.023
ribonucleoside metabolic process GO:0009119 127 0.022
regulation of mitotic sister chromatid separation GO:0010965 28 0.022
glycosyl compound metabolic process GO:1901657 127 0.022
regulation of mitotic metaphase anaphase transition GO:0030071 26 0.022
ribonucleotide catabolic process GO:0009261 109 0.022
response to oxygen containing compound GO:1901700 200 0.022
regulation of anatomical structure morphogenesis GO:0022603 242 0.022
chromatin remodeling GO:0006338 72 0.022
ribonucleotide metabolic process GO:0009259 145 0.021
regulation of hemocyte proliferation GO:0035206 37 0.021
salivary gland development GO:0007431 162 0.021
intracellular signal transduction GO:0035556 300 0.020
appendage morphogenesis GO:0035107 397 0.020
connective tissue development GO:0061448 3 0.020
purine nucleotide catabolic process GO:0006195 109 0.020
negative regulation of neurogenesis GO:0050768 53 0.020
sex differentiation GO:0007548 81 0.020
positive regulation of cellular catabolic process GO:0031331 95 0.020
cellular response to chemical stimulus GO:0070887 199 0.020
regulation of cellular amino acid metabolic process GO:0006521 0 0.020
regulation of immune system process GO:0002682 176 0.019
organophosphate catabolic process GO:0046434 112 0.019
purine ribonucleoside monophosphate catabolic process GO:0009169 38 0.019
purine nucleoside catabolic process GO:0006152 112 0.019
posttranscriptional regulation of gene expression GO:0010608 145 0.019
metaphase anaphase transition of mitotic cell cycle GO:0007091 28 0.019
response to biotic stimulus GO:0009607 294 0.018
regulation of organelle organization GO:0033043 196 0.018
regulation of gene silencing GO:0060968 63 0.018
female meiotic division GO:0007143 70 0.018
positive regulation of developmental process GO:0051094 143 0.018
cell adhesion GO:0007155 136 0.018
positive regulation of molecular function GO:0044093 136 0.017
digestive tract development GO:0048565 149 0.017
purine containing compound catabolic process GO:0072523 112 0.017
regionalization GO:0003002 416 0.017
response to lipid GO:0033993 38 0.017
regulation of sister chromatid segregation GO:0033045 28 0.017
positive regulation of mitotic cell cycle GO:0045931 34 0.016
single organism catabolic process GO:0044712 228 0.016
mitotic g2 m transition checkpoint GO:0044818 70 0.016
positive regulation of cell development GO:0010720 61 0.016
embryonic development via the syncytial blastoderm GO:0001700 148 0.016
male meiosis GO:0007140 52 0.016
axon development GO:0061564 297 0.016
protein import into nucleus GO:0006606 51 0.016
regulation of gliogenesis GO:0014013 11 0.015
columnar cuboidal epithelial cell development GO:0002066 249 0.015
embryonic morphogenesis GO:0048598 206 0.015
response to organic substance GO:0010033 284 0.015
g2 dna damage checkpoint GO:0031572 69 0.015
regulation of neurogenesis GO:0050767 158 0.015
autophagic cell death GO:0048102 83 0.015
tissue morphogenesis GO:0048729 297 0.015
dna endoreduplication GO:0042023 22 0.015
positive regulation of cell proliferation GO:0008284 47 0.014
cellular response to dna damage stimulus GO:0006974 223 0.014
stem cell development GO:0048864 79 0.014
positive regulation of gene expression epigenetic GO:0045815 16 0.014
positive regulation of neuron projection regeneration GO:0070572 3 0.014
induction of programmed cell death by ecdysone GO:0035078 12 0.014
carbohydrate derivative catabolic process GO:1901136 118 0.014
regulation of cellular amine metabolic process GO:0033238 3 0.013
sister chromatid cohesion GO:0007062 18 0.013
cellular response to organic substance GO:0071310 132 0.013
homeostatic process GO:0042592 199 0.013
cytoplasmic microtubule organization GO:0031122 22 0.013
purine nucleoside metabolic process GO:0042278 127 0.013
negative regulation of signal transduction GO:0009968 206 0.013
exocrine system development GO:0035272 162 0.012
defense response GO:0006952 300 0.012
regulation of innate immune response GO:0045088 71 0.012
mitochondrial membrane organization GO:0007006 3 0.012
purine ribonucleoside metabolic process GO:0046128 127 0.012
negative regulation of wnt signaling pathway GO:0030178 28 0.012
dna amplification GO:0006277 11 0.012
mitotic cell cycle embryonic GO:0045448 38 0.012
carboxylic acid metabolic process GO:0019752 92 0.012
defense response to other organism GO:0098542 225 0.012
positive regulation of cellular amine metabolic process GO:0033240 0 0.012
regulation of cellular protein metabolic process GO:0032268 243 0.012
ribonucleoside triphosphate metabolic process GO:0009199 119 0.012
digestive tract morphogenesis GO:0048546 127 0.012
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process GO:0031145 30 0.012
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.011
imaginal disc derived wing morphogenesis GO:0007476 337 0.011
regulation of immune response GO:0050776 118 0.011
negative regulation of multicellular organismal process GO:0051241 142 0.011
Worm
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.011
mrna metabolic process GO:0016071 124 0.011
catabolic process GO:0009056 409 0.011
negative regulation of cell development GO:0010721 62 0.011
nucleoside triphosphate metabolic process GO:0009141 120 0.011
cell cycle comprising mitosis without cytokinesis GO:0033301 25 0.011
jak stat cascade GO:0007259 49 0.011
positive regulation of proteasomal protein catabolic process GO:1901800 20 0.011
forebrain development GO:0030900 2 0.011
negative regulation of mitotic cell cycle GO:0045930 109 0.011
dna packaging GO:0006323 91 0.011
gonad development GO:0008406 50 0.011
nucleosome positioning GO:0016584 3 0.011
cleavage furrow formation GO:0036089 2 0.011
photoreceptor cell fate commitment GO:0046552 41 0.011
nucleosome mobilization GO:0042766 9 0.011
localization of cell GO:0051674 257 0.011
peptidyl lysine methylation GO:0018022 16 0.010
purine nucleoside monophosphate metabolic process GO:0009126 50 0.010
response to organic cyclic compound GO:0014070 89 0.010
negative regulation of chromosome organization GO:2001251 19 0.010
regulation of chromosome segregation GO:0051983 32 0.010
macromolecule methylation GO:0043414 45 0.010
regulation of peptidyl lysine acetylation GO:2000756 7 0.010
ovulation cycle GO:0042698 1 0.010

Acf1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.012
disease of cellular proliferation DOID:14566 0 0.012
organ system cancer DOID:0050686 0 0.012