Drosophila melanogaster

122 known processes

lgs (Dmel_CG2041)

legless

(Aliases: Dmel\CG2041,CG2041,BCL9,Lgl,Lgs)

lgs biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
embryonic development via the syncytial blastoderm GO:0001700 148 0.630
regulation of gtp catabolic process GO:0033124 44 0.605
single organism behavior GO:0044708 391 0.599
regulation of small gtpase mediated signal transduction GO:0051056 93 0.586
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.550
intracellular signal transduction GO:0035556 300 0.476
regulation of ras protein signal transduction GO:0046578 93 0.472
protein modification process GO:0036211 438 0.462
developmental growth GO:0048589 280 0.429
embryonic morphogenesis GO:0048598 206 0.413
negative regulation of signaling GO:0023057 219 0.404
regulation of molecular function GO:0065009 217 0.400
guanosine containing compound metabolic process GO:1901068 74 0.385
guanosine containing compound catabolic process GO:1901069 74 0.354
nucleobase containing compound catabolic process GO:0034655 165 0.347
negative regulation of cell communication GO:0010648 223 0.314
transcription from rna polymerase ii promoter GO:0006366 368 0.303
cellular response to fibroblast growth factor stimulus GO:0044344 10 0.287
positive regulation of gtpase activity GO:0043547 43 0.286
cellular response to dna damage stimulus GO:0006974 223 0.280
establishment of localization in cell GO:0051649 402 0.268
catabolic process GO:0009056 409 0.255
ras protein signal transduction GO:0007265 88 0.250
regulation of gtpase activity GO:0043087 44 0.249
ion transmembrane transport GO:0034220 122 0.247
cellular response to abiotic stimulus GO:0071214 58 0.246
death GO:0016265 284 0.245
positive regulation of ras gtpase activity GO:0032320 36 0.239
regulation of cell cycle phase transition GO:1901987 130 0.238
imaginal disc derived leg morphogenesis GO:0007480 80 0.237
negative regulation of signal transduction GO:0009968 206 0.237
embryonic pattern specification GO:0009880 174 0.228
heart development GO:0007507 82 0.227
positive regulation of rna metabolic process GO:0051254 271 0.223
regulation of intracellular signal transduction GO:1902531 236 0.222
regulation of endopeptidase activity GO:0052548 36 0.208
regulation of phosphorus metabolic process GO:0051174 210 0.206
positive regulation of catabolic process GO:0009896 105 0.205
digestive system development GO:0055123 149 0.198
cellular catabolic process GO:0044248 372 0.195
cellular protein localization GO:0034613 160 0.193
positive regulation of gtp catabolic process GO:0033126 43 0.190
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.188
positive regulation of transcription dna templated GO:0045893 266 0.179
embryo development ending in birth or egg hatching GO:0009792 152 0.176
regulation of ras gtpase activity GO:0032318 38 0.173
heterocycle catabolic process GO:0046700 166 0.169
tube morphogenesis GO:0035239 191 0.168
wnt signaling pathway GO:0016055 98 0.164
dendrite morphogenesis GO:0048813 199 0.164
nucleocytoplasmic transport GO:0006913 72 0.159
negative regulation of cellular protein metabolic process GO:0032269 85 0.158
small gtpase mediated signal transduction GO:0007264 88 0.155
protein localization GO:0008104 284 0.151
positive regulation of phosphate metabolic process GO:0045937 139 0.150
epithelial cell differentiation GO:0030855 322 0.150
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 44 0.148
regulation of cellular protein catabolic process GO:1903362 44 0.144
regulation of cellular protein metabolic process GO:0032268 243 0.143
gtp metabolic process GO:0046039 72 0.139
phosphorylation GO:0016310 294 0.137
regulation of protein import into nucleus GO:0042306 28 0.133
regulation of stress activated protein kinase signaling cascade GO:0070302 42 0.128
cellular macromolecule catabolic process GO:0044265 136 0.127
single organism nuclear import GO:1902593 51 0.127
organic substance catabolic process GO:1901575 308 0.125
regulation of catabolic process GO:0009894 170 0.119
cellular response to radiation GO:0071478 52 0.118
larval lymph gland hemocyte differentiation GO:0035168 11 0.116
regulation of cellular catabolic process GO:0031329 157 0.116
segmentation GO:0035282 207 0.113
tissue morphogenesis GO:0048729 297 0.111
regulation of catalytic activity GO:0050790 185 0.111
intracellular transport GO:0046907 228 0.110
small molecule metabolic process GO:0044281 305 0.109
positive regulation of catalytic activity GO:0043085 118 0.109
retina development in camera type eye GO:0060041 4 0.109
tube development GO:0035295 244 0.106
vesicle mediated transport GO:0016192 381 0.104
digestive tract development GO:0048565 149 0.103
organonitrogen compound metabolic process GO:1901564 318 0.102
localization of cell GO:0051674 257 0.102
synapse assembly GO:0007416 143 0.099
positive regulation of nucleic acid templated transcription GO:1903508 266 0.098
cytoplasmic transport GO:0016482 130 0.098
adult behavior GO:0030534 137 0.097
neurological system process GO:0050877 358 0.097
cellular protein modification process GO:0006464 438 0.097
ribonucleoside triphosphate catabolic process GO:0009203 108 0.095
positive regulation of cellular biosynthetic process GO:0031328 316 0.089
positive regulation of molecular function GO:0044093 136 0.088
organic cyclic compound catabolic process GO:1901361 168 0.088
protein transport GO:0015031 155 0.087
anatomical structure homeostasis GO:0060249 97 0.086
regulation of hydrolase activity GO:0051336 97 0.086
response to abiotic stimulus GO:0009628 341 0.086
establishment of protein localization GO:0045184 163 0.084
cellular macromolecule localization GO:0070727 220 0.084
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.083
endocytosis GO:0006897 310 0.081
circulatory system development GO:0072359 82 0.080
purine ribonucleotide catabolic process GO:0009154 109 0.080
sensory perception GO:0007600 196 0.080
eye development GO:0001654 323 0.078
positive regulation of jun kinase activity GO:0043507 4 0.077
cardiovascular system development GO:0072358 82 0.076
fibroblast growth factor receptor signaling pathway GO:0008543 10 0.075
stem cell development GO:0048864 79 0.073
negative regulation of protein metabolic process GO:0051248 85 0.073
positive regulation of rna biosynthetic process GO:1902680 266 0.073
regulation of purine nucleotide catabolic process GO:0033121 48 0.072
regulation of intracellular protein transport GO:0033157 46 0.071
regulation of wnt signaling pathway GO:0030111 68 0.071
phagocytosis GO:0006909 215 0.071
regulation of protein metabolic process GO:0051246 256 0.071
protein phosphorylation GO:0006468 169 0.070
regulation of synapse structure and activity GO:0050803 128 0.070
macromolecule catabolic process GO:0009057 161 0.067
signal transduction by phosphorylation GO:0023014 107 0.067
negative regulation of response to stimulus GO:0048585 258 0.065
negative regulation of proteolysis GO:0045861 31 0.065
ribonucleoside triphosphate metabolic process GO:0009199 119 0.063
gtp catabolic process GO:0006184 72 0.063
positive regulation of phosphorus metabolic process GO:0010562 139 0.062
eye morphogenesis GO:0048592 260 0.061
single organism intracellular transport GO:1902582 207 0.061
regulation of phosphate metabolic process GO:0019220 210 0.060
dendrite development GO:0016358 204 0.060
regulation of erk1 and erk2 cascade GO:0070372 39 0.059
purine nucleoside catabolic process GO:0006152 112 0.057
response to fibroblast growth factor GO:0071774 10 0.057
post embryonic appendage morphogenesis GO:0035120 385 0.057
positive regulation of developmental growth GO:0048639 62 0.056
mapk cascade GO:0000165 107 0.056
negative regulation of molecular function GO:0044092 51 0.055
rubidium ion transport GO:0035826 1 0.055
intracellular protein transport GO:0006886 104 0.054
negative regulation of gene expression GO:0010629 387 0.053
regulation of cytoplasmic transport GO:1903649 47 0.053
protein targeting to nucleus GO:0044744 51 0.052
regulation of proteolysis GO:0030162 87 0.051
regulation of nucleocytoplasmic transport GO:0046822 35 0.051
axonogenesis GO:0007409 290 0.051
regulation of nucleoside metabolic process GO:0009118 50 0.051
gland development GO:0048732 191 0.051
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.050
nucleoside triphosphate metabolic process GO:0009141 120 0.050
regulation of protein localization GO:0032880 76 0.049
programmed cell death GO:0012501 257 0.049
purine nucleoside triphosphate catabolic process GO:0009146 108 0.049
nucleoside triphosphate catabolic process GO:0009143 108 0.049
positive regulation of cellular catabolic process GO:0031331 95 0.048
purine ribonucleoside catabolic process GO:0046130 112 0.048
regulation of protein modification process GO:0031399 112 0.048
protein maturation GO:0051604 71 0.048
glycosyl compound catabolic process GO:1901658 112 0.048
protein modification by small protein conjugation or removal GO:0070647 106 0.047
protein ubiquitination GO:0016567 70 0.047
single organism cellular localization GO:1902580 180 0.046
negative regulation of wnt signaling pathway GO:0030178 28 0.046
negative regulation of cellular metabolic process GO:0031324 382 0.046
morphogenesis of an epithelium GO:0002009 276 0.046
regulation of multicellular organismal development GO:2000026 414 0.044
ectodermal placode formation GO:0060788 4 0.044
ribonucleoside catabolic process GO:0042454 112 0.043
response to external biotic stimulus GO:0043207 293 0.043
regulation of rab gtpase activity GO:0032313 7 0.043
regulation of nervous system development GO:0051960 248 0.043
immune system development GO:0002520 57 0.043
carbohydrate derivative metabolic process GO:1901135 217 0.043
gene silencing by rna GO:0031047 57 0.042
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 37 0.042
regulation of intracellular transport GO:0032386 64 0.041
regulation of mapk cascade GO:0043408 92 0.041
positive regulation of nucleoside metabolic process GO:0045979 47 0.040
cellular nitrogen compound catabolic process GO:0044270 165 0.040
mitotic nuclear division GO:0007067 213 0.039
nucleoside catabolic process GO:0009164 112 0.039
regulation of programmed cell death GO:0043067 152 0.038
organelle localization GO:0051640 148 0.037
appendage development GO:0048736 401 0.037
developmental growth involved in morphogenesis GO:0060560 65 0.036
regulation of nucleotide catabolic process GO:0030811 48 0.036
regulation of neuron differentiation GO:0045664 103 0.036
cell cycle phase transition GO:0044770 140 0.035
homeostatic process GO:0042592 199 0.035
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 24 0.035
purine nucleoside metabolic process GO:0042278 127 0.035
regulation of g1 s transition of mitotic cell cycle GO:2000045 23 0.034
regulation of localization GO:0032879 275 0.034
positive regulation of intracellular signal transduction GO:1902533 116 0.034
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.034
appendage morphogenesis GO:0035107 397 0.033
organic substance transport GO:0071702 257 0.033
smoothened signaling pathway GO:0007224 49 0.033
periodic partitioning GO:0007365 29 0.033
mesoderm development GO:0007498 78 0.032
ribonucleotide catabolic process GO:0009261 109 0.032
meiosis i GO:0007127 59 0.032
protein import into nucleus GO:0006606 51 0.032
morphogenesis of embryonic epithelium GO:0016331 94 0.031
purine ribonucleoside metabolic process GO:0046128 127 0.031
negative regulation of phosphorylation GO:0042326 35 0.031
negative regulation of protein processing GO:0010955 31 0.030
central nervous system development GO:0007417 201 0.030
forebrain development GO:0030900 2 0.029
positive regulation of transport GO:0051050 92 0.029
nuclear transport GO:0051169 72 0.028
cell cycle g1 s phase transition GO:0044843 31 0.028
spindle assembly GO:0051225 80 0.028
mitotic spindle organization GO:0007052 220 0.028
mitotic dna damage checkpoint GO:0044773 74 0.027
regulation of stress activated mapk cascade GO:0032872 41 0.027
reproductive system development GO:0061458 74 0.027
response to endogenous stimulus GO:0009719 119 0.027
head development GO:0060322 135 0.027
organelle assembly GO:0070925 198 0.027
regulation of stem cell proliferation GO:0072091 40 0.027
purine nucleoside triphosphate metabolic process GO:0009144 119 0.026
response to growth factor GO:0070848 31 0.026
enzyme linked receptor protein signaling pathway GO:0007167 179 0.026
regulation of developmental growth GO:0048638 174 0.026
axon development GO:0061564 297 0.025
regulation of protein localization to nucleus GO:1900180 29 0.025
regulation of growth GO:0040008 233 0.025
response to radiation GO:0009314 155 0.025
regulation of organelle organization GO:0033043 196 0.025
camera type eye development GO:0043010 4 0.025
proteolysis GO:0006508 192 0.024
epithelial cell development GO:0002064 274 0.024
regulation of jnk cascade GO:0046328 40 0.023
regulation of establishment of protein localization GO:0070201 61 0.023
spindle organization GO:0007051 253 0.023
positive regulation of proteolysis GO:0045862 52 0.022
protein processing GO:0016485 68 0.022
positive regulation of purine nucleotide catabolic process GO:0033123 46 0.022
negative regulation of nucleic acid templated transcription GO:1903507 240 0.022
positive regulation of nucleotide catabolic process GO:0030813 46 0.021
reproductive structure development GO:0048608 74 0.021
spermatogenesis GO:0007283 200 0.021
positive regulation of response to stimulus GO:0048584 323 0.021
sensory organ morphogenesis GO:0090596 260 0.021
ectodermal placode development GO:0071696 4 0.020
ubiquitin dependent protein catabolic process GO:0006511 78 0.020
positive regulation of signaling GO:0023056 243 0.020
camera type eye morphogenesis GO:0048593 2 0.020
neuromuscular junction development GO:0007528 149 0.020
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.020
stress activated mapk cascade GO:0051403 52 0.020
regulation of proteasomal protein catabolic process GO:0061136 39 0.020
protein complex biogenesis GO:0070271 201 0.020
collateral sprouting GO:0048668 3 0.020
convergent extension involved in gastrulation GO:0060027 2 0.020
negative regulation of intracellular signal transduction GO:1902532 57 0.019
positive regulation of signal transduction GO:0009967 223 0.019
single organism catabolic process GO:0044712 228 0.019
axon guidance GO:0007411 233 0.019
organic acid metabolic process GO:0006082 103 0.019
response to organic substance GO:0010033 284 0.019
negative regulation of cellular component organization GO:0051129 108 0.018
regulation of mitotic cell cycle phase transition GO:1901990 130 0.018
regulation of cell cycle GO:0051726 291 0.018
nucleobase containing small molecule metabolic process GO:0055086 174 0.018
protein targeting GO:0006605 64 0.018
positive regulation of rab gtpase activity GO:0032851 7 0.018
positive regulation of cell communication GO:0010647 250 0.018
connective tissue development GO:0061448 3 0.018
cellular protein catabolic process GO:0044257 83 0.018
peptidyl amino acid modification GO:0018193 105 0.018
cellular response to growth factor stimulus GO:0071363 30 0.018
regulation of hemocyte proliferation GO:0035206 37 0.018
regulation of transport GO:0051049 181 0.017
establishment or maintenance of cell polarity GO:0007163 167 0.017
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.017
glycosyl compound metabolic process GO:1901657 127 0.017
learning or memory GO:0007611 141 0.017
protein import GO:0017038 55 0.017
cellular response to endogenous stimulus GO:0071495 80 0.017
positive regulation of macromolecule metabolic process GO:0010604 405 0.017
modification dependent macromolecule catabolic process GO:0043632 79 0.017
protein modification by small protein conjugation GO:0032446 79 0.016
nucleoside metabolic process GO:0009116 127 0.016
negative regulation of cell cycle phase transition GO:1901988 103 0.016
regulation of cell cycle process GO:0010564 181 0.016
regulation of phosphorylation GO:0042325 147 0.016
establishment of vesicle localization GO:0051650 51 0.016
segment polarity determination GO:0007367 25 0.016
development of primary sexual characteristics GO:0045137 50 0.016
gastrulation GO:0007369 70 0.016
positive regulation of biosynthetic process GO:0009891 316 0.016
dorsal closure GO:0007391 79 0.015
nucleoside phosphate metabolic process GO:0006753 162 0.015
positive regulation of purine nucleotide metabolic process GO:1900544 55 0.015
eye antennal disc development GO:0035214 60 0.015
synapse organization GO:0050808 196 0.015
telencephalon development GO:0021537 2 0.015
regulation of cellular component biogenesis GO:0044087 201 0.015
purine containing compound catabolic process GO:0072523 112 0.015
protein localization to nucleus GO:0034504 55 0.015
multicellular organism growth GO:0035264 46 0.015
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.015
establishment of organelle localization GO:0051656 122 0.015
neural retina development GO:0003407 4 0.015
regulation of cell cycle g1 s phase transition GO:1902806 23 0.015
nucleotide metabolic process GO:0009117 161 0.015
mesenchymal cell differentiation GO:0048762 1 0.015
erk1 and erk2 cascade GO:0070371 39 0.014
carbohydrate derivative catabolic process GO:1901136 118 0.014
ribose phosphate metabolic process GO:0019693 145 0.014
positive regulation of mapk cascade GO:0043410 63 0.014
sensory perception of sound GO:0007605 56 0.014
negative regulation of chromosome organization GO:2001251 19 0.014
imaginal disc growth GO:0007446 37 0.014
growth GO:0040007 359 0.014
regulation of cellular response to stress GO:0080135 89 0.014
mitotic dna integrity checkpoint GO:0044774 75 0.014
regulation of transmembrane transporter activity GO:0022898 6 0.014
cell death GO:0008219 279 0.014
negative regulation of proteolysis involved in cellular protein catabolic process GO:1903051 17 0.014
regulation of viral genome replication GO:0045069 4 0.014
positive regulation of protein metabolic process GO:0051247 128 0.014
positive regulation of cell development GO:0010720 61 0.013
positive regulation of stem cell differentiation GO:2000738 3 0.013
hematopoietic or lymphoid organ development GO:0048534 57 0.013
regulation of purine nucleotide metabolic process GO:1900542 62 0.013
nucleoside phosphate catabolic process GO:1901292 110 0.013
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.013
dna templated transcription elongation GO:0006354 18 0.013
regulation of response to external stimulus GO:0032101 115 0.013
nuclear import GO:0051170 51 0.013
stem cell proliferation GO:0072089 88 0.013
nuclear division GO:0000280 332 0.013
regulation of protein targeting GO:1903533 29 0.013
sister chromatid segregation GO:0000819 92 0.012
regulation of epithelial cell proliferation GO:0050678 4 0.012
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.012
leg disc morphogenesis GO:0007478 80 0.012
bmp signaling pathway GO:0030509 27 0.012
mesenchymal cell development GO:0014031 1 0.012
aging GO:0007568 143 0.012
regulation of cell development GO:0060284 215 0.012
post embryonic hemopoiesis GO:0035166 17 0.012
photoreceptor cell differentiation GO:0046530 170 0.012
stem cell differentiation GO:0048863 117 0.012
aromatic compound catabolic process GO:0019439 166 0.012
hindbrain development GO:0030902 2 0.012
embryonic organ development GO:0048568 50 0.012
dephosphorylation GO:0016311 51 0.011
dna methylation or demethylation GO:0044728 4 0.011
limb development GO:0060173 1 0.011
histone h3 k27 methylation GO:0070734 6 0.011
spinal cord development GO:0021510 1 0.011
meiotic cell cycle GO:0051321 171 0.011
mitotic cell cycle phase transition GO:0044772 138 0.011
neural precursor cell proliferation GO:0061351 75 0.011
mushroom body development GO:0016319 70 0.011
positive regulation of hydrolase activity GO:0051345 78 0.011
sensory perception of mechanical stimulus GO:0050954 72 0.011
cellular response to light stimulus GO:0071482 37 0.011
regulation of striated muscle contraction GO:0006942 2 0.011
male gamete generation GO:0048232 201 0.011
negative regulation of cell death GO:0060548 81 0.011
instar larval development GO:0002168 55 0.011
hemopoiesis GO:0030097 46 0.010
nephron tubule morphogenesis GO:0072078 3 0.010
mitotic cell cycle checkpoint GO:0007093 88 0.010
negative regulation of rna metabolic process GO:0051253 251 0.010
meiotic cell cycle process GO:1903046 132 0.010
negative regulation of smoothened signaling pathway GO:0045879 16 0.010
adult locomotory behavior GO:0008344 76 0.010
ribonucleotide metabolic process GO:0009259 145 0.010
response to light stimulus GO:0009416 124 0.010

lgs disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.022
disease of anatomical entity DOID:7 0 0.019
cancer DOID:162 0 0.015
organ system cancer DOID:0050686 0 0.015