Drosophila melanogaster

51 known processes

Tpi (Dmel_CG2171)

Triose phosphate isomerase

(Aliases: ND14,wstd,CG2171,Dmel\CG2171,TPI,TPIS,sgk,tpi)

Tpi biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
myoblast fusion GO:0007520 43 0.988
aging GO:0007568 143 0.929
syncytium formation by plasma membrane fusion GO:0000768 43 0.877
paracrine signaling GO:0038001 7 0.851
organonitrogen compound metabolic process GO:1901564 318 0.798
syncytium formation GO:0006949 43 0.779
response to oxygen radical GO:0000305 3 0.744
response to organic substance GO:0010033 284 0.740
response to oxidative stress GO:0006979 86 0.731
response to abiotic stimulus GO:0009628 341 0.715
muscle cell differentiation GO:0042692 103 0.673
oxidation reduction process GO:0055114 123 0.668
small molecule metabolic process GO:0044281 305 0.629
acetaldehyde metabolic process GO:0006117 5 0.550
age dependent general metabolic decline GO:0007571 3 0.511
myotube differentiation GO:0014902 46 0.505
response to hydrogen peroxide GO:0042542 11 0.488
purine nucleoside metabolic process GO:0042278 127 0.419
response to superoxide GO:0000303 3 0.415
single organism biosynthetic process GO:0044711 206 0.397
defense response GO:0006952 300 0.391
response to metal ion GO:0010038 23 0.386
age dependent response to oxidative stress GO:0001306 3 0.375
pyruvate metabolic process GO:0006090 7 0.353
determination of adult lifespan GO:0008340 137 0.351
oxoacid metabolic process GO:0043436 103 0.347
nucleobase containing small molecule metabolic process GO:0055086 174 0.335
muscle structure development GO:0061061 224 0.315
response to oxygen containing compound GO:1901700 200 0.311
response to extracellular stimulus GO:0009991 116 0.286
striated muscle cell differentiation GO:0051146 90 0.259
carboxylic acid metabolic process GO:0019752 92 0.250
multicellular organismal aging GO:0010259 140 0.250
ribonucleoside biosynthetic process GO:0042455 3 0.237
nucleoside metabolic process GO:0009116 127 0.236
hydrogen peroxide catabolic process GO:0042744 6 0.230
immune system process GO:0002376 347 0.220
organic hydroxy compound metabolic process GO:1901615 83 0.217
organonitrogen compound biosynthetic process GO:1901566 117 0.208
response to reactive oxygen species GO:0000302 24 0.205
regulation of programmed cell death GO:0043067 152 0.203
purine containing compound metabolic process GO:0072521 155 0.199
response to heat GO:0009408 63 0.191
single organism behavior GO:0044708 391 0.188
lipid metabolic process GO:0006629 121 0.183
response to inorganic substance GO:0010035 44 0.177
cellular response to chemical stimulus GO:0070887 199 0.174
death GO:0016265 284 0.164
organophosphate metabolic process GO:0019637 195 0.162
Mouse
somatic muscle development GO:0007525 66 0.159
response to organophosphorus GO:0046683 2 0.157
generation of precursor metabolites and energy GO:0006091 42 0.155
purine ribonucleoside metabolic process GO:0046128 127 0.154
organic acid metabolic process GO:0006082 103 0.153
ribonucleoside triphosphate metabolic process GO:0009199 119 0.151
response to nitrogen compound GO:1901698 90 0.146
regulation of cellular response to oxidative stress GO:1900407 4 0.146
carbohydrate derivative metabolic process GO:1901135 217 0.142
Mouse
negative regulation of biosynthetic process GO:0009890 277 0.141
response to external biotic stimulus GO:0043207 293 0.139
response to other organism GO:0051707 293 0.134
oxidative phosphorylation GO:0006119 9 0.129
organic substance catabolic process GO:1901575 308 0.128
immune response GO:0006955 246 0.124
spermatogenesis GO:0007283 200 0.123
atp biosynthetic process GO:0006754 2 0.120
catabolic process GO:0009056 409 0.119
organophosphate biosynthetic process GO:0090407 46 0.118
energy derivation by oxidation of organic compounds GO:0015980 32 0.118
glycosyl compound metabolic process GO:1901657 127 0.117
cellular lipid metabolic process GO:0044255 83 0.115
nucleoside phosphate metabolic process GO:0006753 162 0.107
ribose phosphate metabolic process GO:0019693 145 0.104
response to organonitrogen compound GO:0010243 75 0.103
response to starvation GO:0042594 97 0.100
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.100
peptide metabolic process GO:0006518 80 0.099
positive regulation of transcription dna templated GO:0045893 266 0.098
innate immune response GO:0045087 144 0.097
negative regulation of multicellular organismal process GO:0051241 142 0.096
response to oxygen levels GO:0070482 59 0.095
cellular response to salt stress GO:0071472 1 0.095
cell death GO:0008219 279 0.094
cell aging GO:0007569 2 0.093
cellular response to reactive oxygen species GO:0034614 14 0.093
response to endogenous stimulus GO:0009719 119 0.092
ribonucleoside metabolic process GO:0009119 127 0.091
cellular amino acid metabolic process GO:0006520 61 0.090
apoptotic process GO:0006915 159 0.089
response to nutrient levels GO:0031667 114 0.086
nucleotide metabolic process GO:0009117 161 0.085
monocarboxylic acid metabolic process GO:0032787 29 0.083
cellular component assembly involved in morphogenesis GO:0010927 151 0.083
Worm
single organism catabolic process GO:0044712 228 0.083
cellular response to superoxide GO:0071451 3 0.083
cellular response to starvation GO:0009267 61 0.083
cellular response to dna damage stimulus GO:0006974 223 0.082
response to bacterium GO:0009617 198 0.081
atp metabolic process GO:0046034 49 0.079
cellular response to arsenic containing substance GO:0071243 6 0.079
positive regulation of reactive oxygen species metabolic process GO:2000379 0 0.077
nad metabolic process GO:0019674 1 0.076
nicotinamide nucleotide metabolic process GO:0046496 2 0.074
response to wounding GO:0009611 94 0.073
carbohydrate catabolic process GO:0016052 7 0.073
purine nucleoside triphosphate metabolic process GO:0009144 119 0.072
intracellular signal transduction GO:0035556 300 0.071
purine nucleoside biosynthetic process GO:0042451 3 0.067
response to organic cyclic compound GO:0014070 89 0.065
cellular response to oxidative stress GO:0034599 28 0.062
response to ethanol GO:0045471 59 0.061
response to hexose GO:0009746 3 0.060
regulation of response to oxidative stress GO:1902882 4 0.060
programmed cell death GO:0012501 257 0.059
cellular catabolic process GO:0044248 372 0.059
single organism carbohydrate metabolic process GO:0044723 72 0.058
cellular macromolecular complex assembly GO:0034622 153 0.056
Worm
ribonucleoside triphosphate biosynthetic process GO:0009201 2 0.055
purine ribonucleoside triphosphate biosynthetic process GO:0009206 2 0.055
positive regulation of cell death GO:0010942 69 0.054
epithelial cell differentiation GO:0030855 322 0.053
response to osmotic stress GO:0006970 14 0.053
phosphorylation GO:0016310 294 0.052
glycolytic process GO:0006096 6 0.052
response to temperature stimulus GO:0009266 106 0.052
regulation of anatomical structure size GO:0090066 163 0.052
dorsal appendage formation GO:0046843 47 0.052
purine nucleotide metabolic process GO:0006163 146 0.051
response to transition metal nanoparticle GO:1990267 9 0.051
regulation of cellular catabolic process GO:0031329 157 0.051
ribonucleotide catabolic process GO:0009261 109 0.050
glycosyl compound biosynthetic process GO:1901659 3 0.049
protein complex assembly GO:0006461 200 0.049
Worm
endocytosis GO:0006897 310 0.049
regulation of immune system process GO:0002682 176 0.048
behavioral response to ethanol GO:0048149 49 0.048
response to biotic stimulus GO:0009607 294 0.048
regulation of apoptotic process GO:0042981 130 0.047
positive regulation of response to stimulus GO:0048584 323 0.046
maintenance of location GO:0051235 73 0.046
purine ribonucleoside monophosphate metabolic process GO:0009167 50 0.046
nucleoside biosynthetic process GO:0009163 3 0.046
carbohydrate derivative biosynthetic process GO:1901137 85 0.045
purine ribonucleotide metabolic process GO:0009150 145 0.045
cellular protein complex assembly GO:0043623 71 0.044
Worm
cellular modified amino acid metabolic process GO:0006575 45 0.043
ribonucleotide metabolic process GO:0009259 145 0.043
spermatid differentiation GO:0048515 114 0.043
purine nucleoside monophosphate metabolic process GO:0009126 50 0.041
posttranscriptional regulation of gene expression GO:0010608 145 0.041
positive regulation of programmed cell death GO:0043068 62 0.041
inorganic ion transmembrane transport GO:0098660 73 0.040
regulation of multicellular organismal development GO:2000026 414 0.040
cellular response to metal ion GO:0071248 6 0.039
macromolecular complex assembly GO:0065003 256 0.039
Worm
adult locomotory behavior GO:0008344 76 0.039
cellular respiration GO:0045333 26 0.039
purine containing compound catabolic process GO:0072523 112 0.039
respiratory electron transport chain GO:0022904 11 0.038
purine nucleoside monophosphate biosynthetic process GO:0009127 3 0.038
nucleoside phosphate biosynthetic process GO:1901293 34 0.038
regulation of cell death GO:0010941 173 0.038
cellular response to organic substance GO:0071310 132 0.037
cellular response to hormone stimulus GO:0032870 44 0.037
negative regulation of programmed cell death GO:0043069 72 0.036
epithelial cell development GO:0002064 274 0.036
organonitrogen compound catabolic process GO:1901565 128 0.034
ribonucleoside monophosphate metabolic process GO:0009161 51 0.034
nucleoside monophosphate metabolic process GO:0009123 52 0.034
regulation of intracellular signal transduction GO:1902531 236 0.034
regulation of catabolic process GO:0009894 170 0.033
sulfur compound metabolic process GO:0006790 59 0.033
inorganic cation transmembrane transport GO:0098662 61 0.033
purine ribonucleoside monophosphate biosynthetic process GO:0009168 3 0.031
organophosphate catabolic process GO:0046434 112 0.030
mitochondrion organization GO:0007005 65 0.030
cellular response to extracellular stimulus GO:0031668 64 0.030
response to glucose GO:0009749 2 0.029
cellular response to external stimulus GO:0071496 66 0.029
negative regulation of cell cycle GO:0045786 116 0.029
ion transport GO:0006811 145 0.028
striated muscle myosin thick filament assembly GO:0071688 3 0.028
Worm
purine ribonucleoside biosynthetic process GO:0046129 3 0.028
pyridine containing compound metabolic process GO:0072524 3 0.028
localization of cell GO:0051674 257 0.027
carbohydrate metabolic process GO:0005975 82 0.027
larval development GO:0002164 104 0.027
cellular response to nutrient levels GO:0031669 62 0.027
male gamete generation GO:0048232 201 0.026
regulation of myotube differentiation GO:0010830 6 0.026
homeostatic process GO:0042592 199 0.025
Worm
glucose metabolic process GO:0006006 5 0.025
Mouse
regulation of cellular amine metabolic process GO:0033238 3 0.024
regulation of gtpase activity GO:0043087 44 0.024
ribose phosphate biosynthetic process GO:0046390 28 0.024
response to hyperoxia GO:0055093 3 0.024
small molecule biosynthetic process GO:0044283 37 0.024
electron transport chain GO:0022900 14 0.024
nucleoside triphosphate metabolic process GO:0009141 120 0.024
cellular response to oxygen containing compound GO:1901701 79 0.024
cellular nitrogen compound catabolic process GO:0044270 165 0.023
protein complex biogenesis GO:0070271 201 0.023
Worm
cation transmembrane transport GO:0098655 88 0.023
regulation of cellular protein metabolic process GO:0032268 243 0.022
cellular ketone metabolic process GO:0042180 24 0.022
signal transduction by phosphorylation GO:0023014 107 0.022
positive regulation of cellular biosynthetic process GO:0031328 316 0.022
regulation of anatomical structure morphogenesis GO:0022603 242 0.022
purine ribonucleotide catabolic process GO:0009154 109 0.022
regulation of phosphate metabolic process GO:0019220 210 0.022
appendage morphogenesis GO:0035107 397 0.022
purine ribonucleoside catabolic process GO:0046130 112 0.022
regulation of cell development GO:0060284 215 0.021
spermatid development GO:0007286 98 0.021
positive regulation of biosynthetic process GO:0009891 316 0.021
macromolecule catabolic process GO:0009057 161 0.020
nucleobase containing compound catabolic process GO:0034655 165 0.020
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.020
negative regulation of developmental process GO:0051093 201 0.020
negative regulation of apoptotic process GO:0043066 63 0.020
heart development GO:0007507 82 0.019
vesicle mediated transport GO:0016192 381 0.019
positive regulation of macromolecule metabolic process GO:0010604 405 0.019
positive regulation of cell motility GO:2000147 3 0.019
defense response to gram negative bacterium GO:0050829 94 0.019
regulation of nitric oxide biosynthetic process GO:0045428 1 0.019
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.019
oxidoreduction coenzyme metabolic process GO:0006733 2 0.019
cellular amide metabolic process GO:0043603 80 0.019
metal ion homeostasis GO:0055065 44 0.019
regulation of mapk cascade GO:0043408 92 0.018
cuticle development GO:0042335 86 0.018
alcohol metabolic process GO:0006066 25 0.018
transcription from rna polymerase ii promoter GO:0006366 368 0.018
heart morphogenesis GO:0003007 32 0.018
circulatory system process GO:0003013 37 0.018
ribonucleoside catabolic process GO:0042454 112 0.018
carbohydrate derivative catabolic process GO:1901136 118 0.017
nucleoside catabolic process GO:0009164 112 0.017
glutathione metabolic process GO:0006749 37 0.017
forebrain development GO:0030900 2 0.017
negative regulation of cellular biosynthetic process GO:0031327 277 0.017
cell adhesion GO:0007155 136 0.017
negative regulation of signaling GO:0023057 219 0.017
negative regulation of cell death GO:0060548 81 0.017
response to salt stress GO:0009651 11 0.017
regulation of cellular component size GO:0032535 98 0.017
regulation of lipid metabolic process GO:0019216 15 0.017
regulation of purine nucleotide metabolic process GO:1900542 62 0.017
monovalent inorganic cation transport GO:0015672 40 0.017
response to hypoxia GO:0001666 53 0.017
regulation of response to stress GO:0080134 200 0.016
phagocytosis GO:0006909 215 0.016
lipid biosynthetic process GO:0008610 46 0.016
enzyme linked receptor protein signaling pathway GO:0007167 179 0.016
actin filament based process GO:0030029 220 0.016
Worm
heterocycle catabolic process GO:0046700 166 0.016
positive regulation of phosphorus metabolic process GO:0010562 139 0.016
response to decreased oxygen levels GO:0036293 58 0.016
regulation of dna templated transcription in response to stress GO:0043620 4 0.016
ribonucleoside triphosphate catabolic process GO:0009203 108 0.016
purine nucleotide biosynthetic process GO:0006164 29 0.015
cell type specific apoptotic process GO:0097285 38 0.015
cellular response to insulin stimulus GO:0032869 28 0.015
wing disc morphogenesis GO:0007472 344 0.015
regulation of mitochondrion organization GO:0010821 12 0.015
regulation of catalytic activity GO:0050790 185 0.015
cellular homeostasis GO:0019725 80 0.015
Worm
purine nucleotide catabolic process GO:0006195 109 0.015
regulation of nucleotide catabolic process GO:0030811 48 0.015
glycerolipid metabolic process GO:0046486 34 0.015
response to light stimulus GO:0009416 124 0.015
positive regulation of intracellular signal transduction GO:1902533 116 0.015
response to hormone GO:0009725 45 0.014
plasma membrane organization GO:0007009 26 0.014
nucleoside triphosphate catabolic process GO:0009143 108 0.014
glucan biosynthetic process GO:0009250 2 0.014
heart process GO:0003015 37 0.014
imaginal disc derived wing morphogenesis GO:0007476 337 0.014
regulation of cell differentiation GO:0045595 302 0.014
positive regulation of immune system process GO:0002684 68 0.014
regulation of immune response GO:0050776 118 0.014
positive regulation of molecular function GO:0044093 136 0.014
sex differentiation GO:0007548 81 0.014
cell migration GO:0016477 238 0.013
regulation of nucleoside metabolic process GO:0009118 50 0.013
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.013
mitochondrial atp synthesis coupled electron transport GO:0042775 8 0.013
positive regulation of cell communication GO:0010647 250 0.013
positive regulation of nucleoside metabolic process GO:0045979 47 0.013
positive regulation of nitric oxide biosynthetic process GO:0045429 1 0.013
developmental growth GO:0048589 280 0.013
sterol metabolic process GO:0016125 12 0.013
cellular aldehyde metabolic process GO:0006081 10 0.013
Mouse
negative regulation of cell differentiation GO:0045596 143 0.013
regulation of protein metabolic process GO:0051246 256 0.013
aromatic compound catabolic process GO:0019439 166 0.013
synaptic transmission GO:0007268 288 0.013
cellular response to peptide hormone stimulus GO:0071375 28 0.012
alcohol biosynthetic process GO:0046165 14 0.012
ribonucleotide biosynthetic process GO:0009260 28 0.012
atp synthesis coupled electron transport GO:0042773 8 0.012
lipid storage GO:0019915 38 0.012
cellular amine metabolic process GO:0044106 12 0.012
negative regulation of protein metabolic process GO:0051248 85 0.012
imaginal disc derived appendage development GO:0048737 399 0.012
regulation of signal transduction by p53 class mediator GO:1901796 1 0.012
cell motility GO:0048870 251 0.012
purine ribonucleotide biosynthetic process GO:0009152 28 0.012
positive regulation of signal transduction GO:0009967 223 0.012
nucleoside phosphate catabolic process GO:1901292 110 0.012
regionalization GO:0003002 416 0.011
positive regulation of mapk cascade GO:0043410 63 0.011
carboxylic acid transport GO:0046942 18 0.011
neuron death GO:0070997 27 0.011
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.011
cellular response to endogenous stimulus GO:0071495 80 0.011
anion transport GO:0006820 41 0.011
negative regulation of cellular component organization GO:0051129 108 0.011
proteolysis GO:0006508 192 0.011
negative regulation of lipid metabolic process GO:0045833 3 0.011
wound healing GO:0042060 75 0.011
locomotory behavior GO:0007626 176 0.011
response to toxic substance GO:0009636 22 0.011
regulation of organelle organization GO:0033043 196 0.011
immune response activating signal transduction GO:0002757 2 0.011
response to lipid GO:0033993 38 0.011
alcohol catabolic process GO:0046164 4 0.011
response to monosaccharide GO:0034284 4 0.011
organic hydroxy compound catabolic process GO:1901616 4 0.011
positive regulation of catalytic activity GO:0043085 118 0.010
regulation of phosphorus metabolic process GO:0051174 210 0.010
positive regulation of catabolic process GO:0009896 105 0.010
defense response to bacterium GO:0042742 178 0.010
regulation of hydrolase activity GO:0051336 97 0.010
cell proliferation GO:0008283 299 0.010
cellular biogenic amine catabolic process GO:0042402 1 0.010
negative regulation of organelle organization GO:0010639 56 0.010
response to lipopolysaccharide GO:0032496 4 0.010
regulation of cell morphogenesis GO:0022604 163 0.010

Tpi disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.364
nervous system disease DOID:863 0 0.020
cancer DOID:162 0 0.014
disease of cellular proliferation DOID:14566 0 0.014
organ system cancer DOID:0050686 0 0.014
immune system disease DOID:2914 0 0.014
anemia DOID:2355 0 0.014
hematopoietic system disease DOID:74 0 0.014
central nervous system disease DOID:331 0 0.013
neurodegenerative disease DOID:1289 0 0.013