Drosophila melanogaster

37 known processes

Mlc2 (Dmel_CG2184)

Myosin light chain 2

(Aliases: MLC,CG2184,LC2,MLC 2,DmMLC2,mlc2,Ifm(3)99Eb,mlc-2,RLC,MLC2,RLC2,dro MLC-2,MYL2,MLC-2,Dmel\CG2184,l(3)99Eb,Dmlc2,MRLC)

Mlc2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
sarcomere organization GO:0045214 26 0.993
myofibril assembly GO:0030239 36 0.945
striated muscle cell development GO:0055002 50 0.910
muscle cell development GO:0055001 50 0.809
muscle structure development GO:0061061 224 0.792
cellular component assembly involved in morphogenesis GO:0010927 151 0.786
actin cytoskeleton organization GO:0030036 206 0.771
actin filament based process GO:0030029 220 0.575
striated muscle cell differentiation GO:0051146 90 0.534
actomyosin structure organization GO:0031032 56 0.519
alditol phosphate metabolic process GO:0052646 2 0.430
body morphogenesis GO:0010171 2 0.408
muscle cell differentiation GO:0042692 103 0.341
muscle thin filament assembly GO:0071689 5 0.329
organelle assembly GO:0070925 198 0.316
adult behavior GO:0030534 137 0.311
cell motility GO:0048870 251 0.283
Fly
locomotory behavior GO:0007626 176 0.263
actin filament organization GO:0007015 126 0.263
regulation of actin filament depolymerization GO:0030834 3 0.245
striated muscle myosin thick filament assembly GO:0071688 3 0.227
glycerol 3 phosphate metabolic process GO:0006072 2 0.203
skeletal myofibril assembly GO:0014866 6 0.180
circulatory system process GO:0003013 37 0.170
regulation of anatomical structure morphogenesis GO:0022603 242 0.165
skeletal muscle adaptation GO:0043501 1 0.162
nucleoside triphosphate catabolic process GO:0009143 108 0.146
mitotic nuclear division GO:0007067 213 0.143
somatic muscle development GO:0007525 66 0.131
cell migration GO:0016477 238 0.130
Fly
muscle organ development GO:0007517 127 0.123
regulation of actin filament length GO:0030832 27 0.120
macromolecular complex assembly GO:0065003 256 0.118
skeletal muscle myosin thick filament assembly GO:0030241 3 0.109
positive regulation of nucleoside metabolic process GO:0045979 47 0.107
regulation of cytoskeleton organization GO:0051493 89 0.106
Fly
protein complex assembly GO:0006461 200 0.104
organophosphate metabolic process GO:0019637 195 0.102
negative regulation of cytoskeleton organization GO:0051494 30 0.099
regulation of hydrolase activity GO:0051336 97 0.098
cellular carbohydrate catabolic process GO:0044275 2 0.097
heart process GO:0003015 37 0.092
negative regulation of actin filament depolymerization GO:0030835 2 0.091
regulation of organelle organization GO:0033043 196 0.087
Fly
regulation of protein complex disassembly GO:0043244 29 0.087
camera type eye development GO:0043010 4 0.084
actin filament depolymerization GO:0030042 5 0.083
skeletal muscle tissue development GO:0007519 13 0.079
cellular protein complex disassembly GO:0043624 35 0.079
regulation of multicellular organismal development GO:2000026 414 0.074
localization of cell GO:0051674 257 0.072
Fly
multicellular organismal reproductive behavior GO:0033057 110 0.072
protein complex biogenesis GO:0070271 201 0.071
positive regulation of cellular component organization GO:0051130 156 0.069
positive regulation of purine nucleotide catabolic process GO:0033123 46 0.068
actin polymerization or depolymerization GO:0008154 31 0.068
larval development GO:0002164 104 0.066
regulation of localization GO:0032879 275 0.066
regionalization GO:0003002 416 0.065
Fly
flight behavior GO:0007629 26 0.065
regulation of cell differentiation GO:0045595 302 0.065
cellular macromolecular complex assembly GO:0034622 153 0.064
adult locomotory behavior GO:0008344 76 0.061
regulation of protein complex assembly GO:0043254 42 0.061
cellular protein complex assembly GO:0043623 71 0.061
regulation of actin filament based process GO:0032970 42 0.061
Fly
muscle tissue morphogenesis GO:0060415 2 0.060
protein depolymerization GO:0051261 31 0.059
regulation of actin filament polymerization GO:0030833 25 0.059
brain development GO:0007420 120 0.057
myotube cell development GO:0014904 3 0.057
organic substance catabolic process GO:1901575 308 0.056
ribonucleoside catabolic process GO:0042454 112 0.056
skeletal muscle fiber development GO:0048741 3 0.055
regulation of actin cytoskeleton organization GO:0032956 42 0.055
Fly
nucleotide catabolic process GO:0009166 109 0.054
striated muscle tissue development GO:0014706 27 0.053
multi multicellular organism process GO:0044706 123 0.053
ribonucleoside triphosphate metabolic process GO:0009199 119 0.052
actin filament polymerization GO:0030041 27 0.052
establishment of localization in cell GO:0051649 402 0.051
Fly
positive regulation of macromolecule metabolic process GO:0010604 405 0.051
purine nucleotide metabolic process GO:0006163 146 0.051
male mating behavior GO:0060179 70 0.051
regulation of cellular catabolic process GO:0031329 157 0.050
energy derivation by oxidation of organic compounds GO:0015980 32 0.050
positive regulation of atp catabolic process GO:1903291 3 0.049
actin filament capping GO:0051693 2 0.048
purine nucleotide catabolic process GO:0006195 109 0.048
regulation of organ growth GO:0046620 42 0.047
nucleobase containing small molecule metabolic process GO:0055086 174 0.046
single organism carbohydrate metabolic process GO:0044723 72 0.046
regulation of actin polymerization or depolymerization GO:0008064 27 0.046
positive regulation of catabolic process GO:0009896 105 0.045
regulation of protein depolymerization GO:1901879 27 0.045
nucleobase containing compound catabolic process GO:0034655 165 0.044
negative regulation of actin filament polymerization GO:0030837 7 0.044
carbohydrate derivative catabolic process GO:1901136 118 0.042
ribonucleotide catabolic process GO:0009261 109 0.041
regulation of system process GO:0044057 36 0.041
endocytosis GO:0006897 310 0.041
cellular catabolic process GO:0044248 372 0.041
mesoderm development GO:0007498 78 0.040
stem cell differentiation GO:0048863 117 0.040
multi organism behavior GO:0051705 175 0.040
regulation of cell development GO:0060284 215 0.040
rna processing GO:0006396 147 0.039
cellular nitrogen compound catabolic process GO:0044270 165 0.039
skeletal muscle organ development GO:0060538 48 0.038
regulation of cell death GO:0010941 173 0.038
cation homeostasis GO:0055080 51 0.037
eye development GO:0001654 323 0.037
positive regulation of multicellular organismal process GO:0051240 143 0.037
protein modification process GO:0036211 438 0.037
negative regulation of protein complex disassembly GO:0043242 23 0.037
regulation of cellular component size GO:0032535 98 0.037
response to abiotic stimulus GO:0009628 341 0.036
larval somatic muscle development GO:0007526 19 0.035
regulation of catabolic process GO:0009894 170 0.035
appendage development GO:0048736 401 0.035
Fly
aromatic compound catabolic process GO:0019439 166 0.034
ovulation GO:0030728 4 0.034
carbohydrate derivative metabolic process GO:1901135 217 0.034
cell death GO:0008219 279 0.034
glycosyl compound metabolic process GO:1901657 127 0.033
purine nucleoside metabolic process GO:0042278 127 0.033
macromolecular complex disassembly GO:0032984 37 0.032
nucleoside triphosphate metabolic process GO:0009141 120 0.031
muscle contraction GO:0006936 13 0.031
heterocycle catabolic process GO:0046700 166 0.031
muscle attachment GO:0016203 36 0.031
heart contraction GO:0060047 26 0.030
regulation of cellular localization GO:0060341 136 0.030
regulation of phosphorus metabolic process GO:0051174 210 0.030
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.030
catabolic process GO:0009056 409 0.030
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.029
nucleotide metabolic process GO:0009117 161 0.029
purine ribonucleoside metabolic process GO:0046128 127 0.029
programmed cell death GO:0012501 257 0.029
negative regulation of cell cycle GO:0045786 116 0.029
purine nucleoside triphosphate catabolic process GO:0009146 108 0.028
ribonucleoside monophosphate catabolic process GO:0009158 39 0.028
positive regulation of molecular function GO:0044093 136 0.028
positive regulation of actin filament polymerization GO:0030838 11 0.027
negative regulation of cellular component organization GO:0051129 108 0.027
cell cell junction organization GO:0045216 55 0.027
carbohydrate biosynthetic process GO:0016051 17 0.027
ribose phosphate metabolic process GO:0019693 145 0.027
glycosyl compound catabolic process GO:1901658 112 0.027
adult somatic muscle development GO:0007527 14 0.026
cellular respiration GO:0045333 26 0.026
cellular protein localization GO:0034613 160 0.026
protein polymerization GO:0051258 42 0.026
nucleoside phosphate metabolic process GO:0006753 162 0.026
cardiac muscle tissue development GO:0048738 9 0.026
purine containing compound catabolic process GO:0072523 112 0.025
negative regulation of gene expression GO:0010629 387 0.025
regulation of cellular amine metabolic process GO:0033238 3 0.025
regulation of apoptotic process GO:0042981 130 0.024
maintenance of location GO:0051235 73 0.024
wing disc morphogenesis GO:0007472 344 0.024
Fly
intracellular transport GO:0046907 228 0.024
Fly
nucleoside catabolic process GO:0009164 112 0.024
regulation of anatomical structure size GO:0090066 163 0.024
Fly
rna localization GO:0006403 115 0.024
epithelial cell differentiation GO:0030855 322 0.024
Fly
striated muscle adaptation GO:0014888 1 0.024
regulation of nucleoside metabolic process GO:0009118 50 0.023
electron transport chain GO:0022900 14 0.023
rna splicing GO:0008380 83 0.023
regulation of nucleotide catabolic process GO:0030811 48 0.023
positive regulation of phosphorus metabolic process GO:0010562 139 0.023
regulation of cellular ketone metabolic process GO:0010565 3 0.022
regulation of growth GO:0040008 233 0.022
regulation of phosphate metabolic process GO:0019220 210 0.021
purine nucleoside catabolic process GO:0006152 112 0.021
protein localization GO:0008104 284 0.021
phagocytosis GO:0006909 215 0.021
organonitrogen compound catabolic process GO:1901565 128 0.021
small molecule metabolic process GO:0044281 305 0.021
positive regulation of phosphate metabolic process GO:0045937 139 0.021
mitochondrial transport GO:0006839 8 0.021
oxidation reduction process GO:0055114 123 0.020
striated muscle contraction GO:0006941 5 0.020
regulation of transport GO:0051049 181 0.020
musculoskeletal movement GO:0050881 3 0.020
chromosome segregation GO:0007059 157 0.020
multi organism reproductive behavior GO:0044705 121 0.020
regulation of synapse organization GO:0050807 110 0.020
purine nucleoside triphosphate metabolic process GO:0009144 119 0.019
cellular component disassembly GO:0022411 46 0.019
negative regulation of cellular metabolic process GO:0031324 382 0.019
regulation of heart contraction GO:0008016 21 0.019
purine ribonucleoside monophosphate catabolic process GO:0009169 38 0.019
organelle fission GO:0048285 340 0.019
growth GO:0040007 359 0.019
Fly
regulation of cellular component biogenesis GO:0044087 201 0.019
regulation of cysteine type endopeptidase activity GO:2000116 27 0.018
purine ribonucleotide metabolic process GO:0009150 145 0.018
inorganic cation transmembrane transport GO:0098662 61 0.018
synapse organization GO:0050808 196 0.018
negative regulation of molecular function GO:0044092 51 0.018
telencephalon development GO:0021537 2 0.018
regulation of protein polymerization GO:0032271 28 0.018
positive regulation of purine nucleotide metabolic process GO:1900544 55 0.018
single organism intracellular transport GO:1902582 207 0.018
Fly
organonitrogen compound metabolic process GO:1901564 318 0.018
positive regulation of hydrolase activity GO:0051345 78 0.018
regulation of sarcomere organization GO:0060297 2 0.017
establishment of oocyte nucleus localization involved in oocyte dorsal ventral axis specification GO:0030722 6 0.017
regulation of catalytic activity GO:0050790 185 0.017
regulation of cell cycle process GO:0010564 181 0.017
regulation of rna splicing GO:0043484 69 0.017
embryo development ending in birth or egg hatching GO:0009792 152 0.017
Fly
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.017
compound eye morphogenesis GO:0001745 249 0.017
negative regulation of organelle organization GO:0010639 56 0.017
cell proliferation GO:0008283 299 0.017
mrna processing GO:0006397 104 0.017
positive regulation of apoptotic process GO:0043065 47 0.017
oxoacid metabolic process GO:0043436 103 0.017
cardiovascular system development GO:0072358 82 0.017
vesicle mediated transport GO:0016192 381 0.016
ribonucleoside triphosphate catabolic process GO:0009203 108 0.016
actin filament based movement GO:0030048 26 0.016
Fly
regulation of nucleocytoplasmic transport GO:0046822 35 0.016
purine containing compound metabolic process GO:0072521 155 0.016
heart development GO:0007507 82 0.016
purine nucleoside monophosphate catabolic process GO:0009128 38 0.016
organic cyclic compound catabolic process GO:1901361 168 0.016
regulation of purine nucleotide metabolic process GO:1900542 62 0.016
germarium derived egg chamber formation GO:0007293 101 0.016
mrna metabolic process GO:0016071 124 0.016
muscle tissue development GO:0060537 30 0.016
positive regulation of catalytic activity GO:0043085 118 0.016
developmental maturation GO:0021700 172 0.016
regulation of molecular function GO:0065009 217 0.015
response to oxygen levels GO:0070482 59 0.015
macromolecule catabolic process GO:0009057 161 0.015
regulation of establishment of protein localization GO:0070201 61 0.015
positive regulation of nucleotide metabolic process GO:0045981 55 0.015
purine ribonucleoside catabolic process GO:0046130 112 0.015
negative regulation of phosphorus metabolic process GO:0010563 45 0.015
cellular response to starvation GO:0009267 61 0.015
carbohydrate metabolic process GO:0005975 82 0.015
muscle system process GO:0003012 21 0.015
regulation of purine nucleotide catabolic process GO:0033121 48 0.015
nucleoside metabolic process GO:0009116 127 0.014
positive regulation of nucleotide catabolic process GO:0030813 46 0.014
regulation of cell cycle GO:0051726 291 0.014
oviposition GO:0018991 19 0.014
posttranscriptional regulation of gene expression GO:0010608 145 0.014
regulation of nucleotide metabolic process GO:0006140 62 0.014
nuclear transport GO:0051169 72 0.014
response to lipopolysaccharide GO:0032496 4 0.014
stem cell development GO:0048864 79 0.014
muscle adaptation GO:0043500 1 0.014
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 25 0.014
purine ribonucleoside monophosphate metabolic process GO:0009167 50 0.014
detection of chemical stimulus GO:0009593 93 0.014
regulation of programmed cell death GO:0043067 152 0.013
circulatory system development GO:0072359 82 0.013
regulation of cellular amino acid metabolic process GO:0006521 0 0.013
ion transport GO:0006811 145 0.013
imaginal disc derived appendage development GO:0048737 399 0.013
Fly
cardiac muscle cell differentiation GO:0055007 4 0.013
cortical cytoskeleton organization GO:0030865 29 0.013
tissue morphogenesis GO:0048729 297 0.013
nucleoside monophosphate metabolic process GO:0009123 52 0.013
organophosphate catabolic process GO:0046434 112 0.013
muscle fiber development GO:0048747 12 0.013
regulation of nervous system development GO:0051960 248 0.013
nucleoside phosphate catabolic process GO:1901292 110 0.013
positive regulation of cellular component biogenesis GO:0044089 80 0.012
negative regulation of apoptotic process GO:0043066 63 0.012
negative regulation of protein polymerization GO:0032272 7 0.012
notch signaling pathway GO:0007219 120 0.012
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.012
blood circulation GO:0008015 26 0.012
single organism cellular localization GO:1902580 180 0.012
negative regulation of protein depolymerization GO:1901880 23 0.012
respiratory electron transport chain GO:0022904 11 0.012
multicellular organism growth GO:0035264 46 0.012
positive regulation of apoptotic signaling pathway GO:2001235 4 0.012
nucleoside monophosphate catabolic process GO:0009125 39 0.012
cellular response to organic cyclic compound GO:0071407 32 0.012
ribonucleoside metabolic process GO:0009119 127 0.012
negative regulation of cellular catabolic process GO:0031330 34 0.012
ribonucleotide metabolic process GO:0009259 145 0.012
cytoplasm organization GO:0007028 64 0.012
positive regulation of cytoskeleton organization GO:0051495 21 0.011
apoptotic process GO:0006915 159 0.011
biological adhesion GO:0022610 138 0.011
single organism behavior GO:0044708 391 0.011
single organism nuclear import GO:1902593 51 0.011
regulation of cell projection organization GO:0031344 92 0.011
cytoplasmic transport nurse cell to oocyte GO:0007303 12 0.011
Fly
adherens junction organization GO:0034332 27 0.011
alternative mrna splicing via spliceosome GO:0000380 60 0.011
compound eye development GO:0048749 307 0.011
cellular macromolecule localization GO:0070727 220 0.011
segmentation GO:0035282 207 0.011
nucleocytoplasmic transport GO:0006913 72 0.011
sister chromatid cohesion GO:0007062 18 0.011
organic acid metabolic process GO:0006082 103 0.011
purine ribonucleotide catabolic process GO:0009154 109 0.011
positive regulation of gtpase activity GO:0043547 43 0.010
anterior posterior axis specification GO:0009948 109 0.010
cytokinesis GO:0000910 90 0.010
Fly
germarium derived female germ line cyst formation GO:0030727 42 0.010
protein catabolic process GO:0030163 101 0.010
sister chromatid segregation GO:0000819 92 0.010
atp metabolic process GO:0046034 49 0.010
actin cytoskeleton reorganization GO:0031532 22 0.010
transmembrane transport GO:0055085 139 0.010
regulation of developmental growth GO:0048638 174 0.010
cellular amino acid metabolic process GO:0006520 61 0.010
wound healing GO:0042060 75 0.010
Fly

Mlc2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
myopathy DOID:423 0 0.123
muscular disease DOID:0080000 0 0.123
heart disease DOID:114 0 0.123
cardiomyopathy DOID:0050700 0 0.123
disease of anatomical entity DOID:7 0 0.123
intrinsic cardiomyopathy DOID:0060036 0 0.123
cardiovascular system disease DOID:1287 0 0.123
musculoskeletal system disease DOID:17 0 0.123
muscle tissue disease DOID:66 0 0.123
dilated cardiomyopathy DOID:12930 0 0.067
central nervous system disease DOID:331 0 0.015
neurodegenerative disease DOID:1289 0 0.015
nervous system disease DOID:863 0 0.015