Drosophila melanogaster

0 known processes

l(1)G0289 (Dmel_CG2221)

lethal (1) G0289

(Aliases: CG2221,Dmel\CG2221)

l(1)G0289 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
negative regulation of cellular biosynthetic process GO:0031327 277 0.291
negative regulation of gene expression GO:0010629 387 0.282
gene silencing GO:0016458 138 0.234
imaginal disc derived appendage development GO:0048737 399 0.225
neurological system process GO:0050877 358 0.215
cell cell signaling involved in cell fate commitment GO:0045168 210 0.156
response to other organism GO:0051707 293 0.154
positive regulation of gene expression GO:0010628 290 0.151
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.147
sensory perception GO:0007600 196 0.145
cell recognition GO:0008037 102 0.137
appendage development GO:0048736 401 0.126
mrna metabolic process GO:0016071 124 0.126
imaginal disc derived appendage morphogenesis GO:0035114 395 0.123
response to external biotic stimulus GO:0043207 293 0.122
negative regulation of immune system process GO:0002683 50 0.103
lateral inhibition GO:0046331 206 0.102
cellular catabolic process GO:0044248 372 0.097
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.096
response to biotic stimulus GO:0009607 294 0.095
regulation of defense response GO:0031347 102 0.093
negative regulation of transcription dna templated GO:0045892 237 0.092
negative regulation of biosynthetic process GO:0009890 277 0.089
cell migration GO:0016477 238 0.087
negative regulation of rna biosynthetic process GO:1902679 240 0.086
carbohydrate derivative metabolic process GO:1901135 217 0.085
imaginal disc derived wing morphogenesis GO:0007476 337 0.085
negative regulation of nucleic acid templated transcription GO:1903507 240 0.083
translation GO:0006412 69 0.078
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.076
tissue morphogenesis GO:0048729 297 0.075
nuclear transcribed mrna catabolic process deadenylation dependent decay GO:0000288 14 0.074
mitotic cell cycle phase transition GO:0044772 138 0.070
multi organism behavior GO:0051705 175 0.069
regulation of gene expression epigenetic GO:0040029 128 0.066
single organism behavior GO:0044708 391 0.066
regionalization GO:0003002 416 0.065
negative regulation of response to stimulus GO:0048585 258 0.065
posttranscriptional gene silencing by rna GO:0035194 45 0.065
amide biosynthetic process GO:0043604 42 0.063
single organism catabolic process GO:0044712 228 0.063
catabolic process GO:0009056 409 0.061
regulation of mrna processing GO:0050684 71 0.061
regulation of mitotic cell cycle GO:0007346 190 0.060
compound eye development GO:0048749 307 0.059
negative regulation of rna metabolic process GO:0051253 251 0.059
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.058
response to wounding GO:0009611 94 0.056
cellular macromolecule catabolic process GO:0044265 136 0.054
neuromuscular synaptic transmission GO:0007274 67 0.052
dendrite development GO:0016358 204 0.051
response to abiotic stimulus GO:0009628 341 0.050
dendrite morphogenesis GO:0048813 199 0.050
transcription from rna polymerase ii promoter GO:0006366 368 0.050
regulation of cellular catabolic process GO:0031329 157 0.049
regulation of mrna metabolic process GO:1903311 72 0.049
post embryonic appendage morphogenesis GO:0035120 385 0.048
posttranscriptional regulation of gene expression GO:0010608 145 0.047
organic substance transport GO:0071702 257 0.047
regulation of cell differentiation GO:0045595 302 0.046
gene silencing by mirna GO:0035195 22 0.045
cell cycle phase transition GO:0044770 140 0.045
organic cyclic compound catabolic process GO:1901361 168 0.044
negative regulation of cellular metabolic process GO:0031324 382 0.044
endocytosis GO:0006897 310 0.043
growth GO:0040007 359 0.042
regulation of catabolic process GO:0009894 170 0.042
ribonucleoprotein complex subunit organization GO:0071826 28 0.041
regulation of response to stress GO:0080134 200 0.041
regulation of mitotic cell cycle phase transition GO:1901990 130 0.041
organonitrogen compound metabolic process GO:1901564 318 0.040
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.040
dna damage checkpoint GO:0000077 78 0.040
pigmentation GO:0043473 75 0.040
mrna processing GO:0006397 104 0.040
organic substance catabolic process GO:1901575 308 0.040
apoptotic process GO:0006915 159 0.039
wing disc morphogenesis GO:0007472 344 0.038
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.038
appendage morphogenesis GO:0035107 397 0.038
localization of cell GO:0051674 257 0.038
regulation of multi organism process GO:0043900 131 0.037
organic acid metabolic process GO:0006082 103 0.037
aromatic compound catabolic process GO:0019439 166 0.037
establishment of localization in cell GO:0051649 402 0.036
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.036
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.036
nucleotide catabolic process GO:0009166 109 0.035
regulation of cell cycle GO:0051726 291 0.035
head development GO:0060322 135 0.034
dorsal ventral pattern formation GO:0009953 133 0.034
wing disc pattern formation GO:0035222 66 0.033
response to bacterium GO:0009617 198 0.033
nucleobase containing small molecule metabolic process GO:0055086 174 0.033
positive regulation of cellular biosynthetic process GO:0031328 316 0.033
eye morphogenesis GO:0048592 260 0.032
regulation of localization GO:0032879 275 0.032
learning or memory GO:0007611 141 0.032
camera type eye development GO:0043010 4 0.032
positive regulation of biosynthetic process GO:0009891 316 0.031
mrna catabolic process GO:0006402 33 0.031
cellular response to chemical stimulus GO:0070887 199 0.031
macromolecule catabolic process GO:0009057 161 0.031
positive regulation of rna metabolic process GO:0051254 271 0.031
multicellular organism growth GO:0035264 46 0.030
organelle fission GO:0048285 340 0.030
pronuclear migration GO:0035046 4 0.030
regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay GO:1900151 4 0.030
regulation of cell cycle phase transition GO:1901987 130 0.030
detection of stimulus GO:0051606 156 0.030
nucleobase containing compound catabolic process GO:0034655 165 0.030
humoral immune response GO:0006959 117 0.030
mitotic nuclear division GO:0007067 213 0.030
imaginal disc pattern formation GO:0007447 91 0.029
protein localization GO:0008104 284 0.029
axonogenesis GO:0007409 290 0.029
nitrogen compound transport GO:0071705 85 0.029
rna processing GO:0006396 147 0.029
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.029
regulation of growth GO:0040008 233 0.029
defense response GO:0006952 300 0.028
nucleotide metabolic process GO:0009117 161 0.028
synaptic transmission GO:0007268 288 0.028
long term memory GO:0007616 62 0.028
cellular nitrogen compound catabolic process GO:0044270 165 0.027
mitotic g2 dna damage checkpoint GO:0007095 69 0.027
immune system process GO:0002376 347 0.027
nuclear transcribed mrna catabolic process GO:0000956 24 0.027
nuclear division GO:0000280 332 0.027
cell motility GO:0048870 251 0.027
spermatogenesis GO:0007283 200 0.027
peptide metabolic process GO:0006518 80 0.026
axon guidance GO:0007411 233 0.026
regulation of cellular ketone metabolic process GO:0010565 3 0.026
positive regulation of cell communication GO:0010647 250 0.026
formation of anatomical boundary GO:0048859 37 0.025
purine nucleoside catabolic process GO:0006152 112 0.025
cognition GO:0050890 141 0.025
circadian rhythm GO:0007623 105 0.025
hindbrain development GO:0030902 2 0.025
cellular response to abiotic stimulus GO:0071214 58 0.025
negative regulation of cell cycle GO:0045786 116 0.025
macromolecular complex assembly GO:0065003 256 0.025
positive regulation of macromolecule metabolic process GO:0010604 405 0.024
spermatid differentiation GO:0048515 114 0.024
anion homeostasis GO:0055081 3 0.024
response to lipopolysaccharide GO:0032496 4 0.024
positive regulation of transcription dna templated GO:0045893 266 0.024
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.024
cell death GO:0008219 279 0.024
negative regulation of cell cycle process GO:0010948 109 0.023
gene silencing by rna GO:0031047 57 0.023
posttranscriptional gene silencing GO:0016441 46 0.023
positive regulation of developmental process GO:0051094 143 0.023
nucleoside catabolic process GO:0009164 112 0.023
gland morphogenesis GO:0022612 145 0.023
memory GO:0007613 94 0.023
response to organic substance GO:0010033 284 0.023
regulation of tor signaling GO:0032006 21 0.022
g2 dna damage checkpoint GO:0031572 69 0.022
cell division GO:0051301 248 0.022
small molecule metabolic process GO:0044281 305 0.022
sensory organ morphogenesis GO:0090596 260 0.022
antimicrobial humoral response GO:0019730 99 0.022
regulation of apoptotic process GO:0042981 130 0.022
establishment or maintenance of cytoskeleton polarity GO:0030952 44 0.022
eye development GO:0001654 323 0.021
microtubule based movement GO:0007018 51 0.021
spindle organization GO:0007051 253 0.021
regulation of protein metabolic process GO:0051246 256 0.021
chaeta development GO:0022416 97 0.021
mitotic g2 m transition checkpoint GO:0044818 70 0.021
heterocycle catabolic process GO:0046700 166 0.021
central nervous system development GO:0007417 201 0.021
fertilization GO:0009566 26 0.021
regulation of immune system process GO:0002682 176 0.021
autophagy GO:0006914 108 0.021
defense response to gram negative bacterium GO:0050829 94 0.021
ribosomal large subunit biogenesis GO:0042273 1 0.021
phagocytosis GO:0006909 215 0.021
response to nutrient levels GO:0031667 114 0.021
rna catabolic process GO:0006401 37 0.021
male gamete generation GO:0048232 201 0.021
open tracheal system development GO:0007424 204 0.020
body morphogenesis GO:0010171 2 0.020
oocyte development GO:0048599 124 0.020
organelle assembly GO:0070925 198 0.020
exocrine system development GO:0035272 162 0.020
muscle structure development GO:0061061 224 0.020
organophosphate catabolic process GO:0046434 112 0.020
negative regulation of mitotic cell cycle GO:0045930 109 0.020
regulation of response to external stimulus GO:0032101 115 0.020
regulation of cellular localization GO:0060341 136 0.020
positive regulation of nucleic acid templated transcription GO:1903508 266 0.020
secretion by cell GO:0032940 101 0.020
peptide biosynthetic process GO:0043043 42 0.020
detection of chemical stimulus GO:0009593 93 0.020
positive regulation of rna biosynthetic process GO:1902680 266 0.020
eye photoreceptor cell differentiation GO:0001754 145 0.019
organophosphate metabolic process GO:0019637 195 0.019
epithelial cell migration GO:0010631 148 0.019
defense response to bacterium GO:0042742 178 0.019
nucleoside phosphate metabolic process GO:0006753 162 0.019
notch signaling pathway GO:0007219 120 0.019
regulation of cellular protein metabolic process GO:0032268 243 0.019
nuclear transport GO:0051169 72 0.019
cell maturation GO:0048469 144 0.019
regulation of notch signaling pathway GO:0008593 100 0.019
connective tissue development GO:0061448 3 0.019
rna localization GO:0006403 115 0.019
mitotic cell cycle checkpoint GO:0007093 88 0.019
inter male aggressive behavior GO:0002121 60 0.019
negative regulation of multicellular organismal process GO:0051241 142 0.019
establishment of rna localization GO:0051236 47 0.019
regulation of anatomical structure size GO:0090066 163 0.019
regulation of gene silencing GO:0060968 63 0.019
compound eye photoreceptor cell differentiation GO:0001751 140 0.018
brain development GO:0007420 120 0.018
regulation of oocyte development GO:0060281 27 0.018
embryonic development via the syncytial blastoderm GO:0001700 148 0.018
negative regulation of developmental process GO:0051093 201 0.018
anterior posterior pattern specification GO:0009952 136 0.018
mitotic spindle organization GO:0007052 220 0.018
negative regulation of response to external stimulus GO:0032102 22 0.018
chemotaxis GO:0006935 249 0.018
mesenchymal cell differentiation GO:0048762 1 0.018
negative regulation of cell cycle phase transition GO:1901988 103 0.018
mesenchymal cell development GO:0014031 1 0.017
locomotory behavior GO:0007626 176 0.017
nucleoside triphosphate metabolic process GO:0009141 120 0.017
regulation of embryonic pattern specification GO:1902875 27 0.017
immune response GO:0006955 246 0.017
cellular homeostasis GO:0019725 80 0.017
nuclear transcribed mrna poly a tail shortening GO:0000289 12 0.017
embryo development ending in birth or egg hatching GO:0009792 152 0.017
rna transport GO:0050658 46 0.017
intracellular signal transduction GO:0035556 300 0.017
regulation of small gtpase mediated signal transduction GO:0051056 93 0.017
positive regulation of response to stimulus GO:0048584 323 0.017
formation of organ boundary GO:0010160 30 0.017
embryonic morphogenesis GO:0048598 206 0.017
regulation of developmental growth GO:0048638 174 0.017
purine nucleotide catabolic process GO:0006195 109 0.017
mitotic dna damage checkpoint GO:0044773 74 0.017
regulation of hydrolase activity GO:0051336 97 0.017
negative regulation of protein metabolic process GO:0051248 85 0.017
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 11 0.016
compound eye morphogenesis GO:0001745 249 0.016
morphogenesis of an epithelium GO:0002009 276 0.016
positive regulation of cellular catabolic process GO:0031331 95 0.016
ribonucleoprotein complex assembly GO:0022618 23 0.016
telencephalon development GO:0021537 2 0.016
carboxylic acid metabolic process GO:0019752 92 0.016
defense response to other organism GO:0098542 225 0.016
aggressive behavior GO:0002118 63 0.016
light adaption GO:0036367 3 0.016
sensory perception of mechanical stimulus GO:0050954 72 0.016
positive regulation of defense response GO:0031349 59 0.016
dna repair GO:0006281 54 0.016
death GO:0016265 284 0.015
response to hexose GO:0009746 3 0.015
negative regulation of gene expression epigenetic GO:0045814 77 0.015
positive regulation of signaling GO:0023056 243 0.015
muscle cell development GO:0055001 50 0.015
gland development GO:0048732 191 0.015
regulation of compound eye cone cell fate specification GO:0042682 4 0.015
negative regulation of catabolic process GO:0009895 36 0.015
ion transport GO:0006811 145 0.015
cell aging GO:0007569 2 0.015
purine containing compound catabolic process GO:0072523 112 0.015
chromatin silencing GO:0006342 76 0.015
regulation of lipid transport GO:0032368 3 0.014
skin development GO:0043588 65 0.014
nucleoside phosphate catabolic process GO:1901292 110 0.014
neuron projection guidance GO:0097485 241 0.014
mrna 3 end processing GO:0031124 28 0.014
cuticle pigmentation GO:0048067 22 0.014
programmed cell death GO:0012501 257 0.014
hair cell differentiation GO:0035315 47 0.014
neuron fate commitment GO:0048663 50 0.014
cytoskeleton dependent intracellular transport GO:0030705 44 0.014
stem cell differentiation GO:0048863 117 0.014
regulation of embryonic development GO:0045995 68 0.014
salivary gland development GO:0007431 162 0.014
rna splicing via transesterification reactions GO:0000375 73 0.014
dna integrity checkpoint GO:0031570 81 0.014
small gtpase mediated signal transduction GO:0007264 88 0.014
salivary gland histolysis GO:0035070 88 0.014
germ line stem cell maintenance GO:0030718 50 0.014
developmental maturation GO:0021700 172 0.014
negative regulation of defense response GO:0031348 35 0.014
negative regulation of growth GO:0045926 84 0.014
blastoderm segmentation GO:0007350 159 0.014
regulation of catalytic activity GO:0050790 185 0.014
response to monosaccharide GO:0034284 4 0.014
cellular amide metabolic process GO:0043603 80 0.014
homeostatic process GO:0042592 199 0.013
histone h3 k9 acetylation GO:0043970 3 0.013
cellular response to dna damage stimulus GO:0006974 223 0.013
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.013
wing disc dorsal ventral pattern formation GO:0048190 47 0.013
single organism biosynthetic process GO:0044711 206 0.013
ameboidal type cell migration GO:0001667 151 0.013
carbohydrate derivative catabolic process GO:1901136 118 0.013
purine ribonucleotide metabolic process GO:0009150 145 0.013
regulation of pole plasm oskar mrna localization GO:0007317 27 0.013
intracellular transport GO:0046907 228 0.013
response to ketone GO:1901654 34 0.013
rna phosphodiester bond hydrolysis GO:0090501 17 0.013
regulation of cell division GO:0051302 72 0.013
axon development GO:0061564 297 0.013
positive regulation of signal transduction GO:0009967 223 0.013
regulation of nervous system development GO:0051960 248 0.013
oxoacid metabolic process GO:0043436 103 0.013
negative regulation of translation GO:0017148 28 0.013
single fertilization GO:0007338 24 0.013
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 65 0.013
cellular response to carbohydrate stimulus GO:0071322 4 0.013
neuron recognition GO:0008038 101 0.013
wound healing GO:0042060 75 0.013
photoreceptor cell differentiation GO:0046530 170 0.013
cellular response to light stimulus GO:0071482 37 0.013
single organism intracellular transport GO:1902582 207 0.013
nicotinamide nucleotide metabolic process GO:0046496 2 0.013
cellular component disassembly GO:0022411 46 0.012
muscle tissue development GO:0060537 30 0.012
ribonucleotide catabolic process GO:0009261 109 0.012
retina development in camera type eye GO:0060041 4 0.012
epithelial cell differentiation GO:0030855 322 0.012
single organism carbohydrate metabolic process GO:0044723 72 0.012
regulation of reproductive process GO:2000241 54 0.012
purine nucleotide metabolic process GO:0006163 146 0.012
rna interference GO:0016246 27 0.012
nephron development GO:0072006 3 0.012
urogenital system development GO:0001655 72 0.012
proteolysis GO:0006508 192 0.012
protein modification process GO:0036211 438 0.012
nucleobase containing compound transport GO:0015931 56 0.012
negative regulation of cellular protein metabolic process GO:0032269 85 0.012
regulation of cell development GO:0060284 215 0.012
eye photoreceptor cell fate commitment GO:0042706 37 0.012
protein maturation GO:0051604 71 0.012
ribonucleoside catabolic process GO:0042454 112 0.012
generation of precursor metabolites and energy GO:0006091 42 0.012
positive regulation of response to nutrient levels GO:0032109 8 0.012
chromosome segregation GO:0007059 157 0.012
nucleocytoplasmic transport GO:0006913 72 0.012
purine nucleoside triphosphate metabolic process GO:0009144 119 0.012
biological adhesion GO:0022610 138 0.012
sensory organ boundary specification GO:0008052 22 0.012
cellular protein catabolic process GO:0044257 83 0.011
substrate adhesion dependent cell spreading GO:0034446 2 0.011
larval development GO:0002164 104 0.011
respiratory system development GO:0060541 213 0.011
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.011
r7 cell differentiation GO:0045466 43 0.011
establishment or maintenance of cell polarity GO:0007163 167 0.011
regulation of organelle organization GO:0033043 196 0.011
reproductive behavior GO:0019098 122 0.011
detection of stimulus involved in sensory perception GO:0050906 92 0.011
organonitrogen compound catabolic process GO:1901565 128 0.011
detection of external stimulus GO:0009581 66 0.011
sister chromatid segregation GO:0000819 92 0.011
negative regulation of signal transduction GO:0009968 206 0.011
cellular amino acid metabolic process GO:0006520 61 0.011
phototransduction visible light GO:0007603 27 0.011
regulation of phosphate metabolic process GO:0019220 210 0.011
ribonucleoside triphosphate metabolic process GO:0009199 119 0.011
regulation of cell cycle process GO:0010564 181 0.011
detection of visible light GO:0009584 38 0.011
regulation of epithelial cell differentiation GO:0030856 4 0.011
cell fate determination involved in pattern specification GO:0060582 19 0.011
cellular macromolecule localization GO:0070727 220 0.011
regulation of intracellular signal transduction GO:1902531 236 0.011
chromosome organization GO:0051276 360 0.011
regulation of immune response GO:0050776 118 0.011
multicellular organismal reproductive behavior GO:0033057 110 0.011
protein processing GO:0016485 68 0.011
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 38 0.011
negative regulation of cell differentiation GO:0045596 143 0.011
positive regulation of phosphate metabolic process GO:0045937 139 0.011
vesicle mediated transport GO:0016192 381 0.011
ribonucleotide metabolic process GO:0009259 145 0.011
regulation of peptidase activity GO:0052547 39 0.011
response to oxygen containing compound GO:1901700 200 0.011
detection of hexose stimulus GO:0009732 1 0.010
purine nucleoside metabolic process GO:0042278 127 0.010
immune response activating signal transduction GO:0002757 2 0.010
forebrain development GO:0030900 2 0.010
regulation of nuclear transcribed mrna poly a tail shortening GO:0060211 4 0.010
embryonic heart tube development GO:0035050 22 0.010
golgi organization GO:0007030 66 0.010
purine ribonucleotide catabolic process GO:0009154 109 0.010
signal transduction in response to dna damage GO:0042770 3 0.010
oocyte differentiation GO:0009994 145 0.010
adult chitin containing cuticle pigmentation GO:0048085 16 0.010
glycosyl compound catabolic process GO:1901658 112 0.010
photoreceptor cell fate commitment GO:0046552 41 0.010
axis specification GO:0009798 167 0.010
regulation of transport GO:0051049 181 0.010
oocyte localization involved in germarium derived egg chamber formation GO:0030720 12 0.010

l(1)G0289 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.025
vascular disease DOID:178 0 0.025
cardiovascular system disease DOID:1287 0 0.025
diabetes mellitus DOID:9351 0 0.017
disease of metabolism DOID:0014667 0 0.017
carbohydrate metabolism disease DOID:0050013 0 0.017
glucose metabolism disease DOID:4194 0 0.017
acquired metabolic disease DOID:0060158 0 0.017