Drosophila melanogaster

6 known processes

ttm50 (Dmel_CG2713)

tiny tim 50

(Aliases: i238,Dmel\CG2713,CG2713,i90,Gp99,EG:95B7.3)

ttm50 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
mitochondrion organization GO:0007005 65 0.820
purine nucleoside triphosphate catabolic process GO:0009146 108 0.235
meiotic nuclear division GO:0007126 151 0.209
establishment or maintenance of cell polarity GO:0007163 167 0.190
positive regulation of developmental growth GO:0048639 62 0.188
columnar cuboidal epithelial cell development GO:0002066 249 0.175
vesicle mediated transport GO:0016192 381 0.170
spindle organization GO:0007051 253 0.161
single organism biosynthetic process GO:0044711 206 0.154
spermatid development GO:0007286 98 0.146
insulin receptor signaling pathway GO:0008286 25 0.144
regulation of growth GO:0040008 233 0.137
mitotic spindle organization GO:0007052 220 0.122
growth GO:0040007 359 0.115
lipid biosynthetic process GO:0008610 46 0.113
endocytosis GO:0006897 310 0.111
nuclear division GO:0000280 332 0.108
cellular response to dna damage stimulus GO:0006974 223 0.104
organelle fission GO:0048285 340 0.101
mitotic nuclear division GO:0007067 213 0.094
cellular response to chemical stimulus GO:0070887 199 0.088
nucleoside phosphate catabolic process GO:1901292 110 0.088
response to abiotic stimulus GO:0009628 341 0.085
spermatid differentiation GO:0048515 114 0.082
mitotic g2 m transition checkpoint GO:0044818 70 0.082
small molecule metabolic process GO:0044281 305 0.082
regulation of developmental growth GO:0048638 174 0.081
purine ribonucleoside metabolic process GO:0046128 127 0.081
cellular protein modification process GO:0006464 438 0.078
nucleoside catabolic process GO:0009164 112 0.074
oxidation reduction process GO:0055114 123 0.074
positive regulation of growth GO:0045927 75 0.064
regulation of chromosome organization GO:0033044 64 0.061
organic substance transport GO:0071702 257 0.060
positive regulation of cell growth GO:0030307 19 0.060
mitotic sister chromatid segregation GO:0000070 87 0.060
negative regulation of cellular metabolic process GO:0031324 382 0.060
regulation of multicellular organism growth GO:0040014 40 0.059
regulation of insulin receptor signaling pathway GO:0046626 17 0.055
spindle assembly involved in mitosis GO:0090307 50 0.055
developmental growth GO:0048589 280 0.052
glycosyl compound metabolic process GO:1901657 127 0.051
organonitrogen compound metabolic process GO:1901564 318 0.050
generation of precursor metabolites and energy GO:0006091 42 0.050
nucleobase containing small molecule metabolic process GO:0055086 174 0.050
larval development GO:0002164 104 0.050
cell adhesion GO:0007155 136 0.050
purine ribonucleotide catabolic process GO:0009154 109 0.047
regulation of organelle organization GO:0033043 196 0.047
nucleotide metabolic process GO:0009117 161 0.047
regulation of cellular protein metabolic process GO:0032268 243 0.046
dna metabolic process GO:0006259 227 0.045
carbohydrate derivative metabolic process GO:1901135 217 0.044
cytoplasmic transport GO:0016482 130 0.043
protein secretion GO:0009306 45 0.043
regulation of intracellular signal transduction GO:1902531 236 0.043
negative regulation of epithelial cell proliferation GO:0050680 4 0.043
positive regulation of macromolecule metabolic process GO:0010604 405 0.043
ribonucleoside triphosphate catabolic process GO:0009203 108 0.042
lateral inhibition GO:0046331 206 0.042
negative regulation of signal transduction GO:0009968 206 0.042
sister chromatid segregation GO:0000819 92 0.041
guanosine containing compound metabolic process GO:1901068 74 0.040
lipid homeostasis GO:0055088 33 0.039
purine ribonucleoside catabolic process GO:0046130 112 0.038
chromosome segregation GO:0007059 157 0.038
axonogenesis GO:0007409 290 0.038
steroid biosynthetic process GO:0006694 16 0.038
regulation of mitotic cell cycle GO:0007346 190 0.037
regulation of cell division GO:0051302 72 0.037
cellular response to radiation GO:0071478 52 0.037
instar larval development GO:0002168 55 0.037
purine nucleoside metabolic process GO:0042278 127 0.037
regulation of mitotic cell cycle phase transition GO:1901990 130 0.036
multicellular organism growth GO:0035264 46 0.036
cell cycle arrest GO:0007050 4 0.036
regulation of nuclear division GO:0051783 58 0.036
lipid metabolic process GO:0006629 121 0.036
gtp catabolic process GO:0006184 72 0.036
positive regulation of cellular component organization GO:0051130 156 0.035
meiotic cell cycle GO:0051321 171 0.035
transcription from rna polymerase ii promoter GO:0006366 368 0.034
response to oxygen containing compound GO:1901700 200 0.034
nucleotide catabolic process GO:0009166 109 0.034
regulation of protein modification process GO:0031399 112 0.034
meiotic cell cycle process GO:1903046 132 0.033
actin cytoskeleton organization GO:0030036 206 0.033
small molecule biosynthetic process GO:0044283 37 0.033
wnt signaling pathway GO:0016055 98 0.033
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.033
gtp metabolic process GO:0046039 72 0.033
regulation of cellular response to insulin stimulus GO:1900076 17 0.032
single organism intracellular transport GO:1902582 207 0.032
cell proliferation GO:0008283 299 0.032
cholesterol homeostasis GO:0042632 3 0.032
nucleoside phosphate metabolic process GO:0006753 162 0.032
organophosphate catabolic process GO:0046434 112 0.032
ribose phosphate metabolic process GO:0019693 145 0.031
nucleoside triphosphate metabolic process GO:0009141 120 0.031
tor signaling GO:0031929 32 0.031
cellular response to hormone stimulus GO:0032870 44 0.030
ribonucleoside metabolic process GO:0009119 127 0.030
locomotory behavior GO:0007626 176 0.030
phagocytosis GO:0006909 215 0.030
positive regulation of developmental process GO:0051094 143 0.029
atp metabolic process GO:0046034 49 0.029
catabolic process GO:0009056 409 0.029
intracellular transport GO:0046907 228 0.028
regulation of cell death GO:0010941 173 0.028
regulation of cell proliferation GO:0042127 163 0.028
response to wounding GO:0009611 94 0.027
ribonucleotide metabolic process GO:0009259 145 0.027
golgi organization GO:0007030 66 0.026
purine containing compound catabolic process GO:0072523 112 0.026
response to hormone GO:0009725 45 0.026
mitotic g2 dna damage checkpoint GO:0007095 69 0.026
energy derivation by oxidation of organic compounds GO:0015980 32 0.026
molting cycle GO:0042303 56 0.026
cell growth GO:0016049 108 0.025
endomembrane system organization GO:0010256 119 0.024
negative regulation of signaling GO:0023057 219 0.024
response to organic substance GO:0010033 284 0.024
response to nutrient levels GO:0031667 114 0.024
cell cycle phase transition GO:0044770 140 0.024
response to oxygen levels GO:0070482 59 0.023
regulation of metaphase anaphase transition of cell cycle GO:1902099 26 0.023
positive regulation of multicellular organism growth GO:0040018 21 0.023
negative regulation of transcription dna templated GO:0045892 237 0.022
negative regulation of cell communication GO:0010648 223 0.022
regulation of cell growth GO:0001558 43 0.022
single organism catabolic process GO:0044712 228 0.022
positive regulation of nucleic acid templated transcription GO:1903508 266 0.022
guanosine containing compound catabolic process GO:1901069 74 0.022
heterocycle catabolic process GO:0046700 166 0.022
regulation of cellular component size GO:0032535 98 0.022
g2 dna damage checkpoint GO:0031572 69 0.021
molting cycle chitin based cuticle GO:0007591 56 0.021
chemosensory behavior GO:0007635 106 0.020
negative regulation of rna metabolic process GO:0051253 251 0.020
response to decreased oxygen levels GO:0036293 58 0.020
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.020
male gamete generation GO:0048232 201 0.020
regulation of cell cycle process GO:0010564 181 0.019
carbohydrate derivative catabolic process GO:1901136 118 0.019
regulation of cell shape GO:0008360 113 0.019
purine ribonucleotide metabolic process GO:0009150 145 0.019
asymmetric protein localization GO:0008105 33 0.019
cell division GO:0051301 248 0.019
aging GO:0007568 143 0.019
cellular respiration GO:0045333 26 0.019
purine nucleoside triphosphate metabolic process GO:0009144 119 0.019
protein localization GO:0008104 284 0.019
organelle fusion GO:0048284 46 0.019
negative regulation of cell cycle GO:0045786 116 0.019
neuromuscular junction development GO:0007528 149 0.019
sterol homeostasis GO:0055092 4 0.019
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.018
ribonucleoside triphosphate metabolic process GO:0009199 119 0.018
membrane organization GO:0061024 112 0.018
regulation of mitosis GO:0007088 56 0.018
macromolecular complex disassembly GO:0032984 37 0.018
organic hydroxy compound metabolic process GO:1901615 83 0.018
skin development GO:0043588 65 0.018
gene silencing GO:0016458 138 0.018
regulation of behavior GO:0050795 75 0.018
mitotic cell cycle phase transition GO:0044772 138 0.018
organonitrogen compound biosynthetic process GO:1901566 117 0.017
regulation of mitochondrion organization GO:0010821 12 0.017
positive regulation of lipid storage GO:0010884 4 0.017
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.017
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.017
ribonucleotide catabolic process GO:0009261 109 0.017
negative regulation of growth GO:0045926 84 0.017
response to hypoxia GO:0001666 53 0.017
nucleoside metabolic process GO:0009116 127 0.017
negative regulation of nucleic acid templated transcription GO:1903507 240 0.016
positive regulation of signaling GO:0023056 243 0.016
regulation of cell size GO:0008361 63 0.016
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.016
establishment of protein localization GO:0045184 163 0.016
sex differentiation GO:0007548 81 0.016
spermatogenesis GO:0007283 200 0.016
purine nucleotide catabolic process GO:0006195 109 0.016
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.016
regulation of phosphorus metabolic process GO:0051174 210 0.016
rna polyadenylation GO:0043631 12 0.016
epidermal cell differentiation GO:0009913 51 0.015
response to extracellular stimulus GO:0009991 116 0.015
actin filament based process GO:0030029 220 0.015
response to insulin GO:0032868 29 0.015
negative regulation of cellular biosynthetic process GO:0031327 277 0.015
purine nucleotide metabolic process GO:0006163 146 0.015
mitochondrion morphogenesis GO:0070584 8 0.015
imaginal disc derived wing morphogenesis GO:0007476 337 0.015
negative regulation of programmed cell death GO:0043069 72 0.015
axon guidance GO:0007411 233 0.015
neuron projection guidance GO:0097485 241 0.015
response to light stimulus GO:0009416 124 0.014
neuronal stem cell division GO:0036445 35 0.014
chromosome organization GO:0051276 360 0.014
establishment of organelle localization GO:0051656 122 0.014
meiotic chromosome segregation GO:0045132 59 0.014
cellular response to organic substance GO:0071310 132 0.014
mitotic sister chromatid separation GO:0051306 30 0.014
ribonucleoside catabolic process GO:0042454 112 0.014
intracellular signal transduction GO:0035556 300 0.014
glycosyl compound catabolic process GO:1901658 112 0.014
regulation of mitotic sister chromatid segregation GO:0033047 28 0.014
ribonucleoside biosynthetic process GO:0042455 3 0.014
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 19 0.014
organonitrogen compound catabolic process GO:1901565 128 0.014
positive regulation of cell death GO:0010942 69 0.014
organic acid metabolic process GO:0006082 103 0.014
cellular response to insulin stimulus GO:0032869 28 0.013
establishment of localization in cell GO:0051649 402 0.013
chromatin silencing GO:0006342 76 0.013
cell cell signaling involved in cell fate commitment GO:0045168 210 0.013
regulation of sister chromatid segregation GO:0033045 28 0.013
negative regulation of mitotic cell cycle GO:0045930 109 0.013
inorganic ion transmembrane transport GO:0098660 73 0.013
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.013
single organism cellular localization GO:1902580 180 0.013
organophosphate metabolic process GO:0019637 195 0.013
regulation of anatomical structure size GO:0090066 163 0.013
protein complex biogenesis GO:0070271 201 0.013
response to biotic stimulus GO:0009607 294 0.012
establishment or maintenance of cytoskeleton polarity GO:0030952 44 0.012
chromosome separation GO:0051304 42 0.012
biological adhesion GO:0022610 138 0.012
regulation of cell cycle GO:0051726 291 0.012
regulation of tor signaling GO:0032006 21 0.012
positive regulation of organelle organization GO:0010638 65 0.012
death GO:0016265 284 0.012
gland development GO:0048732 191 0.012
regulation of feeding behavior GO:0060259 16 0.012
glycosyl compound biosynthetic process GO:1901659 3 0.012
regulation of chromatin organization GO:1902275 32 0.012
cellular response to oxygen levels GO:0071453 30 0.012
positive regulation of protein catabolic process GO:0045732 34 0.012
regulation of notch signaling pathway GO:0008593 100 0.012
regulation of programmed cell death GO:0043067 152 0.012
regulation of wnt signaling pathway GO:0030111 68 0.011
cellular nitrogen compound catabolic process GO:0044270 165 0.011
response to radiation GO:0009314 155 0.011
segmentation GO:0035282 207 0.011
negative regulation of cell death GO:0060548 81 0.011
regulation of chromosome segregation GO:0051983 32 0.011
programmed cell death GO:0012501 257 0.011
chromosome condensation GO:0030261 41 0.011
positive regulation of cellular biosynthetic process GO:0031328 316 0.011
mrna polyadenylation GO:0006378 11 0.011
humoral immune response GO:0006959 117 0.011
developmental maturation GO:0021700 172 0.011
enzyme linked receptor protein signaling pathway GO:0007167 179 0.011
regulation of anatomical structure morphogenesis GO:0022603 242 0.011
protein transport GO:0015031 155 0.011
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.011
pharynx development GO:0060465 1 0.010
cellular response to hypoxia GO:0071456 28 0.010
metaphase anaphase transition of cell cycle GO:0044784 28 0.010
response to external biotic stimulus GO:0043207 293 0.010
positive regulation of cellular protein catabolic process GO:1903364 24 0.010
multicellular organismal aging GO:0010259 140 0.010

ttm50 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.043
cancer DOID:162 0 0.033
organ system cancer DOID:0050686 0 0.033
disease of anatomical entity DOID:7 0 0.029
disease of metabolism DOID:0014667 0 0.015
inherited metabolic disorder DOID:655 0 0.015
diabetes mellitus DOID:9351 0 0.013
type 2 diabetes mellitus DOID:9352 0 0.013
carbohydrate metabolism disease DOID:0050013 0 0.013
glucose metabolism disease DOID:4194 0 0.013
acquired metabolic disease DOID:0060158 0 0.013
central nervous system disease DOID:331 0 0.012
nervous system disease DOID:863 0 0.012