Drosophila melanogaster

94 known processes

Brca2 (Dmel_CG30169)

Breast cancer 2, early onset homolog

(Aliases: brca2,30169,BcDNA:SD25109,dmbrca2,CG13584,CG13583,Dmel\CG30169,CG30169)

Brca2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
double strand break repair via synthesis dependent strand annealing GO:0045003 6 0.997
germarium derived oocyte fate determination GO:0007294 26 0.995
recombinational repair GO:0000725 13 0.995
dna repair GO:0006281 54 0.981
non recombinational repair GO:0000726 7 0.980
dna recombination GO:0006310 32 0.979
mitotic dna damage checkpoint GO:0044773 74 0.969
double strand break repair via nonhomologous end joining GO:0006303 5 0.969
chorion containing eggshell formation GO:0007304 105 0.959
negative regulation of cell cycle phase transition GO:1901988 103 0.958
oocyte differentiation GO:0009994 145 0.946
germarium derived egg chamber formation GO:0007293 101 0.942
double strand break repair GO:0006302 26 0.937
karyosome formation GO:0030717 22 0.933
germarium derived oocyte differentiation GO:0030706 29 0.918
double strand break repair via homologous recombination GO:0000724 13 0.910
meiosis i GO:0007127 59 0.906
dna double strand break processing GO:0000729 3 0.896
g2 dna damage checkpoint GO:0031572 69 0.876
nucleotide excision repair GO:0006289 8 0.870
dna damage checkpoint GO:0000077 78 0.837
mitotic g2 m transition checkpoint GO:0044818 70 0.837
cellular response to dna damage stimulus GO:0006974 223 0.804
meiotic cell cycle process GO:1903046 132 0.785
reciprocal meiotic recombination GO:0007131 19 0.749
mitotic g2 dna damage checkpoint GO:0007095 69 0.748
anterior posterior axis specification GO:0009948 109 0.716
regionalization GO:0003002 416 0.707
mitotic cell cycle checkpoint GO:0007093 88 0.655
telomere maintenance via recombination GO:0000722 1 0.641
regulation of cell cycle phase transition GO:1901987 130 0.640
dna synthesis involved in dna repair GO:0000731 5 0.623
eggshell formation GO:0030703 105 0.606
mitotic dna integrity checkpoint GO:0044774 75 0.591
oocyte fate determination GO:0030716 27 0.582
negative regulation of cell cycle GO:0045786 116 0.573
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.563
dorsal ventral axis specification GO:0009950 66 0.559
polarity specification of dorsal ventral axis GO:0009951 6 0.501
meiotic chromosome segregation GO:0045132 59 0.477
specification of axis polarity GO:0065001 6 0.463
negative regulation of mitotic cell cycle GO:0045930 109 0.432
regulation of cell cycle GO:0051726 291 0.430
polarity specification of anterior posterior axis GO:0009949 5 0.428
mitotic cell cycle phase transition GO:0044772 138 0.424
mitotic dna replication checkpoint GO:0033314 5 0.384
axis specification GO:0009798 167 0.375
dna geometric change GO:0032392 16 0.350
response to organic cyclic compound GO:0014070 89 0.338
dorsal ventral pattern formation GO:0009953 133 0.328
intracellular mrna localization GO:0008298 66 0.328
regulation of dna recombination GO:0000018 4 0.325
oocyte construction GO:0007308 112 0.318
dna duplex unwinding GO:0032508 16 0.313
organic cyclic compound catabolic process GO:1901361 168 0.310
oocyte development GO:0048599 124 0.306
dna conformation change GO:0071103 105 0.290
eggshell chorion assembly GO:0007306 66 0.283
negative regulation of cell cycle process GO:0010948 109 0.269
cell cycle phase transition GO:0044770 140 0.265
rna localization GO:0006403 115 0.247
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 11 0.230
organophosphate metabolic process GO:0019637 195 0.220
columnar cuboidal epithelial cell development GO:0002066 249 0.215
postreplication repair GO:0006301 2 0.214
ovarian follicle cell development GO:0030707 248 0.211
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.205
regulation of double strand break repair GO:2000779 3 0.199
regulation of mitotic cell cycle GO:0007346 190 0.198
small molecule metabolic process GO:0044281 305 0.194
regulation of mitotic cell cycle phase transition GO:1901990 130 0.187
dna metabolic process GO:0006259 227 0.175
dorsal appendage formation GO:0046843 47 0.163
translesion synthesis GO:0019985 2 0.162
chromosome segregation GO:0007059 157 0.161
cellular catabolic process GO:0044248 372 0.158
nucleobase containing compound catabolic process GO:0034655 165 0.157
response to organic substance GO:0010033 284 0.157
cell fate determination GO:0001709 91 0.150
regulation of cell cycle process GO:0010564 181 0.148
response to alkaloid GO:0043279 26 0.145
aromatic compound catabolic process GO:0019439 166 0.142
regulation of dna repair GO:0006282 5 0.141
response to nitrogen compound GO:1901698 90 0.139
epithelial cell development GO:0002064 274 0.137
cellular nitrogen compound catabolic process GO:0044270 165 0.134
organic substance catabolic process GO:1901575 308 0.130
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.127
response to organonitrogen compound GO:0010243 75 0.117
chromosome organization GO:0051276 360 0.116
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.115
regulation of response to dna damage stimulus GO:2001020 23 0.115
ribonucleotide metabolic process GO:0009259 145 0.115
dna integrity checkpoint GO:0031570 81 0.113
neurological system process GO:0050877 358 0.109
macromolecule catabolic process GO:0009057 161 0.107
cell cycle checkpoint GO:0000075 95 0.106
positive regulation of biosynthetic process GO:0009891 316 0.105
regulation of cellular catabolic process GO:0031329 157 0.104
gene silencing GO:0016458 138 0.104
heterocycle catabolic process GO:0046700 166 0.104
cellular component assembly involved in morphogenesis GO:0010927 151 0.103
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.101
mitotic recombination GO:0006312 2 0.100
oocyte dorsal ventral axis specification GO:0007310 34 0.100
reciprocal dna recombination GO:0035825 19 0.097
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.095
aging GO:0007568 143 0.094
nucleoside triphosphate catabolic process GO:0009143 108 0.089
cellular macromolecule catabolic process GO:0044265 136 0.087
oocyte axis specification GO:0007309 108 0.086
purine nucleotide metabolic process GO:0006163 146 0.084
actin polymerization or depolymerization GO:0008154 31 0.080
catabolic process GO:0009056 409 0.080
cell maturation GO:0048469 144 0.077
cellular macromolecule localization GO:0070727 220 0.076
single organism biosynthetic process GO:0044711 206 0.076
glycosyl compound metabolic process GO:1901657 127 0.075
regulation of organelle organization GO:0033043 196 0.075
single organism catabolic process GO:0044712 228 0.072
single organism intracellular transport GO:1902582 207 0.071
response to abiotic stimulus GO:0009628 341 0.069
regulation of phosphate metabolic process GO:0019220 210 0.068
epithelial cell differentiation GO:0030855 322 0.067
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.066
regulation of mrna metabolic process GO:1903311 72 0.065
cellular response to organic substance GO:0071310 132 0.065
pole plasm assembly GO:0007315 61 0.064
purine containing compound catabolic process GO:0072523 112 0.064
meiotic chromosome separation GO:0051307 8 0.063
carbohydrate derivative catabolic process GO:1901136 118 0.062
ribonucleoside catabolic process GO:0042454 112 0.061
nuclear division GO:0000280 332 0.060
purine ribonucleoside metabolic process GO:0046128 127 0.059
response to oxygen containing compound GO:1901700 200 0.058
response to endogenous stimulus GO:0009719 119 0.058
purine nucleoside triphosphate catabolic process GO:0009146 108 0.058
purine ribonucleoside monophosphate metabolic process GO:0009167 50 0.057
regulation of multicellular organismal development GO:2000026 414 0.057
organonitrogen compound metabolic process GO:1901564 318 0.056
nucleoside phosphate metabolic process GO:0006753 162 0.056
response to radiation GO:0009314 155 0.055
response to caffeine GO:0031000 12 0.054
anion homeostasis GO:0055081 3 0.053
ribonucleoside metabolic process GO:0009119 127 0.052
enzyme linked receptor protein signaling pathway GO:0007167 179 0.052
positive regulation of gene expression GO:0010628 290 0.051
purine nucleoside metabolic process GO:0042278 127 0.050
dna biosynthetic process GO:0071897 24 0.050
cellular response to chemical stimulus GO:0070887 199 0.050
organophosphate catabolic process GO:0046434 112 0.050
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.049
protein complex biogenesis GO:0070271 201 0.049
purine ribonucleoside catabolic process GO:0046130 112 0.049
nucleobase containing small molecule metabolic process GO:0055086 174 0.048
response to ionizing radiation GO:0010212 32 0.047
dna catabolic process GO:0006308 16 0.046
telomere maintenance GO:0000723 21 0.046
organelle fission GO:0048285 340 0.045
organonitrogen compound catabolic process GO:1901565 128 0.044
mitotic nuclear division GO:0007067 213 0.044
pole plasm rna localization GO:0007316 52 0.044
g protein coupled receptor signaling pathway GO:0007186 136 0.044
developmental maturation GO:0021700 172 0.043
regulation of embryonic development GO:0045995 68 0.043
negative regulation of transposition GO:0010529 12 0.043
chromosome separation GO:0051304 42 0.042
nucleotide catabolic process GO:0009166 109 0.041
regulation of anatomical structure size GO:0090066 163 0.041
purine ribonucleotide metabolic process GO:0009150 145 0.041
female meiotic division GO:0007143 70 0.040
signal transduction in response to dna damage GO:0042770 3 0.040
nucleoside phosphate catabolic process GO:1901292 110 0.039
telomere organization GO:0032200 21 0.039
cellular response to abiotic stimulus GO:0071214 58 0.038
purine ribonucleotide catabolic process GO:0009154 109 0.037
nucleotide metabolic process GO:0009117 161 0.037
negative regulation of transcription dna templated GO:0045892 237 0.036
regulation of actin filament length GO:0030832 27 0.036
response to nutrient levels GO:0031667 114 0.036
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.035
intracellular signal transduction GO:0035556 300 0.035
response to light stimulus GO:0009416 124 0.035
atp metabolic process GO:0046034 49 0.035
anterior posterior pattern specification GO:0009952 136 0.035
pole plasm oskar mrna localization GO:0045451 46 0.033
negative regulation of signal transduction GO:0009968 206 0.033
cellular response to organic cyclic compound GO:0071407 32 0.033
carbohydrate derivative metabolic process GO:1901135 217 0.032
g2 m transition of mitotic cell cycle GO:0000086 19 0.032
programmed cell death GO:0012501 257 0.032
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.031
ribonucleotide catabolic process GO:0009261 109 0.031
negative regulation of gene expression GO:0010629 387 0.031
purine nucleoside monophosphate catabolic process GO:0009128 38 0.031
multicellular organismal aging GO:0010259 140 0.030
cellular response to light stimulus GO:0071482 37 0.030
negative regulation of nucleic acid templated transcription GO:1903507 240 0.030
gene silencing by rna GO:0031047 57 0.030
lipid metabolic process GO:0006629 121 0.029
regulation of mrna processing GO:0050684 71 0.029
apoptotic process GO:0006915 159 0.029
regulation of actin polymerization or depolymerization GO:0008064 27 0.029
purine containing compound metabolic process GO:0072521 155 0.029
cellular response to radiation GO:0071478 52 0.028
nucleoside triphosphate metabolic process GO:0009141 120 0.028
ribonucleoside triphosphate metabolic process GO:0009199 119 0.027
single organism cellular localization GO:1902580 180 0.027
determination of adult lifespan GO:0008340 137 0.027
tripartite regional subdivision GO:0007351 103 0.027
regulation of transposition GO:0010528 13 0.026
transcription from rna polymerase ii promoter GO:0006366 368 0.026
regulation of cellular response to stress GO:0080135 89 0.026
dna replication GO:0006260 48 0.026
positive regulation of nucleic acid templated transcription GO:1903508 266 0.026
phosphorylation GO:0016310 294 0.026
epithelial cell migration GO:0010631 148 0.026
cell aging GO:0007569 2 0.025
homeostatic process GO:0042592 199 0.025
ribose phosphate metabolic process GO:0019693 145 0.025
purine nucleoside catabolic process GO:0006152 112 0.025
eggshell chorion gene amplification GO:0007307 9 0.025
response to purine containing compound GO:0014074 12 0.025
response to temperature stimulus GO:0009266 106 0.024
cell death GO:0008219 279 0.024
sensory perception of pain GO:0019233 4 0.024
cell proliferation GO:0008283 299 0.024
pirna metabolic process GO:0034587 10 0.024
meiotic cell cycle GO:0051321 171 0.023
nucleoside catabolic process GO:0009164 112 0.023
negative regulation of cell division GO:0051782 17 0.023
cellular response to organonitrogen compound GO:0071417 36 0.023
segmentation GO:0035282 207 0.023
oocyte anterior posterior axis specification GO:0007314 72 0.022
regulation of alternative mrna splicing via spliceosome GO:0000381 60 0.022
positive regulation of rna biosynthetic process GO:1902680 266 0.022
resolution of meiotic recombination intermediates GO:0000712 6 0.022
apoptotic signaling pathway GO:0097190 27 0.022
death GO:0016265 284 0.022
positive regulation of cellular catabolic process GO:0031331 95 0.022
positive regulation of macromolecule metabolic process GO:0010604 405 0.021
alternative mrna splicing via spliceosome GO:0000380 60 0.021
ribonucleoside monophosphate metabolic process GO:0009161 51 0.021
protein phosphorylation GO:0006468 169 0.021
mitotic sister chromatid segregation GO:0000070 87 0.021
synaptic transmission GO:0007268 288 0.021
blastoderm segmentation GO:0007350 159 0.021
regulation of actin filament polymerization GO:0030833 25 0.021
cellular response to nitrogen compound GO:1901699 51 0.021
regulation of phosphorus metabolic process GO:0051174 210 0.021
response to metal ion GO:0010038 23 0.021
cellular response to ionizing radiation GO:0071479 15 0.020
response to alcohol GO:0097305 95 0.020
positive regulation of rna metabolic process GO:0051254 271 0.020
positive regulation of phosphorus metabolic process GO:0010562 139 0.020
purine nucleoside monophosphate metabolic process GO:0009126 50 0.020
immune system process GO:0002376 347 0.020
positive regulation of organelle organization GO:0010638 65 0.020
dna dependent dna replication GO:0006261 17 0.020
ribonucleoside triphosphate catabolic process GO:0009203 108 0.020
positive regulation of response to stimulus GO:0048584 323 0.020
compound eye development GO:0048749 307 0.020
oxoacid metabolic process GO:0043436 103 0.019
cell migration GO:0016477 238 0.019
nucleoside metabolic process GO:0009116 127 0.019
cytoplasm organization GO:0007028 64 0.019
oocyte maturation GO:0001556 3 0.019
chorion containing eggshell pattern formation GO:0030381 11 0.019
regulation of gene expression epigenetic GO:0040029 128 0.018
ion homeostasis GO:0050801 55 0.018
dna amplification GO:0006277 11 0.018
organ growth GO:0035265 56 0.018
negative regulation of rna biosynthetic process GO:1902679 240 0.018
mrna processing GO:0006397 104 0.018
meiotic nuclear division GO:0007126 151 0.018
positive regulation of phosphate metabolic process GO:0045937 139 0.018
regulation of double strand break repair via homologous recombination GO:0010569 2 0.018
purine ribonucleoside monophosphate catabolic process GO:0009169 38 0.017
connective tissue development GO:0061448 3 0.017
organic acid metabolic process GO:0006082 103 0.017
nucleoside monophosphate metabolic process GO:0009123 52 0.017
response to oxygen levels GO:0070482 59 0.017
response to decreased oxygen levels GO:0036293 58 0.016
purine nucleotide catabolic process GO:0006195 109 0.016
negative regulation of dna recombination GO:0045910 2 0.016
dna methylation or demethylation GO:0044728 4 0.016
anatomical structure homeostasis GO:0060249 97 0.016
embryonic pattern specification GO:0009880 174 0.016
cellular macromolecular complex assembly GO:0034622 153 0.016
negative regulation of response to stimulus GO:0048585 258 0.016
negative regulation of g1 s transition of mitotic cell cycle GO:2000134 13 0.016
cellular lipid metabolic process GO:0044255 83 0.015
regulation of catabolic process GO:0009894 170 0.015
regulation of response to stress GO:0080134 200 0.015
cell cycle g2 m phase transition GO:0044839 22 0.015
positive regulation of mapk cascade GO:0043410 63 0.015
negative regulation of cellular biosynthetic process GO:0031327 277 0.015
regulation of intracellular signal transduction GO:1902531 236 0.015
glycerolipid metabolic process GO:0046486 34 0.015
intracellular mrna localization involved in pattern specification process GO:0060810 56 0.015
regulation of rna splicing GO:0043484 69 0.015
embryonic axis specification GO:0000578 107 0.015
protein modification process GO:0036211 438 0.015
cellular response to gamma radiation GO:0071480 10 0.015
epithelium migration GO:0090132 148 0.014
oocyte nucleus localization involved in oocyte dorsal ventral axis specification GO:0051663 12 0.014
response to ethanol GO:0045471 59 0.014
regulation of cellular amine metabolic process GO:0033238 3 0.014
cellular protein modification process GO:0006464 438 0.014
regulation of dna metabolic process GO:0051052 34 0.014
tor signaling GO:0031929 32 0.014
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.013
response to other organism GO:0051707 293 0.013
regulation of embryonic pattern specification GO:1902875 27 0.013
negative regulation of cellular metabolic process GO:0031324 382 0.013
negative regulation of cell communication GO:0010648 223 0.013
actin filament organization GO:0007015 126 0.013
chaeta development GO:0022416 97 0.013
cellular homeostasis GO:0019725 80 0.013
cellular cation homeostasis GO:0030003 38 0.013
regulation of transposition rna mediated GO:0010525 3 0.013
intrinsic apoptotic signaling pathway GO:0097193 16 0.013
ribonucleoside monophosphate catabolic process GO:0009158 39 0.013
response to hypoxia GO:0001666 53 0.012
ras protein signal transduction GO:0007265 88 0.012
transmembrane transport GO:0055085 139 0.012
negative regulation of cell cycle g2 m phase transition GO:1902750 8 0.012
vesicle mediated transport GO:0016192 381 0.012
spermatogenesis GO:0007283 200 0.012
cellular response to oxygen containing compound GO:1901701 79 0.012
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.012
toxin metabolic process GO:0009404 2 0.012
modification dependent protein catabolic process GO:0019941 78 0.012
defense response to other organism GO:0098542 225 0.012
response to extracellular stimulus GO:0009991 116 0.012
anterior posterior axis specification embryo GO:0008595 103 0.012
inositol lipid mediated signaling GO:0048017 4 0.011
regulation of developmental growth GO:0048638 174 0.011
cellular protein complex assembly GO:0043623 71 0.011
regulation of hydrolase activity GO:0051336 97 0.011
regulation of small gtpase mediated signal transduction GO:0051056 93 0.011
positive regulation of intracellular signal transduction GO:1902533 116 0.011
single organism behavior GO:0044708 391 0.011
positive regulation of signaling GO:0023056 243 0.011
regulation of catalytic activity GO:0050790 185 0.011
positive regulation of cellular component organization GO:0051130 156 0.011
protein complex assembly GO:0006461 200 0.011
transposition rna mediated GO:0032197 3 0.010
cellular amine metabolic process GO:0044106 12 0.010
localization of cell GO:0051674 257 0.010
dna packaging GO:0006323 91 0.010
ameboidal type cell migration GO:0001667 151 0.010
neuron remodeling GO:0016322 29 0.010
male gamete generation GO:0048232 201 0.010

Brca2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
thoracic cancer DOID:5093 0 0.092
cancer DOID:162 0 0.092
disease of cellular proliferation DOID:14566 0 0.092
organ system cancer DOID:0050686 0 0.092
hypertension DOID:10763 0 0.034
artery disease DOID:0050828 0 0.034
disease of anatomical entity DOID:7 0 0.034
vascular disease DOID:178 0 0.034
cardiovascular system disease DOID:1287 0 0.034
breast cancer DOID:1612 0 0.021