Drosophila melanogaster

145 known processes

Syt1 (Dmel_CG3139)

Synaptotagmin 1

(Aliases: dsytI,l(2)k05909,D. Syt I,DSYT,syt 1,dSYT,syt-1,sytI,Syt,SYT I,l(2)23Ba,Dmel\CG3139,syt1,SytI,Droso1,syt,syt I,Dsyt2,l(2)23AB1,Syt-1,CG3139,SYT1,SYT,Syt I,dsyt1,DSYT2)

Syt1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
synaptic transmission GO:0007268 288 1.000
regulation of synaptic transmission GO:0050804 69 0.981
synaptic vesicle recycling GO:0036465 28 0.978
neuromuscular synaptic transmission GO:0007274 67 0.960
synapse organization GO:0050808 196 0.937
regulation of neurotransmitter levels GO:0001505 38 0.929
neurotransmitter transport GO:0006836 37 0.926
synaptic vesicle endocytosis GO:0048488 28 0.912
establishment of vesicle localization GO:0051650 51 0.897
neurotransmitter secretion GO:0007269 35 0.893
neuromuscular junction development GO:0007528 149 0.870
single organism membrane fusion GO:0044801 42 0.861
signal release GO:0023061 49 0.829
synaptic vesicle transport GO:0048489 50 0.795
single organism behavior GO:0044708 391 0.742
membrane fusion GO:0061025 42 0.700
neuron neuron synaptic transmission GO:0007270 14 0.665
Mouse
establishment of localization in cell GO:0051649 402 0.492
synaptic vesicle localization GO:0097479 53 0.476
locomotory behavior GO:0007626 176 0.459
establishment of organelle localization GO:0051656 122 0.431
establishment of synaptic vesicle localization GO:0097480 50 0.430
regulation of synaptic growth at neuromuscular junction GO:0008582 89 0.409
synaptic growth at neuromuscular junction GO:0051124 119 0.400
synaptic vesicle fusion to presynaptic membrane GO:0031629 7 0.395
adult locomotory behavior GO:0008344 76 0.373
endocytosis GO:0006897 310 0.315
regulation of localization GO:0032879 275 0.280
vesicle localization GO:0051648 55 0.276
secretion by cell GO:0032940 101 0.274
developmental growth GO:0048589 280 0.255
ion transmembrane transport GO:0034220 122 0.245
regulation of synapse organization GO:0050807 110 0.216
synapse assembly GO:0007416 143 0.214
secretion GO:0046903 109 0.209
neurotransmitter metabolic process GO:0042133 2 0.204
single organism membrane organization GO:0044802 93 0.193
cation transmembrane transport GO:0098655 88 0.186
cell motility GO:0048870 251 0.179
membrane organization GO:0061024 112 0.178
negative regulation of response to stimulus GO:0048585 258 0.166
regulation of cellular localization GO:0060341 136 0.165
cognition GO:0050890 141 0.155
regulation of neurotransmitter secretion GO:0046928 14 0.147
Worm
cell proliferation GO:0008283 299 0.129
response to heat GO:0009408 63 0.128
larval behavior GO:0030537 42 0.124
negative regulation of synaptic growth at neuromuscular junction GO:0045886 39 0.123
regulation of synapse assembly GO:0051963 94 0.116
synaptic transmission glutamatergic GO:0035249 7 0.116
Mouse
response to mechanical stimulus GO:0009612 28 0.114
regulation of nervous system development GO:0051960 248 0.113
cell migration GO:0016477 238 0.112
synaptic vesicle exocytosis GO:0016079 16 0.111
Mouse
cell maturation GO:0048469 144 0.104
developmental maturation GO:0021700 172 0.103
homeostatic process GO:0042592 199 0.103
transmembrane transport GO:0055085 139 0.102
chemical homeostasis GO:0048878 92 0.100
positive regulation of synaptic transmission GO:0050806 15 0.096
Mouse
larval locomotory behavior GO:0008345 27 0.092
positive regulation of synaptic growth at neuromuscular junction GO:0045887 26 0.089
programmed cell death GO:0012501 257 0.087
organonitrogen compound biosynthetic process GO:1901566 117 0.085
regulation of secretion by cell GO:1903530 39 0.084
Rat Worm
response to starvation GO:0042594 97 0.084
response to alcohol GO:0097305 95 0.083
multi multicellular organism process GO:0044706 123 0.077
regulation of multicellular organismal development GO:2000026 414 0.076
macromolecular complex assembly GO:0065003 256 0.072
multicellular organismal reproductive behavior GO:0033057 110 0.072
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.071
organic hydroxy compound metabolic process GO:1901615 83 0.071
axonogenesis GO:0007409 290 0.071
regulation of excitatory postsynaptic membrane potential GO:0060079 3 0.070
learning or memory GO:0007611 141 0.069
cellular chemical homeostasis GO:0055082 40 0.067
regulation of organelle organization GO:0033043 196 0.065
regulation of multi organism process GO:0043900 131 0.064
inorganic cation transmembrane transport GO:0098662 61 0.063
response to organic substance GO:0010033 284 0.062
organelle localization GO:0051640 148 0.062
small molecule metabolic process GO:0044281 305 0.060
cellular metal ion homeostasis GO:0006875 31 0.060
positive regulation of macromolecule metabolic process GO:0010604 405 0.060
regulation of neurotransmitter transport GO:0051588 14 0.059
Worm
adult behavior GO:0030534 137 0.059
positive regulation of cellular biosynthetic process GO:0031328 316 0.057
organelle assembly GO:0070925 198 0.057
regulation of synapse structure and activity GO:0050803 128 0.056
cellular homeostasis GO:0019725 80 0.055
positive regulation of cellular component biogenesis GO:0044089 80 0.054
receptor clustering GO:0043113 3 0.052
vesicle mediated transport GO:0016192 381 0.052
regulation of synaptic vesicle transport GO:1902803 10 0.051
organic substance transport GO:0071702 257 0.051
positive regulation of transport GO:0051050 92 0.048
regulation of synaptic vesicle endocytosis GO:1900242 7 0.048
protein modification process GO:0036211 438 0.047
body morphogenesis GO:0010171 2 0.046
positive regulation of neurotransmitter secretion GO:0001956 2 0.045
positive regulation of synaptic vesicle endocytosis GO:1900244 4 0.045
organonitrogen compound metabolic process GO:1901564 318 0.045
cation transport GO:0006812 110 0.044
oxoacid metabolic process GO:0043436 103 0.044
epithelial cell migration GO:0010631 148 0.044
regulation of immune system process GO:0002682 176 0.043
regulation of phosphorus metabolic process GO:0051174 210 0.043
Yeast
neurotransmitter receptor metabolic process GO:0045213 3 0.043
phenol containing compound metabolic process GO:0018958 57 0.042
cellular response to nutrient levels GO:0031669 62 0.042
localization of cell GO:0051674 257 0.041
salivary gland morphogenesis GO:0007435 145 0.040
macromolecule catabolic process GO:0009057 161 0.040
regulation of cell death GO:0010941 173 0.039
Worm
regulation of transport GO:0051049 181 0.038
positive regulation of synaptic vesicle recycling GO:1903423 4 0.038
immune system process GO:0002376 347 0.038
protein localization GO:0008104 284 0.038
regulation of cell differentiation GO:0045595 302 0.038
cellular macromolecule localization GO:0070727 220 0.037
response to abiotic stimulus GO:0009628 341 0.037
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.037
regulation of reproductive process GO:2000241 54 0.037
regulation of ion transmembrane transport GO:0034765 27 0.036
feeding behavior GO:0007631 50 0.036
Worm
mitotic nuclear division GO:0007067 213 0.036
positive regulation of secretion GO:0051047 22 0.036
Rat
regulation of neurogenesis GO:0050767 158 0.036
heart contraction GO:0060047 26 0.035
cellular protein localization GO:0034613 160 0.035
regulation of secretion GO:0051046 44 0.035
Rat Worm
negative regulation of cellular component organization GO:0051129 108 0.035
regulation of epithelial cell proliferation GO:0050678 4 0.034
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.034
regulation of apoptotic process GO:0042981 130 0.034
cation homeostasis GO:0055080 51 0.034
cellular response to chemical stimulus GO:0070887 199 0.034
protein complex biogenesis GO:0070271 201 0.034
memory GO:0007613 94 0.034
vesicle fusion GO:0006906 19 0.033
regulation of synaptic vesicle exocytosis GO:2000300 3 0.033
cytokinesis GO:0000910 90 0.032
exocytosis GO:0006887 28 0.031
Mouse Rat
central nervous system development GO:0007417 201 0.031
positive regulation of biosynthetic process GO:0009891 316 0.031
sensory perception GO:0007600 196 0.031
positive regulation of rna metabolic process GO:0051254 271 0.031
mrna metabolic process GO:0016071 124 0.031
cell division GO:0051301 248 0.030
positive regulation of cell communication GO:0010647 250 0.030
Mouse
cellular cation homeostasis GO:0030003 38 0.030
regulation of protein metabolic process GO:0051246 256 0.030
regulation of cellular component biogenesis GO:0044087 201 0.030
cell death GO:0008219 279 0.030
Worm
carboxylic acid metabolic process GO:0019752 92 0.030
response to temperature stimulus GO:0009266 106 0.030
posttranscriptional regulation of gene expression GO:0010608 145 0.029
neurological system process GO:0050877 358 0.029
heart process GO:0003015 37 0.029
transcription from rna polymerase ii promoter GO:0006366 368 0.029
response to other organism GO:0051707 293 0.029
neuromuscular process GO:0050905 21 0.029
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 65 0.028
regulation of system process GO:0044057 36 0.028
organic substance catabolic process GO:1901575 308 0.027
negative regulation of hormone biosynthetic process GO:0032353 1 0.027
positive regulation of phosphate metabolic process GO:0045937 139 0.027
regulation of neuron projection development GO:0010975 69 0.027
rna processing GO:0006396 147 0.027
sensory perception of mechanical stimulus GO:0050954 72 0.026
regulation of cell maturation GO:1903429 27 0.026
regulation of cell development GO:0060284 215 0.026
positive regulation of response to stimulus GO:0048584 323 0.026
regulation of vesicle mediated transport GO:0060627 59 0.025
flight behavior GO:0007629 26 0.025
stem cell differentiation GO:0048863 117 0.025
amine metabolic process GO:0009308 12 0.025
growth GO:0040007 359 0.025
single organism biosynthetic process GO:0044711 206 0.024
positive regulation of organelle organization GO:0010638 65 0.024
protein complex assembly GO:0006461 200 0.024
multi organism behavior GO:0051705 175 0.024
embryonic morphogenesis GO:0048598 206 0.024
male courtship behavior GO:0008049 63 0.024
dendrite development GO:0016358 204 0.024
positive regulation of signaling GO:0023056 243 0.024
Mouse
vesicle organization GO:0016050 44 0.023
regulation of cell projection organization GO:0031344 92 0.023
chemotaxis GO:0006935 249 0.023
catecholamine biosynthetic process GO:0042423 3 0.022
columnar cuboidal epithelial cell development GO:0002066 249 0.022
multicellular organismal aging GO:0010259 140 0.022
regulation of behavior GO:0050795 75 0.021
Worm
membrane depolarization GO:0051899 4 0.021
regulation of necrotic cell death GO:0010939 1 0.021
Worm
positive regulation of cellular component organization GO:0051130 156 0.021
regulation of membrane potential GO:0042391 35 0.021
regulation of cellular amine metabolic process GO:0033238 3 0.021
negative regulation of gene expression GO:0010629 387 0.021
response to endogenous stimulus GO:0009719 119 0.021
regulation of ion transport GO:0043269 39 0.021
synaptic transmission dopaminergic GO:0001963 2 0.020
peptide metabolic process GO:0006518 80 0.020
carbohydrate metabolic process GO:0005975 82 0.020
regulation of cell morphogenesis involved in differentiation GO:0010769 61 0.020
dopamine biosynthetic process GO:0042416 3 0.020
catabolic process GO:0009056 409 0.020
tissue migration GO:0090130 155 0.020
rna localization GO:0006403 115 0.020
cytoplasmic transport GO:0016482 130 0.019
epithelial cell differentiation GO:0030855 322 0.019
intracellular transport GO:0046907 228 0.019
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.019
cellular component assembly involved in morphogenesis GO:0010927 151 0.019
organelle fusion GO:0048284 46 0.018
myofibril assembly GO:0030239 36 0.018
cellular amine metabolic process GO:0044106 12 0.018
regulation of steroid metabolic process GO:0019218 2 0.018
epithelial cell development GO:0002064 274 0.018
regulation of heart contraction GO:0008016 21 0.018
cellular catabolic process GO:0044248 372 0.018
negative regulation of cell differentiation GO:0045596 143 0.017
regulation of blood circulation GO:1903522 21 0.017
regulation of endocytosis GO:0030100 37 0.017
response to extracellular stimulus GO:0009991 116 0.017
circulatory system process GO:0003013 37 0.017
positive regulation of transcription dna templated GO:0045893 266 0.017
positive regulation of signal transduction GO:0009967 223 0.017
cellular amino acid metabolic process GO:0006520 61 0.017
nucleobase containing small molecule metabolic process GO:0055086 174 0.017
positive regulation of protein metabolic process GO:0051247 128 0.016
negative regulation of cellular metabolic process GO:0031324 382 0.016
digestive tract morphogenesis GO:0048546 127 0.016
cell growth GO:0016049 108 0.016
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.016
positive regulation of multicellular organismal process GO:0051240 143 0.015
regulation of synaptic vesicle recycling GO:1903421 7 0.015
cellular ion homeostasis GO:0006873 39 0.015
phagocytosis GO:0006909 215 0.015
centriole assembly GO:0098534 24 0.015
dopamine metabolic process GO:0042417 7 0.015
cellular amide metabolic process GO:0043603 80 0.015
larval development GO:0002164 104 0.015
neuron maturation GO:0042551 31 0.015
sensory perception of sound GO:0007605 56 0.015
cuticle pigmentation GO:0048067 22 0.015
negative regulation of multicellular organismal process GO:0051241 142 0.015
water homeostasis GO:0030104 3 0.014
negative regulation of cellular biosynthetic process GO:0031327 277 0.014
cellular response to organic substance GO:0071310 132 0.014
metal ion transport GO:0030001 74 0.014
muscle structure development GO:0061061 224 0.014
oocyte maturation GO:0001556 3 0.014
digestive tract development GO:0048565 149 0.014
positive regulation of synapse assembly GO:0051965 29 0.014
monocarboxylic acid biosynthetic process GO:0072330 7 0.014
dna metabolic process GO:0006259 227 0.014
cellular response to carbohydrate stimulus GO:0071322 4 0.014
negative regulation of developmental process GO:0051093 201 0.013
single organism cellular localization GO:1902580 180 0.013
cell cell signaling involved in cell fate commitment GO:0045168 210 0.013
organonitrogen compound catabolic process GO:1901565 128 0.013
negative regulation of cellular protein metabolic process GO:0032269 85 0.013
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.013
anatomical structure homeostasis GO:0060249 97 0.013
regulation of protein modification process GO:0031399 112 0.013
embryonic pattern specification GO:0009880 174 0.013
regulation of response to stress GO:0080134 200 0.013
intracellular signal transduction GO:0035556 300 0.013
enzyme linked receptor protein signaling pathway GO:0007167 179 0.013
cellular response to monosaccharide stimulus GO:0071326 2 0.013
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.012
regulation of membrane depolarization GO:0003254 1 0.012
single organism carbohydrate metabolic process GO:0044723 72 0.012
negative regulation of epithelial cell proliferation GO:0050680 4 0.012
ion homeostasis GO:0050801 55 0.012
positive regulation of intracellular signal transduction GO:1902533 116 0.012
single organism catabolic process GO:0044712 228 0.012
protein phosphorylation GO:0006468 169 0.012
regulation of cellular protein metabolic process GO:0032268 243 0.012
positive regulation of phosphorus metabolic process GO:0010562 139 0.012
regulation of cell cycle GO:0051726 291 0.012
intracellular distribution of mitochondria GO:0048312 5 0.012
purine containing compound metabolic process GO:0072521 155 0.012
cellular response to endogenous stimulus GO:0071495 80 0.012
defense response to other organism GO:0098542 225 0.012
regulation of phosphate metabolic process GO:0019220 210 0.012
Yeast
cellular protein modification process GO:0006464 438 0.012
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.012
respiratory system development GO:0060541 213 0.012
negative regulation of biosynthetic process GO:0009890 277 0.012
compound eye photoreceptor cell differentiation GO:0001751 140 0.012
epidermis development GO:0008544 65 0.012
negative regulation of neuromuscular synaptic transmission GO:1900074 7 0.012
regulation of programmed cell death GO:0043067 152 0.012
synaptic transmission gabaergic GO:0051932 1 0.012
regulation of protein kinase activity GO:0045859 51 0.011
morphogenesis of embryonic epithelium GO:0016331 94 0.011
positive regulation of developmental process GO:0051094 143 0.011
apoptotic process GO:0006915 159 0.011
glutamate metabolic process GO:0006536 5 0.011
sensory perception of pain GO:0019233 4 0.011
response to hormone GO:0009725 45 0.011
regulation of feeding behavior GO:0060259 16 0.011
Worm
tissue morphogenesis GO:0048729 297 0.011
regulation of cell cycle process GO:0010564 181 0.011
centrosome organization GO:0051297 163 0.011
calcium ion homeostasis GO:0055074 23 0.011
positive regulation of nucleic acid templated transcription GO:1903508 266 0.011
extrinsic apoptotic signaling pathway GO:0097191 1 0.011
axon guidance GO:0007411 233 0.011
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 38 0.011
organic acid metabolic process GO:0006082 103 0.011
apoptotic process involved in morphogenesis GO:0060561 3 0.010
compound eye development GO:0048749 307 0.010
negative regulation of nervous system development GO:0051961 92 0.010
autophagic vacuole assembly GO:0000045 2 0.010
regulation of cellular ketone metabolic process GO:0010565 3 0.010
wing disc morphogenesis GO:0007472 344 0.010
peripheral nervous system development GO:0007422 52 0.010
cellular response to oxygen containing compound GO:1901701 79 0.010
synaptic transmission cholinergic GO:0007271 9 0.010
gland morphogenesis GO:0022612 145 0.010

Syt1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.036
nervous system disease DOID:863 0 0.034
central nervous system disease DOID:331 0 0.026
neurodegenerative disease DOID:1289 0 0.026
cancer DOID:162 0 0.025
disease of cellular proliferation DOID:14566 0 0.025
organ system cancer DOID:0050686 0 0.019
neuropathy DOID:870 0 0.017
musculoskeletal system disease DOID:17 0 0.010