Drosophila melanogaster

41 known processes

TotA (Dmel_CG31509)

Turandot A

(Aliases: totA,Turt,Dmel\CG31509,tot,Tot,Tot-A,CG31509)

TotA biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
response to mercury ion GO:0046689 3 0.434
insecticide catabolic process GO:0046701 1 0.363
lauric acid metabolic process GO:0048252 1 0.325
defense response to other organism GO:0098542 225 0.231
insecticide metabolic process GO:0017143 2 0.222
secondary metabolite catabolic process GO:0090487 1 0.204
toxin catabolic process GO:0009407 1 0.177
response to other organism GO:0051707 293 0.176
xenobiotic catabolic process GO:0042178 1 0.170
secondary metabolic process GO:0019748 75 0.138
response to organophosphorus GO:0046683 2 0.131
fat soluble vitamin biosynthetic process GO:0042362 1 0.125
defense response GO:0006952 300 0.120
steroid catabolic process GO:0006706 1 0.117
response to organic substance GO:0010033 284 0.116
response to external biotic stimulus GO:0043207 293 0.115
vitamin biosynthetic process GO:0009110 1 0.114
vitamin metabolic process GO:0006766 2 0.106
catabolic process GO:0009056 409 0.103
response to bacterium GO:0009617 198 0.101
lipid metabolic process GO:0006629 121 0.098
cellular catabolic process GO:0044248 372 0.095
response to biotic stimulus GO:0009607 294 0.095
defense response to bacterium GO:0042742 178 0.090
response to insecticide GO:0017085 14 0.083
organonitrogen compound metabolic process GO:1901564 318 0.073
positive regulation of gene expression GO:0010628 290 0.071
organic hydroxy compound metabolic process GO:1901615 83 0.071
small molecule metabolic process GO:0044281 305 0.068
organonitrogen compound catabolic process GO:1901565 128 0.065
homeostatic process GO:0042592 199 0.060
carboxylic acid metabolic process GO:0019752 92 0.060
single organism behavior GO:0044708 391 0.059
polyol biosynthetic process GO:0046173 3 0.058
organic substance catabolic process GO:1901575 308 0.057
immune system process GO:0002376 347 0.056
oxoacid metabolic process GO:0043436 103 0.056
single organism catabolic process GO:0044712 228 0.056
cellular ketone metabolic process GO:0042180 24 0.056
imaginal disc derived appendage morphogenesis GO:0035114 395 0.055
developmental growth GO:0048589 280 0.055
response to metal ion GO:0010038 23 0.055
anion homeostasis GO:0055081 3 0.055
behavioral response to ethanol GO:0048149 49 0.054
growth GO:0040007 359 0.054
cellular response to chemical stimulus GO:0070887 199 0.054
wing disc morphogenesis GO:0007472 344 0.053
ion homeostasis GO:0050801 55 0.053
cellular hormone metabolic process GO:0034754 23 0.052
cellular ion homeostasis GO:0006873 39 0.051
response to oxygen containing compound GO:1901700 200 0.050
imaginal disc derived appendage development GO:0048737 399 0.050
response to abiotic stimulus GO:0009628 341 0.050
multi organism behavior GO:0051705 175 0.048
response to toxic substance GO:0009636 22 0.048
nuclear division GO:0000280 332 0.047
post embryonic appendage morphogenesis GO:0035120 385 0.046
aging GO:0007568 143 0.046
appendage development GO:0048736 401 0.045
regulation of anatomical structure size GO:0090066 163 0.045
response to organic cyclic compound GO:0014070 89 0.044
cellular lipid metabolic process GO:0044255 83 0.043
organic hydroxy compound biosynthetic process GO:1901617 21 0.043
aggressive behavior GO:0002118 63 0.042
ketone biosynthetic process GO:0042181 16 0.042
organic acid metabolic process GO:0006082 103 0.042
sensory perception of chemical stimulus GO:0007606 116 0.042
steroid biosynthetic process GO:0006694 16 0.041
medium chain fatty acid metabolic process GO:0051791 1 0.041
regulation of growth GO:0040008 233 0.039
cellular nitrogen compound catabolic process GO:0044270 165 0.038
imaginal disc derived wing morphogenesis GO:0007476 337 0.038
positive regulation of macromolecule metabolic process GO:0010604 405 0.038
chemical homeostasis GO:0048878 92 0.038
cellular amine metabolic process GO:0044106 12 0.038
response to nitrogen compound GO:1901698 90 0.038
single organism biosynthetic process GO:0044711 206 0.037
defense response to gram negative bacterium GO:0050829 94 0.037
protein modification process GO:0036211 438 0.037
hormone metabolic process GO:0042445 33 0.037
organelle fission GO:0048285 340 0.036
phosphorylation GO:0016310 294 0.036
immune response GO:0006955 246 0.036
columnar cuboidal epithelial cell development GO:0002066 249 0.036
positive regulation of multicellular organismal process GO:0051240 143 0.036
ecdysteroid metabolic process GO:0045455 19 0.036
response to ddt GO:0046680 5 0.036
organophosphate metabolic process GO:0019637 195 0.035
vesicle mediated transport GO:0016192 381 0.035
cellular amino acid metabolic process GO:0006520 61 0.034
lipid biosynthetic process GO:0008610 46 0.034
immune response regulating signaling pathway GO:0002764 2 0.034
neurological system process GO:0050877 358 0.034
small molecule biosynthetic process GO:0044283 37 0.033
amine metabolic process GO:0009308 12 0.033
negative regulation of cellular metabolic process GO:0031324 382 0.033
intracellular signal transduction GO:0035556 300 0.031
ethanolamine containing compound metabolic process GO:0042439 4 0.031
ecdysteroid biosynthetic process GO:0045456 15 0.031
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.031
cellular homeostasis GO:0019725 80 0.030
appendage morphogenesis GO:0035107 397 0.029
positive regulation of cell communication GO:0010647 250 0.029
positive regulation of signaling GO:0023056 243 0.029
epithelium migration GO:0090132 148 0.029
cellular protein modification process GO:0006464 438 0.028
positive regulation of signal transduction GO:0009967 223 0.028
cell proliferation GO:0008283 299 0.027
cell death GO:0008219 279 0.027
taxis GO:0042330 304 0.027
septate junction assembly GO:0019991 26 0.026
alcohol metabolic process GO:0006066 25 0.026
cellular macromolecule localization GO:0070727 220 0.026
regulation of protein metabolic process GO:0051246 256 0.026
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.026
adult behavior GO:0030534 137 0.026
regionalization GO:0003002 416 0.026
ras protein signal transduction GO:0007265 88 0.026
oxidation reduction process GO:0055114 123 0.026
ribonucleoside metabolic process GO:0009119 127 0.026
regulation of developmental growth GO:0048638 174 0.026
tissue morphogenesis GO:0048729 297 0.026
response to extracellular stimulus GO:0009991 116 0.026
response to transition metal nanoparticle GO:1990267 9 0.025
open tracheal system development GO:0007424 204 0.025
negative regulation of cell communication GO:0010648 223 0.025
regulation of catalytic activity GO:0050790 185 0.025
g protein coupled receptor signaling pathway GO:0007186 136 0.025
monocarboxylic acid metabolic process GO:0032787 29 0.025
epithelial cell differentiation GO:0030855 322 0.025
sensory perception GO:0007600 196 0.025
endocytosis GO:0006897 310 0.025
programmed cell death GO:0012501 257 0.025
negative regulation of gene expression GO:0010629 387 0.025
male gamete generation GO:0048232 201 0.024
response to temperature stimulus GO:0009266 106 0.024
negative regulation of signal transduction GO:0009968 206 0.024
positive regulation of response to stimulus GO:0048584 323 0.024
death GO:0016265 284 0.024
negative regulation of response to stimulus GO:0048585 258 0.023
cellular response to heat GO:0034605 24 0.023
circulatory system process GO:0003013 37 0.023
neuron recognition GO:0008038 101 0.023
regulation of intracellular signal transduction GO:1902531 236 0.023
establishment of localization in cell GO:0051649 402 0.023
hormone biosynthetic process GO:0042446 20 0.023
epidermis development GO:0008544 65 0.023
carbohydrate derivative metabolic process GO:1901135 217 0.023
response to copper ion GO:0046688 4 0.023
hormone catabolic process GO:0042447 3 0.023
phagocytosis GO:0006909 215 0.023
alcohol biosynthetic process GO:0046165 14 0.023
actin filament based process GO:0030029 220 0.023
response to nutrient levels GO:0031667 114 0.023
response to oxidative stress GO:0006979 86 0.023
small gtpase mediated signal transduction GO:0007264 88 0.023
regulation of cellular amine metabolic process GO:0033238 3 0.023
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.023
regulation of cellular ketone metabolic process GO:0010565 3 0.023
regulation of hormone levels GO:0010817 40 0.022
purine nucleoside metabolic process GO:0042278 127 0.022
cellular chemical homeostasis GO:0055082 40 0.022
acetylcholine metabolic process GO:0008291 2 0.022
regulation of tube size GO:0035150 46 0.022
ovarian follicle cell migration GO:0007297 121 0.022
regulation of molecular function GO:0065009 217 0.022
response to inorganic substance GO:0010035 44 0.022
steroid metabolic process GO:0008202 20 0.022
acetate ester metabolic process GO:1900619 2 0.022
purine ribonucleoside metabolic process GO:0046128 127 0.022
regulation of cellular amino acid metabolic process GO:0006521 0 0.022
regulation of phosphorus metabolic process GO:0051174 210 0.022
morphogenesis of an epithelium GO:0002009 276 0.022
cellular response to abiotic stimulus GO:0071214 58 0.021
ameboidal type cell migration GO:0001667 151 0.021
biological adhesion GO:0022610 138 0.021
neurotransmitter catabolic process GO:0042135 1 0.021
regulation of nervous system development GO:0051960 248 0.021
innate immune response GO:0045087 144 0.021
peptide metabolic process GO:0006518 80 0.021
organic cyclic compound catabolic process GO:1901361 168 0.021
eye morphogenesis GO:0048592 260 0.020
purine containing compound metabolic process GO:0072521 155 0.020
female meiosis chromosome segregation GO:0016321 33 0.020
regulation of blood circulation GO:1903522 21 0.020
macromolecule catabolic process GO:0009057 161 0.020
meiotic cell cycle GO:0051321 171 0.020
chemotaxis GO:0006935 249 0.020
phosphatidic acid metabolic process GO:0046473 1 0.020
multi multicellular organism process GO:0044706 123 0.020
neuron projection guidance GO:0097485 241 0.020
regulation of transport GO:0051049 181 0.020
nucleoside phosphate metabolic process GO:0006753 162 0.020
choline metabolic process GO:0019695 1 0.020
nucleobase containing compound catabolic process GO:0034655 165 0.019
positive regulation of phosphate metabolic process GO:0045937 139 0.019
negative regulation of protein metabolic process GO:0051248 85 0.019
positive regulation of biosynthetic process GO:0009891 316 0.019
negative regulation of signaling GO:0023057 219 0.019
cell cell junction organization GO:0045216 55 0.019
response to light stimulus GO:0009416 124 0.019
organic substance transport GO:0071702 257 0.019
localization of cell GO:0051674 257 0.019
sterol metabolic process GO:0016125 12 0.019
regulation of response to stress GO:0080134 200 0.019
cell motility GO:0048870 251 0.019
cell recognition GO:0008037 102 0.019
embryonic development via the syncytial blastoderm GO:0001700 148 0.019
regulation of mapk cascade GO:0043408 92 0.019
ion transmembrane transport GO:0034220 122 0.019
response to alcohol GO:0097305 95 0.018
nucleobase containing small molecule metabolic process GO:0055086 174 0.018
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.018
positive regulation of phosphorus metabolic process GO:0010562 139 0.018
axon guidance GO:0007411 233 0.018
regulation of phosphate metabolic process GO:0019220 210 0.018
immune effector process GO:0002252 98 0.018
ecdysone metabolic process GO:0008205 11 0.018
neurotransmitter metabolic process GO:0042133 2 0.018
chromosome segregation GO:0007059 157 0.018
carbohydrate derivative catabolic process GO:1901136 118 0.018
response to heat GO:0009408 63 0.018
regulation of organelle organization GO:0033043 196 0.018
regulation of immune system process GO:0002682 176 0.018
regulation of cellular protein metabolic process GO:0032268 243 0.018
tissue migration GO:0090130 155 0.018
lipid catabolic process GO:0016042 21 0.018
response to radiation GO:0009314 155 0.018
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.018
nucleoside metabolic process GO:0009116 127 0.018
actin cytoskeleton organization GO:0030036 206 0.018
spermatogenesis GO:0007283 200 0.018
cell adhesion GO:0007155 136 0.017
regulation of multicellular organismal development GO:2000026 414 0.017
aromatic compound catabolic process GO:0019439 166 0.017
cellular response to dna damage stimulus GO:0006974 223 0.017
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.017
epithelial cell development GO:0002064 274 0.017
transcription from rna polymerase ii promoter GO:0006366 368 0.017
cellular protein localization GO:0034613 160 0.017
cation homeostasis GO:0055080 51 0.017
fatty acid metabolic process GO:0006631 20 0.017
synaptic transmission GO:0007268 288 0.017
cellular response to biotic stimulus GO:0071216 4 0.017
response to ethanol GO:0045471 59 0.016
metal ion transport GO:0030001 74 0.016
immune response activating signal transduction GO:0002757 2 0.016
mapk cascade GO:0000165 107 0.016
exocrine system development GO:0035272 162 0.016
tergite morphogenesis GO:0007490 1 0.016
nucleoside catabolic process GO:0009164 112 0.016
skin development GO:0043588 65 0.016
organelle assembly GO:0070925 198 0.016
compound eye morphogenesis GO:0001745 249 0.016
regulation of neurogenesis GO:0050767 158 0.016
metal ion homeostasis GO:0055065 44 0.016
meiotic nuclear division GO:0007126 151 0.016
tube development GO:0035295 244 0.016
pigment metabolic process GO:0042440 84 0.016
antimicrobial humoral response GO:0019730 99 0.016
protein phosphorylation GO:0006468 169 0.016
organonitrogen compound biosynthetic process GO:1901566 117 0.016
sterol homeostasis GO:0055092 4 0.016
cellular response to lipopolysaccharide GO:0071222 3 0.016
ecdysone biosynthetic process GO:0006697 9 0.015
regulation of cell cycle GO:0051726 291 0.015
positive regulation of molecular function GO:0044093 136 0.015
lipid localization GO:0010876 54 0.015
positive regulation of catalytic activity GO:0043085 118 0.015
cuticle development GO:0042335 86 0.015
macromolecular complex assembly GO:0065003 256 0.015
positive regulation of cell motility GO:2000147 3 0.015
spindle organization GO:0007051 253 0.015
positive regulation of rna metabolic process GO:0051254 271 0.015
regulation of neuron projection development GO:0010975 69 0.015
positive regulation of cell migration GO:0030335 2 0.015
response to paraquat GO:1901562 4 0.015
digestive tract development GO:0048565 149 0.015
central nervous system development GO:0007417 201 0.014
regulation of small gtpase mediated signal transduction GO:0051056 93 0.014
mating behavior GO:0007617 106 0.014
epithelial cell migration GO:0010631 148 0.014
axon development GO:0061564 297 0.014
salivary gland development GO:0007431 162 0.014
response to lipopolysaccharide GO:0032496 4 0.014
positive regulation of immune system process GO:0002684 68 0.014
cation transport GO:0006812 110 0.014
signal transduction by phosphorylation GO:0023014 107 0.014
protein localization GO:0008104 284 0.014
negative regulation of cellular protein metabolic process GO:0032269 85 0.014
regulation of catabolic process GO:0009894 170 0.014
choline catabolic process GO:0042426 1 0.014
regulation of phosphorylation GO:0042325 147 0.014
terpenoid metabolic process GO:0006721 7 0.014
lipopolysaccharide mediated signaling pathway GO:0031663 1 0.014
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.014
nucleotide metabolic process GO:0009117 161 0.014
positive regulation of intracellular signal transduction GO:1902533 116 0.014
negative regulation of cellular component organization GO:0051129 108 0.014
body morphogenesis GO:0010171 2 0.014
transmembrane transport GO:0055085 139 0.014
embryonic morphogenesis GO:0048598 206 0.014
regulation of apoptotic process GO:0042981 130 0.014
posttranscriptional regulation of gene expression GO:0010608 145 0.014
proteolysis GO:0006508 192 0.014
cellular response to radiation GO:0071478 52 0.014
response to monosaccharide GO:0034284 4 0.013
cellular response to molecule of bacterial origin GO:0071219 3 0.013
maintenance of location GO:0051235 73 0.013
multicellular organismal aging GO:0010259 140 0.013
actin filament organization GO:0007015 126 0.013
glycosyl compound metabolic process GO:1901657 127 0.013
regulation of programmed cell death GO:0043067 152 0.013
digestive system development GO:0055123 149 0.013
regulation of cell differentiation GO:0045595 302 0.013
dna metabolic process GO:0006259 227 0.013
regulation of cell proliferation GO:0042127 163 0.013
transition metal ion homeostasis GO:0055076 17 0.013
cellular response to oxygen containing compound GO:1901701 79 0.013
triglyceride homeostasis GO:0070328 18 0.013
response to uv GO:0009411 24 0.013
embryo development ending in birth or egg hatching GO:0009792 152 0.013
regulation of localization GO:0032879 275 0.013
positive regulation of rna biosynthetic process GO:1902680 266 0.013
sterol biosynthetic process GO:0016126 9 0.013
cellular response to oxidative stress GO:0034599 28 0.013
regulation of system process GO:0044057 36 0.013
toxin metabolic process GO:0009404 2 0.013
regulation of cellular catabolic process GO:0031329 157 0.013
blood circulation GO:0008015 26 0.013
connective tissue development GO:0061448 3 0.013
autophagic cell death GO:0048102 83 0.013
chromosome organization GO:0051276 360 0.013
respiratory system development GO:0060541 213 0.013
mating GO:0007618 120 0.013
compound eye development GO:0048749 307 0.013
regulation of ras protein signal transduction GO:0046578 93 0.012
cell migration GO:0016477 238 0.012
response to wounding GO:0009611 94 0.012
positive regulation of cellular catabolic process GO:0031331 95 0.012
glycosyl compound catabolic process GO:1901658 112 0.012
regulation of cell development GO:0060284 215 0.012
heterocycle catabolic process GO:0046700 166 0.012
ion transport GO:0006811 145 0.012
sensory organ morphogenesis GO:0090596 260 0.012
cellular metal ion homeostasis GO:0006875 31 0.012
telencephalon development GO:0021537 2 0.012
cell maturation GO:0048469 144 0.012
developmental maturation GO:0021700 172 0.012
mitotic nuclear division GO:0007067 213 0.012
cellular response to starvation GO:0009267 61 0.012
regulation of cell death GO:0010941 173 0.012
cellular biogenic amine catabolic process GO:0042402 1 0.012
male mating behavior GO:0060179 70 0.012
cellular cation homeostasis GO:0030003 38 0.012
transition metal ion transport GO:0000041 16 0.012
negative regulation of biosynthetic process GO:0009890 277 0.012
regulation of cell morphogenesis GO:0022604 163 0.012
cellular macromolecule catabolic process GO:0044265 136 0.012
endomembrane system organization GO:0010256 119 0.012
cellular response to organic substance GO:0071310 132 0.012
developmental programmed cell death GO:0010623 138 0.011
response to caffeine GO:0031000 12 0.011
positive regulation of nucleic acid templated transcription GO:1903508 266 0.011
fat soluble vitamin metabolic process GO:0006775 1 0.011
positive regulation of cellular protein metabolic process GO:0032270 118 0.011
apoptotic process GO:0006915 159 0.011
mrna metabolic process GO:0016071 124 0.011
rho protein signal transduction GO:0007266 14 0.011
dorsal closure GO:0007391 79 0.011
sensory perception of smell GO:0007608 80 0.011
leg disc development GO:0035218 92 0.011
eye development GO:0001654 323 0.011
axis specification GO:0009798 167 0.011
positive regulation of developmental process GO:0051094 143 0.011
dendrite morphogenesis GO:0048813 199 0.011
gland development GO:0048732 191 0.011
response to endogenous stimulus GO:0009719 119 0.011
negative regulation of developmental process GO:0051093 201 0.011
chitin based cuticle development GO:0040003 49 0.011
wound healing GO:0042060 75 0.011
glycerolipid metabolic process GO:0046486 34 0.011
kidney development GO:0001822 3 0.011
regulation of immune response GO:0050776 118 0.011
establishment of protein localization GO:0045184 163 0.011
regulation of i kappab kinase nf kappab signaling GO:0043122 2 0.011
regulation of cellular component biogenesis GO:0044087 201 0.011
positive regulation of transcription dna templated GO:0045893 266 0.011
ribonucleoside triphosphate catabolic process GO:0009203 108 0.011
cation transmembrane transport GO:0098655 88 0.011
ovarian follicle cell development GO:0030707 248 0.011
ribose phosphate metabolic process GO:0019693 145 0.011
meiotic cell cycle process GO:1903046 132 0.011
response to hexose GO:0009746 3 0.011
neuropeptide signaling pathway GO:0007218 45 0.011
ribonucleotide metabolic process GO:0009259 145 0.011
response to purine containing compound GO:0014074 12 0.011
cell junction assembly GO:0034329 42 0.011
ribonucleoside catabolic process GO:0042454 112 0.011
purine ribonucleotide metabolic process GO:0009150 145 0.011
determination of adult lifespan GO:0008340 137 0.010
cellular component assembly involved in morphogenesis GO:0010927 151 0.010
mitotic spindle organization GO:0007052 220 0.010
dendrite development GO:0016358 204 0.010
gland morphogenesis GO:0022612 145 0.010
drinking behavior GO:0042756 2 0.010
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.010
purine nucleoside catabolic process GO:0006152 112 0.010
negative regulation of rna metabolic process GO:0051253 251 0.010
oxidoreduction coenzyme metabolic process GO:0006733 2 0.010
camera type eye development GO:0043010 4 0.010
positive regulation of cellular component organization GO:0051130 156 0.010
purine nucleotide metabolic process GO:0006163 146 0.010
organic hydroxy compound catabolic process GO:1901616 4 0.010
synaptic target recognition GO:0008039 45 0.010
segmentation GO:0035282 207 0.010
phosphatidylinositol mediated signaling GO:0048015 4 0.010
ribonucleoside triphosphate metabolic process GO:0009199 119 0.010
amide biosynthetic process GO:0043604 42 0.010
regulation of response to biotic stimulus GO:0002831 63 0.010
regulation of vesicle mediated transport GO:0060627 59 0.010
protein complex biogenesis GO:0070271 201 0.010
purine containing compound catabolic process GO:0072523 112 0.010

TotA disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
essential hypertension DOID:10825 0 0.179
artery disease DOID:0050828 0 0.179
hypertension DOID:10763 0 0.179
disease of anatomical entity DOID:7 0 0.179
vascular disease DOID:178 0 0.179
cardiovascular system disease DOID:1287 0 0.179
disease of metabolism DOID:0014667 0 0.019
nervous system disease DOID:863 0 0.015
acquired metabolic disease DOID:0060158 0 0.011
inherited metabolic disorder DOID:655 0 0.011
musculoskeletal system disease DOID:17 0 0.010