Drosophila melanogaster

164 known processes

Pax (Dmel_CG31794)

Paxillin

(Aliases: Dpax,PDLP,CG31794,CG18576,pax,DPaxillin,DPxn,Dmel\CG31794,CG18061,DPxn37,CT40481,CT42454)

Pax biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
myoblast fusion GO:0007520 43 0.999
syncytium formation by plasma membrane fusion GO:0000768 43 0.994
myotube differentiation GO:0014902 46 0.977
syncytium formation GO:0006949 43 0.908
muscle cell differentiation GO:0042692 103 0.869
muscle structure development GO:0061061 224 0.706
actin filament based process GO:0030029 220 0.640
actin cytoskeleton organization GO:0030036 206 0.545
actin filament organization GO:0007015 126 0.432
imaginal disc derived appendage development GO:0048737 399 0.291
negative regulation of signaling GO:0023057 219 0.280
Human Mouse
regulation of myoblast fusion GO:1901739 6 0.270
regulation of muscle cell differentiation GO:0051147 8 0.264
immune system process GO:0002376 347 0.235
Human Mouse
morphogenesis of an epithelium GO:0002009 276 0.218
Mouse
cell cell signaling involved in cell fate commitment GO:0045168 210 0.209
regulation of cell morphogenesis GO:0022604 163 0.207
Human Mouse
post embryonic appendage morphogenesis GO:0035120 385 0.206
tissue morphogenesis GO:0048729 297 0.203
Mouse
embryo development ending in birth or egg hatching GO:0009792 152 0.201
cell adhesion GO:0007155 136 0.186
Human Mouse
kidney development GO:0001822 3 0.186
kidney epithelium development GO:0072073 3 0.181
imaginal disc derived appendage morphogenesis GO:0035114 395 0.176
wing disc morphogenesis GO:0007472 344 0.152
positive regulation of signaling GO:0023056 243 0.151
Human Mouse
imaginal disc derived wing morphogenesis GO:0007476 337 0.144
regulation of hydrolase activity GO:0051336 97 0.141
regulation of response to stress GO:0080134 200 0.136
response to organic substance GO:0010033 284 0.121
Human Mouse
regulation of immune system process GO:0002682 176 0.114
Human Mouse
regulation of cysteine type endopeptidase activity GO:2000116 27 0.106
regulation of myotube differentiation GO:0010830 6 0.105
appendage morphogenesis GO:0035107 397 0.100
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 38 0.099
Human
organelle assembly GO:0070925 198 0.094
muscle cell development GO:0055001 50 0.094
appendage development GO:0048736 401 0.092
intracellular signal transduction GO:0035556 300 0.090
Mouse
striated muscle cell differentiation GO:0051146 90 0.088
positive regulation of cell motility GO:2000147 3 0.086
organic substance transport GO:0071702 257 0.084
response to extracellular stimulus GO:0009991 116 0.083
biological adhesion GO:0022610 138 0.083
Human Mouse
lateral inhibition GO:0046331 206 0.082
positive regulation of signal transduction GO:0009967 223 0.081
Human Mouse
striated muscle myosin thick filament assembly GO:0071688 3 0.079
cell death GO:0008219 279 0.079
muscle attachment GO:0016203 36 0.078
positive regulation of response to stimulus GO:0048584 323 0.077
Human Mouse
organonitrogen compound metabolic process GO:1901564 318 0.074
cellular component assembly involved in morphogenesis GO:0010927 151 0.074
protein localization GO:0008104 284 0.072
cellular catabolic process GO:0044248 372 0.069
secretion GO:0046903 109 0.067
cellular macromolecular complex assembly GO:0034622 153 0.066
negative regulation of gene expression GO:0010629 387 0.065
positive regulation of cell migration GO:0030335 2 0.064
negative regulation of signal transduction GO:0009968 206 0.064
Human Mouse
vesicle mediated transport GO:0016192 381 0.063
protein modification process GO:0036211 438 0.062
Mouse
actomyosin structure organization GO:0031032 56 0.061
purine ribonucleotide metabolic process GO:0009150 145 0.061
single organism catabolic process GO:0044712 228 0.059
regulation of localization GO:0032879 275 0.058
response to nutrient levels GO:0031667 114 0.058
cuticle development GO:0042335 86 0.058
response to transforming growth factor beta GO:0071559 18 0.057
Human Mouse
feeding behavior GO:0007631 50 0.056
positive regulation of cell communication GO:0010647 250 0.056
Human Mouse
cellular protein complex assembly GO:0043623 71 0.055
regulation of peptidase activity GO:0052547 39 0.055
spermatid differentiation GO:0048515 114 0.053
endocytosis GO:0006897 310 0.053
lipid localization GO:0010876 54 0.052
defense response GO:0006952 300 0.051
muscle organ development GO:0007517 127 0.051
single organism carbohydrate metabolic process GO:0044723 72 0.048
regulation of wnt signaling pathway GO:0030111 68 0.048
catabolic process GO:0009056 409 0.047
regulation of anatomical structure morphogenesis GO:0022603 242 0.047
digestive system development GO:0055123 149 0.047
response to starvation GO:0042594 97 0.047
ribose phosphate metabolic process GO:0019693 145 0.047
phosphorylation GO:0016310 294 0.046
Mouse
cellular response to external stimulus GO:0071496 66 0.046
exocrine system development GO:0035272 162 0.045
positive regulation of intracellular signal transduction GO:1902533 116 0.045
Mouse
body morphogenesis GO:0010171 2 0.044
guanosine containing compound catabolic process GO:1901069 74 0.042
mitochondrion organization GO:0007005 65 0.041
wound healing GO:0042060 75 0.041
organic acid metabolic process GO:0006082 103 0.040
wnt signaling pathway GO:0016055 98 0.040
regulation of phosphorus metabolic process GO:0051174 210 0.040
regulation of mapk cascade GO:0043408 92 0.040
Mouse
homeostatic process GO:0042592 199 0.039
regulation of phosphate metabolic process GO:0019220 210 0.039
regulation of intracellular signal transduction GO:1902531 236 0.038
regulation of cellular localization GO:0060341 136 0.038
establishment of protein localization GO:0045184 163 0.038
myofibril assembly GO:0030239 36 0.037
carboxylic acid metabolic process GO:0019752 92 0.037
regulation of notch signaling pathway GO:0008593 100 0.037
regulation of programmed cell death GO:0043067 152 0.036
nucleobase containing small molecule metabolic process GO:0055086 174 0.036
positive regulation of wnt signaling pathway GO:0030177 25 0.035
mesoderm development GO:0007498 78 0.034
negative regulation of response to stimulus GO:0048585 258 0.034
Human Mouse
oxoacid metabolic process GO:0043436 103 0.034
positive regulation of i kappab kinase nf kappab signaling GO:0043123 1 0.034
protein catabolic process GO:0030163 101 0.034
Human
regulation of cellular component size GO:0032535 98 0.034
renal system development GO:0072001 72 0.033
regulation of catalytic activity GO:0050790 185 0.033
regulation of mitotic cell cycle GO:0007346 190 0.032
regulation of cell cycle GO:0051726 291 0.032
nucleotide metabolic process GO:0009117 161 0.032
positive regulation of cysteine type endopeptidase activity GO:2001056 24 0.031
open tracheal system development GO:0007424 204 0.031
regulation of striated muscle cell differentiation GO:0051153 8 0.031
embryonic morphogenesis GO:0048598 206 0.030
Mouse
response to biotic stimulus GO:0009607 294 0.030
cytoskeleton dependent cytokinesis GO:0061640 81 0.029
protein phosphorylation GO:0006468 169 0.029
Mouse
positive regulation of protein localization to nucleus GO:1900182 21 0.029
myotube cell development GO:0014904 3 0.029
maintenance of location GO:0051235 73 0.029
response to organophosphorus GO:0046683 2 0.029
negative regulation of rna biosynthetic process GO:1902679 240 0.029
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.028
cilium assembly GO:0042384 38 0.028
cellular response to starvation GO:0009267 61 0.028
positive regulation of cell death GO:0010942 69 0.028
nephron epithelium development GO:0072009 3 0.028
cell proliferation GO:0008283 299 0.028
salivary gland development GO:0007431 162 0.028
actin cytoskeleton reorganization GO:0031532 22 0.028
regulation of syncytium formation by plasma membrane fusion GO:0060142 6 0.028
heart development GO:0007507 82 0.027
carbohydrate metabolic process GO:0005975 82 0.027
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.027
Human
negative regulation of multicellular organismal process GO:0051241 142 0.027
protein secretion GO:0009306 45 0.027
notch signaling pathway GO:0007219 120 0.026
immune response GO:0006955 246 0.026
regionalization GO:0003002 416 0.026
regulation of organ morphogenesis GO:2000027 78 0.026
gland morphogenesis GO:0022612 145 0.026
skeletal muscle organ development GO:0060538 48 0.026
nephron tubule development GO:0072080 3 0.026
regulation of phosphorylation GO:0042325 147 0.026
Mouse
mesenchymal cell differentiation GO:0048762 1 0.025
Human
response to external biotic stimulus GO:0043207 293 0.025
regulation of i kappab kinase nf kappab signaling GO:0043122 2 0.025
establishment or maintenance of cell polarity GO:0007163 167 0.025
skeletal muscle fiber development GO:0048741 3 0.024
positive regulation of programmed cell death GO:0043068 62 0.024
digestive tract morphogenesis GO:0048546 127 0.024
gland development GO:0048732 191 0.024
activation of cysteine type endopeptidase activity GO:0097202 17 0.024
integrin mediated signaling pathway GO:0007229 3 0.023
Mouse
positive regulation of protein complex assembly GO:0031334 22 0.023
urogenital system development GO:0001655 72 0.023
death GO:0016265 284 0.023
cellular response to chemical stimulus GO:0070887 199 0.022
Human Mouse
response to glucose GO:0009749 2 0.022
cellular macromolecule localization GO:0070727 220 0.022
cellular response to extracellular stimulus GO:0031668 64 0.021
actin filament bundle organization GO:0061572 28 0.021
respiratory system development GO:0060541 213 0.021
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 23 0.021
positive regulation of cell proliferation GO:0008284 47 0.021
sensory organ morphogenesis GO:0090596 260 0.021
cell aging GO:0007569 2 0.021
compound eye morphogenesis GO:0001745 249 0.021
cellular amino acid metabolic process GO:0006520 61 0.021
regulation of cell death GO:0010941 173 0.021
striated muscle cell development GO:0055002 50 0.020
regulation of organelle organization GO:0033043 196 0.020
response to abiotic stimulus GO:0009628 341 0.020
Rat
regulation of cellular ketone metabolic process GO:0010565 3 0.020
regulation of stress activated mapk cascade GO:0032872 41 0.020
regulation of transport GO:0051049 181 0.020
response to wounding GO:0009611 94 0.020
response to lipid GO:0033993 38 0.020
secretion by cell GO:0032940 101 0.020
protein polymerization GO:0051258 42 0.020
lipid storage GO:0019915 38 0.019
circulatory system development GO:0072359 82 0.019
purine containing compound metabolic process GO:0072521 155 0.019
heterocycle catabolic process GO:0046700 166 0.019
protein complex assembly GO:0006461 200 0.019
regulation of cell differentiation GO:0045595 302 0.019
establishment or maintenance of cytoskeleton polarity GO:0030952 44 0.019
substrate adhesion dependent cell spreading GO:0034446 2 0.018
Mouse
negative regulation of cell cycle GO:0045786 116 0.018
autophagic vacuole assembly GO:0000045 2 0.018
negative regulation of molecular function GO:0044092 51 0.018
cell division GO:0051301 248 0.018
growth GO:0040007 359 0.018
programmed cell death GO:0012501 257 0.018
compound eye development GO:0048749 307 0.018
regulation of cell motility GO:2000145 23 0.018
regulation of actin cytoskeleton organization GO:0032956 42 0.018
immune response activating signal transduction GO:0002757 2 0.017
Human Mouse
forebrain development GO:0030900 2 0.017
nephron development GO:0072006 3 0.017
negative regulation of notch signaling pathway GO:0045746 41 0.017
regulation of cellular component biogenesis GO:0044087 201 0.017
positive regulation of mapk cascade GO:0043410 63 0.017
Mouse
guanosine containing compound metabolic process GO:1901068 74 0.016
connective tissue development GO:0061448 3 0.016
positive regulation of apoptotic process GO:0043065 47 0.016
regulation of secretion GO:0051046 44 0.016
eye morphogenesis GO:0048592 260 0.016
nephron morphogenesis GO:0072028 3 0.016
response to nitrogen compound GO:1901698 90 0.016
Human
salivary gland morphogenesis GO:0007435 145 0.016
cardiovascular system development GO:0072358 82 0.016
cell cycle phase transition GO:0044770 140 0.016
multi organism behavior GO:0051705 175 0.016
neurotransmitter transport GO:0006836 37 0.016
response to decreased oxygen levels GO:0036293 58 0.015
organonitrogen compound catabolic process GO:1901565 128 0.015
cellular protein localization GO:0034613 160 0.015
response to hexose GO:0009746 3 0.015
spermatogenesis GO:0007283 200 0.015
positive regulation of molecular function GO:0044093 136 0.015
Mouse
carbohydrate derivative metabolic process GO:1901135 217 0.015
mapk cascade GO:0000165 107 0.015
Mouse
positive regulation of protein transport GO:0051222 37 0.015
proteolysis GO:0006508 192 0.015
Human
positive regulation of cellular amine metabolic process GO:0033240 0 0.015
regulation of cellular amine metabolic process GO:0033238 3 0.015
cellular response to organic substance GO:0071310 132 0.014
Human Mouse
positive regulation of catalytic activity GO:0043085 118 0.014
Mouse
positive regulation of cell development GO:0010720 61 0.014
Human
response to organic cyclic compound GO:0014070 89 0.014
positive regulation of lipid metabolic process GO:0045834 4 0.014
response to other organism GO:0051707 293 0.014
organic substance catabolic process GO:1901575 308 0.014
response to endogenous stimulus GO:0009719 119 0.014
Human Mouse
response to inorganic substance GO:0010035 44 0.014
positive regulation of hydrolase activity GO:0051345 78 0.014
response to mercury ion GO:0046689 3 0.014
single organism biosynthetic process GO:0044711 206 0.014
negative regulation of cell communication GO:0010648 223 0.014
Human Mouse
tube development GO:0035295 244 0.013
Mouse
regulation of cell shape GO:0008360 113 0.013
Mouse
regulation of endopeptidase activity GO:0052548 36 0.013
regulation of molecular function GO:0065009 217 0.013
cellular nitrogen compound catabolic process GO:0044270 165 0.013
regulation of cellular amino acid metabolic process GO:0006521 0 0.013
epidermis development GO:0008544 65 0.013
regulation of cellular component movement GO:0051270 42 0.013
cellular protein modification process GO:0006464 438 0.013
Mouse
single organismal cell cell adhesion GO:0016337 45 0.013
positive regulation of phosphorylation GO:0042327 87 0.013
Mouse
plasma membrane organization GO:0007009 26 0.013
mesenchymal cell development GO:0014031 1 0.012
Human
protein transport GO:0015031 155 0.012
ion transport GO:0006811 145 0.012
central nervous system development GO:0007417 201 0.012
response to oxygen levels GO:0070482 59 0.012
single organism membrane organization GO:0044802 93 0.012
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.012
negative regulation of catalytic activity GO:0043086 42 0.012
bmp signaling pathway GO:0030509 27 0.012
adherens junction assembly GO:0034333 11 0.012
Mouse
regulation of cell morphogenesis involved in differentiation GO:0010769 61 0.012
Human
cell junction organization GO:0034330 57 0.012
Mouse
immune system development GO:0002520 57 0.012
cellular response to oxygen containing compound GO:1901701 79 0.012
Human
establishment of localization in cell GO:0051649 402 0.012
glycosyl compound metabolic process GO:1901657 127 0.012
determination of adult lifespan GO:0008340 137 0.012
organelle fission GO:0048285 340 0.012
regulation of cellular protein metabolic process GO:0032268 243 0.012
Mouse
carbohydrate derivative biosynthetic process GO:1901137 85 0.012
myosin filament assembly GO:0031034 5 0.012
autophagy GO:0006914 108 0.012
purine nucleoside triphosphate metabolic process GO:0009144 119 0.012
nucleocytoplasmic transport GO:0006913 72 0.012
leg disc morphogenesis GO:0007478 80 0.011
extracellular matrix assembly GO:0085029 13 0.011
protein complex biogenesis GO:0070271 201 0.011
phagocytosis GO:0006909 215 0.011
single organism nuclear import GO:1902593 51 0.011
cellular response to nutrient levels GO:0031669 62 0.011
anatomical structure homeostasis GO:0060249 97 0.011
regulation of proteolysis GO:0030162 87 0.011
multicellular organismal reproductive behavior GO:0033057 110 0.011
monovalent inorganic cation transport GO:0015672 40 0.011
ribonucleoside biosynthetic process GO:0042455 3 0.011
positive regulation of protein import into nucleus GO:0042307 21 0.011
protein targeting to nucleus GO:0044744 51 0.011
regulation of mitotic cell cycle phase transition GO:1901990 130 0.011
cardiac muscle tissue development GO:0048738 9 0.011
chromatin silencing GO:0006342 76 0.011
hematopoietic progenitor cell differentiation GO:0002244 1 0.011
apoptotic process GO:0006915 159 0.010
regulation of establishment of protein localization GO:0070201 61 0.010
response to calcium ion GO:0051592 1 0.010
regulation of embryonic development GO:0045995 68 0.010
negative regulation of cellular protein metabolic process GO:0032269 85 0.010
regulation of anatomical structure size GO:0090066 163 0.010
cellular ketone metabolic process GO:0042180 24 0.010
imaginal disc derived wing margin morphogenesis GO:0008587 41 0.010
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.010
membrane organization GO:0061024 112 0.010
positive regulation of cellular protein metabolic process GO:0032270 118 0.010
Mouse
adult behavior GO:0030534 137 0.010
cytoplasmic transport GO:0016482 130 0.010
convergent extension GO:0060026 2 0.010

Pax disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
musculoskeletal system disease DOID:17 0 0.035
disease of anatomical entity DOID:7 0 0.035
muscular disease DOID:0080000 0 0.017
cardiomyopathy DOID:0050700 0 0.017
heart disease DOID:114 0 0.017
cardiovascular system disease DOID:1287 0 0.017
intrinsic cardiomyopathy DOID:0060036 0 0.017
muscle tissue disease DOID:66 0 0.017
myopathy DOID:423 0 0.017