Drosophila melanogaster

205 known processes

Gef64C (Dmel_CG32239)

Guanine nucleotide exchange factor GEF64C

(Aliases: EP3035,RhoGEF,RhoGEF64C,Dmel\CG32239,CG13710,GEF(64C),GEF,CG32239,CG13709,EP(3)3035,GEF64C)

Gef64C biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
aggressive behavior GO:0002118 63 0.407
imaginal disc derived appendage morphogenesis GO:0035114 395 0.259
aging GO:0007568 143 0.207
regulation of production of molecular mediator of immune response GO:0002700 44 0.197
negative regulation of cellular biosynthetic process GO:0031327 277 0.187
axon development GO:0061564 297 0.181
regulation of nervous system development GO:0051960 248 0.170
imaginal disc derived wing morphogenesis GO:0007476 337 0.153
central nervous system development GO:0007417 201 0.146
appendage development GO:0048736 401 0.146
biological adhesion GO:0022610 138 0.143
Mouse
imaginal disc derived appendage development GO:0048737 399 0.134
post embryonic appendage morphogenesis GO:0035120 385 0.133
multi organism behavior GO:0051705 175 0.124
organonitrogen compound metabolic process GO:1901564 318 0.123
gland development GO:0048732 191 0.121
dendrite guidance GO:0070983 21 0.117
forebrain development GO:0030900 2 0.114
response to biotic stimulus GO:0009607 294 0.107
regulation of cell differentiation GO:0045595 302 0.103
Mouse
taxis GO:0042330 304 0.100
cell death GO:0008219 279 0.098
Human
regulation of cell development GO:0060284 215 0.089
Mouse
wing disc morphogenesis GO:0007472 344 0.086
epithelial cell development GO:0002064 274 0.085
determination of adult lifespan GO:0008340 137 0.085
actin cytoskeleton organization GO:0030036 206 0.085
cellular catabolic process GO:0044248 372 0.079
response to other organism GO:0051707 293 0.077
response to starvation GO:0042594 97 0.076
response to external biotic stimulus GO:0043207 293 0.076
inter male aggressive behavior GO:0002121 60 0.071
humoral immune response GO:0006959 117 0.068
response to bacterium GO:0009617 198 0.068
regulation of immune system process GO:0002682 176 0.067
negative regulation of response to stimulus GO:0048585 258 0.067
intracellular signal transduction GO:0035556 300 0.067
regulation of response to external stimulus GO:0032101 115 0.065
negative regulation of developmental process GO:0051093 201 0.065
peptide metabolic process GO:0006518 80 0.064
regulation of catalytic activity GO:0050790 185 0.063
antimicrobial humoral response GO:0019730 99 0.063
regulation of multicellular organismal development GO:2000026 414 0.061
regulation of protein metabolic process GO:0051246 256 0.061
olfactory learning GO:0008355 56 0.057
protein modification process GO:0036211 438 0.057
positive regulation of proteolysis GO:0045862 52 0.056
epidermis development GO:0008544 65 0.055
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.055
response to extracellular stimulus GO:0009991 116 0.054
death GO:0016265 284 0.052
Human
response to organic substance GO:0010033 284 0.051
columnar cuboidal epithelial cell development GO:0002066 249 0.051
appendage morphogenesis GO:0035107 397 0.050
antimicrobial peptide production GO:0002775 46 0.049
salivary gland development GO:0007431 162 0.046
regulation of notch signaling pathway GO:0008593 100 0.046
positive regulation of catabolic process GO:0009896 105 0.045
regulation of antimicrobial humoral response GO:0002759 50 0.045
neural precursor cell proliferation GO:0061351 75 0.045
regulation of intracellular signal transduction GO:1902531 236 0.044
transcription from rna polymerase ii promoter GO:0006366 368 0.044
ras protein signal transduction GO:0007265 88 0.043
negative regulation of cell differentiation GO:0045596 143 0.043
cell migration GO:0016477 238 0.043
Mouse
actin filament based process GO:0030029 220 0.042
single organism biosynthetic process GO:0044711 206 0.042
morphogenesis of an epithelium GO:0002009 276 0.042
negative regulation of nervous system development GO:0051961 92 0.041
organonitrogen compound biosynthetic process GO:1901566 117 0.041
programmed cell death GO:0012501 257 0.039
Human
positive regulation of cellular biosynthetic process GO:0031328 316 0.039
protein phosphorylation GO:0006468 169 0.039
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.037
regulation of cell death GO:0010941 173 0.036
Human
small gtpase mediated signal transduction GO:0007264 88 0.036
feeding behavior GO:0007631 50 0.035
negative regulation of signaling GO:0023057 219 0.035
phosphorylation GO:0016310 294 0.035
response to lipopolysaccharide GO:0032496 4 0.035
protein catabolic process GO:0030163 101 0.034
telencephalon development GO:0021537 2 0.034
negative regulation of cellular metabolic process GO:0031324 382 0.034
lipid metabolic process GO:0006629 121 0.034
negative regulation of biosynthetic process GO:0009890 277 0.034
epithelial cell differentiation GO:0030855 322 0.033
regulation of lipid metabolic process GO:0019216 15 0.033
muscle structure development GO:0061061 224 0.032
tissue morphogenesis GO:0048729 297 0.032
positive regulation of phosphate metabolic process GO:0045937 139 0.032
long term memory GO:0007616 62 0.032
protein localization GO:0008104 284 0.032
ventral cord development GO:0007419 16 0.031
response to nitrogen compound GO:1901698 90 0.031
axon guidance GO:0007411 233 0.031
skin development GO:0043588 65 0.031
memory GO:0007613 94 0.031
negative regulation of cellular component organization GO:0051129 108 0.031
localization of cell GO:0051674 257 0.031
Mouse
startle response GO:0001964 16 0.030
positive regulation of signal transduction GO:0009967 223 0.030
negative regulation of growth GO:0045926 84 0.030
peptide biosynthetic process GO:0043043 42 0.030
positive regulation of developmental process GO:0051094 143 0.030
Mouse
negative regulation of cell communication GO:0010648 223 0.029
response to ethanol GO:0045471 59 0.029
regulation of localization GO:0032879 275 0.029
regulation of phosphorus metabolic process GO:0051174 210 0.029
chemosensory behavior GO:0007635 106 0.029
chemotaxis GO:0006935 249 0.029
regulation of epithelial cell differentiation GO:0030856 4 0.029
neuron fate commitment GO:0048663 50 0.028
regulation of ras protein signal transduction GO:0046578 93 0.028
regulation of cellular amide metabolic process GO:0034248 39 0.028
regulation of immune effector process GO:0002697 52 0.028
cellular response to chemical stimulus GO:0070887 199 0.027
Human
regulation of phosphate metabolic process GO:0019220 210 0.027
positive regulation of macromolecule metabolic process GO:0010604 405 0.027
axonogenesis GO:0007409 290 0.027
response to organonitrogen compound GO:0010243 75 0.026
apoptotic process GO:0006915 159 0.026
Human
small molecule metabolic process GO:0044281 305 0.026
catabolic process GO:0009056 409 0.026
tube development GO:0035295 244 0.026
macromolecule catabolic process GO:0009057 161 0.026
single organism behavior GO:0044708 391 0.026
positive regulation of catalytic activity GO:0043085 118 0.025
positive regulation of cell migration GO:0030335 2 0.025
head development GO:0060322 135 0.025
negative regulation of immune system process GO:0002683 50 0.025
regulation of multi organism process GO:0043900 131 0.025
cell motility GO:0048870 251 0.025
Mouse
organic substance catabolic process GO:1901575 308 0.024
establishment or maintenance of cell polarity GO:0007163 167 0.024
single organism catabolic process GO:0044712 228 0.024
phenol containing compound metabolic process GO:0018958 57 0.023
positive regulation of cell communication GO:0010647 250 0.023
regulation of humoral immune response GO:0002920 51 0.023
regulation of molecular function GO:0065009 217 0.023
autophagy GO:0006914 108 0.023
regulation of response to stress GO:0080134 200 0.023
regulation of cellular component biogenesis GO:0044087 201 0.023
negative regulation of notch signaling pathway GO:0045746 41 0.022
cellular protein modification process GO:0006464 438 0.022
regulation of antimicrobial peptide biosynthetic process GO:0002805 38 0.022
protein complex assembly GO:0006461 200 0.022
tissue migration GO:0090130 155 0.022
ovarian follicle cell development GO:0030707 248 0.022
regulation of synapse organization GO:0050807 110 0.022
regulation of response to biotic stimulus GO:0002831 63 0.022
organic substance transport GO:0071702 257 0.022
cellular amide metabolic process GO:0043603 80 0.022
ameboidal type cell migration GO:0001667 151 0.022
developmental programmed cell death GO:0010623 138 0.022
positive regulation of cellular protein metabolic process GO:0032270 118 0.022
chemical homeostasis GO:0048878 92 0.022
axon choice point recognition GO:0016198 26 0.022
morphogenesis of a branching epithelium GO:0061138 45 0.022
organ formation GO:0048645 39 0.022
mating behavior GO:0007617 106 0.021
proteolysis GO:0006508 192 0.021
steroid catabolic process GO:0006706 1 0.021
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.021
positive regulation of response to stimulus GO:0048584 323 0.020
cellular response to nitrogen compound GO:1901699 51 0.020
endocytosis GO:0006897 310 0.020
anatomical structure homeostasis GO:0060249 97 0.020
cellular ketone metabolic process GO:0042180 24 0.020
regulation of programmed cell death GO:0043067 152 0.020
Human
vesicle mediated transport GO:0016192 381 0.020
gland morphogenesis GO:0022612 145 0.020
regulation of proteolysis GO:0030162 87 0.020
positive regulation of signaling GO:0023056 243 0.020
cellular response to endogenous stimulus GO:0071495 80 0.019
morphogenesis of a branching structure GO:0001763 45 0.019
defense response GO:0006952 300 0.019
regulation of neuron differentiation GO:0045664 103 0.019
regulation of cellular component size GO:0032535 98 0.019
positive regulation of cellular catabolic process GO:0031331 95 0.019
amide biosynthetic process GO:0043604 42 0.019
phototransduction GO:0007602 52 0.018
mushroom body development GO:0016319 70 0.018
immune system process GO:0002376 347 0.018
positive regulation of nucleic acid templated transcription GO:1903508 266 0.018
locomotory behavior GO:0007626 176 0.018
axon midline choice point recognition GO:0016199 26 0.018
branching morphogenesis of an epithelial tube GO:0048754 45 0.018
regulation of mapk cascade GO:0043408 92 0.018
respiratory system development GO:0060541 213 0.018
positive regulation of rna metabolic process GO:0051254 271 0.017
regulation of immune response GO:0050776 118 0.017
homeostatic process GO:0042592 199 0.017
glial cell migration GO:0008347 31 0.017
response to abiotic stimulus GO:0009628 341 0.017
Human
regulation of cellular catabolic process GO:0031329 157 0.017
phagocytosis GO:0006909 215 0.017
regulation of insulin receptor signaling pathway GO:0046626 17 0.017
negative regulation of protein metabolic process GO:0051248 85 0.017
positive regulation of hydrolase activity GO:0051345 78 0.017
response to nutrient levels GO:0031667 114 0.017
cell recognition GO:0008037 102 0.017
cellular homeostasis GO:0019725 80 0.016
carboxylic acid metabolic process GO:0019752 92 0.016
protein modification by small protein conjugation or removal GO:0070647 106 0.016
convergent extension GO:0060026 2 0.016
positive regulation of multicellular organismal process GO:0051240 143 0.016
defense response to bacterium GO:0042742 178 0.016
positive regulation of phosphorus metabolic process GO:0010562 139 0.016
olfactory behavior GO:0042048 97 0.016
androgen metabolic process GO:0008209 1 0.016
positive regulation of cellular component organization GO:0051130 156 0.016
Mouse
cellular macromolecule localization GO:0070727 220 0.016
mitotic nuclear division GO:0007067 213 0.016
body morphogenesis GO:0010171 2 0.016
multicellular organismal aging GO:0010259 140 0.016
cellular amino acid metabolic process GO:0006520 61 0.016
immune effector process GO:0002252 98 0.016
brain development GO:0007420 120 0.016
cell proliferation GO:0008283 299 0.016
positive regulation of cellular component biogenesis GO:0044089 80 0.015
positive regulation of gtpase activity GO:0043547 43 0.015
negative regulation of signal transduction GO:0009968 206 0.015
enzyme linked receptor protein signaling pathway GO:0007167 179 0.015
regulation of cellular ketone metabolic process GO:0010565 3 0.015
intracellular transport GO:0046907 228 0.015
response to light stimulus GO:0009416 124 0.015
hindbrain development GO:0030902 2 0.015
regulation of cellular component movement GO:0051270 42 0.015
camera type eye development GO:0043010 4 0.015
epithelial cell migration GO:0010631 148 0.015
r7 cell differentiation GO:0045466 43 0.015
regulation of cellular amine metabolic process GO:0033238 3 0.015
single organism intracellular transport GO:1902582 207 0.015
dna metabolic process GO:0006259 227 0.015
positive regulation of gene expression GO:0010628 290 0.014
dendrite morphogenesis GO:0048813 199 0.014
positive regulation of protein metabolic process GO:0051247 128 0.014
regulation of cellular response to insulin stimulus GO:1900076 17 0.014
regulation of growth GO:0040008 233 0.014
response to organic cyclic compound GO:0014070 89 0.014
stem cell differentiation GO:0048863 117 0.014
regulation of catabolic process GO:0009894 170 0.014
mapk cascade GO:0000165 107 0.014
lamellipodium organization GO:0097581 21 0.014
photoreceptor cell axon guidance GO:0072499 23 0.014
reproductive behavior GO:0019098 122 0.014
regulation of embryonic development GO:0045995 68 0.014
brain morphogenesis GO:0048854 16 0.014
kidney development GO:0001822 3 0.014
rhythmic process GO:0048511 106 0.013
dendrite development GO:0016358 204 0.013
camera type eye morphogenesis GO:0048593 2 0.013
tube morphogenesis GO:0035239 191 0.013
negative regulation of cell development GO:0010721 62 0.013
neuron recognition GO:0008038 101 0.013
sensory perception GO:0007600 196 0.013
response to oxidative stress GO:0006979 86 0.013
Human
exocrine system development GO:0035272 162 0.013
carbohydrate derivative metabolic process GO:1901135 217 0.013
immune response GO:0006955 246 0.013
negative regulation of cellular protein metabolic process GO:0032269 85 0.013
lateral inhibition GO:0046331 206 0.013
establishment of tissue polarity GO:0007164 87 0.013
regulation of mitotic cell cycle GO:0007346 190 0.012
cellular response to organonitrogen compound GO:0071417 36 0.012
single organism cell adhesion GO:0098602 47 0.012
Mouse
extrinsic apoptotic signaling pathway GO:0097191 1 0.012
negative regulation of response to external stimulus GO:0032102 22 0.012
epidermal cell differentiation GO:0009913 51 0.012
cellular response to ethanol GO:0071361 4 0.012
establishment of localization in cell GO:0051649 402 0.012
estrogen metabolic process GO:0008210 1 0.012
male courtship behavior GO:0008049 63 0.012
negative regulation of phosphorylation GO:0042326 35 0.012
macromolecular complex assembly GO:0065003 256 0.012
response to endogenous stimulus GO:0009719 119 0.012
regulation of circadian rhythm GO:0042752 49 0.012
cell cell signaling involved in cell fate commitment GO:0045168 210 0.012
retina development in camera type eye GO:0060041 4 0.012
catechol containing compound metabolic process GO:0009712 10 0.012
serotonin receptor signaling pathway GO:0007210 5 0.012
regionalization GO:0003002 416 0.012
regulation of cell cycle process GO:0010564 181 0.012
developmental maturation GO:0021700 172 0.012
carbohydrate metabolic process GO:0005975 82 0.012
negative regulation of defense response GO:0031348 35 0.012
positive regulation of organelle organization GO:0010638 65 0.012
regulation of transferase activity GO:0051338 58 0.012
regulation of epithelial cell migration open tracheal system GO:2000274 11 0.012
developmental cell growth GO:0048588 52 0.012
cellular response to biotic stimulus GO:0071216 4 0.012
regulation of protein transport GO:0051223 57 0.012
positive regulation of transcription dna templated GO:0045893 266 0.012
secondary metabolic process GO:0019748 75 0.012
regulation of cellular protein metabolic process GO:0032268 243 0.012
lipid catabolic process GO:0016042 21 0.012
central complex development GO:0048036 9 0.012
lipid biosynthetic process GO:0008610 46 0.011
regulation of antibacterial peptide production GO:0002786 22 0.011
positive regulation of nucleoside metabolic process GO:0045979 47 0.011
embryonic pattern specification GO:0009880 174 0.011
negative regulation of multicellular organismal process GO:0051241 142 0.011
positive regulation of developmental growth GO:0048639 62 0.011
regulation of cell cycle GO:0051726 291 0.011
digestive system development GO:0055123 149 0.011
negative regulation of cell death GO:0060548 81 0.011
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.011
regulation of small gtpase mediated signal transduction GO:0051056 93 0.011
male mating behavior GO:0060179 70 0.011
rac protein signal transduction GO:0016601 3 0.011
pigment metabolic process GO:0042440 84 0.011
regulation of neuron apoptotic process GO:0043523 16 0.011
purine containing compound metabolic process GO:0072521 155 0.011
response to peptide hormone GO:0043434 29 0.011
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 24 0.011
epithelium migration GO:0090132 148 0.011
circadian rhythm GO:0007623 105 0.011
cellular protein localization GO:0034613 160 0.011
cytoplasmic transport GO:0016482 130 0.011
courtship behavior GO:0007619 68 0.011
regulation of defense response GO:0031347 102 0.011
histolysis GO:0007559 102 0.011
single organism carbohydrate metabolic process GO:0044723 72 0.010
dorsal ventral axon guidance GO:0033563 2 0.010
response to peptide GO:1901652 29 0.010
signal transduction by phosphorylation GO:0023014 107 0.010
cell adhesion GO:0007155 136 0.010
Mouse
oxoacid metabolic process GO:0043436 103 0.010
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.010
organophosphate metabolic process GO:0019637 195 0.010
regulation of phosphorylation GO:0042325 147 0.010
positive regulation of transport GO:0051050 92 0.010
regulation of neurogenesis GO:0050767 158 0.010
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.010
regulation of glial cell differentiation GO:0045685 1 0.010
hemocyte differentiation GO:0042386 38 0.010

Gef64C disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.021
nervous system disease DOID:863 0 0.021
sensory system disease DOID:0050155 0 0.011
eye and adnexa disease DOID:1492 0 0.011
eye disease DOID:5614 0 0.011