Drosophila melanogaster

25 known processes

msl-2 (Dmel_CG3241)

male-specific lethal 2

(Aliases: MSL-2,Dmel\CG3241,Msl2,MSL2,msl,CG3241,Msl-2,kmA,MSL,msl2,Msl 1-3,km(2)A)

msl-2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
histone h4 k16 acetylation GO:0043984 4 0.894
Human
histone h4 acetylation GO:0043967 13 0.581
Human
negative regulation of gene expression epigenetic GO:0045814 77 0.450
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.293
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.287
positive regulation of gene expression GO:0010628 290 0.257
negative regulation of gene expression GO:0010629 387 0.232
dosage compensation GO:0007549 16 0.220
positive regulation of cellular biosynthetic process GO:0031328 316 0.208
chromatin silencing GO:0006342 76 0.198
negative regulation of nucleic acid templated transcription GO:1903507 240 0.190
positive regulation of biosynthetic process GO:0009891 316 0.172
positive regulation of transcription dna templated GO:0045893 266 0.166
negative regulation of cellular metabolic process GO:0031324 382 0.161
negative regulation of rna biosynthetic process GO:1902679 240 0.132
peptidyl lysine acetylation GO:0018394 39 0.129
Human
peptidyl lysine modification GO:0018205 57 0.127
Human
negative regulation of chromatin silencing GO:0031936 9 0.127
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.123
regulation of gene silencing GO:0060968 63 0.115
negative regulation of biosynthetic process GO:0009890 277 0.106
regulation of chromatin silencing GO:0031935 36 0.103
internal peptidyl lysine acetylation GO:0018393 38 0.102
Human
protein modification process GO:0036211 438 0.099
internal protein amino acid acetylation GO:0006475 38 0.099
Human
positive regulation of rna metabolic process GO:0051254 271 0.099
negative regulation of cellular biosynthetic process GO:0031327 277 0.087
posttranscriptional regulation of gene expression GO:0010608 145 0.084
negative regulation of transcription dna templated GO:0045892 237 0.073
protein acylation GO:0043543 42 0.069
Human
positive regulation of macromolecule metabolic process GO:0010604 405 0.068
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.068
positive regulation of rna biosynthetic process GO:1902680 266 0.067
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.066
positive regulation of nucleic acid templated transcription GO:1903508 266 0.065
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.063
regulation of gene expression epigenetic GO:0040029 128 0.062
chromatin modification GO:0016568 147 0.061
Human
positive regulation of gene expression epigenetic GO:0045815 16 0.060
positive regulation of response to stimulus GO:0048584 323 0.060
axon cargo transport GO:0008088 29 0.053
regionalization GO:0003002 416 0.052
sensory perception of chemical stimulus GO:0007606 116 0.050
synaptic transmission GO:0007268 288 0.048
sex determination GO:0007530 18 0.045
negative regulation of rna metabolic process GO:0051253 251 0.045
smoothened signaling pathway GO:0007224 49 0.044
covalent chromatin modification GO:0016569 106 0.044
Human
mrna splicing via spliceosome GO:0000398 73 0.043
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 18 0.043
cell death GO:0008219 279 0.042
histone modification GO:0016570 106 0.042
Human
protein acetylation GO:0006473 39 0.041
Human
anterograde axon cargo transport GO:0008089 6 0.040
cellular protein modification process GO:0006464 438 0.040
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.038
regulation of immune system process GO:0002682 176 0.038
chromatin organization GO:0006325 207 0.037
Human
negative regulation of cell communication GO:0010648 223 0.034
chromatin assembly or disassembly GO:0006333 52 0.034
programmed cell death GO:0012501 257 0.033
cell proliferation GO:0008283 299 0.033
male mating behavior GO:0060179 70 0.033
rna splicing GO:0008380 83 0.033
organelle fission GO:0048285 340 0.033
body morphogenesis GO:0010171 2 0.033
regulation of cellular amino acid metabolic process GO:0006521 0 0.031
chromosome organization GO:0051276 360 0.031
Human
transmembrane transport GO:0055085 139 0.031
cellular homeostasis GO:0019725 80 0.031
histone acetylation GO:0016573 38 0.029
Human
mating GO:0007618 120 0.029
chromatin remodeling GO:0006338 72 0.028
regulation of alternative mrna splicing via spliceosome GO:0000381 60 0.028
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 38 0.028
zinc ion homeostasis GO:0055069 6 0.027
appendage morphogenesis GO:0035107 397 0.027
wing disc morphogenesis GO:0007472 344 0.026
eye photoreceptor cell development GO:0042462 81 0.026
regulation of intracellular signal transduction GO:1902531 236 0.025
cellular response to chemical stimulus GO:0070887 199 0.025
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 73 0.025
cellular catabolic process GO:0044248 372 0.025
growth GO:0040007 359 0.025
positive regulation of cell communication GO:0010647 250 0.025
immune system process GO:0002376 347 0.024
neurological system process GO:0050877 358 0.024
peptidyl amino acid modification GO:0018193 105 0.023
Human
regulation of response to external stimulus GO:0032101 115 0.023
establishment of synaptic vesicle localization GO:0097480 50 0.023
negative regulation of response to stimulus GO:0048585 258 0.023
eye photoreceptor cell differentiation GO:0001754 145 0.022
rna processing GO:0006396 147 0.022
organic acid metabolic process GO:0006082 103 0.022
imaginal disc derived wing morphogenesis GO:0007476 337 0.021
small molecule metabolic process GO:0044281 305 0.021
male courtship behavior veined wing generated song production GO:0045433 20 0.021
positive regulation of peptidase activity GO:0010952 29 0.021
regulation of cell cycle process GO:0010564 181 0.021
macromolecular complex assembly GO:0065003 256 0.020
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 65 0.020
alternative mrna splicing via spliceosome GO:0000380 60 0.020
defense response GO:0006952 300 0.020
response to pain GO:0048265 3 0.020
homeostatic process GO:0042592 199 0.020
oxoacid metabolic process GO:0043436 103 0.019
positive regulation of cysteine type endopeptidase activity GO:2001056 24 0.019
gene silencing GO:0016458 138 0.019
positive regulation of signal transduction GO:0009967 223 0.019
positive regulation of signaling GO:0023056 243 0.019
synaptic vesicle localization GO:0097479 53 0.019
death GO:0016265 284 0.019
regulation of response to stress GO:0080134 200 0.019
compound eye development GO:0048749 307 0.018
photoreceptor cell differentiation GO:0046530 170 0.018
organic substance catabolic process GO:1901575 308 0.018
mrna metabolic process GO:0016071 124 0.018
developmental growth GO:0048589 280 0.018
mitotic cell cycle checkpoint GO:0007093 88 0.017
regulation of cellular ketone metabolic process GO:0010565 3 0.017
catabolic process GO:0009056 409 0.017
female meiotic division GO:0007143 70 0.017
spindle organization GO:0007051 253 0.017
translation GO:0006412 69 0.017
vesicle mediated transport GO:0016192 381 0.016
response to organic substance GO:0010033 284 0.016
stem cell differentiation GO:0048863 117 0.016
carbohydrate derivative metabolic process GO:1901135 217 0.016
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.016
chromosome segregation GO:0007059 157 0.016
carboxylic acid metabolic process GO:0019752 92 0.016
limb development GO:0060173 1 0.016
regulation of rna splicing GO:0043484 69 0.015
negative regulation of smoothened signaling pathway GO:0045879 16 0.015
axonogenesis GO:0007409 290 0.015
negative regulation of neuron apoptotic process GO:0043524 14 0.015
establishment of vesicle localization GO:0051650 51 0.015
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 23 0.015
cation transmembrane transport GO:0098655 88 0.015
compound eye photoreceptor cell differentiation GO:0001751 140 0.015
appendage development GO:0048736 401 0.015
male courtship behavior veined wing extension GO:0048065 22 0.015
negative regulation of cellular response to oxidative stress GO:1900408 1 0.015
regulation of cellular amine metabolic process GO:0033238 3 0.015
response to abiotic stimulus GO:0009628 341 0.015
reproductive system development GO:0061458 74 0.015
vesicle localization GO:0051648 55 0.015
rna splicing via transesterification reactions GO:0000375 73 0.015
limb morphogenesis GO:0035108 1 0.015
regulation of cellular response to stress GO:0080135 89 0.015
ion transmembrane transport GO:0034220 122 0.015
response to other organism GO:0051707 293 0.015
imaginal disc derived appendage development GO:0048737 399 0.015
female meiosis chromosome segregation GO:0016321 33 0.015
endocytosis GO:0006897 310 0.015
organic cyclic compound catabolic process GO:1901361 168 0.015
male courtship behavior GO:0008049 63 0.014
enzyme linked receptor protein signaling pathway GO:0007167 179 0.014
sensory perception GO:0007600 196 0.014
somatic muscle development GO:0007525 66 0.014
aromatic compound catabolic process GO:0019439 166 0.014
chemical homeostasis GO:0048878 92 0.014
protein complex biogenesis GO:0070271 201 0.014
response to lipopolysaccharide GO:0032496 4 0.014
post embryonic appendage morphogenesis GO:0035120 385 0.014
cellular ketone metabolic process GO:0042180 24 0.014
meiotic cell cycle GO:0051321 171 0.014
learning GO:0007612 75 0.014
defense response to other organism GO:0098542 225 0.014
regulation of notch signaling pathway GO:0008593 100 0.014
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.013
regulation of molecular function GO:0065009 217 0.013
ommochrome biosynthetic process GO:0006727 19 0.013
inorganic ion transmembrane transport GO:0098660 73 0.013
dna integrity checkpoint GO:0031570 81 0.013
heterochromatin assembly GO:0031507 13 0.013
regulation of phosphate metabolic process GO:0019220 210 0.013
single organism membrane organization GO:0044802 93 0.013
phosphorylation GO:0016310 294 0.013
posttranscriptional gene silencing GO:0016441 46 0.013
microtubule based transport GO:0010970 42 0.013
l glutamate import GO:0051938 1 0.013
positive regulation of endopeptidase activity GO:0010950 26 0.013
dna metabolic process GO:0006259 227 0.013
cell growth GO:0016049 108 0.013
immune system development GO:0002520 57 0.013
cell fate determination GO:0001709 91 0.013
dna packaging GO:0006323 91 0.013
indole containing compound biosynthetic process GO:0042435 4 0.013
regulation of mrna metabolic process GO:1903311 72 0.013
regulation of localization GO:0032879 275 0.012
histone exchange GO:0043486 21 0.012
ion homeostasis GO:0050801 55 0.012
heterocycle catabolic process GO:0046700 166 0.012
amine metabolic process GO:0009308 12 0.012
detection of chemical stimulus GO:0009593 93 0.012
regulation of response to oxidative stress GO:1902882 4 0.012
dendrite morphogenesis GO:0048813 199 0.012
axon development GO:0061564 297 0.012
meiotic cell cycle process GO:1903046 132 0.012
g protein coupled receptor signaling pathway GO:0007186 136 0.012
determination of adult lifespan GO:0008340 137 0.012
regulation of mrna splicing via spliceosome GO:0048024 64 0.012
open tracheal system development GO:0007424 204 0.012
response to monosaccharide GO:0034284 4 0.012
cytoskeleton dependent intracellular transport GO:0030705 44 0.012
organonitrogen compound metabolic process GO:1901564 318 0.012
cell junction organization GO:0034330 57 0.012
multi organism reproductive behavior GO:0044705 121 0.012
meiotic chromosome segregation GO:0045132 59 0.012
single fertilization GO:0007338 24 0.011
regulation of endocytosis GO:0030100 37 0.011
developmental growth involved in morphogenesis GO:0060560 65 0.011
cellular component assembly involved in morphogenesis GO:0010927 151 0.011
golgi vesicle transport GO:0048193 27 0.011
respiratory system development GO:0060541 213 0.011
behavioral response to ethanol GO:0048149 49 0.011
regulation of protein metabolic process GO:0051246 256 0.011
cellular nitrogen compound catabolic process GO:0044270 165 0.011
transcription from rna polymerase ii promoter GO:0006366 368 0.011
connective tissue development GO:0061448 3 0.011
protein prenylation GO:0018342 3 0.011
morphogenesis of embryonic epithelium GO:0016331 94 0.011
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 4 0.011
lipid metabolic process GO:0006629 121 0.011
single organism catabolic process GO:0044712 228 0.011
negative regulation of cell differentiation GO:0045596 143 0.011
nucleotide excision repair GO:0006289 8 0.011
imaginal disc derived wing vein specification GO:0007474 48 0.011
nucleoside triphosphate catabolic process GO:0009143 108 0.011
response to bacterium GO:0009617 198 0.011
mrna processing GO:0006397 104 0.011
stem cell division GO:0017145 69 0.011
response to starvation GO:0042594 97 0.011
meiosis i GO:0007127 59 0.011
establishment of localization in cell GO:0051649 402 0.011
regulation of cell cycle GO:0051726 291 0.011
regulation of smoothened signaling pathway GO:0008589 28 0.011
regulation of mrna processing GO:0050684 71 0.011
gland morphogenesis GO:0022612 145 0.011
bmp signaling pathway GO:0030509 27 0.011
apoptotic process involved in morphogenesis GO:0060561 3 0.010
defense response to bacterium GO:0042742 178 0.010
cell cycle checkpoint GO:0000075 95 0.010
posttranscriptional gene silencing by rna GO:0035194 45 0.010
ovarian follicle cell stalk formation GO:0030713 17 0.010
dna damage checkpoint GO:0000077 78 0.010
photoreceptor cell development GO:0042461 96 0.010
stress activated protein kinase signaling cascade GO:0031098 55 0.010
establishment of organelle localization GO:0051656 122 0.010
negative regulation of neuron death GO:1901215 18 0.010
signal transduction by phosphorylation GO:0023014 107 0.010
imaginal disc growth GO:0007446 37 0.010
midgut development GO:0007494 23 0.010
cell projection assembly GO:0030031 94 0.010
cell fate specification GO:0001708 71 0.010
regulation of cell substrate adhesion GO:0010810 2 0.010
cell division GO:0051301 248 0.010

msl-2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.036
disease of metabolism DOID:0014667 0 0.018
cancer DOID:162 0 0.017
disease of cellular proliferation DOID:14566 0 0.017
organ system cancer DOID:0050686 0 0.017
cardiovascular system disease DOID:1287 0 0.013
acquired metabolic disease DOID:0060158 0 0.012
nervous system disease DOID:863 0 0.011
musculoskeletal system disease DOID:17 0 0.010