Drosophila melanogaster

16 known processes

Smc5 (Dmel_CG32438)

CG32438 gene product from transcript CG32438-RE

(Aliases: SMC5,DmSMC5,Dmel\CG32438,CG32438,CG7783)

Smc5 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
dna repair GO:0006281 54 0.884
mitotic recombination GO:0006312 2 0.489
dna metabolic process GO:0006259 227 0.486
response to uv GO:0009411 24 0.373
mitotic dna damage checkpoint GO:0044773 74 0.372
cellular response to dna damage stimulus GO:0006974 223 0.350
regulation of response to stress GO:0080134 200 0.297
recombinational repair GO:0000725 13 0.281
negative regulation of cellular metabolic process GO:0031324 382 0.268
regulation of mitotic cell cycle GO:0007346 190 0.265
double strand break repair GO:0006302 26 0.263
response to radiation GO:0009314 155 0.256
mitotic g2 dna damage checkpoint GO:0007095 69 0.249
negative regulation of cell cycle phase transition GO:1901988 103 0.222
double strand break repair via homologous recombination GO:0000724 13 0.212
dna double strand break processing GO:0000729 3 0.194
g2 dna damage checkpoint GO:0031572 69 0.183
dna recombination GO:0006310 32 0.174
response to alkaloid GO:0043279 26 0.167
chromosome organization GO:0051276 360 0.159
dna damage checkpoint GO:0000077 78 0.153
regulation of cellular response to stress GO:0080135 89 0.151
response to abiotic stimulus GO:0009628 341 0.149
regulation of mitotic cell cycle phase transition GO:1901990 130 0.148
cellular macromolecule catabolic process GO:0044265 136 0.143
dna duplex unwinding GO:0032508 16 0.142
dna conformation change GO:0071103 105 0.134
regulation of dna recombination GO:0000018 4 0.134
double strand break repair via synthesis dependent strand annealing GO:0045003 6 0.127
nucleotide excision repair GO:0006289 8 0.119
response to light stimulus GO:0009416 124 0.117
mitotic cell cycle phase transition GO:0044772 138 0.111
cell cycle checkpoint GO:0000075 95 0.090
regulation of dna repair GO:0006282 5 0.090
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.089
response to ionizing radiation GO:0010212 32 0.087
mitotic nuclear division GO:0007067 213 0.085
nucleobase containing compound catabolic process GO:0034655 165 0.085
macromolecule catabolic process GO:0009057 161 0.083
aromatic compound catabolic process GO:0019439 166 0.082
organic substance catabolic process GO:1901575 308 0.081
homeostatic process GO:0042592 199 0.081
mitotic dna integrity checkpoint GO:0044774 75 0.081
cellular catabolic process GO:0044248 372 0.079
dna catabolic process GO:0006308 16 0.077
chromatin silencing GO:0006342 76 0.076
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.075
small molecule metabolic process GO:0044281 305 0.075
meiosis i GO:0007127 59 0.074
telomere maintenance GO:0000723 21 0.072
postreplication repair GO:0006301 2 0.072
cell proliferation GO:0008283 299 0.068
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.068
exocrine system development GO:0035272 162 0.065
cellular response to abiotic stimulus GO:0071214 58 0.064
regulation of response to dna damage stimulus GO:2001020 23 0.064
regulation of cell cycle GO:0051726 291 0.063
cellular response to chemical stimulus GO:0070887 199 0.061
translesion synthesis GO:0019985 2 0.061
catabolic process GO:0009056 409 0.059
regulation of gene expression epigenetic GO:0040029 128 0.059
programmed cell death GO:0012501 257 0.059
double strand break repair via nonhomologous end joining GO:0006303 5 0.057
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.052
negative regulation of cellular biosynthetic process GO:0031327 277 0.052
cellular response to radiation GO:0071478 52 0.051
protein catabolic process GO:0030163 101 0.050
response to nitrogen compound GO:1901698 90 0.049
proteolysis GO:0006508 192 0.048
regulation of cellular protein metabolic process GO:0032268 243 0.047
anatomical structure homeostasis GO:0060249 97 0.047
regionalization GO:0003002 416 0.046
cell aging GO:0007569 2 0.045
negative regulation of biosynthetic process GO:0009890 277 0.045
innate immune response GO:0045087 144 0.045
response to purine containing compound GO:0014074 12 0.045
salivary gland development GO:0007431 162 0.044
dna replication GO:0006260 48 0.044
death GO:0016265 284 0.044
protein modification by small protein conjugation or removal GO:0070647 106 0.042
cellular protein modification process GO:0006464 438 0.040
organic cyclic compound catabolic process GO:1901361 168 0.040
reciprocal meiotic recombination GO:0007131 19 0.039
behavioral response to ethanol GO:0048149 49 0.038
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.038
regulation of cell development GO:0060284 215 0.037
protein modification process GO:0036211 438 0.036
response to organic cyclic compound GO:0014070 89 0.036
cellular nitrogen compound catabolic process GO:0044270 165 0.035
meiotic chromosome segregation GO:0045132 59 0.035
heterocycle catabolic process GO:0046700 166 0.034
regulation of protein metabolic process GO:0051246 256 0.034
regulation of cell cycle process GO:0010564 181 0.034
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 11 0.034
negative regulation of mitotic cell cycle GO:0045930 109 0.032
negative regulation of cellular protein metabolic process GO:0032269 85 0.032
telomere maintenance via recombination GO:0000722 1 0.032
central nervous system development GO:0007417 201 0.032
establishment of localization in cell GO:0051649 402 0.032
dna synthesis involved in dna repair GO:0000731 5 0.031
organelle fission GO:0048285 340 0.031
cellular response to ionizing radiation GO:0071479 15 0.030
negative regulation of gene expression GO:0010629 387 0.029
mitotic cell cycle checkpoint GO:0007093 88 0.028
regulation of double strand break repair GO:2000779 3 0.027
regulation of neural precursor cell proliferation GO:2000177 35 0.027
dna geometric change GO:0032392 16 0.026
cellular macromolecule localization GO:0070727 220 0.026
purine ribonucleoside monophosphate catabolic process GO:0009169 38 0.026
regulation of chromatin silencing GO:0031935 36 0.026
glycosyl compound metabolic process GO:1901657 127 0.025
metal ion transport GO:0030001 74 0.025
chromosome separation GO:0051304 42 0.024
regulation of multicellular organismal development GO:2000026 414 0.024
imaginal disc derived appendage morphogenesis GO:0035114 395 0.023
axonogenesis GO:0007409 290 0.023
negative regulation of cell cycle GO:0045786 116 0.022
organophosphate metabolic process GO:0019637 195 0.022
response to organonitrogen compound GO:0010243 75 0.022
single organism biosynthetic process GO:0044711 206 0.022
regulation of defense response GO:0031347 102 0.022
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.022
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.021
negative regulation of response to stimulus GO:0048585 258 0.020
cation transport GO:0006812 110 0.020
nuclear division GO:0000280 332 0.020
vesicle mediated transport GO:0016192 381 0.020
regulation of cell differentiation GO:0045595 302 0.019
dna integrity checkpoint GO:0031570 81 0.019
cation transmembrane transport GO:0098655 88 0.019
body morphogenesis GO:0010171 2 0.019
telomere capping GO:0016233 11 0.019
negative regulation of transcription dna templated GO:0045892 237 0.019
immune response GO:0006955 246 0.018
organonitrogen compound metabolic process GO:1901564 318 0.018
salivary gland cell autophagic cell death GO:0035071 83 0.018
ribonucleotide metabolic process GO:0009259 145 0.018
aging GO:0007568 143 0.018
non recombinational repair GO:0000726 7 0.017
negative regulation of protein metabolic process GO:0051248 85 0.017
single organism behavior GO:0044708 391 0.017
mitotic g2 m transition checkpoint GO:0044818 70 0.017
regulation of gene silencing GO:0060968 63 0.017
gene silencing GO:0016458 138 0.017
cell death GO:0008219 279 0.017
negative regulation of developmental process GO:0051093 201 0.017
meiotic cell cycle process GO:1903046 132 0.016
dorsal ventral pattern formation GO:0009953 133 0.016
gland development GO:0048732 191 0.016
intracellular transport GO:0046907 228 0.016
ribonucleoside metabolic process GO:0009119 127 0.016
negative regulation of dna recombination GO:0045910 2 0.016
reciprocal dna recombination GO:0035825 19 0.016
negative regulation of cell cycle process GO:0010948 109 0.015
regulation of cell proliferation GO:0042127 163 0.015
rna localization GO:0006403 115 0.015
sex determination GO:0007530 18 0.015
negative regulation of nucleic acid templated transcription GO:1903507 240 0.015
dna packaging GO:0006323 91 0.015
establishment of protein localization GO:0045184 163 0.014
cell cycle phase transition GO:0044770 140 0.014
positive regulation of macromolecule metabolic process GO:0010604 405 0.014
gland morphogenesis GO:0022612 145 0.014
protein ubiquitination GO:0016567 70 0.014
regulation of immune system process GO:0002682 176 0.014
signal transduction in response to dna damage GO:0042770 3 0.014
ion transport GO:0006811 145 0.014
ribonucleoside catabolic process GO:0042454 112 0.013
nucleoside phosphate metabolic process GO:0006753 162 0.013
cellular protein catabolic process GO:0044257 83 0.013
regulation of dna metabolic process GO:0051052 34 0.013
mitotic sister chromatid segregation GO:0000070 87 0.013
tissue morphogenesis GO:0048729 297 0.013
response to organic substance GO:0010033 284 0.013
dendrite development GO:0016358 204 0.013
endocytosis GO:0006897 310 0.013
oxoacid metabolic process GO:0043436 103 0.013
positive regulation of gene expression GO:0010628 290 0.013
positive regulation of cellular biosynthetic process GO:0031328 316 0.012
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.012
regulation of programmed cell death GO:0043067 152 0.012
meiotic cell cycle GO:0051321 171 0.012
ribose phosphate metabolic process GO:0019693 145 0.012
defense response GO:0006952 300 0.012
regulation of cell division GO:0051302 72 0.012
regulation of apoptotic process GO:0042981 130 0.012
negative regulation of cell differentiation GO:0045596 143 0.012
dorsal ventral axis specification GO:0009950 66 0.011
regulation of innate immune response GO:0045088 71 0.011
negative regulation of dna metabolic process GO:0051053 12 0.011
imaginal disc derived wing morphogenesis GO:0007476 337 0.011
negative regulation of cell death GO:0060548 81 0.011
negative regulation of cell development GO:0010721 62 0.011
positive regulation of mitotic cell cycle GO:0045931 34 0.011
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.011
cellular response to oxygen containing compound GO:1901701 79 0.011
meiotic nuclear division GO:0007126 151 0.011
chromatin remodeling GO:0006338 72 0.011
purine nucleoside catabolic process GO:0006152 112 0.011
regulation of cell death GO:0010941 173 0.011
histolysis GO:0007559 102 0.011
immune system process GO:0002376 347 0.011
nucleotide metabolic process GO:0009117 161 0.010
macromolecular complex assembly GO:0065003 256 0.010
alternative mrna splicing via spliceosome GO:0000380 60 0.010
salivary gland morphogenesis GO:0007435 145 0.010
nucleobase containing small molecule metabolic process GO:0055086 174 0.010
negative regulation of cell communication GO:0010648 223 0.010
purine nucleoside monophosphate catabolic process GO:0009128 38 0.010
regulation of phosphorus metabolic process GO:0051174 210 0.010
positive regulation of response to stimulus GO:0048584 323 0.010
sister chromatid segregation GO:0000819 92 0.010
regulation of peptidase activity GO:0052547 39 0.010
muscle organ development GO:0007517 127 0.010

Smc5 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.024
disease of cellular proliferation DOID:14566 0 0.024