Drosophila melanogaster

39 known processes

Sk2 (Dmel_CG32484)

Sphingosine kinase 2

(Aliases: Dmel\CG32484,Sphk2,CG32484,CG2159,SK2)

Sk2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
protein modification process GO:0036211 438 0.380
regulation of phosphorus metabolic process GO:0051174 210 0.283
cellular protein modification process GO:0006464 438 0.229
locomotory behavior GO:0007626 176 0.199
intracellular signal transduction GO:0035556 300 0.189
epithelial cell differentiation GO:0030855 322 0.184
positive regulation of cell communication GO:0010647 250 0.163
Worm
sensory organ morphogenesis GO:0090596 260 0.149
regulation of nervous system development GO:0051960 248 0.113
organophosphate metabolic process GO:0019637 195 0.112
organonitrogen compound metabolic process GO:1901564 318 0.106
positive regulation of signaling GO:0023056 243 0.101
Worm
positive regulation of response to stimulus GO:0048584 323 0.098
central nervous system development GO:0007417 201 0.082
Mouse
phosphorylation GO:0016310 294 0.082
positive regulation of phosphate metabolic process GO:0045937 139 0.079
appendage morphogenesis GO:0035107 397 0.079
compound eye morphogenesis GO:0001745 249 0.075
negative regulation of cellular metabolic process GO:0031324 382 0.074
cellular lipid metabolic process GO:0044255 83 0.072
small molecule metabolic process GO:0044281 305 0.069
Mouse
oxoacid metabolic process GO:0043436 103 0.069
wing disc morphogenesis GO:0007472 344 0.067
brain development GO:0007420 120 0.065
Mouse
establishment of localization in cell GO:0051649 402 0.064
Worm
positive regulation of phosphorus metabolic process GO:0010562 139 0.062
transcription from rna polymerase ii promoter GO:0006366 368 0.062
organonitrogen compound biosynthetic process GO:1901566 117 0.061
carboxylic acid metabolic process GO:0019752 92 0.060
regulation of catabolic process GO:0009894 170 0.059
endocytosis GO:0006897 310 0.057
negative regulation of response to stimulus GO:0048585 258 0.057
chromatin modification GO:0016568 147 0.057
lipid metabolic process GO:0006629 121 0.055
cognition GO:0050890 141 0.055
regulation of protein metabolic process GO:0051246 256 0.055
compound eye development GO:0048749 307 0.055
morphogenesis of an epithelium GO:0002009 276 0.054
post embryonic appendage morphogenesis GO:0035120 385 0.054
negative regulation of signal transduction GO:0009968 206 0.053
regulation of cell differentiation GO:0045595 302 0.053
cellular catabolic process GO:0044248 372 0.052
ribose phosphate metabolic process GO:0019693 145 0.050
stem cell differentiation GO:0048863 117 0.049
regulation of intracellular signal transduction GO:1902531 236 0.049
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.047
regulation of multicellular organismal development GO:2000026 414 0.046
negative regulation of multicellular organismal process GO:0051241 142 0.046
imaginal disc derived appendage development GO:0048737 399 0.046
single organism catabolic process GO:0044712 228 0.045
imaginal disc derived wing morphogenesis GO:0007476 337 0.045
carbohydrate derivative metabolic process GO:1901135 217 0.043
imaginal disc derived appendage morphogenesis GO:0035114 395 0.043
telencephalon development GO:0021537 2 0.043
adult locomotory behavior GO:0008344 76 0.043
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.043
appendage development GO:0048736 401 0.042
positive regulation of macromolecule metabolic process GO:0010604 405 0.042
ras protein signal transduction GO:0007265 88 0.041
single organism biosynthetic process GO:0044711 206 0.041
protein phosphorylation GO:0006468 169 0.040
nucleoside triphosphate catabolic process GO:0009143 108 0.039
organic acid metabolic process GO:0006082 103 0.039
enzyme linked receptor protein signaling pathway GO:0007167 179 0.037
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.036
positive regulation of biosynthetic process GO:0009891 316 0.036
purine nucleotide metabolic process GO:0006163 146 0.035
erbb signaling pathway GO:0038127 58 0.035
regulation of phosphate metabolic process GO:0019220 210 0.035
cellular amine metabolic process GO:0044106 12 0.034
intracellular transport GO:0046907 228 0.033
single organism behavior GO:0044708 391 0.033
purine nucleoside triphosphate metabolic process GO:0009144 119 0.033
nucleoside phosphate metabolic process GO:0006753 162 0.033
response to nutrient levels GO:0031667 114 0.033
positive regulation of signal transduction GO:0009967 223 0.032
eye development GO:0001654 323 0.032
forebrain development GO:0030900 2 0.032
amine metabolic process GO:0009308 12 0.032
response to organic substance GO:0010033 284 0.032
nucleobase containing compound catabolic process GO:0034655 165 0.031
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.031
positive regulation of cellular biosynthetic process GO:0031328 316 0.030
protein localization GO:0008104 284 0.030
organic substance transport GO:0071702 257 0.030
Worm
nucleotide metabolic process GO:0009117 161 0.030
cell motility GO:0048870 251 0.029
regulation of small gtpase mediated signal transduction GO:0051056 93 0.029
epidermal growth factor receptor signaling pathway GO:0007173 58 0.029
establishment or maintenance of cell polarity GO:0007163 167 0.029
guanosine containing compound metabolic process GO:1901068 74 0.028
cellular amino acid metabolic process GO:0006520 61 0.028
positive regulation of intracellular signal transduction GO:1902533 116 0.028
cell proliferation GO:0008283 299 0.028
Mouse
spermatogenesis GO:0007283 200 0.028
germarium derived egg chamber formation GO:0007293 101 0.027
autophagy GO:0006914 108 0.027
small gtpase mediated signal transduction GO:0007264 88 0.027
ion transport GO:0006811 145 0.027
Worm
positive regulation of phosphorylation GO:0042327 87 0.026
nucleobase containing small molecule metabolic process GO:0055086 174 0.026
death GO:0016265 284 0.026
localization of cell GO:0051674 257 0.026
cell death GO:0008219 279 0.025
cellular response to starvation GO:0009267 61 0.025
peptidyl amino acid modification GO:0018193 105 0.025
positive regulation of developmental process GO:0051094 143 0.025
axonogenesis GO:0007409 290 0.025
positive regulation of multicellular organismal process GO:0051240 143 0.024
cell migration GO:0016477 238 0.024
axon development GO:0061564 297 0.024
regulation of cellular catabolic process GO:0031329 157 0.024
purine ribonucleotide metabolic process GO:0009150 145 0.024
regulation of cellular ketone metabolic process GO:0010565 3 0.024
mapk cascade GO:0000165 107 0.024
regulation of ras protein signal transduction GO:0046578 93 0.024
regulation of phosphorylation GO:0042325 147 0.024
regulation of autophagy GO:0010506 62 0.023
positive regulation of rna metabolic process GO:0051254 271 0.023
response to extracellular stimulus GO:0009991 116 0.023
glycosyl compound catabolic process GO:1901658 112 0.023
adult behavior GO:0030534 137 0.023
response to starvation GO:0042594 97 0.023
response to oxygen containing compound GO:1901700 200 0.022
glycosyl compound metabolic process GO:1901657 127 0.022
single organism intracellular transport GO:1902582 207 0.022
positive regulation of catalytic activity GO:0043085 118 0.022
negative regulation of signaling GO:0023057 219 0.022
positive regulation of molecular function GO:0044093 136 0.022
catabolic process GO:0009056 409 0.022
carbohydrate metabolic process GO:0005975 82 0.021
positive regulation of lipid storage GO:0010884 4 0.021
regulation of gtpase activity GO:0043087 44 0.021
response to lipopolysaccharide GO:0032496 4 0.021
eye morphogenesis GO:0048592 260 0.021
chromatin organization GO:0006325 207 0.021
rna processing GO:0006396 147 0.021
positive regulation of gene expression GO:0010628 290 0.021
lipid localization GO:0010876 54 0.021
gland development GO:0048732 191 0.021
regulation of neurogenesis GO:0050767 158 0.021
regulation of mapk cascade GO:0043408 92 0.020
cellular response to extracellular stimulus GO:0031668 64 0.020
gland morphogenesis GO:0022612 145 0.020
negative regulation of phosphorus metabolic process GO:0010563 45 0.020
regulation of apoptotic process GO:0042981 130 0.019
organic substance catabolic process GO:1901575 308 0.019
positive regulation of cellular catabolic process GO:0031331 95 0.019
regulation of cellular protein metabolic process GO:0032268 243 0.019
endomembrane system organization GO:0010256 119 0.019
organophosphate catabolic process GO:0046434 112 0.019
regulation of cell death GO:0010941 173 0.019
programmed cell death GO:0012501 257 0.019
regulation of neurotransmitter levels GO:0001505 38 0.019
Worm
covalent chromatin modification GO:0016569 106 0.019
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.019
purine containing compound catabolic process GO:0072523 112 0.019
ribonucleoside triphosphate metabolic process GO:0009199 119 0.018
regulation of hydrolase activity GO:0051336 97 0.018
aromatic compound catabolic process GO:0019439 166 0.018
secretion GO:0046903 109 0.018
Worm
actin cytoskeleton organization GO:0030036 206 0.018
organonitrogen compound catabolic process GO:1901565 128 0.018
regulation of developmental growth GO:0048638 174 0.018
body morphogenesis GO:0010171 2 0.018
positive regulation of rna biosynthetic process GO:1902680 266 0.018
positive regulation of catabolic process GO:0009896 105 0.018
positive regulation of mapk cascade GO:0043410 63 0.018
oocyte maturation GO:0001556 3 0.018
regulation of response to stress GO:0080134 200 0.018
regulation of molecular function GO:0065009 217 0.018
developmental pigmentation GO:0048066 68 0.018
gtp metabolic process GO:0046039 72 0.018
photoreceptor cell fate commitment GO:0046552 41 0.018
regulation of cell cycle GO:0051726 291 0.017
secretion by cell GO:0032940 101 0.017
Worm
negative regulation of cell death GO:0060548 81 0.017
macromolecule catabolic process GO:0009057 161 0.017
single organism carbohydrate metabolic process GO:0044723 72 0.017
regulation of cellular amino acid metabolic process GO:0006521 0 0.017
negative regulation of cell differentiation GO:0045596 143 0.017
response to lipid GO:0033993 38 0.017
regulation of cellular amine metabolic process GO:0033238 3 0.017
negative regulation of rna metabolic process GO:0051253 251 0.017
skin development GO:0043588 65 0.017
learning or memory GO:0007611 141 0.017
regulation of programmed cell death GO:0043067 152 0.016
detection of light stimulus GO:0009583 58 0.016
eye photoreceptor cell differentiation GO:0001754 145 0.016
vesicle mediated transport GO:0016192 381 0.016
response to abiotic stimulus GO:0009628 341 0.016
regulation of organelle organization GO:0033043 196 0.016
oxidation reduction process GO:0055114 123 0.016
cellular nitrogen compound catabolic process GO:0044270 165 0.016
signal transduction by phosphorylation GO:0023014 107 0.016
positive regulation of protein metabolic process GO:0051247 128 0.015
negative regulation of cell communication GO:0010648 223 0.015
morphogenesis of a polarized epithelium GO:0001738 93 0.015
cellular response to nutrient levels GO:0031669 62 0.015
regulation of catalytic activity GO:0050790 185 0.015
positive regulation of gtpase activity GO:0043547 43 0.015
nucleoside triphosphate metabolic process GO:0009141 120 0.015
positive regulation of purine nucleotide metabolic process GO:1900544 55 0.015
cellular response to lipopolysaccharide GO:0071222 3 0.015
eye antennal disc development GO:0035214 60 0.015
macroautophagy GO:0016236 42 0.015
multi multicellular organism process GO:0044706 123 0.015
response to other organism GO:0051707 293 0.015
regulation of erk1 and erk2 cascade GO:0070372 39 0.015
heterocycle catabolic process GO:0046700 166 0.014
regulation of cytoskeleton organization GO:0051493 89 0.014
negative regulation of cellular protein metabolic process GO:0032269 85 0.014
neurological system process GO:0050877 358 0.014
chaeta development GO:0022416 97 0.014
ethanolamine containing compound metabolic process GO:0042439 4 0.014
positive regulation of transcription dna templated GO:0045893 266 0.014
digestive tract morphogenesis GO:0048546 127 0.014
response to heat GO:0009408 63 0.014
negative regulation of biosynthetic process GO:0009890 277 0.014
organic cyclic compound catabolic process GO:1901361 168 0.014
pigment metabolic process involved in pigmentation GO:0043474 33 0.014
multicellular organismal reproductive behavior GO:0033057 110 0.014
positive regulation of gtp catabolic process GO:0033126 43 0.014
salivary gland cell autophagic cell death GO:0035071 83 0.014
ribonucleotide metabolic process GO:0009259 145 0.014
protein modification by small protein conjugation GO:0032446 79 0.014
regulation of protein modification process GO:0031399 112 0.013
compound eye photoreceptor cell differentiation GO:0001751 140 0.013
embryo development ending in birth or egg hatching GO:0009792 152 0.013
regulation of neuron differentiation GO:0045664 103 0.013
regulation of purine nucleotide catabolic process GO:0033121 48 0.013
mrna metabolic process GO:0016071 124 0.013
glycerophospholipid metabolic process GO:0006650 23 0.013
lipid storage GO:0019915 38 0.013
tube development GO:0035295 244 0.013
organelle localization GO:0051640 148 0.013
negative regulation of protein metabolic process GO:0051248 85 0.013
neuron fate commitment GO:0048663 50 0.013
nuclear body organization GO:0030575 6 0.013
cellular response to organic substance GO:0071310 132 0.013
negative regulation of gene expression GO:0010629 387 0.013
positive regulation of erk1 and erk2 cascade GO:0070374 36 0.012
response to copper ion GO:0046688 4 0.012
carbohydrate derivative biosynthetic process GO:1901137 85 0.012
salivary gland morphogenesis GO:0007435 145 0.012
apoptotic process GO:0006915 159 0.012
glycoprotein biosynthetic process GO:0009101 41 0.012
gtp catabolic process GO:0006184 72 0.012
exocrine system development GO:0035272 162 0.012
phosphatidylethanolamine metabolic process GO:0046337 1 0.012
nucleoside metabolic process GO:0009116 127 0.012
purine ribonucleotide catabolic process GO:0009154 109 0.012
positive regulation of nucleotide catabolic process GO:0030813 46 0.012
ribonucleotide catabolic process GO:0009261 109 0.012
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.012
phagocytosis GO:0006909 215 0.012
regulation of neuron projection development GO:0010975 69 0.012
epithelial cell development GO:0002064 274 0.012
nucleoside phosphate catabolic process GO:1901292 110 0.012
cellular response to dna damage stimulus GO:0006974 223 0.012
regulation of endopeptidase activity GO:0052548 36 0.012
digestive tract development GO:0048565 149 0.012
flight behavior GO:0007629 26 0.011
regulation of nucleoside metabolic process GO:0009118 50 0.011
aging GO:0007568 143 0.011
regulation of cellular component movement GO:0051270 42 0.011
regulation of erbb signaling pathway GO:1901184 42 0.011
notch signaling pathway GO:0007219 120 0.011
immune system development GO:0002520 57 0.011
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.011
female germ line cyst formation GO:0048135 42 0.011
purine containing compound metabolic process GO:0072521 155 0.011
rna 3 end processing GO:0031123 45 0.011
ribonucleoside triphosphate catabolic process GO:0009203 108 0.011
regulation of phosphatidylinositol 3 kinase signaling GO:0014066 4 0.011
developmental growth GO:0048589 280 0.011
purine nucleotide catabolic process GO:0006195 109 0.011
regulation of mrna metabolic process GO:1903311 72 0.011
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.011
compound eye photoreceptor fate commitment GO:0001752 36 0.011
regulation of gtp catabolic process GO:0033124 44 0.011
response to organic cyclic compound GO:0014070 89 0.011
eye photoreceptor cell fate commitment GO:0042706 37 0.011
salivary gland development GO:0007431 162 0.011
neurotransmitter transport GO:0006836 37 0.011
Worm
positive regulation of nucleotide metabolic process GO:0045981 55 0.011
positive regulation of transport GO:0051050 92 0.011
Worm
protein transport GO:0015031 155 0.011
regulation of nucleotide metabolic process GO:0006140 62 0.010
guanosine containing compound catabolic process GO:1901069 74 0.010
gliogenesis GO:0042063 80 0.010
glycoprotein metabolic process GO:0009100 41 0.010
ovarian follicle cell migration GO:0007297 121 0.010
spindle organization GO:0007051 253 0.010
purine nucleoside catabolic process GO:0006152 112 0.010
regulation of cell motility GO:2000145 23 0.010
synaptic transmission GO:0007268 288 0.010
Worm
regulation of cell development GO:0060284 215 0.010
regulation of multi organism process GO:0043900 131 0.010
regulation of protein phosphorylation GO:0001932 64 0.010
mrna 3 end processing GO:0031124 28 0.010
long chain fatty acid metabolic process GO:0001676 3 0.010
positive regulation of cell death GO:0010942 69 0.010
regulation of cell migration GO:0030334 22 0.010
mrna processing GO:0006397 104 0.010

Sk2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.029
nervous system disease DOID:863 0 0.029